CN105764899B - Plk-4抑制剂的盐和晶型 - Google Patents

Plk-4抑制剂的盐和晶型 Download PDF

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CN105764899B
CN105764899B CN201480064037.9A CN201480064037A CN105764899B CN 105764899 B CN105764899 B CN 105764899B CN 201480064037 A CN201480064037 A CN 201480064037A CN 105764899 B CN105764899 B CN 105764899B
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compound
cancer
fumarate
salt
maleate
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CN105764899A (zh
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P·B·桑普森
M·费赫
H·W·鲍尔斯
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University Health Network
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201480064037.9A 2013-10-18 2014-10-17 Plk-4抑制剂的盐和晶型 Active CN105764899B (zh)

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Application Number Priority Date Filing Date Title
CN202110510808.4A CN113248486A (zh) 2013-10-18 2014-10-17 Plk-4抑制剂的盐和晶型

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361892564P 2013-10-18 2013-10-18
US61/892,564 2013-10-18
PCT/CA2014/051001 WO2015054793A1 (en) 2013-10-18 2014-10-17 Salt and crystal forms of plk-4 inhibitor

Related Child Applications (1)

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CN105764899B true CN105764899B (zh) 2021-06-01

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EP (1) EP3057965B1 (https=)
JP (1) JP6492072B2 (https=)
KR (3) KR20220063299A (https=)
CN (2) CN105764899B (https=)
AU (1) AU2014336929B9 (https=)
CA (1) CA2926845C (https=)
CY (1) CY1121484T1 (https=)
DK (1) DK3057965T3 (https=)
EA (1) EA031569B1 (https=)
ES (1) ES2718603T3 (https=)
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IL (1) IL245038B (https=)
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Publication number Priority date Publication date Assignee Title
ES2465971T3 (es) 2009-04-06 2014-06-09 University Health Network Inhibidores de quinasa y método para tratar cáncer con los mismos
SI2556071T1 (sl) 2010-04-06 2016-12-30 University Health Network Kinazni inhibitorji in njihova uporaba pri zdravljenju raka
HUE043194T2 (hu) 2013-10-18 2019-08-28 Univ Health Network PLK-4 inhibitor sója és kristályformái
WO2019046949A1 (en) * 2017-09-08 2019-03-14 University Health Network POLYTHERAPIES FOR INHIBITING KINASE 4 OF THE POLO TYPE
CA3137191A1 (en) 2019-04-24 2020-10-29 University Health Network Crystal form s4 of the plk4 inhibitor (ir,2s)-(e)-2-(3-(4-((cis-2,6-dimethylmorpholino)methyl)styryl)- 1 h-imidazol-6-yl)-5'-methoxyspiro[cyclopropane-l,3'-indolin]-2'-one fumarate
BR112022011052A2 (pt) * 2019-12-06 2022-08-16 Univ Health Network Tratamento para leucemia mieloide aguda ou síndrome mielodisplásica
JP7717842B2 (ja) 2021-05-11 2025-08-04 オリック ファーマシューティカルズ，インク． ポロ様キナーゼ４阻害剤

Citations (7)

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WO2007110559A1 (en) * 2006-03-29 2007-10-04 Pliva Hrvatska D.O.O. Pharmaceutically acceptable salts and polymorphic forms of sildenafil
CN101155791A (zh) * 2005-02-03 2008-04-02 拜耳先灵医药股份有限公司 作为极体样激酶（plk）抑制剂药剂的噻唑烷酮
WO2012048411A1 (en) * 2010-10-13 2012-04-19 University Health Network Plk-4 inhibitors and method of treating cancer with same
US8263596B2 (en) * 2010-04-06 2012-09-11 University Health Network Kinase inhibitors and method of treating cancer
WO2012121764A1 (en) * 2010-11-25 2012-09-13 Ratiopharm Gmbh Novel salts and polymorphic forms of afatinib
CN103122001A (zh) * 2007-09-25 2013-05-29 武田药品工业株式会社 Polo样激酶抑制剂
US8481525B2 (en) * 2009-04-06 2013-07-09 University Of Health Network Kinase inhibitors and method of treating cancer with same

