KR102494596B1 - 2-아미노-벤즈이미다졸 유도체 및 5-리폭시게나아제 및/또는 프로스타글란딘 e 합성효소 억제제로서의 이들의 용도 - Google Patents
2-아미노-벤즈이미다졸 유도체 및 5-리폭시게나아제 및/또는 프로스타글란딘 e 합성효소 억제제로서의 이들의 용도 Download PDFInfo
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462031337P | 2014-07-31 | 2014-07-31 | |
| US62/031,337 | 2014-07-31 | ||
| PCT/EP2015/067644 WO2016016421A1 (en) | 2014-07-31 | 2015-07-31 | 2-amino-benzimidazole derivatives and their use as 5-lipoxygenase and/or prostaglandin e synthase inhibitors |
Publications (2)
| Publication Number | Publication Date |
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| KR20170045234A KR20170045234A (ko) | 2017-04-26 |
| KR102494596B1 true KR102494596B1 (ko) | 2023-01-31 |
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| US (1) | US11447486B2 (https=) |
| EP (1) | EP3177597B1 (https=) |
| JP (1) | JP6785217B2 (https=) |
| KR (1) | KR102494596B1 (https=) |
| CN (1) | CN106879256B (https=) |
| AU (1) | AU2015295248B2 (https=) |
| BR (1) | BR112017001918A2 (https=) |
| CA (1) | CA2955565A1 (https=) |
| ES (1) | ES2795748T3 (https=) |
| RU (1) | RU2732416C2 (https=) |
| SG (1) | SG11201700439VA (https=) |
| WO (1) | WO2016016421A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6849197B2 (ja) * | 2016-02-12 | 2021-03-24 | ファーマクシス リミテッド | リジルオキシダーゼのインドールおよびアザインドールハロアリルアミン誘導体阻害剤およびその使用 |
| GB201617630D0 (en) | 2016-10-18 | 2016-11-30 | Cellcentric Ltd | Pharmaceutical compounds |
| CN107141282B (zh) * | 2017-03-29 | 2019-11-05 | 重庆文理学院 | 一种苯并咪唑杂氮环丁酮衍生物及其在抗肿瘤药物中的应用 |
| HRP20250272T1 (hr) | 2017-10-19 | 2025-04-25 | Teijin Pharma Limited | Derivati benzimidazola i njihova uporaba |
| GB201806320D0 (en) | 2018-04-18 | 2018-05-30 | Cellcentric Ltd | Process |
| JP2021534215A (ja) * | 2018-08-24 | 2021-12-09 | ゼニオプロ ゲーエムベーハー | 病的症状の治療における使用のための芳香族分子 |
| EP3939975A4 (en) * | 2019-03-15 | 2022-11-30 | Nippon Soda Co., Ltd. | HETEROCYCLIC COMPOUND AND AGRICULTURAL OR HORTICULTURAL BACTERICIDE |
| EP4081199A4 (en) * | 2019-12-23 | 2024-01-17 | SRI International | LIPOXYGENASE INHIBITORS |
| CN115667224A (zh) * | 2020-02-26 | 2023-01-31 | 斯克里普斯研究学院 | 具有抗炎活性的scl15a4小分子的抑制剂 |
| KR20240035820A (ko) | 2021-07-09 | 2024-03-18 | 플렉시움 인코포레이티드 | Ikzf2를 조절하는 아릴 화합물 및 약학 조성물 |
| WO2023107705A1 (en) | 2021-12-10 | 2023-06-15 | Incyte Corporation | Bicyclic amines as cdk12 inhibitors |
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| WO2005042520A1 (de) * | 2003-10-24 | 2005-05-12 | Merck Patent Gmbh | Benzimidazolylderivate |
| WO2012076672A1 (en) * | 2010-12-10 | 2012-06-14 | Boehringer Ingelheim International Gmbh | 2 -aminobenz imidazole derivatives useful in the treatment of inflammation |
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| DE2730720C2 (de) * | 1977-07-07 | 1979-07-12 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von praktisch reinem l-Amino-8-nitro-43dihydroxy-anthrachinon |
| US4835161A (en) * | 1986-02-03 | 1989-05-30 | Janssen Pharmaceutica N.V. | Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines |
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| GB9825652D0 (en) * | 1998-11-23 | 1999-01-13 | Celltech Therapeutics Ltd | Chemical compounds |
| PA8535601A1 (es) * | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
| EP1429765A2 (en) * | 2001-09-14 | 2004-06-23 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| ES2367422T3 (es) * | 2001-10-09 | 2011-11-03 | Amgen Inc. | Derivados de imidazol como agentes antiinflamatorios. |
