KR102454460B1 - 암 치료를 위한 항-fam19a5 항체의 용도 - Google Patents

암 치료를 위한 항-fam19a5 항체의 용도 Download PDF

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KR102454460B1
KR102454460B1 KR1020197027050A KR20197027050A KR102454460B1 KR 102454460 B1 KR102454460 B1 KR 102454460B1 KR 1020197027050 A KR1020197027050 A KR 1020197027050A KR 20197027050 A KR20197027050 A KR 20197027050A KR 102454460 B1 KR102454460 B1 KR 102454460B1
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seq
antibody
fam19a5
amino acid
acid sequence
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KR1020197027050A
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Korean (ko)
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KR20190109574A (ko
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김봉철
조은비
김동식
이재근
권순구
성재영
심주원
김태우
강신혁
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주식회사 뉴라클사이언스
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020197027050A 2017-06-27 2018-06-27 암 치료를 위한 항-fam19a5 항체의 용도 KR102454460B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020227006389A KR20220031738A (ko) 2017-06-27 2018-06-27 암 치료를 위한 항-fam19a5 항체의 용도

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762525633P 2017-06-27 2017-06-27
US62/525,633 2017-06-27
US201762582886P 2017-11-07 2017-11-07
US62/582,886 2017-11-07
US201762597920P 2017-12-12 2017-12-12
US62/597,920 2017-12-12
PCT/IB2018/054784 WO2019003164A1 (en) 2017-06-27 2018-06-27 USE OF ANTI-FAM19A5 ANTIBODIES FOR THE TREATMENT OF CANCERS

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020227006389A Division KR20220031738A (ko) 2017-06-27 2018-06-27 암 치료를 위한 항-fam19a5 항체의 용도

Publications (2)

Publication Number Publication Date
KR20190109574A KR20190109574A (ko) 2019-09-25
KR102454460B1 true KR102454460B1 (ko) 2022-10-17

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KR1020227006389A KR20220031738A (ko) 2017-06-27 2018-06-27 암 치료를 위한 항-fam19a5 항체의 용도
KR1020237033663A KR20230142819A (ko) 2017-06-27 2018-06-27 암 치료를 위한 항-fam19a5 항체의 용도
KR1020197027050A KR102454460B1 (ko) 2017-06-27 2018-06-27 암 치료를 위한 항-fam19a5 항체의 용도

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KR1020227006389A KR20220031738A (ko) 2017-06-27 2018-06-27 암 치료를 위한 항-fam19a5 항체의 용도
KR1020237033663A KR20230142819A (ko) 2017-06-27 2018-06-27 암 치료를 위한 항-fam19a5 항체의 용도

Country Status (8)

Country Link
US (2) US11560425B2 (de)
EP (1) EP3645040A4 (de)
JP (2) JP7012384B2 (de)
KR (3) KR20220031738A (de)
CN (1) CN111093700A (de)
AU (1) AU2018291081A1 (de)
CA (1) CA3067416A1 (de)
WO (1) WO2019003164A1 (de)

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KR102574549B1 (ko) * 2017-06-27 2023-09-07 주식회사 뉴라클사이언스 항-fam19a5 항체 및 이의 용도
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EP3645040A4 (de) 2017-06-27 2021-05-05 Neuracle Science Co., Ltd Verwendung von anti-fam19a5-antikörpern zur krebsbehandlung
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AU2019363368A1 (en) 2018-10-16 2021-05-13 Neuracle Science Co., Ltd. Use of anti-FAM19A5 antibodies

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JP2020525505A (ja) 2020-08-27
US11560425B2 (en) 2023-01-24
KR20190109574A (ko) 2019-09-25
CN111093700A (zh) 2020-05-01
CA3067416A1 (en) 2019-01-03
US20200223914A1 (en) 2020-07-16
JP2021088593A (ja) 2021-06-10
JP7012384B2 (ja) 2022-02-14
AU2018291081A1 (en) 2020-01-16
JP7282401B2 (ja) 2023-05-29
KR20230142819A (ko) 2023-10-11
EP3645040A4 (de) 2021-05-05
WO2019003164A1 (en) 2019-01-03
KR20220031738A (ko) 2022-03-11
EP3645040A1 (de) 2020-05-06
US20230348584A1 (en) 2023-11-02

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