MX394430B - Proceso para la preparación de 5-fluoro-1h-pirazoles. - Google Patents

Proceso para la preparación de 5-fluoro-1h-pirazoles.

Info

Publication number
MX394430B
MX394430B MX2016006976A MX2016006976A MX394430B MX 394430 B MX394430 B MX 394430B MX 2016006976 A MX2016006976 A MX 2016006976A MX 2016006976 A MX2016006976 A MX 2016006976A MX 394430 B MX394430 B MX 394430B
Authority
MX
Mexico
Prior art keywords
pyrazoles
fluoro
preparation
hydrazine
olefin
Prior art date
Application number
MX2016006976A
Other languages
English (en)
Other versions
MX2016006976A (es
Inventor
Arnd Neeff
Christian Funke
Elena Ivanovna Kaminskaya
Norbert Lui
Sergii Pazenok
Vadim Mikhailovich Timoshenko
Yuriy Grigorievich Shermolovich
Original Assignee
Elanco Animal Health Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elanco Animal Health Gmbh filed Critical Elanco Animal Health Gmbh
Publication of MX2016006976A publication Critical patent/MX2016006976A/es
Publication of MX394430B publication Critical patent/MX394430B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un nuevo proceso para la preparación de 5-fluoro-1H-pirazoles de la fórmula general (I) como se describe en la presente, que resulta de la reacción de una olefina con hidrazina en presencia de agua y una base.
MX2016006976A 2013-11-27 2014-11-25 Proceso para la preparación de 5-fluoro-1h-pirazoles. MX394430B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13194561 2013-11-27
PCT/EP2014/075490 WO2015078846A1 (en) 2013-11-27 2014-11-25 Process for the preparation of 5-fluoro-1h-pyrazoles

Publications (2)

Publication Number Publication Date
MX2016006976A MX2016006976A (es) 2016-09-07
MX394430B true MX394430B (es) 2025-03-24

Family

ID=49674200

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016006976A MX394430B (es) 2013-11-27 2014-11-25 Proceso para la preparación de 5-fluoro-1h-pirazoles.

Country Status (11)

Country Link
US (1) US9725415B2 (es)
EP (1) EP3083566B1 (es)
JP (1) JP6678581B2 (es)
KR (1) KR102367319B1 (es)
CN (1) CN105934429B (es)
BR (1) BR112016011890B1 (es)
ES (1) ES2939161T3 (es)
IL (1) IL245474B (es)
MX (1) MX394430B (es)
TW (1) TWI688557B (es)
WO (1) WO2015078846A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014012975A1 (en) * 2012-07-19 2014-01-23 Bayer Cropscience Ag Process for the preparation of 5-fluoro-1h-pyrazoles
WO2015078847A1 (en) * 2013-11-27 2015-06-04 Bayer Cropscience Ag Process for the preparation of 5-fluoro-1h-pyrazoles
EP3590927A1 (en) 2018-07-05 2020-01-08 Bayer Animal Health GmbH Novel compounds for controlling arthropods
EP3771711A1 (en) 2019-07-29 2021-02-03 Bayer Animal Health GmbH Pyrazole derivatives for controlling arthropods
CR20220112A (es) 2019-08-14 2022-06-21 Vetoquinol Sa Composiciones que comprenden tigolaner para el control de parásitos
EP4157830B1 (en) * 2020-05-27 2025-04-30 Vetoquinol SA Method for preparing 2-chloro-n-(1-cyanocyclopropyl)-5-[2'-methyl-5'-(pentafluoroethyl)-4'-(trifluoromethyl)-2'h-1,3'-bipyrazol-4-yl]benzamide
WO2021242581A1 (en) 2020-05-29 2021-12-02 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic heterocyclic compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1456419A1 (ru) 1987-06-18 1989-02-07 Институт элементоорганических соединений им.А.Н.Несмеянова Способ получени 1-замещенных 3-пентафторэтил-4-трифторметил-5-фторпиразолов
JP2817863B2 (ja) * 1992-02-21 1998-10-30 宇部興産株式会社 含フッ素ピラゾール化合物、その製法及び有害生物防除剤
US5254774A (en) 1992-12-28 1993-10-19 Minnesota Mining And Manufacturing Company Preparation of hexafluoropropene oligomers
WO2005040110A1 (en) * 2003-10-08 2005-05-06 Eli Lilly And Company Pyrrole and pyrazole derivatives as potentiators of glutamate receptors
HRP20151078T1 (hr) * 2006-03-22 2015-11-20 F. Hoffmann - La Roche Ag Pirazoli kao 11-beta-hsd-1
AU2009203977A1 (en) 2008-01-11 2009-07-16 The Regents Of The University Of California Activators of executioner procaspases 3, 6 and 7
EP2184273A1 (de) * 2008-11-05 2010-05-12 Bayer CropScience AG Halogen-substituierte Verbindungen als Pestizide
AR085318A1 (es) * 2011-02-09 2013-09-25 Syngenta Participations Ag Derivados de triazol que tienen actividad insecticida
WO2014012975A1 (en) * 2012-07-19 2014-01-23 Bayer Cropscience Ag Process for the preparation of 5-fluoro-1h-pyrazoles
KR102191469B1 (ko) * 2013-02-06 2020-12-16 바이엘 애니멀 헬스 게엠베하 해충 방제제로서의 할로겐-치환된 피라졸 유도체

