CN107105667B - 用于成像亨廷顿蛋白的探针 - Google Patents
用于成像亨廷顿蛋白的探针 Download PDFInfo
- Publication number
- CN107105667B CN107105667B CN201580058314.XA CN201580058314A CN107105667B CN 107105667 B CN107105667 B CN 107105667B CN 201580058314 A CN201580058314 A CN 201580058314A CN 107105667 B CN107105667 B CN 107105667B
- Authority
- CN
- China
- Prior art keywords
- imidazo
- benzofuran
- methoxy
- pyridine
- carbonitrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462043590P | 2014-08-29 | 2014-08-29 | |
| US62/043,590 | 2014-08-29 | ||
| PCT/US2015/047401 WO2016033440A1 (en) | 2014-08-29 | 2015-08-28 | Probes for imaging huntingtin protein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107105667A CN107105667A (zh) | 2017-08-29 |
| CN107105667B true CN107105667B (zh) | 2021-08-17 |
Family
ID=55400645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580058314.XA Active CN107105667B (zh) | 2014-08-29 | 2015-08-28 | 用于成像亨廷顿蛋白的探针 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US11104691B2 (https=) |
| EP (1) | EP3197277B1 (https=) |
| JP (1) | JP6754353B2 (https=) |
| KR (1) | KR102410733B1 (https=) |
| CN (1) | CN107105667B (https=) |
| AU (2) | AU2015308769A1 (https=) |
| BR (1) | BR112017004140B1 (https=) |
| CA (1) | CA2959533C (https=) |
| DK (1) | DK3197277T3 (https=) |
| EA (1) | EA039923B1 (https=) |
| ES (1) | ES2905095T3 (https=) |
| HR (1) | HRP20220001T1 (https=) |
| HU (1) | HUE057702T2 (https=) |
| IL (1) | IL250802B (https=) |
| MX (1) | MX386798B (https=) |
| PL (1) | PL3197277T3 (https=) |
| PT (1) | PT3197277T (https=) |
| SG (1) | SG11201701592SA (https=) |
| SI (1) | SI3197277T1 (https=) |
| WO (1) | WO2016033440A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA035646B1 (ru) | 2014-08-29 | 2020-07-21 | Сиэйчдиай Фаундэйшн, Инк. | Зонды для визуализации белка хантингтина |
| SI3186241T1 (sl) | 2014-08-29 | 2021-03-31 | Chdi Foundation, Inc. | Sonde za slikanje Huntingtonovega proteina |
| CA2959505A1 (en) | 2014-08-29 | 2016-03-03 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| CN107105667B (zh) | 2014-08-29 | 2021-08-17 | Chdi基金会股份有限公司 | 用于成像亨廷顿蛋白的探针 |
| MX382156B (es) | 2015-08-28 | 2025-03-13 | Chdi Foundation Inc | Sondas para formar imagenes de proteina de huntingtina. |
| WO2019075402A1 (en) * | 2017-10-12 | 2019-04-18 | University Of Kansas | METHODS FOR TREATING GASTROINTESTINAL SYNDROME INDUCED BY RADIATION |
| US11389438B2 (en) | 2019-02-25 | 2022-07-19 | Chdi Foundation, Inc. | Compounds for targeting mutant huntingtin protein and uses thereof |
| MX2021013574A (es) | 2019-05-09 | 2021-12-10 | Hoffmann La Roche | Sintesis de imidazo[1,2-a]pirimidinas etiquetadas. |
| CN114773312B (zh) * | 2021-10-29 | 2024-03-26 | 北京鑫诺康桥药物研究有限公司 | 一种盐酸阿罗洛尔中间体的制备工艺 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040023972A1 (en) * | 2000-10-13 | 2004-02-05 | Gruenenthal Gmbh | Use of substituted imidazo[1,2-a]-pyridin-, -pyrimidin-and-pyrazin-3-yl-amine derivatives in the preparation of medicaments for inhibiting NOS |
| CN101909658A (zh) * | 2007-10-30 | 2010-12-08 | 日本医事物理股份有限公司 | 对淀粉样蛋白具有亲和性的新化合物的应用及制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2500358A1 (en) * | 2003-08-13 | 2005-02-24 | Bf Research Institute, Inc. | Probes for diseases in which amyloid accumulates, agents for staining amyloid, drugs for treatment and prophylaxis of diseases with accumulated amyloid, and probes for diagnosis of neurofibrillary tangles and agents for staining neurofibrillary tangles |
| WO2007148755A1 (ja) * | 2006-06-21 | 2007-12-27 | Nihon Medi-Physics Co., Ltd. | 新規アミロイド親和性化合物 |
| WO2008016648A2 (en) * | 2006-08-01 | 2008-02-07 | Cytokinetics, Incorporated | Certain chemical entities, compositions and methods |
| US20090252680A1 (en) * | 2006-11-17 | 2009-10-08 | Nihon- Medi-Physics Co., Ltd | Novel compound with affinity for amyloid |
| CA2670436A1 (en) * | 2006-11-30 | 2008-06-05 | Nihon Medi-Physics Co., Ltd. | Novel compound having affinity for amyloid |
| WO2008091195A1 (en) | 2007-01-22 | 2008-07-31 | Astrazeneca Ab | Novel heteroaryl substituted imidazo [1,2 -a] pyridine derivatives |
