KR102377189B1 - C9orf72 유전자좌에서 파괴를 갖는 비-인간 동물 - Google Patents

C9orf72 유전자좌에서 파괴를 갖는 비-인간 동물

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Publication number
KR102377189B1
KR102377189B1 KR1020207035238A KR20207035238A KR102377189B1 KR 102377189 B1 KR102377189 B1 KR 102377189B1 KR 1020207035238 A KR1020207035238 A KR 1020207035238A KR 20207035238 A KR20207035238 A KR 20207035238A KR 102377189 B1 KR102377189 B1 KR 102377189B1
Authority
KR
South Korea
Prior art keywords
c9orf72
disruption
human animals
locus
c9orf72 locus
Prior art date
Application number
KR1020207035238A
Other languages
English (en)
Other versions
KR20200140934A (ko
Inventor
아만다 아타나시오
부르신 이키즈
궈춘 공
마이클 엘. 라크루아-프랄리쉬
카-만 비너스 라이
데이비드 엠. 발렌주엘라
Original Assignee
리제너론 파마슈티칼스 인코포레이티드
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Publication of KR20200140934A publication Critical patent/KR20200140934A/ko
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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knockout animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/02—Breeding vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0381—Animal model for diseases of the hematopoietic system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
KR1020207035238A 2015-05-29 2016-05-26 C9orf72 유전자좌에서 파괴를 갖는 비-인간 동물 KR102377189B1 (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201562168171P 2015-05-29 2015-05-29
US62/168,171 2015-05-29
US201562232658P 2015-09-25 2015-09-25
US62/232,658 2015-09-25
US201562245382P 2015-10-23 2015-10-23
US62/245,382 2015-10-23
KR1020177037383A KR102190661B1 (ko) 2015-05-29 2016-05-26 C9orf72 유전자좌에서 파괴를 갖는 비-인간 동물
PCT/US2016/034304 WO2016196185A1 (en) 2015-05-29 2016-05-26 Non-human animals having a disruption in a c9orf72 locus

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020177037383A Division KR102190661B1 (ko) 2015-05-29 2016-05-26 C9orf72 유전자좌에서 파괴를 갖는 비-인간 동물

Publications (2)

Publication Number Publication Date
KR20200140934A KR20200140934A (ko) 2020-12-16
KR102377189B1 true KR102377189B1 (ko) 2022-03-22

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KR1020207035238A KR102377189B1 (ko) 2015-05-29 2016-05-26 C9orf72 유전자좌에서 파괴를 갖는 비-인간 동물
KR1020177037383A KR102190661B1 (ko) 2015-05-29 2016-05-26 C9orf72 유전자좌에서 파괴를 갖는 비-인간 동물

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Country Status (15)

Country Link
US (2) US10285388B2 (ko)
EP (2) EP3689139A1 (ko)
JP (3) JP6619822B2 (ko)
KR (2) KR102377189B1 (ko)
CN (1) CN107920498A (ko)
AU (2) AU2016270587B2 (ko)
BR (1) BR112017025507A2 (ko)
CA (1) CA2986048C (ko)
ES (1) ES2784360T3 (ko)
HK (1) HK1248465A1 (ko)
IL (2) IL255385A0 (ko)
MX (1) MX2017015369A (ko)
RU (2) RU2725737C2 (ko)
SG (1) SG10201911257YA (ko)
WO (1) WO2016196185A1 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210260219A1 (en) * 2015-12-23 2021-08-26 Crispr Therapeutics Ag Materials and methods for treatment of amyotrophic lateral sclerosis and/or frontal temporal lobular degeneration
EP3518667A1 (en) 2016-09-30 2019-08-07 Regeneron Pharmaceuticals, Inc. Non-human animals having a hexanucleotide repeat expansion in a c9orf72 locus
CN109963570A (zh) 2017-01-21 2019-07-02 宁波知明生物科技有限公司 芍药苷-6’-o-苯磺酸酯在治疗干燥综合征的应用
CN107693542B (zh) * 2017-09-05 2020-03-10 中山大学附属第三医院 一种系统性红斑狼疮动物模型的构建方法及其应用
CN109452229B (zh) * 2018-11-19 2021-10-22 百奥赛图(北京)医药科技股份有限公司 狗源化pd-1基因改造动物模型的制备方法及应用
EP3732291A1 (en) 2018-12-20 2020-11-04 Regeneron Pharmaceuticals, Inc. Nuclease-mediated repeat expansion
CN113046390B (zh) * 2020-03-09 2024-01-09 百奥赛图江苏基因生物技术有限公司 Csf1r基因人源化的非人动物及其构建方法和应用

