KR102395737B1 - Plk-4 억제제의 염 및 결정체들 - Google Patents

Plk-4 억제제의 염 및 결정체들 Download PDF

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KR102395737B1
KR102395737B1 KR1020217036751A KR20217036751A KR102395737B1 KR 102395737 B1 KR102395737 B1 KR 102395737B1 KR 1020217036751 A KR1020217036751 A KR 1020217036751A KR 20217036751 A KR20217036751 A KR 20217036751A KR 102395737 B1 KR102395737 B1 KR 102395737B1
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compound
cancer
fumarate
maleate
crystalline form
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KR20210137251A (ko
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피터 브렌트 샘슨
미클로시 페헤르
하인즈 더블유 폴스
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유니버시티 헬스 네트워크
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020217036751A 2013-10-18 2014-10-17 Plk-4 억제제의 염 및 결정체들 Active KR102395737B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020227015022A KR20220063299A (ko) 2013-10-18 2014-10-17 Plk-4 억제제의 염 및 결정체들

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361892564P 2013-10-18 2013-10-18
US61/892,564 2013-10-18
KR1020167012155A KR20160070106A (ko) 2013-10-18 2014-10-17 Plk-4 억제제의 염 및 결정체들
PCT/CA2014/051001 WO2015054793A1 (en) 2013-10-18 2014-10-17 Salt and crystal forms of plk-4 inhibitor

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020167012155A Division KR20160070106A (ko) 2013-10-18 2014-10-17 Plk-4 억제제의 염 및 결정체들

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020227015022A Division KR20220063299A (ko) 2013-10-18 2014-10-17 Plk-4 억제제의 염 및 결정체들

Publications (2)

Publication Number Publication Date
KR20210137251A KR20210137251A (ko) 2021-11-17
KR102395737B1 true KR102395737B1 (ko) 2022-05-10

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ID=52827507

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020217036751A Active KR102395737B1 (ko) 2013-10-18 2014-10-17 Plk-4 억제제의 염 및 결정체들
KR1020227015022A Ceased KR20220063299A (ko) 2013-10-18 2014-10-17 Plk-4 억제제의 염 및 결정체들
KR1020167012155A Ceased KR20160070106A (ko) 2013-10-18 2014-10-17 Plk-4 억제제의 염 및 결정체들

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020227015022A Ceased KR20220063299A (ko) 2013-10-18 2014-10-17 Plk-4 억제제의 염 및 결정체들
KR1020167012155A Ceased KR20160070106A (ko) 2013-10-18 2014-10-17 Plk-4 억제제의 염 및 결정체들

Country Status (27)

Country Link
US (5) US9884855B2 (https=)
EP (1) EP3057965B1 (https=)
JP (1) JP6492072B2 (https=)
KR (3) KR102395737B1 (https=)
CN (2) CN105764899B (https=)
AU (1) AU2014336929B9 (https=)
CA (1) CA2926845C (https=)
CY (1) CY1121484T1 (https=)
DK (1) DK3057965T3 (https=)
EA (1) EA031569B1 (https=)
ES (1) ES2718603T3 (https=)
HR (1) HRP20190564T1 (https=)
HU (1) HUE043194T2 (https=)
IL (1) IL245038B (https=)
LT (1) LT3057965T (https=)
ME (1) ME03377B (https=)
MX (1) MX359069B (https=)
NZ (1) NZ718744A (https=)
PL (1) PL3057965T3 (https=)
PT (1) PT3057965T (https=)
RS (1) RS58413B1 (https=)
SG (1) SG11201602783SA (https=)
SI (1) SI3057965T1 (https=)
SM (1) SMT201900124T1 (https=)
TR (1) TR201902875T4 (https=)
TW (1) TWI659952B (https=)
WO (1) WO2015054793A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5629752B2 (ja) 2009-04-06 2014-11-26 ユニバーシティ・ヘルス・ネットワークＵｎｉｖｅｒｓｉｔｙ Ｈｅａｌｔｈ Ｎｅｔｗｏｒｋ キナーゼインヒビターおよびこれを用いた癌の治療方法
JP5442906B2 (ja) 2010-04-06 2014-03-19 ユニバーシティ・ヘルス・ネットワーク キナーゼインヒビターおよびこれを用いた癌の治療方法
RS58413B1 (sr) 2013-10-18 2019-04-30 Univ Health Network So i kristalni oblici inhibitora plk-4
AU2018328773B2 (en) * 2017-09-08 2023-11-16 University Health Network Combination therapies for inhibition of Polo-like Kinase 4
SG11202111003UA (en) * 2019-04-24 2021-11-29 Univ Health Network Crystal form s4 of the plk4 inhibitor (1r,2s)-(e)-2-(3-(4-((cis-2,6-dimethylmorpholino)methyl)styryl)- 1 h-imidazol-6- yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one fumarate
JP2023505301A (ja) * 2019-12-06 2023-02-08 ユニバーシティー ヘルス ネットワーク 急性骨髄性白血病または骨髄異形成症候群に対する治療
MX2023013225A (es) 2021-05-11 2024-01-15 Oric Pharmaceuticals Inc Inhibidores de la cinasa 4 similar a polo.

