JP6542771B2 - 核酸プローブ及びゲノム断片検出方法 - Google Patents

核酸プローブ及びゲノム断片検出方法 Download PDF

Info

Publication number
JP6542771B2
JP6542771B2 JP2016535002A JP2016535002A JP6542771B2 JP 6542771 B2 JP6542771 B2 JP 6542771B2 JP 2016535002 A JP2016535002 A JP 2016535002A JP 2016535002 A JP2016535002 A JP 2016535002A JP 6542771 B2 JP6542771 B2 JP 6542771B2
Authority
JP
Japan
Prior art keywords
sequence
target
nucleic acid
probe
head
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016535002A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016537990A5 (https=
JP2016537990A (ja
Inventor
オスカー，フレドリク ダール，カール
オスカー，フレドリク ダール，カール
エリクソン，ジョン，ウロフ
Original Assignee
バナディス ダイアグノスティクス
バナディス ダイアグノスティクス
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by バナディス ダイアグノスティクス, バナディス ダイアグノスティクス filed Critical バナディス ダイアグノスティクス
Publication of JP2016537990A publication Critical patent/JP2016537990A/ja
Publication of JP2016537990A5 publication Critical patent/JP2016537990A5/ja
Application granted granted Critical
Publication of JP6542771B2 publication Critical patent/JP6542771B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/682—Signal amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6832—Enhancement of hybridisation reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • C12Q1/6855—Ligating adaptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/50—Other enzymatic activities
    • C12Q2521/501—Ligase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/161—Modifications characterised by incorporating target specific and non-target specific sites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/191—Modifications characterised by incorporating an adaptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/30—Oligonucleotides characterised by their secondary structure
    • C12Q2525/301—Hairpin oligonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/30—Oligonucleotides characterised by their secondary structure
    • C12Q2525/307—Circular oligonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2531/00—Reactions of nucleic acids characterised by
    • C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
    • C12Q2531/125—Rolling circle
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/143—Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2016535002A 2013-12-02 2014-11-26 核酸プローブ及びゲノム断片検出方法 Active JP6542771B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1321191.7A GB2520763A (en) 2013-12-02 2013-12-02 Nucleic acid probe and method of detecting genomic fragments
GB1321191.7 2013-12-02
PCT/IB2014/003061 WO2015083001A2 (en) 2013-12-02 2014-11-26 Nucleic acid probe and method of detecting genomic fragments

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019110035A Division JP6571895B1 (ja) 2013-12-02 2019-06-13 核酸プローブ及びゲノム断片検出方法

Publications (3)

Publication Number Publication Date
JP2016537990A JP2016537990A (ja) 2016-12-08
JP2016537990A5 JP2016537990A5 (https=) 2017-12-28
JP6542771B2 true JP6542771B2 (ja) 2019-07-10

Family

ID=49979619

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016535002A Active JP6542771B2 (ja) 2013-12-02 2014-11-26 核酸プローブ及びゲノム断片検出方法
JP2019110035A Active JP6571895B1 (ja) 2013-12-02 2019-06-13 核酸プローブ及びゲノム断片検出方法
JP2019146042A Active JP6766236B2 (ja) 2013-12-02 2019-08-08 核酸プローブ及びゲノム断片検出方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2019110035A Active JP6571895B1 (ja) 2013-12-02 2019-06-13 核酸プローブ及びゲノム断片検出方法
JP2019146042A Active JP6766236B2 (ja) 2013-12-02 2019-08-08 核酸プローブ及びゲノム断片検出方法

Country Status (12)