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523226A (en) 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
US5670356A (en) 1994-12-12 1997-09-23 Promega Corporation Modified luciferase
US5874304A (en) 1996-01-18 1999-02-23 University Of Florida Research Foundation, Inc. Humanized green fluorescent protein genes and methods
AU8587598A (en) 1997-07-26 1999-02-16 Wisconsin Alumni Research Foundation Trans-species nuclear transfer
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US20050144655A1 (en) 2000-10-31 2005-06-30 Economides Aris N. Methods of modifying eukaryotic cells
US7105348B2 (en) 2000-10-31 2006-09-12 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
AUPR451401A0 (en) 2001-04-20 2001-05-24 Monash University A method of nuclear transfer
US7612250B2 (en) 2002-07-29 2009-11-03 Trustees Of Tufts College Nuclear transfer embryo formation method
AU2005295269B2 (en) 2004-10-19 2010-05-13 Regeneron Pharmaceuticals, Inc. Method for generating an animal homozygous for a genetic modification
CN101117633B (zh) 2006-08-03 2011-07-20 上海交通大学附属儿童医院 一种细胞核移植方法
JP2008307007A (ja) * 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
WO2009103027A2 (en) 2008-02-15 2009-08-20 Synthetic Genomics, Inc. Methods for in vitro joining and combinatorial assembly of nucleic acid molecules
US8470594B2 (en) * 2008-04-15 2013-06-25 President And Fellows Of Harvard College Methods for identifying agents that affect the survival of motor neurons
RU2425880C2 (ru) * 2009-07-30 2011-08-10 Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН Способ получения трансгенных мышей
WO2011020005A1 (en) 2009-08-14 2011-02-17 Regeneron Pharmaceuticals, Inc. miRNA-REGULATED DIFFERENTIATION-DEPENDENT SELF-DELETING CASSETTE
KR20120050485A (ko) 2009-08-14 2012-05-18 레비비코르 인코포레이션 당뇨병 치료를 위한 복수 형질전환 돼지
WO2013030588A1 (en) * 2011-08-31 2013-03-07 The University Of Manchester Method for diagnosing a neurodegenerative disease
WO2013041577A1 (en) 2011-09-20 2013-03-28 Vib Vzw Methods for the diagnosis of amyotrophic lateral sclerosis and frontotemporal lobar degeneration
CA2869016C (en) 2012-04-25 2020-05-05 Regeneron Pharmaceuticals, Inc. Nuclease-mediated targeting with large targeting vectors
WO2014062736A1 (en) * 2012-10-15 2014-04-24 Isis Pharmaceuticals, Inc. Methods for monitoring c9orf72 expression
PT2906696T (pt) 2012-10-15 2019-12-16 Univ California Métodos para modular a expressão de c9orf72
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
SG10201706741VA (en) 2013-02-20 2017-10-30 Regeneron Pharma Genetic modification of rats
BR112015026197B1 (pt) 2013-04-16 2022-12-06 Regeneron Pharmaceuticals, Inc Método para modificação marcada de um lócus genômico de interesse em uma célula de rato pluripotente
WO2015059265A1 (en) 2013-10-25 2015-04-30 Cellectis Design of rare-cutting endonucleases for efficient and specific targeting dna sequences comprising highly repetitive motives
BR112016013547A2 (pt) 2013-12-12 2017-10-03 Broad Inst Inc Composições e métodos de uso de sistemas crispr-cas em distúrbios de repetições de nucleotídeos
WO2015143078A1 (en) 2014-03-18 2015-09-24 University Of Massachusetts Raav-based compositions and methods for treating amyotrophic lateral sclerosis
WO2015153760A2 (en) 2014-04-01 2015-10-08 Sangamo Biosciences, Inc. Methods and compositions for prevention or treatment of a nervous system disorder
DK3155099T3 (en) 2014-06-23 2018-05-07 Regeneron Pharma NUCLEASE MEDIATED DNA COLLECTION
CA3172866A1 (en) 2014-06-26 2015-12-30 Regeneron Pharamaceuticals, Inc. Methods and compositions for targeted genetic modifications and methods of use
KR20230070319A (ko) 2014-11-21 2023-05-22 리제너론 파마슈티칼스 인코포레이티드 쌍 형성된 가이드 rna를 사용하는 표적화된 유전자 변형을 위한 방법 및 조성물
EP3850946B1 (en) 2014-12-05 2023-09-27 Regeneron Pharmaceuticals, Inc. Non-human animals having a humanized cluster of differentiation 47 gene
US11326184B2 (en) 2014-12-19 2022-05-10 Regeneron Pharmaceuticals, Inc. Methods and compositions for targeted genetic modification through single-step multiple targeting
US10793855B2 (en) 2015-01-06 2020-10-06 Ionis Pharmaceuticals, Inc. Compositions for modulating expression of C9ORF72 antisense transcript
EP3289081B1 (en) 2015-04-27 2019-03-27 Genethon Compositions and methods for the treatment of nucleotide repeat expansion disorders
WO2016179112A1 (en) 2015-05-01 2016-11-10 Precision Biosciences, Inc. Precise deletion of chromoscomal sequences in vivo and treatment of nucleotide repeat expansion disorders using engineered nucleases
CA3035810A1 (en) 2015-09-02 2017-03-09 University Of Massachusetts Detection of gene loci with crispr arrayed repeats and/or polychromatic single guide ribonucleic acids
US20210260219A1 (en) 2015-12-23 2021-08-26 Crispr Therapeutics Ag Materials and methods for treatment of amyotrophic lateral sclerosis and/or frontal temporal lobular degeneration
WO2017178590A1 (en) 2016-04-14 2017-10-19 Université de Lausanne Treatment and/or prevention of dna-triplet repeat diseases or disorders
EP3488001A4 (en) 2016-07-25 2019-05-29 Mayo Foundation for Medical Education and Research TREATMENT OF CANCER
EP3518667A1 (en) 2016-09-30 2019-08-07 Regeneron Pharmaceuticals, Inc. Non-human animals having a hexanucleotide repeat expansion in a c9orf72 locus
CN110337493B (zh) 2016-10-28 2024-03-12 吉尼松公司 用于治疗肌强直性营养不良的组合物和方法
JP7157052B2 (ja) 2016-10-28 2022-10-19 ジェネトン 筋緊張性ジストロフィーの治療のための組成物および方法
EP3592365A4 (en) 2017-03-10 2021-01-13 The Board Of Regents Of The University Of Texas System TREATMENT OF ENDOTHELIAL CORNEAL DYSTROPHY OF FUCHS
CA3059213A1 (en) 2017-05-09 2018-11-15 University Of Massachusetts Methods of treating amyotrophic lateral sclerosis (als)
EP3716767A4 (en) 2017-10-24 2021-11-24 Sangamo Therapeutics, Inc. METHODS AND COMPOSITIONS FOR TREATMENT OF RARE DISEASES
AU2019288212A1 (en) * 2018-06-18 2020-12-03 Denali Therapeutics Inc. Fusion proteins comprising progranulin

