KR102390285B1 - 핵산 프로브 및 게놈 단편을 검출하는 방법 - Google Patents

핵산 프로브 및 게놈 단편을 검출하는 방법 Download PDF

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KR102390285B1
KR102390285B1 KR1020167017435A KR20167017435A KR102390285B1 KR 102390285 B1 KR102390285 B1 KR 102390285B1 KR 1020167017435 A KR1020167017435 A KR 1020167017435A KR 20167017435 A KR20167017435 A KR 20167017435A KR 102390285 B1 KR102390285 B1 KR 102390285B1
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nucleic acid
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칼 오스카 프레드릭 달
죤 올로프 에릭손
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바나디스 다이아그노스틱스
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KR1020167017435A 2013-12-02 2014-11-26 핵산 프로브 및 게놈 단편을 검출하는 방법 Active KR102390285B1 (ko)

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GB1321191.7A GB2520763A (en) 2013-12-02 2013-12-02 Nucleic acid probe and method of detecting genomic fragments
GB1321191.7 2013-12-02
PCT/IB2014/003061 WO2015083001A2 (en) 2013-12-02 2014-11-26 Nucleic acid probe and method of detecting genomic fragments

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KR102390285B1 true KR102390285B1 (ko) 2022-04-25

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US (3) US10240198B2 (https=)
EP (2) EP3077540B1 (https=)
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CN (2) CN108707652B (https=)
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GB (1) GB2520763A (https=)
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Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2520765A (en) 2013-12-02 2015-06-03 Vanadis Diagnostics Ab Multiplex detection of nucleic acids
GB2520763A (en) 2013-12-02 2015-06-03 Vanadis Diagnostics Ab Nucleic acid probe and method of detecting genomic fragments
US10174383B2 (en) 2014-08-13 2019-01-08 Vanadis Diagnostics Method of estimating the amount of a methylated locus in a sample
GB201507376D0 (en) 2015-04-30 2015-06-17 Vanadis Diagnostics Ab Use of a porous transparent capillary membrane for counting rolling circle amplification products
KR102753113B1 (ko) * 2015-09-18 2025-01-09 바나디스 다이아그노스틱스 Dna 샘플의 분석을 위한 프로브 세트 및 이의 사용 방법
JPWO2017135383A1 (ja) * 2016-02-03 2018-12-06 国立大学法人豊橋技術科学大学 偽環状二重鎖ポリヌクレオチドと、それを用いた遺伝子発現阻害剤
BR112019007865A2 (pt) 2016-10-27 2019-07-02 Vanadis Diagnostics método para processamento de produtos de amplificação do círculo rolante
CN110225979B (zh) * 2017-05-23 2024-05-31 深圳华大基因股份有限公司 基于滚环扩增的基因组目标区域富集方法及其应用
US11117128B2 (en) 2017-08-25 2021-09-14 Vanadis Diagnostics Ab Filtration device
CN120905352A (zh) 2018-04-02 2025-11-07 埃努梅拉分子股份有限公司 用于对核酸分子进行计数的方法、系统和组合物
SG11202105957YA (en) * 2018-12-05 2021-07-29 Egi Tech Shen Zhen Co Limited Rolling circle amplification method, method for preparing sequencing library, and dna nanosphere prepared therefrom
CN109652506A (zh) * 2018-12-20 2019-04-19 派德洛格(天津)生物科技有限公司 荧光原位检测人EGFR基因21号外显子p.L858R突变的方法及试剂盒
EP3947718A4 (en) 2019-04-02 2022-12-21 Enumera Molecular, Inc. METHODS, SYSTEMS AND COMPOSITIONS FOR COUNTING NUCLEIC ACID MOLECULES
US20230242971A1 (en) * 2020-05-08 2023-08-03 Roche Sequencing Solutions, Inc. Removal of excess oligonucleotides from a reation mixture
WO2022008649A1 (en) * 2020-07-08 2022-01-13 F. Hoffmann-La Roche Ag Spatial analysis of multiple targets in tissue samples
US12467081B2 (en) 2020-11-23 2025-11-11 Pleno, Inc. Encoded endonuclease assays
WO2022212559A1 (en) * 2021-03-31 2022-10-06 Jumpcode Genomics, Inc. Methods for targeted nucleic acid sequencing
WO2022232425A2 (en) * 2021-04-29 2022-11-03 Illumina, Inc. Amplification techniques for nucleic acid characterization
WO2023282164A1 (ja) * 2021-07-08 2023-01-12 国立大学法人九州大学 プローブ、プローブセット、及び哺乳動物の核酸検出キット
MX2024002592A (es) * 2021-09-03 2024-06-11 Micronoma Inc Métodos para identificar biomarcadores microbianos asociados con cáncer.
GB202213930D0 (en) * 2022-09-23 2022-11-09 Xu Bo Padlock blocking oligonucleotide

