KR102367319B1 - 5-플루오로-1h-피라졸의 제조 방법 - Google Patents

5-플루오로-1h-피라졸의 제조 방법 Download PDF

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KR102367319B1
KR102367319B1 KR1020167017080A KR20167017080A KR102367319B1 KR 102367319 B1 KR102367319 B1 KR 102367319B1 KR 1020167017080 A KR1020167017080 A KR 1020167017080A KR 20167017080 A KR20167017080 A KR 20167017080A KR 102367319 B1 KR102367319 B1 KR 102367319B1
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KR20160089509A (ko
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세르기 파제노크
노르베르트 루이
크리스티안 푼케
아른트 네프
바딤 미하일로비치 티모센코
엘레나 이바노브나 카민스카야
유리 그리고리에비치 셰르몰로비치
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바이엘 애니멀 헬스 게엠베하
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020167017080A 2013-11-27 2014-11-25 5-플루오로-1h-피라졸의 제조 방법 Active KR102367319B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13194561 2013-11-27
EP13194561.0 2013-11-27
PCT/EP2014/075490 WO2015078846A1 (en) 2013-11-27 2014-11-25 Process for the preparation of 5-fluoro-1h-pyrazoles

Publications (2)

Publication Number Publication Date
KR20160089509A KR20160089509A (ko) 2016-07-27
KR102367319B1 true KR102367319B1 (ko) 2022-02-23

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KR1020167017080A Active KR102367319B1 (ko) 2013-11-27 2014-11-25 5-플루오로-1h-피라졸의 제조 방법

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Country Link
US (1) US9725415B2 (enExample)
EP (1) EP3083566B1 (enExample)
JP (1) JP6678581B2 (enExample)
KR (1) KR102367319B1 (enExample)
CN (1) CN105934429B (enExample)
BR (1) BR112016011890B1 (enExample)
ES (1) ES2939161T3 (enExample)
IL (1) IL245474B (enExample)
MX (1) MX394430B (enExample)
TW (1) TWI688557B (enExample)
WO (1) WO2015078846A1 (enExample)

Families Citing this family (7)

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Publication number Priority date Publication date Assignee Title
KR102044202B1 (ko) * 2012-07-19 2019-11-13 바이엘 애니멀 헬스 게엠베하 5-플루오로-1h-피라졸의 제조 방법
CN105934428B (zh) * 2013-11-27 2019-07-19 拜耳动物保健有限责任公司 制备5-氟-1h-吡唑的方法
EP3590927A1 (en) 2018-07-05 2020-01-08 Bayer Animal Health GmbH Novel compounds for controlling arthropods
EP3771711A1 (en) 2019-07-29 2021-02-03 Bayer Animal Health GmbH Pyrazole derivatives for controlling arthropods
PH12022550328A1 (en) 2019-08-14 2023-02-06 Vetoquinol Sa Compositions comprising tigolaner for controlling parasites
HRP20250608T1 (hr) 2020-05-27 2025-10-10 Vetoquinol Sa Metoda za dobivanje 2-kloro-n-(1-cijanociklopropil)-5-[2'-metil-5'-(pentafluoroetil)-4'- (trifluorometil)-2'h-1,3'-bipirazol-4-il]benzamida
PH12022553222A1 (en) 2020-05-29 2024-02-12 Boehringer Ingelheim Animal Health Usa Inc Anthelmintic heterocyclic compounds

Citations (1)

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Publication number Priority date Publication date Assignee Title
KR102044202B1 (ko) * 2012-07-19 2019-11-13 바이엘 애니멀 헬스 게엠베하 5-플루오로-1h-피라졸의 제조 방법

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SU1456419A1 (ru) 1987-06-18 1989-02-07 Институт элементоорганических соединений им.А.Н.Несмеянова Способ получени 1-замещенных 3-пентафторэтил-4-трифторметил-5-фторпиразолов
JP2817863B2 (ja) * 1992-02-21 1998-10-30 宇部興産株式会社 含フッ素ピラゾール化合物、その製法及び有害生物防除剤
US5254774A (en) 1992-12-28 1993-10-19 Minnesota Mining And Manufacturing Company Preparation of hexafluoropropene oligomers
DE602004021011D1 (de) 2003-10-08 2009-06-18 Lilly Co Eli Pyrrol- und pyrazolderivate als potentiatoren von glutamatrezeptoren
AU2007228887B2 (en) * 2006-03-22 2012-02-02 F. Hoffmann-La Roche Ag Pyrazoles as 11-beta-HSD-1
US8642788B2 (en) 2008-01-11 2014-02-04 The Regents Of The University Of California Activators of executioner procaspases 3, 6 and 7
EP2184273A1 (de) * 2008-11-05 2010-05-12 Bayer CropScience AG Halogen-substituierte Verbindungen als Pestizide
UY33895A (es) * 2011-02-09 2012-09-28 Syngenta Participations Ag Compuestos insecticidas, método para combatir y controlar insectos, ácaros, nematodos o moluscos, y composición insecticida, acaricida o nematicida
JP6321042B2 (ja) * 2013-02-06 2018-05-09 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 新規なハロゲン置換された化合物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102044202B1 (ko) * 2012-07-19 2019-11-13 바이엘 애니멀 헬스 게엠베하 5-플루오로-1h-피라졸의 제조 방법

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BULLETIN OF THE ACADEMY OF SCIENCES OF THE USSR DIVISION OF CHEMICAL SCIENCE, Vol. 39(11), pp. 2338-2344(1990).
Journal of Fluorine Chemistry, Vol. 98(1), pp. 29-36(1999).

Also Published As

Publication number Publication date
BR112016011890B1 (pt) 2021-11-16
WO2015078846A1 (en) 2015-06-04
TWI688557B (zh) 2020-03-21
TW201609662A (zh) 2016-03-16
KR20160089509A (ko) 2016-07-27
CN105934429A (zh) 2016-09-07
BR112016011890A2 (enExample) 2017-08-08
US20160289194A1 (en) 2016-10-06
MX2016006976A (es) 2016-09-07
US9725415B2 (en) 2017-08-08
EP3083566B1 (en) 2022-12-21
CN105934429B (zh) 2022-03-04
JP6678581B2 (ja) 2020-04-08
IL245474B (en) 2019-12-31
IL245474A0 (en) 2016-06-30
MX394430B (es) 2025-03-24
JP2016538301A (ja) 2016-12-08
EP3083566A1 (en) 2016-10-26
ES2939161T3 (es) 2023-04-19

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