KR102425265B1 - 난 단백질 제형 및 이의 제조 방법 - Google Patents
난 단백질 제형 및 이의 제조 방법 Download PDFInfo
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- KR102425265B1 KR102425265B1 KR1020177004749A KR20177004749A KR102425265B1 KR 102425265 B1 KR102425265 B1 KR 102425265B1 KR 1020177004749 A KR1020177004749 A KR 1020177004749A KR 20177004749 A KR20177004749 A KR 20177004749A KR 102425265 B1 KR102425265 B1 KR 102425265B1
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- protein
- pharmaceutical formulation
- egg white
- egg
- white protein
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Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2924349B1 (fr) | 2007-12-03 | 2010-01-01 | Dbv Tech | Methode de desensibilitation aux allergenes |
DK3482771T3 (da) | 2013-03-14 | 2023-03-20 | Nestle Sa | Fremstilling af jordnøddeformuleringer til oral desensibilisering |
US9492535B2 (en) | 2013-03-14 | 2016-11-15 | Aimmune Therapeutics, Inc. | Peanut formulations and uses thereof |
KR102425265B1 (ko) | 2014-08-25 | 2022-07-26 | 에이뮨 테라퓨틱스, 인코퍼레이티드 | 난 단백질 제형 및 이의 제조 방법 |
CN107205432A (zh) | 2014-11-11 | 2017-09-26 | 克莱拉食品公司 | 用于生成卵清蛋白的方法和组合物 |
US10143742B2 (en) | 2015-02-20 | 2018-12-04 | The Board Of Trustees Of The Leland Stanford Junior University | Mixed allergen compositions and methods for using the same |
US10149904B2 (en) | 2015-02-20 | 2018-12-11 | The Board Of Trusteees Of The Leland Stanford Junior University | Mixed allergen compositions and methods for using the same |
US11452774B2 (en) | 2015-02-20 | 2022-09-27 | The Board Of Trustees Of The Leland Stanford Junior University | Mixed allergen compositions and methods for using the same |
US10166286B2 (en) | 2015-02-20 | 2019-01-01 | The Board Of Trustees Of The Leland Stanford Junior University | Mixed allergen compositions and methods for using the same |
FI3258962T3 (fi) | 2015-02-20 | 2023-04-12 | Sekoitetut allergeenikoostumukset ja menetelmät niiden käyttämiseksi | |
US11185561B2 (en) * | 2017-01-28 | 2021-11-30 | National Center For Child Health And Development | Method and composition for preventing egg allergy |
CN106990192B (zh) * | 2017-04-17 | 2019-05-21 | 大连工业大学 | 一种测定胶原蛋白分子质量的方法 |
BR112020001162B1 (pt) | 2017-07-18 | 2023-11-21 | Before Brands, Inc | Método para fabricar uma composição alergênica misturada |
WO2019089978A1 (en) | 2017-11-02 | 2019-05-09 | Aimmune Therapeutics, Inc. | Methods of oral immunotherapy |
US11406563B2 (en) | 2018-07-27 | 2022-08-09 | Société des Produits Nestlé S.A. | Oral immunotherapy unit dose dispensing systems and methods |
CN109107536B (zh) * | 2018-08-27 | 2021-06-15 | 西北大学 | 一种以卞胺为配基的高效疏水相互作用色谱介质及其制备方法与应用 |
AU2019401576A1 (en) * | 2018-12-17 | 2021-06-24 | Société des Produits Nestlé S.A. | Formulations for egg oral immunotherapy, methods of manufacture, and treatments for egg allergy |
WO2020154476A1 (en) | 2019-01-23 | 2020-07-30 | Before Brands, Inc. | Methods for making mixed allergen compositions |
FR3091975A1 (fr) * | 2019-01-24 | 2020-07-31 | Daniel Morin | compléments alimentaires permettant de contribuer à la lutte contre les intolérances et allergies alimentaires |
WO2020231843A1 (en) | 2019-05-10 | 2020-11-19 | Aimmune Therapeutics, Inc. | Methods for improving the quality of life of a patient with a peanut allergy |
AU2020309602A1 (en) | 2019-07-11 | 2022-02-24 | Clara Foods Co. | Protein compositions and consumable products thereof |
US10927360B1 (en) | 2019-08-07 | 2021-02-23 | Clara Foods Co. | Compositions comprising digestive enzymes |
CN111631337A (zh) * | 2020-05-30 | 2020-09-08 | 泉州玺阅日化有限公司 | 一种含动物白蛋白的保健泡腾片及其制备方法 |
WO2022236022A2 (en) * | 2021-05-07 | 2022-11-10 | AllerGenis LLC | Peptides and methods for detecting egg allergies |
WO2024015080A1 (en) * | 2022-07-15 | 2024-01-18 | Qualitas Health Inc. | Marine microalgal protein preparation |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102715542A (zh) * | 2012-06-21 | 2012-10-10 | 吉林大学 | 一种蛋清即冲速溶片及其制作方法 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2356426A1 (fr) * | 1976-06-29 | 1978-01-27 | Truffier Jean Claude | Fraction ovomucoide du blanc de l'oeuf de caille, ayant des proprietes antiproteasiques |