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US2483323A (en) * 1945-08-01 1949-09-27 Kay Fries Chemicals Inc Method of preparing phenyl ethyl alcohol
US7205328B2 (en) 2002-10-21 2007-04-17 Irm Llc Oxindoles with anti-HIV activity
US8227640B2 (en) * 2007-03-23 2012-07-24 Institute Of Bioengineering And Nanotechnology Palladium catalysts
EP2235004A4 (en) * 2007-12-21 2011-05-04 Univ Health Network INDAZOLYL, BENZIMIDAZOLYL, BENZOTRIAZOLYL-SUBSTITUTED INDOLUND DERIVATIVES AS A KINASE-HEMMER FOR CANCER TREATMENT
US8586598B2 (en) 2009-04-29 2013-11-19 Nerviano Medical Sciences S.R.L. CDK inhibitor salts
ES2706066T3 (es) * 2010-07-02 2019-03-27 Univ Health Network Procedimiento dirigido a enfermedades mutantes con PTEN y composiciones para las mismas
US20140051679A1 (en) 2011-10-12 2014-02-20 Univeristy Health Networks Kinase inhibitors and method of treating cancer with same
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HUE043194T2 (hu) 2013-10-18 2019-08-28 Univ Health Network PLK-4 inhibitor sója és kristályformái

Patent Citations (9)

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CN101155791A (zh) * 2005-02-03 2008-04-02 拜耳先灵医药股份有限公司 作为极体样激酶（plk）抑制剂药剂的噻唑烷酮
WO2007110559A1 (en) * 2006-03-29 2007-10-04 Pliva Hrvatska D.O.O. Pharmaceutically acceptable salts and polymorphic forms of sildenafil
CN103122001A (zh) * 2007-09-25 2013-05-29 武田药品工业株式会社 Polo样激酶抑制剂
US8481525B2 (en) * 2009-04-06 2013-07-09 University Of Health Network Kinase inhibitors and method of treating cancer with same
US8263596B2 (en) * 2010-04-06 2012-09-11 University Health Network Kinase inhibitors and method of treating cancer
CN102892766A (zh) * 2010-04-06 2013-01-23 大学健康网络 激酶抑制剂和用其治疗癌症的方法
US8481533B2 (en) * 2010-04-06 2013-07-09 University Health Network Kinase inhibitors and method of treating cancer
WO2012048411A1 (en) * 2010-10-13 2012-04-19 University Health Network Plk-4 inhibitors and method of treating cancer with same
WO2012121764A1 (en) * 2010-11-25 2012-09-13 Ratiopharm Gmbh Novel salts and polymorphic forms of afatinib

Non-Patent Citations (1)

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Functional Characterization of CFI-400945,a Polo-like Kinase 4 Inhibitor,as a Potential Anticancer Agent;Jacqueline M. Mason et al.;《Cancer Cell》;20140811;第26卷;163-176 *

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Publication number Publication date
PL3057965T3 (pl) 2019-08-30
HRP20190564T1 (hr) 2019-05-17
US11667627B2 (en) 2023-06-06
TWI659952B (zh) 2019-05-21
CN105764899A (zh) 2016-07-13
EA031569B1 (ru) 2019-01-31
IL245038B (en) 2019-11-28
HUE043194T2 (hu) 2019-08-28
US10919886B2 (en) 2021-02-16
KR20220063299A (ko) 2022-05-17
IL245038A0 (en) 2016-05-31
KR20160070106A (ko) 2016-06-17
KR20210137251A (ko) 2021-11-17
CY1121484T1 (el) 2020-05-29
US10392374B2 (en) 2019-08-27
RS58413B1 (sr) 2019-04-30
SMT201900124T1 (it) 2019-05-10
MX2016004963A (es) 2016-06-28
ES2718603T3 (es) 2019-07-03
US20210269428A1 (en) 2021-09-02
ME03377B (me) 2020-01-20
US9884855B2 (en) 2018-02-06
TW201609717A (zh) 2016-03-16
AU2014336929B2 (en) 2018-11-22
NZ718744A (en) 2021-07-30
EA201690755A1 (ru) 2016-09-30
EP3057965B1 (en) 2019-01-02
CA2926845C (en) 2023-06-13
DK3057965T3 (en) 2019-04-01
EP3057965A1 (en) 2016-08-24
AU2014336929B9 (en) 2019-03-21
TR201902875T4 (tr) 2019-03-21
US20190248775A1 (en) 2019-08-15
MX359069B (es) 2018-09-12
US20200140428A1 (en) 2020-05-07
WO2015054793A1 (en) 2015-04-23
CN113248486A (zh) 2021-08-13
JP2016537326A (ja) 2016-12-01
JP6492072B2 (ja) 2019-03-27
KR102395737B1 (ko) 2022-05-10
SI3057965T1 (sl) 2019-04-30
PT3057965T (pt) 2019-04-23
LT3057965T (lt) 2019-03-12
US10472353B2 (en) 2019-11-12
CA2926845A1 (en) 2015-04-23
EP3057965A4 (en) 2017-05-24
SG11201602783SA (en) 2016-05-30
US20160264559A1 (en) 2016-09-15
US20180155335A1 (en) 2018-06-07

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