CN105934429B - 制备5-氟-1h-吡唑的方法 - Google Patents
制备5-氟-1h-吡唑的方法 Download PDFInfo
- Publication number
- CN105934429B CN105934429B CN201480074160.9A CN201480074160A CN105934429B CN 105934429 B CN105934429 B CN 105934429B CN 201480074160 A CN201480074160 A CN 201480074160A CN 105934429 B CN105934429 B CN 105934429B
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- CN
- China
- Prior art keywords
- alkyl
- formula
- compound
- cyano
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/16—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13194561 | 2013-11-27 | ||
| EP13194561.0 | 2013-11-27 | ||
| PCT/EP2014/075490 WO2015078846A1 (en) | 2013-11-27 | 2014-11-25 | Process for the preparation of 5-fluoro-1h-pyrazoles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105934429A CN105934429A (zh) | 2016-09-07 |
| CN105934429B true CN105934429B (zh) | 2022-03-04 |
Family
ID=49674200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480074160.9A Active CN105934429B (zh) | 2013-11-27 | 2014-11-25 | 制备5-氟-1h-吡唑的方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9725415B2 (enExample) |
| EP (1) | EP3083566B1 (enExample) |
| JP (1) | JP6678581B2 (enExample) |
| KR (1) | KR102367319B1 (enExample) |
| CN (1) | CN105934429B (enExample) |
| BR (1) | BR112016011890B1 (enExample) |
| ES (1) | ES2939161T3 (enExample) |
| IL (1) | IL245474B (enExample) |
| MX (1) | MX394430B (enExample) |
| TW (1) | TWI688557B (enExample) |
| WO (1) | WO2015078846A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102044202B1 (ko) * | 2012-07-19 | 2019-11-13 | 바이엘 애니멀 헬스 게엠베하 | 5-플루오로-1h-피라졸의 제조 방법 |
| CN105934428B (zh) * | 2013-11-27 | 2019-07-19 | 拜耳动物保健有限责任公司 | 制备5-氟-1h-吡唑的方法 |
| EP3590927A1 (en) | 2018-07-05 | 2020-01-08 | Bayer Animal Health GmbH | Novel compounds for controlling arthropods |
| EP3771711A1 (en) | 2019-07-29 | 2021-02-03 | Bayer Animal Health GmbH | Pyrazole derivatives for controlling arthropods |
| PH12022550328A1 (en) | 2019-08-14 | 2023-02-06 | Vetoquinol Sa | Compositions comprising tigolaner for controlling parasites |
| HRP20250608T1 (hr) | 2020-05-27 | 2025-10-10 | Vetoquinol Sa | Metoda za dobivanje 2-kloro-n-(1-cijanociklopropil)-5-[2'-metil-5'-(pentafluoroetil)-4'- (trifluorometil)-2'h-1,3'-bipirazol-4-il]benzamida |
| PH12022553222A1 (en) | 2020-05-29 | 2024-02-12 | Boehringer Ingelheim Animal Health Usa Inc | Anthelmintic heterocyclic compounds |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102317263A (zh) * | 2008-11-05 | 2012-01-11 | 拜耳作物科学股份公司 | 用作杀虫剂的卤素取代化合物 |
| WO2014012975A1 (en) * | 2012-07-19 | 2014-01-23 | Bayer Cropscience Ag | Process for the preparation of 5-fluoro-1h-pyrazoles |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1456419A1 (ru) | 1987-06-18 | 1989-02-07 | Институт элементоорганических соединений им.А.Н.Несмеянова | Способ получени 1-замещенных 3-пентафторэтил-4-трифторметил-5-фторпиразолов |
| JP2817863B2 (ja) * | 1992-02-21 | 1998-10-30 | 宇部興産株式会社 | 含フッ素ピラゾール化合物、その製法及び有害生物防除剤 |
| US5254774A (en) | 1992-12-28 | 1993-10-19 | Minnesota Mining And Manufacturing Company | Preparation of hexafluoropropene oligomers |
