KR102410733B1 - 헌팅틴 단백질을 영상화하기 위한 프로브 - Google Patents

헌팅틴 단백질을 영상화하기 위한 프로브 Download PDF

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Publication number
KR102410733B1
KR102410733B1 KR1020177007881A KR20177007881A KR102410733B1 KR 102410733 B1 KR102410733 B1 KR 102410733B1 KR 1020177007881 A KR1020177007881 A KR 1020177007881A KR 20177007881 A KR20177007881 A KR 20177007881A KR 102410733 B1 KR102410733 B1 KR 102410733B1
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South Korea
Prior art keywords
imidazo
pyridine
carbonitrile
methoxy
methylamino
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Korean (ko)
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KR20170047303A (ko
Inventor
셀리아 도밍게즈
존 휘트약
조나단 바드
알렉스 키셀료프
크리스토퍼 존 브라운
마이클 에드워드 프라임
피터 데이비드 존슨
다니엘 클락-프류
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씨에이치디아이 파운데이션, 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020177007881A 2014-08-29 2015-08-28 헌팅틴 단백질을 영상화하기 위한 프로브 Active KR102410733B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462043590P 2014-08-29 2014-08-29
US62/043,590 2014-08-29
PCT/US2015/047401 WO2016033440A1 (en) 2014-08-29 2015-08-28 Probes for imaging huntingtin protein

Publications (2)

Publication Number Publication Date
KR20170047303A KR20170047303A (ko) 2017-05-04
KR102410733B1 true KR102410733B1 (ko) 2022-06-20

Family

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KR1020177007881A Active KR102410733B1 (ko) 2014-08-29 2015-08-28 헌팅틴 단백질을 영상화하기 위한 프로브

Country Status (20)

Country Link
US (2) US11104691B2 (https=)
EP (1) EP3197277B1 (https=)
JP (1) JP6754353B2 (https=)
KR (1) KR102410733B1 (https=)
CN (1) CN107105667B (https=)
AU (2) AU2015308769A1 (https=)
BR (1) BR112017004140B1 (https=)
CA (1) CA2959533C (https=)
DK (1) DK3197277T3 (https=)
EA (1) EA039923B1 (https=)
ES (1) ES2905095T3 (https=)
HR (1) HRP20220001T1 (https=)
HU (1) HUE057702T2 (https=)
IL (1) IL250802B (https=)
MX (1) MX386798B (https=)
PL (1) PL3197277T3 (https=)
PT (1) PT3197277T (https=)
SG (1) SG11201701592SA (https=)
SI (1) SI3197277T1 (https=)
WO (1) WO2016033440A1 (https=)

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* Cited by examiner, † Cited by third party
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EA035646B1 (ru) 2014-08-29 2020-07-21 Сиэйчдиай Фаундэйшн, Инк. Зонды для визуализации белка хантингтина
SI3186241T1 (sl) 2014-08-29 2021-03-31 Chdi Foundation, Inc. Sonde za slikanje Huntingtonovega proteina
CA2959505A1 (en) 2014-08-29 2016-03-03 Chdi Foundation, Inc. Probes for imaging huntingtin protein
CN107105667B (zh) 2014-08-29 2021-08-17 Chdi基金会股份有限公司 用于成像亨廷顿蛋白的探针
MX382156B (es) 2015-08-28 2025-03-13 Chdi Foundation Inc Sondas para formar imagenes de proteina de huntingtina.
WO2019075402A1 (en) * 2017-10-12 2019-04-18 University Of Kansas METHODS FOR TREATING GASTROINTESTINAL SYNDROME INDUCED BY RADIATION
US11389438B2 (en) 2019-02-25 2022-07-19 Chdi Foundation, Inc. Compounds for targeting mutant huntingtin protein and uses thereof
MX2021013574A (es) 2019-05-09 2021-12-10 Hoffmann La Roche Sintesis de imidazo[1,2-a]pirimidinas etiquetadas.
CN114773312B (zh) * 2021-10-29 2024-03-26 北京鑫诺康桥药物研究有限公司 一种盐酸阿罗洛尔中间体的制备工艺

Citations (3)

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US20110065727A1 (en) 2008-03-21 2011-03-17 Sanofi-Aventis POLYSUBSTITUTED DERIVATIVES OF 2-HETEROARYL-6-PHENYLIMIDAZO[1,2-a]PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF
US20110171739A1 (en) 2008-09-23 2011-07-14 Wista Laboratories Ltd. Ligands for aggregated tau molecules
WO2015044095A1 (en) 2013-09-26 2015-04-02 F. Hoffmann-La Roche Ag Imidazo[1,2-a]pyridin-7-amines as imaging tools

