KR102444117B1 - 유전자 변형 동물을 생산하기 위한 조성물 및 방법 - Google Patents

유전자 변형 동물을 생산하기 위한 조성물 및 방법 Download PDF

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KR102444117B1
KR102444117B1 KR1020167015094A KR20167015094A KR102444117B1 KR 102444117 B1 KR102444117 B1 KR 102444117B1 KR 1020167015094 A KR1020167015094 A KR 1020167015094A KR 20167015094 A KR20167015094 A KR 20167015094A KR 102444117 B1 KR102444117 B1 KR 102444117B1
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KR20160084431A (ko
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프랭크 코엔티젠
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오즈진 홀딩스 프로프라이어터리 리미티드
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C12N15/8775—Murine embryos
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A01K2267/025—Animal producing cells or organs for transplantation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
KR1020167015094A 2013-11-07 2014-11-07 유전자 변형 동물을 생산하기 위한 조성물 및 방법 Active KR102444117B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020227031535A KR20220142474A (ko) 2013-11-07 2014-11-07 유전자 변형 동물을 생산하기 위한 조성물 및 방법

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AU2013904307 2013-11-07
AU2013904307A AU2013904307A0 (en) 2013-11-07 Compositions and methods for producing genetically modified animals
AU2014902162A AU2014902162A0 (en) 2014-06-06 Compostion and methods for producing genetically modified animals
AU2014902162 2014-06-06
PCT/AU2014/050339 WO2015066768A1 (en) 2013-11-07 2014-11-07 Compositions and methods for producing genetically modified animals

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020227031535A Division KR20220142474A (ko) 2013-11-07 2014-11-07 유전자 변형 동물을 생산하기 위한 조성물 및 방법

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KR20160084431A KR20160084431A (ko) 2016-07-13
KR102444117B1 true KR102444117B1 (ko) 2022-09-16

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KR1020167015094A Active KR102444117B1 (ko) 2013-11-07 2014-11-07 유전자 변형 동물을 생산하기 위한 조성물 및 방법
KR1020247010776A Ceased KR20240049835A (ko) 2013-11-07 2014-11-07 유전자 변형 동물을 생산하기 위한 조성물 및 방법
KR1020227031535A Ceased KR20220142474A (ko) 2013-11-07 2014-11-07 유전자 변형 동물을 생산하기 위한 조성물 및 방법

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KR1020247010776A Ceased KR20240049835A (ko) 2013-11-07 2014-11-07 유전자 변형 동물을 생산하기 위한 조성물 및 방법
KR1020227031535A Ceased KR20220142474A (ko) 2013-11-07 2014-11-07 유전자 변형 동물을 생산하기 위한 조성물 및 방법

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US (2) US20160360736A1 (enExample)
EP (2) EP3066204B1 (enExample)
JP (2) JP6845013B2 (enExample)
KR (3) KR102444117B1 (enExample)
CN (1) CN105899667A (enExample)
AU (2) AU2014346342C1 (enExample)
CA (1) CA2928744C (enExample)
DK (1) DK3066204T3 (enExample)
ES (1) ES2886146T3 (enExample)
HU (1) HUE055766T2 (enExample)
IL (2) IL245306A0 (enExample)
NZ (2) NZ719493A (enExample)
PT (1) PT3066204T (enExample)
SG (2) SG10202112147UA (enExample)
WO (1) WO2015066768A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ719493A (en) 2013-11-07 2020-02-28 Ozgene Holdings Pty Ltd Compositions and methods for producing genetically modified animals
BR112020013546A2 (pt) * 2018-01-12 2020-12-01 The Regents Of The University Of California derivação eficiente de células-tronco embrionárias pluripotentes estáveis de bovinos
GB201816633D0 (en) * 2018-10-12 2018-11-28 Univ Edinburgh Genetically modified avians and method for the reconstitution thereof
CN113136439B (zh) * 2021-05-28 2022-04-08 兰州大学 一种检测绵羊lipe基因单核苷酸多态性的方法及其应用
CN114592011B (zh) * 2022-05-10 2022-08-05 广东药康生物科技有限公司 一种ptdss2条件性基因敲除小鼠模型的构建方法