| DE602004021011D1 (de) | 2003-10-08 | 2009-06-18 | Lilly Co Eli | Pyrrol- und pyrazolderivate als potentiatoren von glutamatrezeptoren |
| AU2007228887B2 (en) * | 2006-03-22 | 2012-02-02 | F. Hoffmann-La Roche Ag | Pyrazoles as 11-beta-HSD-1 |
| US8642788B2 (en) | 2008-01-11 | 2014-02-04 | The Regents Of The University Of California | Activators of executioner procaspases 3, 6 and 7 |
| UY33895A (es) * | 2011-02-09 | 2012-09-28 | Syngenta Participations Ag | Compuestos insecticidas, método para combatir y controlar insectos, ácaros, nematodos o moluscos, y composición insecticida, acaricida o nematicida |
| JP6321042B2 (ja) * | 2013-02-06 | 2018-05-09 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | 新規なハロゲン置換された化合物 |
-
2014
- 2014-11-25 US US15/037,564 patent/US9725415B2/en active Active
- 2014-11-25 CN CN201480074160.9A patent/CN105934429B/zh active Active
- 2014-11-25 BR BR112016011890-1A patent/BR112016011890B1/pt active IP Right Grant
- 2014-11-25 KR KR1020167017080A patent/KR102367319B1/ko active Active
- 2014-11-25 WO PCT/EP2014/075490 patent/WO2015078846A1/en not_active Ceased
- 2014-11-25 TW TW103140710A patent/TWI688557B/zh active
- 2014-11-25 EP EP14805819.1A patent/EP3083566B1/en active Active
- 2014-11-25 ES ES14805819T patent/ES2939161T3/es active Active
- 2014-11-25 JP JP2016534680A patent/JP6678581B2/ja active Active
- 2014-11-25 MX MX2016006976A patent/MX394430B/es unknown
-
2016
- 2016-05-04 IL IL245474A patent/IL245474B/en active IP Right Grant
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102317263A (zh) * | 2008-11-05 | 2012-01-11 | 拜耳作物科学股份公司 | 用作杀虫剂的卤素取代化合物 |
| WO2014012975A1 (en) * | 2012-07-19 | 2014-01-23 | Bayer Cropscience Ag | Process for the preparation of 5-fluoro-1h-pyrazoles |
| CN104470900A (zh) * | 2012-07-19 | 2015-03-25 | 拜尔农作物科学股份公司 | 5-氟-1h-吡唑的制备方法 |
Non-Patent Citations (1)
| Title |
|---|
| Ki-Whan Chi，等.Synthesis of ¯uorinated N-arylpyrazoles with per¯uoro-2-methyl-2-pentene and arylhydrazines.《Journal of Fluorine Chemistry》.1999,第98卷(第1期),第29-36页. * |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112016011890B1 (pt) | 2021-11-16 |
| WO2015078846A1 (en) | 2015-06-04 |
| TWI688557B (zh) | 2020-03-21 |
| TW201609662A (zh) | 2016-03-16 |
| KR20160089509A (ko) | 2016-07-27 |
| CN105934429A (zh) | 2016-09-07 |
| BR112016011890A2 (enExample) | 2017-08-08 |
| US20160289194A1 (en) | 2016-10-06 |
| MX2016006976A (es) | 2016-09-07 |
| US9725415B2 (en) | 2017-08-08 |
| EP3083566B1 (en) | 2022-12-21 |
| JP6678581B2 (ja) | 2020-04-08 |
| IL245474B (en) | 2019-12-31 |
| KR102367319B1 (ko) | 2022-02-23 |
| IL245474A0 (en) | 2016-06-30 |
| MX394430B (es) | 2025-03-24 |
| JP2016538301A (ja) | 2016-12-08 |
| EP3083566A1 (en) | 2016-10-26 |
| ES2939161T3 (es) | 2023-04-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20181203 Address after: Leverkusen, Germany Applicant after: Bayer Animal Hearth Caring AG Address before: Germany's Rhine River Monheim Applicant before: Bayer Cropscience AG |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant |