KR102393280B1 - Tlr7 작용제 결정형 a, 이의 제조 방법 및 용도 - Google Patents

Tlr7 작용제 결정형 a, 이의 제조 방법 및 용도 Download PDF

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KR102393280B1
KR102393280B1 KR1020187024627A KR20187024627A KR102393280B1 KR 102393280 B1 KR102393280 B1 KR 102393280B1 KR 1020187024627 A KR1020187024627 A KR 1020187024627A KR 20187024627 A KR20187024627 A KR 20187024627A KR 102393280 B1 KR102393280 B1 KR 102393280B1
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KR20180104117A (ko
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자오종 딩
페이 순
잉후 후
이룽 주
젱 왕
루이 자오
링 양
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치아타이 티안큉 파마수티컬 그룹 주식회사
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020187024627A 2016-02-05 2017-02-04 Tlr7 작용제 결정형 a, 이의 제조 방법 및 용도 Active KR102393280B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610082029.8 2016-02-05
CN201610082029.8A CN107043379A (zh) 2016-02-05 2016-02-05 一种tlr7激动剂的晶型a、其制备方法和医药用途
PCT/CN2017/072891 WO2017133684A1 (zh) 2016-02-05 2017-02-04 一种tlr7激动剂的晶型a、其制备方法和用途

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KR20180104117A KR20180104117A (ko) 2018-09-19
KR102393280B1 true KR102393280B1 (ko) 2022-05-02

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JP (1) JP6889171B2 (https=)
KR (1) KR102393280B1 (https=)
CN (2) CN107043379A (https=)
AR (1) AR107548A1 (https=)
AU (1) AU2017215801B2 (https=)
CA (1) CA3013518C (https=)
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TN2018000112A1 (en) 2015-10-29 2019-10-04 Novartis Ag Antibody conjugates comprising toll-like receptor agonist
CN107043379A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的晶型a、其制备方法和医药用途
CN107043378A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体
CN107043380A (zh) 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
CN112105620B (zh) * 2018-05-25 2026-02-24 正大天晴药业集团股份有限公司 用于治疗肺癌的tlr7激动剂及其药物组合
JP7287708B2 (ja) 2019-02-08 2023-06-06 プロジェニア インコーポレイテッド Ｔｏｌｌ－ｌｉｋｅ受容体７または８アゴニストとコレステロールの結合体およびその用途
WO2020188448A1 (en) * 2019-03-15 2020-09-24 Janssen Sciences Ireland Unlimited Company Toll-like receptor agonists for use in the treatment of hepatitis b
CN113543788B (zh) * 2019-04-23 2023-12-19 正大天晴药业集团股份有限公司 一种tlr7激动剂的固体药物组合物
JP7811014B2 (ja) 2020-03-02 2026-02-04 プロジェニア インコーポレイテッド 病原菌外壁成分基盤の生病原体模倣ナノ粒子及びその製造方法
JP2023536954A (ja) 2020-08-04 2023-08-30 プロジェニア インコーポレイテッド 活性化部位が一時的に不活性化したトール様受容体７または８作用薬と機能性薬物の結合体およびその用途
US20230355750A1 (en) 2020-08-04 2023-11-09 Progeneer Inc. Kinetically acting adjuvant ensemble
CN116322751A (zh) 2020-08-04 2023-06-23 蛋白科技先锋 包含能够动力学控制的佐剂的mRNA疫苗
CN119431359A (zh) * 2023-07-28 2025-02-14 苏州申拓医药科技有限公司 一种tlr7/8激动剂的可药用盐、晶型及其制备方法、药物组合物和用途

Citations (2)

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WO2013103967A1 (en) 2012-01-05 2013-07-11 Northeastern University Allosteric modulators of cb1 cannabinoid receptors
JP2014504644A (ja) 2011-02-04 2014-02-24 デュケイン ユニバーシティー オブ ザ ホリー スピリット 抗チューブリン活性を有する二環式および三環式のピリミジンチロシンキナーゼ阻害剤ならびに患者の処置方法