Also Published As

Publication number Publication date
KR20160089509A (ko) 2016-07-27
CN105934429B (zh) 2022-03-04
ES2939161T3 (es) 2023-04-19
JP6678581B2 (ja) 2020-04-08
MX2016006976A (es) 2016-09-07
IL245474B (en) 2019-12-31
TWI688557B (zh) 2020-03-21
CN105934429A (zh) 2016-09-07
WO2015078846A1 (en) 2015-06-04
US20160289194A1 (en) 2016-10-06
KR102367319B1 (ko) 2022-02-23
TW201609662A (zh) 2016-03-16
BR112016011890A2 (es) 2017-08-08
BR112016011890B1 (pt) 2021-11-16
EP3083566A1 (en) 2016-10-26
JP2016538301A (ja) 2016-12-08
EP3083566B1 (en) 2022-12-21
US9725415B2 (en) 2017-08-08
IL245474A0 (en) 2016-06-30

Similar Documents

Publication Publication Date Title
CL2016002455A1 (es) Anticuerpos multiespecíficos.
UY34765A (es) Compuestos novedosos.
UY34342A (es) ?derivados de pirrolopirimidina y purina?.
DOP2017000078A (es) Indazoles sustituidos con bencilo como inhibidores de bub1.
EA201692219A1 (ru) Способы получения противовирусных соединений
EA201600091A1 (ru) 4-членные кольцевые карбоксамиды, применяемые в качестве нематоцидов
UY34559A (es) Inhibidores de bromodominios
MX378288B (es) Inhibidores de pirimidina del fgfr4.
UY34697A (es) Métodos para preparar análogos de nucleótidos
UY34515A (es) Triazolopiridinas sustituidas
UY34632A (es) Compuestos de oxazolidin- 2- ona y usos de los mismos
MX394430B (es) Proceso para la preparación de 5-fluoro-1h-pirazoles.
UY34763A (es) Inhibidores de la agregación plaquetaria
CL2018000649A1 (es) Nuevos compuestos bicíclicos como inhibidores duales de atx / ca
EA201400178A1 (ru) Лечение рака молочной железы
MX392317B (es) Proceso para la preparación de etilenglicol a partir de azúcares.
AR095075A1 (es) Acoplamiento electroquímico de anilinas
UY34767A (es) Inhibidores cíclicos del enlace éter de dgat1
UY33976A (es) Derivados de pirazolo-pirimidina.
MX384794B (es) Proceso para la preparacion de 5-fluoro-1h-pirazoles a partir de hexafluoropropeno.
MX386134B (es) Proceso para la preparación de 5-fluoro-1h-pirazoles.
CL2016001488A1 (es) Quinazolin-thf-aminas como inhibidores de pde1
UY34677A (es) Imidazopiridazinas sustituidas
RU2012151073A (ru) Способ стабилизации раствора дигидрокверцетина
UY34072A (es) Derivados sustituidos de indol