| FR2928923B1 (fr) | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques |
| JP2011529086A (ja) * | 2008-07-24 | 2011-12-01 | シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッド | Ａｄ病変を同定するために有用な造影剤 |
| CA2737028C (en) * | 2008-09-23 | 2017-06-27 | Wista Laboratories Ltd. | Ligands for aggregated tau molecules |
| WO2010141805A1 (en) * | 2009-06-05 | 2010-12-09 | Janssen Pharmaceutica Nv | Heterocyclic amides as modulators of trpa1 |
| AU2012259929B2 (en) * | 2011-05-20 | 2016-08-04 | Nihon Medi-Physics Co., Ltd. | Novel compound having affinity for amyloid |
| CA2839199C (en) * | 2011-06-24 | 2018-11-06 | Nihon Medi-Physics Co., Ltd. | Novel compound with amyloid affinity |
| JP2013237655A (ja) * | 2012-05-17 | 2013-11-28 | Kyoto Univ | コンフォメーション病診断用分子プローブ |
| WO2014076021A1 (en) * | 2012-11-14 | 2014-05-22 | F. Hoffmann-La Roche Ag | Imidazopyridine derivatives |
| RU2675818C2 (ru) | 2013-03-14 | 2018-12-25 | Галапаго Нв | Новые соединения и фармацевтические композиции, их содержащие, для лечения воспалительных расстройств |
| CA2920068A1 (en) * | 2013-09-26 | 2015-04-02 | F. Hoffmann-La Roche Ag | Imidazo[1,2-a]pyridin-7-amines as imaging tools |
| SI3186241T1 (sl) | 2014-08-29 | 2021-03-31 | Chdi Foundation, Inc. | Sonde za slikanje Huntingtonovega proteina |
| CA2959505A1 (en) | 2014-08-29 | 2016-03-03 | Chdi Foundation, Inc. | Probes for imaging huntingtin protein |
| EA035646B1 (ru) | 2014-08-29 | 2020-07-21 | Сиэйчдиай Фаундэйшн, Инк. | Зонды для визуализации белка хантингтина |
| CN107105667B (zh) | 2014-08-29 | 2021-08-17 | Chdi基金会股份有限公司 | 用于成像亨廷顿蛋白的探针 |
| MX382156B (es) | 2015-08-28 | 2025-03-13 | Chdi Foundation Inc | Sondas para formar imagenes de proteina de huntingtina. |
-
2015
- 2015-08-28 CN CN201580058314.XA patent/CN107105667B/zh active Active
- 2015-08-28 WO PCT/US2015/047401 patent/WO2016033440A1/en not_active Ceased
- 2015-08-28 SI SI201531778T patent/SI3197277T1/sl unknown
- 2015-08-28 ES ES15836261T patent/ES2905095T3/es active Active
- 2015-08-28 AU AU2015308769A patent/AU2015308769A1/en not_active Abandoned
- 2015-08-28 EA EA201790400A patent/EA039923B1/ru unknown
- 2015-08-28 KR KR1020177007881A patent/KR102410733B1/ko active Active
- 2015-08-28 CA CA2959533A patent/CA2959533C/en active Active
- 2015-08-28 HR HRP20220001TT patent/HRP20220001T1/hr unknown
- 2015-08-28 DK DK15836261.6T patent/DK3197277T3/da active
- 2015-08-28 PL PL15836261T patent/PL3197277T3/pl unknown
- 2015-08-28 PT PT158362616T patent/PT3197277T/pt unknown
- 2015-08-28 JP JP2017511926A patent/JP6754353B2/ja active Active
- 2015-08-28 US US15/507,203 patent/US11104691B2/en active Active
- 2015-08-28 BR BR112017004140-5A patent/BR112017004140B1/pt active IP Right Grant
- 2015-08-28 MX MX2017002702A patent/MX386798B/es unknown
- 2015-08-28 HU HUE15836261A patent/HUE057702T2/hu unknown
- 2015-08-28 EP EP15836261.6A patent/EP3197277B1/en active Active
- 2015-08-28 SG SG11201701592SA patent/SG11201701592SA/en unknown
-
2017
- 2017-02-26 IL IL250802A patent/IL250802B/en active IP Right Grant
-
2019
- 2019-12-20 AU AU2019283999A patent/AU2019283999B2/en active Active
-
2021
- 2021-06-21 US US17/353,627 patent/US11851446B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040023972A1 (en) * | 2000-10-13 | 2004-02-05 | Gruenenthal Gmbh | Use of substituted imidazo[1,2-a]-pyridin-, -pyrimidin-and-pyrazin-3-yl-amine derivatives in the preparation of medicaments for inhibiting NOS |
| CN101909658A (zh) * | 2007-10-30 | 2010-12-08 | 日本医事物理股份有限公司 | 对淀粉样蛋白具有亲和性的新化合物的应用及制备方法 |
Non-Patent Citations (2)
| Title |
|---|
| Behrooz Hooshyar Yousefiet al..Development of an improved radioiodinated 2-phenylimidazo[1,2-a]pyridine for non-invasive imaging of amyloid plaques.《Med. Chem. Commun.》.2012,第3卷第775-779页，第778页Scheme 2. * |
| Structure-Activity Relationship of Imidazo[1,2-a]pyridines as Ligands for Detecting β-Amyloid Plaques in the Brain;Zhi-Ping Zhuang et al.;《J. Med. Chem.》;20021218;第46卷(第2期);第237-243页，第239页Scheme 3 * |
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| GR01 | Patent grant |