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
WO2001094625A2 (en) * 2000-06-06 2001-12-13 Tm Bioscience Corporation Capture moieties for nucleic acids and uses thereof
US6573051B2 (en) 2001-03-09 2003-06-03 Molecular Staging, Inc. Open circle probes with intramolecular stem structures
US7208295B2 (en) 2001-11-19 2007-04-24 Affymetrix, Inc. Multiplex oligonucleotide addition and target amplification
US20040171047A1 (en) * 2002-05-22 2004-09-02 Dahl Gary A. Target-dependent transcription
AU2003298672A1 (en) 2002-11-19 2005-01-28 Singulex, Inc. Detection of target molecules through interaction with probes
JP4230457B2 (ja) 2002-12-18 2009-02-25 サード・ウェーブ・テクノロジーズ・インク 低分子核酸の検出方法
EP1680517B1 (en) * 2003-11-04 2010-03-31 Applied Biosystems, LLC Concatameric ligation products: compositions, methods and kits for same
SE0401270D0 (sv) 2004-05-18 2004-05-18 Fredrik Dahl Method for amplifying specific nucleic acids in parallel
WO2006076650A2 (en) 2005-01-12 2006-07-20 Applera Corporation Compositions, methods, and kits for selective amplification of nucleic acids
US7645576B2 (en) 2005-03-18 2010-01-12 The Chinese University Of Hong Kong Method for the detection of chromosomal aneuploidies
AU2006264564B2 (en) 2005-07-04 2012-04-19 Erasmus University Medical Center Chromosome conformation capture-on-chip (4c) assay
US20070087355A1 (en) 2005-10-14 2007-04-19 Barrett Michael T Comparative genomic hybridization assays and compositions for practicing the same
WO2007083766A1 (ja) * 2006-01-20 2007-07-26 Olympus Corporation 分子内プローブによる核酸配列の検出方法
US8038595B2 (en) 2006-01-25 2011-10-18 Beth Israel Deaconess Medical Center Devices and methods for tissue transplant and regeneration
US7901884B2 (en) * 2006-05-03 2011-03-08 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring
WO2008033442A2 (en) * 2006-09-12 2008-03-20 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for performing low background multiplex nucleic acid amplification reactions
US20090061424A1 (en) * 2007-08-30 2009-03-05 Sigma-Aldrich Company Universal ligation array for analyzing gene expression or genomic variations
US9388457B2 (en) * 2007-09-14 2016-07-12 Affymetrix, Inc. Locus specific amplification using array probes
GB0912909D0 (en) * 2009-07-23 2009-08-26 Olink Genomics Ab Probes for specific analysis of nucleic acids
CA2777322A1 (en) 2009-08-12 2011-02-17 President And Fellows Of Harvard College Biodetection methods and compositions
US8916349B2 (en) * 2009-11-23 2014-12-23 Becton, Dickinson And Company Assay method for target nucleic acid by signal amplification using probe hybridization and restriction
US9023769B2 (en) * 2009-11-30 2015-05-05 Complete Genomics, Inc. cDNA library for nucleic acid sequencing
GB0921264D0 (en) * 2009-12-03 2010-01-20 Olink Genomics Ab Method for amplification of target nucleic acid
EP2569447A4 (en) * 2010-05-14 2013-11-27 Fluidigm Corp ASSAYS FOR THE DETECTION OF GENOTYPES, MUTATIONS OR ANEUPLOIDY
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
GB2492042B (en) 2011-05-11 2020-04-15 Agilent Technologies Inc Selector probes for nucleic acid analysis comprising at each end a non-adjacent target specific region
WO2012168803A2 (en) 2011-06-07 2012-12-13 Koninklijke Philips Electronics N.V. Providing nucleotide sequence data
CN104093854A (zh) * 2011-12-02 2014-10-08 凯杰有限公司 表征组合物中的rna的方法和试剂盒
US9193994B2 (en) * 2012-04-20 2015-11-24 Samsung Electronics Co., Ltd. Polynucleotide and use thereof
CN102899417A (zh) * 2012-10-24 2013-01-30 武汉大学 一种microRNAs荧光检测探针
WO2014165267A2 (en) 2013-03-12 2014-10-09 Counsyl, Inc. Systems and methods for prenatal genetic analysis
GB2520763A (en) 2013-12-02 2015-06-03 Vanadis Diagnostics Ab Nucleic acid probe and method of detecting genomic fragments
GB2520765A (en) 2013-12-02 2015-06-03 Vanadis Diagnostics Ab Multiplex detection of nucleic acids

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Goransson 등, Nucleic Acids Research, Vol 37, No. 1, 페이지 1-9 (2008.11.25.)*
Lizardi 등, Nature Genetics, Vol. 19, No. 3, 페이지 225-232 (1998.07.)*

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AU2021200461B2 (en) 2022-10-06
US20190194748A1 (en) 2019-06-27
US20200318186A1 (en) 2020-10-08
KR20160096633A (ko) 2016-08-16
JP2016537990A (ja) 2016-12-08
AU2014358861B2 (en) 2020-12-10
HK1258148A1 (zh) 2019-11-08
CN105899680B (zh) 2018-06-15
US20170016065A1 (en) 2017-01-19
CA2931013A1 (en) 2015-06-11
JP6766236B2 (ja) 2020-10-07
CN105899680A (zh) 2016-08-24
EP3077540A2 (en) 2016-10-12
EP3770273B1 (en) 2021-09-29
CN108707652B (zh) 2022-04-15
ES2818920T3 (es) 2021-04-14
GB2520763A (en) 2015-06-03
WO2015083001A2 (en) 2015-06-11
WO2015083001A3 (en) 2015-11-26
RU2733888C2 (ru) 2020-10-07
AU2014358861A1 (en) 2016-06-09
GB201321191D0 (en) 2014-01-15
BR112016012264A2 (pt) 2017-09-26
US10240198B2 (en) 2019-03-26
CN108707652A (zh) 2018-10-26
ES2899693T3 (es) 2022-03-14
US10731214B2 (en) 2020-08-04
EP3077540B1 (en) 2020-09-02
JP6542771B2 (ja) 2019-07-10
JP2019176867A (ja) 2019-10-17
JP2019216734A (ja) 2019-12-26
AU2021200461A1 (en) 2021-02-25
EP3770273A1 (en) 2021-01-27
JP6571895B1 (ja) 2019-09-04
BR112016012264B1 (pt) 2023-04-25

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