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
US2483323A (en) * 1945-08-01 1949-09-27 Kay Fries Chemicals Inc Method of preparing phenyl ethyl alcohol
US7205328B2 (en) 2002-10-21 2007-04-17 Irm Llc Oxindoles with anti-HIV activity
DE102005005395A1 (de) 2005-02-03 2006-08-10 Schering Aktiengesellschaft Thiazolidinone, deren Herstellung und Verwendung als Arzneimittel
GB0606234D0 (en) * 2006-03-29 2006-05-10 Pliva Istrazivanje I Razvoj D Pharmaceutically acceptable salts and polymorphic forms
WO2008118097A1 (en) * 2007-03-23 2008-10-02 Agency For Science, Technology And Research Palladium catalysts
WO2009042711A1 (en) * 2007-09-25 2009-04-02 Takeda Pharmaceutical Company Limited Polo-like kinase inhibitors
EP2235004A4 (en) 2007-12-21 2011-05-04 Univ Health Network INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL-SUBSTITUTED INDOLUND DERIVATIVES AS A KINASE-HEMMER FOR CANCER TREATMENT
JP5629752B2 (ja) * 2009-04-06 2014-11-26 ユニバーシティ・ヘルス・ネットワークＵｎｉｖｅｒｓｉｔｙ Ｈｅａｌｔｈ Ｎｅｔｗｏｒｋ キナーゼインヒビターおよびこれを用いた癌の治療方法
EP2424868B1 (en) * 2009-04-29 2018-01-10 Nerviano Medical Sciences S.r.l. Cdk inhibitor salts
JP5442906B2 (ja) * 2010-04-06 2014-03-19 ユニバーシティ・ヘルス・ネットワーク キナーゼインヒビターおよびこれを用いた癌の治療方法
US8933070B2 (en) 2010-07-02 2015-01-13 University Health Network Methods of targeting PTEN mutant diseases and compositions therefor
WO2012048411A1 (en) 2010-10-13 2012-04-19 University Health Network Plk-4 inhibitors and method of treating cancer with same
CN103476770B (zh) * 2010-11-25 2017-02-15 拉蒂欧制药有限责任公司 阿法替尼盐和多晶型物
EP2766352B1 (en) 2011-10-12 2018-06-06 University Health Network (UHN) Indazole compounds as kinase inhibitors and method of treating cancer with same
RS58413B1 (sr) 2013-10-18 2019-04-30 Univ Health Network So i kristalni oblici inhibitora plk-4
SG11201602882VA (en) 2013-10-18 2016-05-30 Univ Health Network Treatment for pancreatic cancer

Also Published As

Publication number Publication date
CY1121484T1 (el) 2020-05-29
EP3057965B1 (en) 2019-01-02
ES2718603T3 (es) 2019-07-03
KR20220063299A (ko) 2022-05-17
US20190248775A1 (en) 2019-08-15
PL3057965T3 (pl) 2019-08-30
DK3057965T3 (en) 2019-04-01
EA031569B1 (ru) 2019-01-31
EP3057965A1 (en) 2016-08-24
HRP20190564T1 (hr) 2019-05-17
JP2016537326A (ja) 2016-12-01
IL245038B (en) 2019-11-28
CN105764899B (zh) 2021-06-01
US11667627B2 (en) 2023-06-06
US20210269428A1 (en) 2021-09-02
EA201690755A1 (ru) 2016-09-30
US20180155335A1 (en) 2018-06-07
US10392374B2 (en) 2019-08-27
US10919886B2 (en) 2021-02-16
TR201902875T4 (tr) 2019-03-21
JP6492072B2 (ja) 2019-03-27
IL245038A0 (en) 2016-05-31
KR20210137251A (ko) 2021-11-17
US20160264559A1 (en) 2016-09-15
LT3057965T (lt) 2019-03-12
RS58413B1 (sr) 2019-04-30
PT3057965T (pt) 2019-04-23
NZ718744A (en) 2021-07-30
TW201609717A (zh) 2016-03-16
WO2015054793A1 (en) 2015-04-23
ME03377B (me) 2020-01-20
US10472353B2 (en) 2019-11-12
US20200140428A1 (en) 2020-05-07
US9884855B2 (en) 2018-02-06
CA2926845C (en) 2023-06-13
AU2014336929B9 (en) 2019-03-21
SG11201602783SA (en) 2016-05-30
HUE043194T2 (hu) 2019-08-28
EP3057965A4 (en) 2017-05-24
CN113248486A (zh) 2021-08-13
SI3057965T1 (sl) 2019-04-30
MX2016004963A (es) 2016-06-28
AU2014336929B2 (en) 2018-11-22
CA2926845A1 (en) 2015-04-23
CN105764899A (zh) 2016-07-13
TWI659952B (zh) 2019-05-21
SMT201900124T1 (it) 2019-05-10
KR20160070106A (ko) 2016-06-17
MX359069B (es) 2018-09-12

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