FR2489690A1 (fr) | 1979-05-07 | 1982-03-12 | Coturnix | Procede d'obtention de la fraction ovomucoide et d'un extrait d'ovomucoide de l'oeuf de caille, produits ainsi obtenus et leur application a titre de medicament |
EP0600832A1 (de) * | 1992-11-27 | 1994-06-08 | Ciba-Geigy Ag | Diaminobenzoe- und Diaminophthalsäurederivate und ihre Verfahren als Proteinkinase-Inhibitoren |
EP1370244A1 (en) * | 2001-03-12 | 2003-12-17 | Novo Nordisk A/S | Novel tablets and capsules and a process for its preparation |
GB2379216A (en) * | 2001-08-28 | 2003-03-05 | Maurice Ward Gittos | Piperidin-2,6-dione salts useful for the treatment of stress-related affective disorders |
FR2836379B1 (fr) * | 2002-02-28 | 2007-06-01 | Dit Bon Michel Betend | Formes galeniques solides de medicaments homeopathiques, dont les allergenes ou antigenes, en dilutions homeopathiques pour preparation extemporanee pour un seul individu pour administration sublinguale |
EP1388297A1 (en) * | 2002-08-06 | 2004-02-11 | Nestec S.A. | Calcium absorption enhancer |
BR0315084A (pt) * | 2002-10-05 | 2005-08-16 | Hanmi Pharm Ind Co Ltd | Composição farmacêutica compreendendo hemiidrato cristalino de metanossulfonato de sibutramina |
US7064146B2 (en) | 2003-06-24 | 2006-06-20 | Medicinova, Inc. | Pharmaceutical compositions of isolated orthorhombic crystalline 4-[6-acetyl-3-[3-(4-acetyl-3-hydroxy-2-propylphenylthio)propoxy]-2-propylphenoxy]butyric acid and methods of use |
US7825133B2 (en) * | 2003-11-14 | 2010-11-02 | Shanghai Genomics, Inc. | Derivatives of pyridone and the use of them |
CA2635594A1 (en) * | 2005-12-30 | 2007-07-12 | Advancis Pharmaceutical Corporation | Gastric release pulse system for drug delivery |
CN101808516B (zh) | 2007-07-30 | 2013-08-28 | 阿迪生物科学公司 | 作为mek抑制剂的包括多晶型物的n-(芳氨基)磺酰胺衍生物和组合物、其使用方法和制备方法 |
CN102413814A (zh) | 2009-04-29 | 2012-04-11 | 瑞恩药品公司 | 用于神经保护和治疗神经变性病症的克拉维酸类物质制剂 |
TWI471146B (zh) | 2009-12-02 | 2015-02-01 | Aptalis Pharma Ltd | 菲索特芬那定(fexofenadine)微膠囊及包含其之組合物 |
ES2905656T3 (es) | 2010-04-12 | 2022-04-11 | Somalogic Operating Co Inc | Pirimidinas modificadas en posición 5 y su uso |
US8603527B2 (en) | 2010-10-25 | 2013-12-10 | Signal Pharmaceuticals, Llc | Pharmaceutical formulations of a substituted diaminopurine |
US10300092B2 (en) * | 2011-01-08 | 2019-05-28 | KANE, Penny Coleen | Bee bloom compositions, methods of extraction and uses thereof |
GB201104537D0 (en) | 2011-03-17 | 2011-05-04 | Cambridge Entpr Ltd | Treatment for peanut allergy |
EP2717722A1 (en) * | 2011-06-07 | 2014-04-16 | Dialpha | Composition comprising cashew apple extract |
KR101484587B1 (ko) * | 2012-05-22 | 2015-01-26 | 경상대학교산학협력단 | 미역귀와 멍게껍질의 혼합물 추출액을 포함하는 아토피성 피부염 개선용 조성물 |
KR101415697B1 (ko) * | 2012-08-28 | 2014-07-04 | (주)뉴메드 | 산사 및 진피의 복합 추출물을 유효성분으로 함유하는 비만 또는 지질 관련 대사성 질환의 치료 또는 예방용 약학 조성물 |
US9492535B2 (en) * | 2013-03-14 | 2016-11-15 | Aimmune Therapeutics, Inc. | Peanut formulations and uses thereof |
DK3482771T3 (da) | 2013-03-14 | 2023-03-20 | Nestle Sa | Fremstilling af jordnøddeformuleringer til oral desensibilisering |
CN103734478B (zh) * | 2013-12-31 | 2014-10-01 | 深圳市红瑞生物科技有限公司 | 维他命膏及其制备方法 |
KR102425265B1 (ko) | 2014-08-25 | 2022-07-26 | 에이뮨 테라퓨틱스, 인코퍼레이티드 | 난 단백질 제형 및 이의 제조 방법 |
IT201600078969A1 (it) * | 2016-07-27 | 2018-01-27 | Buonamici Gugliemo | Integratore alimentare |
US20180200361A1 (en) | 2017-01-13 | 2018-07-19 | Aimmune Therapeutics Inc | Methods of manufacture of nut flours and formulations for oral immunotherapy |
US10668112B2 (en) * | 2017-03-31 | 2020-06-02 | Vivekananda Ramana | Formulation for targeting cancer in humans and canines |
WO2019089978A1 (en) | 2017-11-02 | 2019-05-09 | Aimmune Therapeutics, Inc. | Methods of oral immunotherapy |
US10721937B1 (en) * | 2019-05-09 | 2020-07-28 | Codex Beauty Corporation | Preservative systems and compositions and methods incorporating same |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102715542A (zh) * | 2012-06-21 | 2012-10-10 | 吉林大学 | 一种蛋清即冲速溶片及其制作方法 |
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CN106535931A (zh) | 2017-03-22 |
CA2955252A1 (en) | 2016-03-03 |
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AU2022201099A1 (en) | 2022-03-10 |
US20160051639A1 (en) | 2016-02-25 |
AU2015306683B2 (en) | 2021-11-25 |
EP4275760A2 (en) | 2023-11-15 |
JP6910946B2 (ja) | 2021-07-28 |
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