Country Link
US (3) US10240198B2 (https=)
EP (2) EP3077540B1 (https=)
JP (3) JP6542771B2 (https=)
KR (1) KR102390285B1 (https=)
CN (2) CN108707652B (https=)
AU (2) AU2014358861B2 (https=)
BR (1) BR112016012264B1 (https=)
CA (1) CA2931013C (https=)
ES (2) ES2899693T3 (https=)
GB (1) GB2520763A (https=)
RU (1) RU2733888C2 (https=)
WO (1) WO2015083001A2 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2520765A (en) 2013-12-02 2015-06-03 Vanadis Diagnostics Ab Multiplex detection of nucleic acids
GB2520763A (en) 2013-12-02 2015-06-03 Vanadis Diagnostics Ab Nucleic acid probe and method of detecting genomic fragments
US10174383B2 (en) 2014-08-13 2019-01-08 Vanadis Diagnostics Method of estimating the amount of a methylated locus in a sample
GB201507376D0 (en) 2015-04-30 2015-06-17 Vanadis Diagnostics Ab Use of a porous transparent capillary membrane for counting rolling circle amplification products
KR102753113B1 (ko) * 2015-09-18 2025-01-09 바나디스 다이아그노스틱스 Dna 샘플의 분석을 위한 프로브 세트 및 이의 사용 방법
JPWO2017135383A1 (ja) * 2016-02-03 2018-12-06 国立大学法人豊橋技術科学大学 偽環状二重鎖ポリヌクレオチドと、それを用いた遺伝子発現阻害剤
BR112019007865A2 (pt) 2016-10-27 2019-07-02 Vanadis Diagnostics método para processamento de produtos de amplificação do círculo rolante
CN110225979B (zh) * 2017-05-23 2024-05-31 深圳华大基因股份有限公司 基于滚环扩增的基因组目标区域富集方法及其应用
US11117128B2 (en) 2017-08-25 2021-09-14 Vanadis Diagnostics Ab Filtration device
CN120905352A (zh) 2018-04-02 2025-11-07 埃努梅拉分子股份有限公司 用于对核酸分子进行计数的方法、系统和组合物
SG11202105957YA (en) * 2018-12-05 2021-07-29 Egi Tech Shen Zhen Co Limited Rolling circle amplification method, method for preparing sequencing library, and dna nanosphere prepared therefrom
CN109652506A (zh) * 2018-12-20 2019-04-19 派德洛格(天津)生物科技有限公司 荧光原位检测人EGFR基因21号外显子p.L858R突变的方法及试剂盒
EP3947718A4 (en) 2019-04-02 2022-12-21 Enumera Molecular, Inc. METHODS, SYSTEMS AND COMPOSITIONS FOR COUNTING NUCLEIC ACID MOLECULES
US20230242971A1 (en) * 2020-05-08 2023-08-03 Roche Sequencing Solutions, Inc. Removal of excess oligonucleotides from a reation mixture
WO2022008649A1 (en) * 2020-07-08 2022-01-13 F. Hoffmann-La Roche Ag Spatial analysis of multiple targets in tissue samples
US12467081B2 (en) 2020-11-23 2025-11-11 Pleno, Inc. Encoded endonuclease assays
WO2022212559A1 (en) * 2021-03-31 2022-10-06 Jumpcode Genomics, Inc. Methods for targeted nucleic acid sequencing
WO2022232425A2 (en) * 2021-04-29 2022-11-03 Illumina, Inc. Amplification techniques for nucleic acid characterization
WO2023282164A1 (ja) * 2021-07-08 2023-01-12 国立大学法人九州大学 プローブ、プローブセット、及び哺乳動物の核酸検出キット
MX2024002592A (es) * 2021-09-03 2024-06-11 Micronoma Inc Métodos para identificar biomarcadores microbianos asociados con cáncer.
GB202213930D0 (en) * 2022-09-23 2022-11-09 Xu Bo Padlock blocking oligonucleotide

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
WO2001094625A2 (en) * 2000-06-06 2001-12-13 Tm Bioscience Corporation Capture moieties for nucleic acids and uses thereof
US6573051B2 (en) 2001-03-09 2003-06-03 Molecular Staging, Inc. Open circle probes with intramolecular stem structures
US7208295B2 (en) 2001-11-19 2007-04-24 Affymetrix, Inc. Multiplex oligonucleotide addition and target amplification
US20040171047A1 (en) * 2002-05-22 2004-09-02 Dahl Gary A. Target-dependent transcription
AU2003298672A1 (en) 2002-11-19 2005-01-28 Singulex, Inc. Detection of target molecules through interaction with probes
JP4230457B2 (ja) 2002-12-18 2009-02-25 サード・ウェーブ・テクノロジーズ・インク 低分子核酸の検出方法
EP1680517B1 (en) * 2003-11-04 2010-03-31 Applied Biosystems, LLC Concatameric ligation products: compositions, methods and kits for same
SE0401270D0 (sv) 2004-05-18 2004-05-18 Fredrik Dahl Method for amplifying specific nucleic acids in parallel
WO2006076650A2 (en) 2005-01-12 2006-07-20 Applera Corporation Compositions, methods, and kits for selective amplification of nucleic acids
US7645576B2 (en) 2005-03-18 2010-01-12 The Chinese University Of Hong Kong Method for the detection of chromosomal aneuploidies
AU2006264564B2 (en) 2005-07-04 2012-04-19 Erasmus University Medical Center Chromosome conformation capture-on-chip (4c) assay
US20070087355A1 (en) 2005-10-14 2007-04-19 Barrett Michael T Comparative genomic hybridization assays and compositions for practicing the same
WO2007083766A1 (ja) * 2006-01-20 2007-07-26 Olympus Corporation 分子内プローブによる核酸配列の検出方法
US8038595B2 (en) 2006-01-25 2011-10-18 Beth Israel Deaconess Medical Center Devices and methods for tissue transplant and regeneration
US7901884B2 (en) * 2006-05-03 2011-03-08 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring
WO2008033442A2 (en) * 2006-09-12 2008-03-20 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for performing low background multiplex nucleic acid amplification reactions
US20090061424A1 (en) * 2007-08-30 2009-03-05 Sigma-Aldrich Company Universal ligation array for analyzing gene expression or genomic variations
US9388457B2 (en) * 2007-09-14 2016-07-12 Affymetrix, Inc. Locus specific amplification using array probes
GB0912909D0 (en) * 2009-07-23 2009-08-26 Olink Genomics Ab Probes for specific analysis of nucleic acids
CA2777322A1 (en) 2009-08-12 2011-02-17 President And Fellows Of Harvard College Biodetection methods and compositions
US8916349B2 (en) * 2009-11-23 2014-12-23 Becton, Dickinson And Company Assay method for target nucleic acid by signal amplification using probe hybridization and restriction
US9023769B2 (en) * 2009-11-30 2015-05-05 Complete Genomics, Inc. cDNA library for nucleic acid sequencing
GB0921264D0 (en) * 2009-12-03 2010-01-20 Olink Genomics Ab Method for amplification of target nucleic acid
EP2569447A4 (en) * 2010-05-14 2013-11-27 Fluidigm Corp ASSAYS FOR THE DETECTION OF GENOTYPES, MUTATIONS OR ANEUPLOIDY
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
GB2492042B (en) 2011-05-11 2020-04-15 Agilent Technologies Inc Selector probes for nucleic acid analysis comprising at each end a non-adjacent target specific region
WO2012168803A2 (en) 2011-06-07 2012-12-13 Koninklijke Philips Electronics N.V. Providing nucleotide sequence data
CN104093854A (zh) * 2011-12-02 2014-10-08 凯杰有限公司 表征组合物中的rna的方法和试剂盒
US9193994B2 (en) * 2012-04-20 2015-11-24 Samsung Electronics Co., Ltd. Polynucleotide and use thereof
CN102899417A (zh) * 2012-10-24 2013-01-30 武汉大学 一种microRNAs荧光检测探针
WO2014165267A2 (en) 2013-03-12 2014-10-09 Counsyl, Inc. Systems and methods for prenatal genetic analysis
GB2520763A (en) 2013-12-02 2015-06-03 Vanadis Diagnostics Ab Nucleic acid probe and method of detecting genomic fragments
GB2520765A (en) 2013-12-02 2015-06-03 Vanadis Diagnostics Ab Multiplex detection of nucleic acids

