KR102393280B1 - Tlr7 작용제 결정형 a, 이의 제조 방법 및 용도 - Google Patents

Tlr7 작용제 결정형 a, 이의 제조 방법 및 용도 Download PDF

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KR102393280B1
KR102393280B1 KR1020187024627A KR20187024627A KR102393280B1 KR 102393280 B1 KR102393280 B1 KR 102393280B1 KR 1020187024627 A KR1020187024627 A KR 1020187024627A KR 20187024627 A KR20187024627 A KR 20187024627A KR 102393280 B1 KR102393280 B1 KR 102393280B1
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KR20180104117A (ko
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자오종 딩
페이 순
잉후 후
이룽 주
젱 왕
루이 자오
링 양
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치아타이 티안큉 파마수티컬 그룹 주식회사
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020187024627A 2016-02-05 2017-02-04 Tlr7 작용제 결정형 a, 이의 제조 방법 및 용도 Active KR102393280B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610082029.8 2016-02-05
CN201610082029.8A CN107043379A (zh) 2016-02-05 2016-02-05 一种tlr7激动剂的晶型a、其制备方法和医药用途
PCT/CN2017/072891 WO2017133684A1 (zh) 2016-02-05 2017-02-04 一种tlr7激动剂的晶型a、其制备方法和用途

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KR20180104117A KR20180104117A (ko) 2018-09-19
KR102393280B1 true KR102393280B1 (ko) 2022-05-02

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US (2) US10442811B2 (OSRAM)
EP (1) EP3412672B1 (OSRAM)
JP (1) JP6889171B2 (OSRAM)
KR (1) KR102393280B1 (OSRAM)
CN (2) CN107043379A (OSRAM)
AR (1) AR107548A1 (OSRAM)
AU (1) AU2017215801B2 (OSRAM)
CA (1) CA3013518C (OSRAM)
CL (1) CL2018002092A1 (OSRAM)
DK (1) DK3412672T3 (OSRAM)
EA (1) EA035951B1 (OSRAM)
ES (1) ES2830443T3 (OSRAM)
HR (1) HRP20201644T1 (OSRAM)
HU (1) HUE051399T2 (OSRAM)
IL (1) IL260968B (OSRAM)
LT (1) LT3412672T (OSRAM)
MX (1) MX374297B (OSRAM)
NZ (1) NZ744884A (OSRAM)
PH (1) PH12018501643A1 (OSRAM)
PL (1) PL3412672T3 (OSRAM)
PT (1) PT3412672T (OSRAM)
SG (1) SG11201806683UA (OSRAM)
SI (1) SI3412672T1 (OSRAM)
TW (1) TWI754629B (OSRAM)
UA (1) UA121161C2 (OSRAM)
WO (1) WO2017133684A1 (OSRAM)
ZA (1) ZA201805186B (OSRAM)

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MA44334A (fr) 2015-10-29 2018-09-05 Novartis Ag Conjugués d'anticorps comprenant un agoniste du récepteur de type toll
CN107043378A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体
CN107043379A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的晶型a、其制备方法和医药用途
CN107043380A (zh) 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
JP7385602B2 (ja) 2018-05-25 2023-11-22 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド 肺癌を治療するためのｔｌｒ７アゴニストおよびその医薬の組み合わせ
WO2020162705A1 (ko) 2019-02-08 2020-08-13 성균관대학교산학협력단 톨-유사 수용체 7 또는 8 작용자와 콜레스테롤의 결합체 및 그 용도
WO2020188448A1 (en) * 2019-03-15 2020-09-24 Janssen Sciences Ireland Unlimited Company Toll-like receptor agonists for use in the treatment of hepatitis b
KR20220004098A (ko) * 2019-04-23 2022-01-11 치아타이 티안큉 파마수티컬 그룹 주식회사 Tlr7 작용물질을 포함하는 고형 제약학적 조성물
WO2021177679A1 (ko) 2020-03-02 2021-09-10 성균관대학교산학협력단 병원균 외벽 성분 기반 생병원체 모방 나노 입자 및 그 제조 방법
EP4194010A4 (en) 2020-08-04 2025-03-26 Progeneer Inc. Conjugate of a functional drug and a toll-like receptor 7 or 8 agonist with a temporarily inactivated drug site, and use thereof
JP7690221B2 (ja) 2020-08-04 2025-06-10 プロジェニア インコーポレイテッド 動力学的に作用するアジュバントアンサンブル
CN116322751A (zh) 2020-08-04 2023-06-23 蛋白科技先锋 包含能够动力学控制的佐剂的mRNA疫苗
CN119431359A (zh) * 2023-07-28 2025-02-14 苏州申拓医药科技有限公司 一种tlr7/8激动剂的可药用盐、晶型及其制备方法、药物组合物和用途