| AU2003220970A1 (en) * | 2002-03-01 | 2003-09-16 | Smithkline Beecham Corporation | Diamino-pyrimidines and their use as angiogenesis inhibitors |
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| WO2005079791A1 (en) * | 2004-02-12 | 2005-09-01 | Boehringer Ingelheim Pharmaceuticals, Inc. | Thiophene -2- carboxylic acid - (1h - benzimidazol - 2 yl) - amide derivatives and related compounds as inhibitors of the tec kinase itk (interleukin -2- inducible t cell kinase) for the treatment of inflammation, immunological and allergic disorders |
| AU2005225471B2 (en) | 2004-03-26 | 2011-05-12 | Methylgene Inc. | Inhibitors of histone deacetylase |
| CN101489553A (zh) | 2006-07-03 | 2009-07-22 | 神经研究公司 | 单胺再摄取抑制剂和钾通道激活剂的组合 |
| JP2009542604A (ja) | 2006-07-06 | 2009-12-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 4−ヘテロシクロアルキルピリミジン、それらの調製方法及び医薬としての使用 |
| EP2471507B1 (en) | 2006-09-29 | 2017-03-01 | Johnson & Johnson Vision Care, Inc. | Ophthalmic devices used in the treatment of ocular allergies |
| AR074343A1 (es) | 2008-11-14 | 2011-01-12 | Amgen Inc | Derivados de piridina y pirimidina como inhibidores de la fosfodiesterasa 10 |
| CN101955483A (zh) | 2009-07-13 | 2011-01-26 | 上海药明康德新药开发有限公司 | 2-取代[1,2,4]三唑[1,5-a]苯并咪唑的合成方法 |
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-
2015
- 2015-07-31 JP JP2017504727A patent/JP6785217B2/ja active Active
- 2015-07-31 SG SG11201700439VA patent/SG11201700439VA/en unknown
- 2015-07-31 CA CA2955565A patent/CA2955565A1/en not_active Abandoned
- 2015-07-31 BR BR112017001918A patent/BR112017001918A2/pt not_active Application Discontinuation
- 2015-07-31 ES ES15748009T patent/ES2795748T3/es active Active
- 2015-07-31 CN CN201580053161.XA patent/CN106879256B/zh active Active
- 2015-07-31 WO PCT/EP2015/067644 patent/WO2016016421A1/en not_active Ceased
- 2015-07-31 US US15/327,560 patent/US11447486B2/en active Active
- 2015-07-31 RU RU2017103148A patent/RU2732416C2/ru active
- 2015-07-31 AU AU2015295248A patent/AU2015295248B2/en active Active
- 2015-07-31 EP EP15748009.6A patent/EP3177597B1/en active Active
- 2015-07-31 KR KR1020177005644A patent/KR102494596B1/ko active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2005042520A1 (de) * | 2003-10-24 | 2005-05-12 | Merck Patent Gmbh | Benzimidazolylderivate |
| WO2012076672A1 (en) * | 2010-12-10 | 2012-06-14 | Boehringer Ingelheim International Gmbh | 2 -aminobenz imidazole derivatives useful in the treatment of inflammation |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106879256B (zh) | 2021-08-03 |
| RU2017103148A3 (https=) | 2018-10-04 |
| EP3177597B1 (en) | 2020-03-11 |
| JP6785217B2 (ja) | 2020-11-18 |
| US20170166563A1 (en) | 2017-06-15 |
| EP3177597A1 (en) | 2017-06-14 |
| ES2795748T3 (es) | 2020-11-24 |
| SG11201700439VA (en) | 2017-02-27 |
| US11447486B2 (en) | 2022-09-20 |
| AU2015295248B2 (en) | 2019-05-16 |
| WO2016016421A1 (en) | 2016-02-04 |
| AU2015295248A1 (en) | 2017-02-02 |
| CN106879256A (zh) | 2017-06-20 |
| RU2732416C2 (ru) | 2020-09-16 |
| RU2017103148A (ru) | 2018-08-30 |
| BR112017001918A2 (pt) | 2017-11-28 |
| KR20170045234A (ko) | 2017-04-26 |
| CA2955565A1 (en) | 2016-02-04 |
| JP2017522339A (ja) | 2017-08-10 |
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