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JP2001008577A (ja) 1999-06-30 2001-01-16 Mitsubishi Chemicals Corp 生殖毒性化学物質のモニタリングに使用されるトランスジェニックマウス
US20050125853A1 (en) * 2002-03-22 2005-06-09 St. Jude Children's Resarch Hospital Method for generating genetically modified animals
US20060085866A1 (en) * 2004-10-19 2006-04-20 William Poueymirou Method for generating an animal homozygous for a genetic modification
JP2008178385A (ja) 2006-12-27 2008-08-07 Kao Corp ペット用シート
JP2010271421A (ja) 2009-05-19 2010-12-02 Mark Corporation:Kk ラベルシート
CN209403260U (zh) 2018-11-14 2019-09-20 绍兴兴科元管业有限公司 一种宠物尿垫组件

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JP4537056B2 (ja) 2001-07-19 2010-09-01 ランクホルスト インダテク ビー． ブイ． ポリオレフィンフィルム、テープ又はヤーン
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NZ719493A (en) 2013-11-07 2020-02-28 Ozgene Holdings Pty Ltd Compositions and methods for producing genetically modified animals
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Publication number Priority date Publication date Assignee Title
JP2001008577A (ja) 1999-06-30 2001-01-16 Mitsubishi Chemicals Corp 生殖毒性化学物質のモニタリングに使用されるトランスジェニックマウス
US20050125853A1 (en) * 2002-03-22 2005-06-09 St. Jude Children's Resarch Hospital Method for generating genetically modified animals
US20060085866A1 (en) * 2004-10-19 2006-04-20 William Poueymirou Method for generating an animal homozygous for a genetic modification
JP2008178385A (ja) 2006-12-27 2008-08-07 Kao Corp ペット用シート
JP2010271421A (ja) 2009-05-19 2010-12-02 Mark Corporation:Kk ラベルシート
CN209403260U (zh) 2018-11-14 2019-09-20 绍兴兴科元管业有限公司 一种宠物尿垫组件

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Publication number Publication date
NZ719493A (en) 2020-02-28
EP3066204B1 (en) 2021-06-02
US20220201992A1 (en) 2022-06-30
CN105899667A (zh) 2016-08-24
EP4043575A1 (en) 2022-08-17
EP3066204A4 (en) 2017-06-21
AU2014346342C1 (en) 2020-08-13
KR20160084431A (ko) 2016-07-13
EP3066204A1 (en) 2016-09-14
IL307495B1 (en) 2025-07-01
KR20240049835A (ko) 2024-04-17
AU2014346342B2 (en) 2020-02-20
US20160360736A1 (en) 2016-12-15
WO2015066768A1 (en) 2015-05-14
JP2016539660A (ja) 2016-12-22
HUE055766T2 (hu) 2021-12-28
SG10202112147UA (en) 2021-12-30
PT3066204T (pt) 2021-09-06
DK3066204T3 (da) 2021-08-30
SG11201603352SA (en) 2016-05-30
IL307495A (en) 2023-12-01
KR20220142474A (ko) 2022-10-21
AU2014346342A1 (en) 2016-05-19
NZ758970A (en) 2022-10-28
ES2886146T3 (es) 2021-12-16
JP6845013B2 (ja) 2021-03-17
JP2020202857A (ja) 2020-12-24
AU2020202321B2 (en) 2021-12-16
CA2928744C (en) 2022-12-06
CA2928744A1 (en) 2015-05-14
IL245306A0 (en) 2016-06-30
IL307495B2 (en) 2025-11-01
US11937586B2 (en) 2024-03-26
AU2020202321A1 (en) 2020-04-23

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