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WO2013103967A1 (en) 2012-01-05 2013-07-11 Northeastern University Allosteric modulators of cb1 cannabinoid receptors
JP2014504644A (ja) 2011-02-04 2014-02-24 デュケイン ユニバーシティー オブ ザ ホリー スピリット 抗チューブリン活性を有する二環式および三環式のピリミジンチロシンキナーゼ阻害剤ならびに患者の処置方法

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JP3376479B2 (ja) * 1991-08-12 2003-02-10 武田薬品工業株式会社 縮合ピリミジン誘導体、その製造法および用途
CN101304748A (zh) * 2005-08-22 2008-11-12 加利福尼亚大学董事会 Tlr激动剂
PE20120106A1 (es) 2008-12-09 2012-02-20 Gilead Sciences Inc Moduladores de receptores tipo toll
DK2906563T3 (en) * 2012-10-10 2018-06-06 Janssen Sciences Ireland Uc PYRROLO [3,2-D] PYRIMIDINE DERIVATIVES FOR TREATING VIRUS INFECTIONS AND OTHER DISEASES
WO2014081643A1 (en) * 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds
WO2014081644A1 (en) * 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds
PT2922549T (pt) * 2012-11-20 2017-09-01 Glaxosmithkline Llc Novos compostos
CR20160512A (es) 2014-05-01 2016-12-21 Novartis Ag Compuestos y composiciones como agonistas del receptor tipo toll 7
CN105367576A (zh) 2014-08-15 2016-03-02 正大天晴药业集团股份有限公司 作为tlr7激动剂的吡咯并嘧啶化合物
BR112017002811B1 (pt) * 2014-08-15 2022-09-06 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Compostos de pirrolopirimidina usados como agonista de tlr7 e seu uso, composição farmacêutica e kit
CN107043380A (zh) 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
CN107043379A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的晶型a、其制备方法和医药用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014504644A (ja) 2011-02-04 2014-02-24 デュケイン ユニバーシティー オブ ザ ホリー スピリット 抗チューブリン活性を有する二環式および三環式のピリミジンチロシンキナーゼ阻害剤ならびに患者の処置方法
WO2013103967A1 (en) 2012-01-05 2013-07-11 Northeastern University Allosteric modulators of cb1 cannabinoid receptors

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TW201728589A (zh) 2017-08-16
SG11201806683UA (en) 2018-09-27
KR20180104117A (ko) 2018-09-19
EP3412672A4 (en) 2019-07-17
CN107043379A (zh) 2017-08-15
WO2017133684A1 (zh) 2017-08-10
US20190040071A1 (en) 2019-02-07
EP3412672A1 (en) 2018-12-12
US10442811B2 (en) 2019-10-15
CA3013518C (en) 2022-07-19
JP6889171B2 (ja) 2021-06-18
AR107548A1 (es) 2018-05-09
LT3412672T (lt) 2020-11-10
EA201891768A1 (ru) 2019-01-31
MX374297B (es) 2025-03-06
PT3412672T (pt) 2020-11-11
UA121161C2 (uk) 2020-04-10
TWI754629B (zh) 2022-02-11
JP2019505533A (ja) 2019-02-28
AU2017215801A1 (en) 2018-08-23
PH12018501643A1 (en) 2019-06-03
CN108602831B (zh) 2020-11-03
EP3412672B1 (en) 2020-07-15
SI3412672T1 (sl) 2021-02-26
AU2017215801B2 (en) 2020-09-10
BR112018015880A2 (pt) 2018-12-26
CN108602831B9 (zh) 2020-12-04
MX2018009501A (es) 2018-12-11
ES2830443T3 (es) 2021-06-03
PL3412672T3 (pl) 2021-01-25
HRP20201644T1 (hr) 2020-12-25
ZA201805186B (en) 2024-08-28
EA035951B1 (ru) 2020-09-04
CA3013518A1 (en) 2017-08-10
NZ744884A (en) 2022-09-30
HK1259170A1 (zh) 2019-11-29
HUE051399T2 (hu) 2021-03-01
US10947245B2 (en) 2021-03-16
CL2018002092A1 (es) 2018-12-07
US20200039988A1 (en) 2020-02-06
IL260968B (en) 2022-05-01
CN108602831A (zh) 2018-09-28
DK3412672T3 (da) 2020-10-19

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