Also Published As

Publication number Publication date
EP3302048A1 (en) 2018-04-11
NZ737000A (en) 2021-02-26
KR20180012323A (ko) 2018-02-05
IL255385A0 (en) 2017-12-31
BR112017025507A2 (pt) 2018-08-07
CA2986048A1 (en) 2016-12-08
JP2018518165A (ja) 2018-07-12
IL286176A (en) 2021-10-31
CN107920498A (zh) 2018-04-17
AU2021201827A1 (en) 2021-04-22
AU2021201827B2 (en) 2023-11-09
AU2016270587B2 (en) 2020-12-24
ES2784360T3 (es) 2020-09-24
RU2017145143A (ru) 2019-07-02
EP3689139A1 (en) 2020-08-05
EP3302048B1 (en) 2020-02-19
JP2021118745A (ja) 2021-08-12
KR102190661B1 (ko) 2020-12-14
WO2016196185A1 (en) 2016-12-08
US11547101B2 (en) 2023-01-10
US20160345547A1 (en) 2016-12-01
SG10201911257YA (en) 2020-01-30
MX2017015369A (es) 2018-07-06
AU2016270587A1 (en) 2017-11-30
RU2725737C2 (ru) 2020-07-03
RU2020115485A (ru) 2020-06-11
KR20200140934A (ko) 2020-12-16
RU2017145143A3 (ko) 2019-10-17
HK1248465A1 (zh) 2018-10-19
US10285388B2 (en) 2019-05-14
US20190216062A1 (en) 2019-07-18
CA2986048C (en) 2021-10-26
JP6619822B2 (ja) 2019-12-11
JP2019201671A (ja) 2019-11-28
JP6884831B2 (ja) 2021-06-09

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