Also Published As

Publication number Publication date
CA2931013C (en) 2023-06-06
AU2021200461B2 (en) 2022-10-06
US20190194748A1 (en) 2019-06-27
US20200318186A1 (en) 2020-10-08
KR20160096633A (ko) 2016-08-16
JP2016537990A (ja) 2016-12-08
AU2014358861B2 (en) 2020-12-10
HK1258148A1 (zh) 2019-11-08
CN105899680B (zh) 2018-06-15
US20170016065A1 (en) 2017-01-19
CA2931013A1 (en) 2015-06-11
JP6766236B2 (ja) 2020-10-07
CN105899680A (zh) 2016-08-24
EP3077540A2 (en) 2016-10-12
EP3770273B1 (en) 2021-09-29
CN108707652B (zh) 2022-04-15
ES2818920T3 (es) 2021-04-14
GB2520763A (en) 2015-06-03
WO2015083001A2 (en) 2015-06-11
WO2015083001A3 (en) 2015-11-26
RU2733888C2 (ru) 2020-10-07
AU2014358861A1 (en) 2016-06-09
GB201321191D0 (en) 2014-01-15
BR112016012264A2 (pt) 2017-09-26
US10240198B2 (en) 2019-03-26
CN108707652A (zh) 2018-10-26
ES2899693T3 (es) 2022-03-14
US10731214B2 (en) 2020-08-04
EP3077540B1 (en) 2020-09-02
JP2019176867A (ja) 2019-10-17
JP2019216734A (ja) 2019-12-26
AU2021200461A1 (en) 2021-02-25
EP3770273A1 (en) 2021-01-27
KR102390285B1 (ko) 2022-04-25
JP6571895B1 (ja) 2019-09-04
BR112016012264B1 (pt) 2023-04-25

Similar Documents

Publication Publication Date Title
JP6766236B2 (ja) 核酸プローブ及びゲノム断片検出方法
JP6749236B2 (ja) 核酸の多重検出
HK40044594A (en) Method of detecting genomic fragments
HK40044594B (en) Method of detecting genomic fragments
HK1258148B (en) Nucleic acid probe and method of detecting genomic fragments
HK40043771B (en) Multiplex detection of nucleic acids
HK40043771A (en) Multiplex detection of nucleic acids
HK1229860A1 (en) Nucleic acid probe for detecting genomic fragments
HK1229860B (en) Nucleic acid probe for detecting genomic fragments
HK1230245B (en) Multiplex detection of nucleic acids
HK1230245A1 (en) Multiplex detection of nucleic acids

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171117

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20171117

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20180906

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20181005

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181225

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20190517

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20190613

R150 Certificate of patent or registration of utility model

Ref document number: 6542771

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250