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JP3376479B2 (ja) * 1991-08-12 2003-02-10 武田薬品工業株式会社 縮合ピリミジン誘導体、その製造法および用途
ES2577514T3 (es) * 2005-08-22 2016-07-15 The Regents Of The University Of California Antagonistas de TLR
ES2467108T3 (es) 2008-12-09 2014-06-11 Gilead Sciences, Inc. Moduladores de receptores tipo toll
LT2906563T (lt) * 2012-10-10 2018-06-11 Janssen Sciences Ireland Uc Pirolo[3,2-d]pirimidino dariniai virusinių infekcijų ir kitų ligų gydymui
KR20150085081A (ko) * 2012-11-20 2015-07-22 글락소스미스클라인 엘엘씨 신규 화합물
MX358025B (es) * 2012-11-20 2018-08-02 Glaxosmithkline Llc Star Compuestos novedosos.
US9550785B2 (en) 2012-11-20 2017-01-24 Glaxosmithkline Llc Pyrrolopyrimidines as therapeutic agents for the treatment of diseases
JP6484253B2 (ja) * 2014-05-01 2019-03-13 ノバルティス アーゲー Ｔｏｌｌ様受容体７アゴニストとしての化合物および組成物
HUE054672T2 (hu) 2014-08-15 2021-09-28 Chia Tai Tianqing Pharmaceutical Group Co Ltd TLR7 agonistaként alkalmazott pirrolopirimidin vegyületek
CN105367576A (zh) 2014-08-15 2016-03-02 正大天晴药业集团股份有限公司 作为tlr7激动剂的吡咯并嘧啶化合物
CN107043380A (zh) 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
CN107043379A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的晶型a、其制备方法和医药用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014504644A (ja) 2011-02-04 2014-02-24 デュケイン ユニバーシティー オブ ザ ホリー スピリット 抗チューブリン活性を有する二環式および三環式のピリミジンチロシンキナーゼ阻害剤ならびに患者の処置方法
WO2013103967A1 (en) 2012-01-05 2013-07-11 Northeastern University Allosteric modulators of cb1 cannabinoid receptors

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TWI754629B (zh) 2022-02-11
EA035951B1 (ru) 2020-09-04
ES2830443T3 (es) 2021-06-03
US20190040071A1 (en) 2019-02-07
UA121161C2 (uk) 2020-04-10
MX2018009501A (es) 2018-12-11
JP2019505533A (ja) 2019-02-28
TW201728589A (zh) 2017-08-16
CL2018002092A1 (es) 2018-12-07
PL3412672T3 (pl) 2021-01-25
IL260968B (en) 2022-05-01
LT3412672T (lt) 2020-11-10
NZ744884A (en) 2022-09-30
DK3412672T3 (da) 2020-10-19
CN108602831B (zh) 2020-11-03
CN108602831A (zh) 2018-09-28
EA201891768A1 (ru) 2019-01-31
EP3412672A4 (en) 2019-07-17
CA3013518A1 (en) 2017-08-10
JP6889171B2 (ja) 2021-06-18
CN108602831B9 (zh) 2020-12-04
HK1259170A1 (zh) 2019-11-29
US10947245B2 (en) 2021-03-16
US20200039988A1 (en) 2020-02-06
ZA201805186B (en) 2024-08-28
AU2017215801A1 (en) 2018-08-23
SG11201806683UA (en) 2018-09-27
PH12018501643A1 (en) 2019-06-03
AU2017215801B2 (en) 2020-09-10
MX374297B (es) 2025-03-06
PT3412672T (pt) 2020-11-11
EP3412672A1 (en) 2018-12-12
EP3412672B1 (en) 2020-07-15
US10442811B2 (en) 2019-10-15
KR20180104117A (ko) 2018-09-19
CA3013518C (en) 2022-07-19
WO2017133684A1 (zh) 2017-08-10
AR107548A1 (es) 2018-05-09
SI3412672T1 (sl) 2021-02-26
BR112018015880A2 (pt) 2018-12-26
CN107043379A (zh) 2017-08-15
HRP20201644T1 (hr) 2020-12-25
HUE051399T2 (hu) 2021-03-01

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