KR102497070B1 - 고효능 글루코코르티코이드의 설계를 위한 구조 및 메커니즘 - Google Patents

고효능 글루코코르티코이드의 설계를 위한 구조 및 메커니즘 Download PDF

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KR102497070B1
KR102497070B1 KR1020197013291A KR20197013291A KR102497070B1 KR 102497070 B1 KR102497070 B1 KR 102497070B1 KR 1020197013291 A KR1020197013291 A KR 1020197013291A KR 20197013291 A KR20197013291 A KR 20197013291A KR 102497070 B1 KR102497070 B1 KR 102497070B1
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KR20190068577A (ko
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화창 에릭 쉬
위안정 허
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반 안델 리서치 인스티튜트
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C07J71/0047—Nitrogen only at position 2(3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020197013291A 2016-10-14 2017-10-13 고효능 글루코코르티코이드의 설계를 위한 구조 및 메커니즘 Active KR102497070B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662408314P 2016-10-14 2016-10-14
US62/408,314 2016-10-14
PCT/US2017/056447 WO2018071736A1 (en) 2016-10-14 2017-10-13 Structures and mechanism for the design of highly potent glucocorticoids

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KR20190068577A KR20190068577A (ko) 2019-06-18
KR102497070B1 true KR102497070B1 (ko) 2023-02-06

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US (1) US10954265B2 (https=)
EP (1) EP3525870B1 (https=)
JP (2) JP7146750B2 (https=)
KR (1) KR102497070B1 (https=)
CN (1) CN110382033B (https=)
ES (1) ES2945983T3 (https=)
MA (1) MA46539A (https=)
PH (1) PH12019500801A1 (https=)
RU (1) RU2019111101A (https=)
SG (1) SG11201903209TA (https=)
WO (1) WO2018071736A1 (https=)
ZA (1) ZA201902595B (https=)

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WO2025119398A1 (zh) * 2023-12-08 2025-06-12 浙江柏拉阿图医药科技有限公司 高效力糖皮质激素多晶型及其制备方法和用途
WO2025157225A1 (zh) * 2024-01-24 2025-07-31 浙江柏拉阿图医药科技有限公司 一种高效力糖皮质激素化合物及其制备和用途

Citations (1)

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US20100256105A1 (en) * 2009-04-03 2010-10-07 Astrazeneca R&D Novel compounds

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DK66202C (da) 1945-03-03 1948-01-12 Danske Securitas As Kodekontakt til elektriske Alarmanlæg.
DK71662C (da) 1946-09-05 1950-11-06 Ingenioer Frank Broadbent Tørrecentrifuge.
US4049813A (en) 1976-07-15 1977-09-20 Sandoz, Inc. Substituted isoxazolo pyridinones
US5837698A (en) * 1996-05-02 1998-11-17 G. D. Searle & Co. Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
CA2451057A1 (en) 2001-06-14 2002-12-27 Banyu Pharmaceutical Co., Ltd. Novel isoxazolopyridone derivatives and use thereof
GB0119911D0 (en) 2001-08-15 2001-10-10 Novartis Ag Organic Compounds
WO2005048927A2 (en) * 2003-11-13 2005-06-02 Combinatorx, Incorporated Methods and reagents for the treatment of inflammatory disorders
EP1940863B1 (en) * 2005-09-02 2012-09-05 Nicox S.A. Nitrooxy derivatives of glucocorticoids
CN1813768A (zh) * 2005-11-18 2006-08-09 成都力思特制药股份有限公司 治疗呼吸系统疾病的药用组合物及其在制药中的应用
NZ584160A (en) 2007-10-04 2011-05-27 Astrazeneca Ab Steroidal [3,2-c] pyrazole compounds, with glucocorticoid activity
CN101945885A (zh) * 2007-12-20 2011-01-12 阿斯利康(瑞典)有限公司 用作糖皮质激素受体激动剂的甾类衍生物
CA2749585A1 (en) 2009-01-13 2010-07-22 Van Andel Research Institute Methods of using substituted isoxazolo pyridinones as dissociated glucocorticoids
UY32520A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
UY32525A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
JP2012530140A (ja) * 2009-06-16 2012-11-29 メルク・シャープ・アンド・ドーム・コーポレーション グルココルチコイド受容体アゴニストとしての新規［３，２−ｃ］ヘテロアリールステロイド、組成物およびこの使用
JP2016531852A (ja) * 2013-09-25 2016-10-13 ヴァン アンデル リサーチ インスティテュート 非常に強力なグルココルチコイド
TWI695831B (zh) * 2014-09-13 2020-06-11 香港商南北兄弟藥業投資有限公司 Ｃｒｔｈ２拮抗劑化合物及其用途

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100256105A1 (en) * 2009-04-03 2010-10-07 Astrazeneca R&D Novel compounds

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JP2022132464A (ja) 2022-09-08
RU2019111101A3 (https=) 2020-11-27
JP7146750B2 (ja) 2022-10-04
US10954265B2 (en) 2021-03-23
MA46539A (fr) 2019-08-21
EP3525870A4 (en) 2020-04-29
WO2018071736A9 (en) 2019-05-23
EP3525870A1 (en) 2019-08-21
CN110382033A (zh) 2019-10-25
WO2018071736A1 (en) 2018-04-19
ZA201902595B (en) 2021-04-28
SG11201903209TA (en) 2019-05-30
KR20190068577A (ko) 2019-06-18
CN110382033B (zh) 2022-04-15
PH12019500801A1 (en) 2019-11-11
RU2019111101A (ru) 2020-11-16
EP3525870B1 (en) 2023-05-10
US20190263853A1 (en) 2019-08-29
ES2945983T3 (es) 2023-07-11
JP2019532071A (ja) 2019-11-07

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