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CA2500358A1 (en) * 2003-08-13 2005-02-24 Bf Research Institute, Inc. Probes for diseases in which amyloid accumulates, agents for staining amyloid, drugs for treatment and prophylaxis of diseases with accumulated amyloid, and probes for diagnosis of neurofibrillary tangles and agents for staining neurofibrillary tangles
WO2007148755A1 (ja) * 2006-06-21 2007-12-27 Nihon Medi-Physics Co., Ltd. 新規アミロイド親和性化合物
WO2008016648A2 (en) * 2006-08-01 2008-02-07 Cytokinetics, Incorporated Certain chemical entities, compositions and methods
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WO2008091195A1 (en) 2007-01-22 2008-07-31 Astrazeneca Ab Novel heteroaryl substituted imidazo [1,2 -a] pyridine derivatives
EP2216052A4 (en) 2007-10-30 2012-11-21 Nihon Mediphysics Co Ltd USE OF A NEW COMPOUND WITH AFFINITY FOR AMYLOID AND METHOD FOR THE PRODUCTION THEREOF
JP2011529086A (ja) * 2008-07-24 2011-12-01 シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッド Ａｄ病変を同定するために有用な造影剤
WO2010141805A1 (en) * 2009-06-05 2010-12-09 Janssen Pharmaceutica Nv Heterocyclic amides as modulators of trpa1
AU2012259929B2 (en) * 2011-05-20 2016-08-04 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
CA2839199C (en) * 2011-06-24 2018-11-06 Nihon Medi-Physics Co., Ltd. Novel compound with amyloid affinity
JP2013237655A (ja) * 2012-05-17 2013-11-28 Kyoto Univ コンフォメーション病診断用分子プローブ
WO2014076021A1 (en) * 2012-11-14 2014-05-22 F. Hoffmann-La Roche Ag Imidazopyridine derivatives
RU2675818C2 (ru) 2013-03-14 2018-12-25 Галапаго Нв Новые соединения и фармацевтические композиции, их содержащие, для лечения воспалительных расстройств
SI3186241T1 (sl) 2014-08-29 2021-03-31 Chdi Foundation, Inc. Sonde za slikanje Huntingtonovega proteina
CA2959505A1 (en) 2014-08-29 2016-03-03 Chdi Foundation, Inc. Probes for imaging huntingtin protein
EA035646B1 (ru) 2014-08-29 2020-07-21 Сиэйчдиай Фаундэйшн, Инк. Зонды для визуализации белка хантингтина
CN107105667B (zh) 2014-08-29 2021-08-17 Chdi基金会股份有限公司 用于成像亨廷顿蛋白的探针
MX382156B (es) 2015-08-28 2025-03-13 Chdi Foundation Inc Sondas para formar imagenes de proteina de huntingtina.

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US20110065727A1 (en) 2008-03-21 2011-03-17 Sanofi-Aventis POLYSUBSTITUTED DERIVATIVES OF 2-HETEROARYL-6-PHENYLIMIDAZO[1,2-a]PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF
US20110171739A1 (en) 2008-09-23 2011-07-14 Wista Laboratories Ltd. Ligands for aggregated tau molecules
WO2015044095A1 (en) 2013-09-26 2015-04-02 F. Hoffmann-La Roche Ag Imidazo[1,2-a]pyridin-7-amines as imaging tools

Also Published As

Publication number Publication date
PT3197277T (pt) 2022-02-01
JP6754353B2 (ja) 2020-09-09
DK3197277T3 (da) 2022-01-31
JP2017529340A (ja) 2017-10-05
AU2019283999A1 (en) 2020-01-23
EA201790400A1 (ru) 2017-09-29
CN107105667A (zh) 2017-08-29
KR20170047303A (ko) 2017-05-04
PL3197277T3 (pl) 2022-04-04
SI3197277T1 (sl) 2022-04-29
WO2016033440A1 (en) 2016-03-03
EP3197277A4 (en) 2018-04-18
US20170283439A1 (en) 2017-10-05
EA039923B1 (ru) 2022-03-28
AU2015308769A1 (en) 2017-03-23
MX386798B (es) 2025-03-19
EP3197277A1 (en) 2017-08-02
HRP20220001T1 (hr) 2022-04-01
IL250802A0 (en) 2017-04-30
SG11201701592SA (en) 2017-03-30
US11104691B2 (en) 2021-08-31
CA2959533C (en) 2023-03-07
IL250802B (en) 2020-08-31
CA2959533A1 (en) 2016-03-03
AU2019283999B2 (en) 2021-07-22
BR112017004140A2 (pt) 2017-12-12
HUE057702T2 (hu) 2022-05-28
US11851446B2 (en) 2023-12-26
MX2017002702A (es) 2017-10-23
ES2905095T3 (es) 2022-04-07
US20210380608A1 (en) 2021-12-09
CN107105667B (zh) 2021-08-17
BR112017004140B1 (pt) 2023-01-10
EP3197277B1 (en) 2021-12-22

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