KR102348320B1 - 항암 조성물 - Google Patents

항암 조성물 Download PDF

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Publication number
KR102348320B1
KR102348320B1 KR1020177018239A KR20177018239A KR102348320B1 KR 102348320 B1 KR102348320 B1 KR 102348320B1 KR 1020177018239 A KR1020177018239 A KR 1020177018239A KR 20177018239 A KR20177018239 A KR 20177018239A KR 102348320 B1 KR102348320 B1 KR 102348320B1
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solid dispersion
hpmcas
weight
prostate cancer
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KR20170086656A (ko
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데니스 마틴 헤스터
제이슨 미카엘 본
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아라곤 파마슈티컬스, 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020177018239A 2014-12-05 2015-12-03 항암 조성물 Active KR102348320B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14196594.7 2014-12-05
EP14196594 2014-12-05
PCT/US2015/063661 WO2016090098A1 (en) 2014-12-05 2015-12-03 Anticancer compositions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020207035390A Division KR20200141533A (ko) 2014-12-05 2015-12-03 항암 조성물

Publications (2)

Publication Number Publication Date
KR20170086656A KR20170086656A (ko) 2017-07-26
KR102348320B1 true KR102348320B1 (ko) 2022-01-10

Family

ID=52006906

Family Applications (2)

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KR1020207035390A Ceased KR20200141533A (ko) 2014-12-05 2015-12-03 항암 조성물
KR1020177018239A Active KR102348320B1 (ko) 2014-12-05 2015-12-03 항암 조성물

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020207035390A Ceased KR20200141533A (ko) 2014-12-05 2015-12-03 항암 조성물

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US (3) US20170360754A1 (enExample)
EP (2) EP3226841B1 (enExample)
JP (2) JP6937692B2 (enExample)
KR (2) KR20200141533A (enExample)
CN (2) CN114886852A (enExample)
AR (1) AR102926A1 (enExample)
AU (3) AU2015358490B2 (enExample)
BR (1) BR112017011788A2 (enExample)
CA (1) CA2969656A1 (enExample)
CL (1) CL2017001371A1 (enExample)
CO (1) CO2017005572A2 (enExample)
CR (1) CR20170216A (enExample)
EA (1) EA201791222A1 (enExample)
ES (1) ES2996833T3 (enExample)
HR (1) HRP20241719T1 (enExample)
HU (1) HUE069689T2 (enExample)
IL (2) IL252323B (enExample)
MA (1) MA41107B1 (enExample)
MD (1) MD3226841T2 (enExample)
MX (2) MX387933B (enExample)
NZ (1) NZ770528A (enExample)
PH (1) PH12017500964A1 (enExample)
PL (1) PL3226841T3 (enExample)
RS (1) RS66323B1 (enExample)
SG (1) SG11201704267VA (enExample)
SM (1) SMT202400518T1 (enExample)
TW (2) TWI702966B (enExample)
UA (1) UA120950C2 (enExample)
WO (1) WO2016090098A1 (enExample)

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AU2015358490A1 (en) 2017-06-08
EP4494636A2 (en) 2025-01-22
CN114886852A (zh) 2022-08-12
MX387933B (es) 2025-03-19
TW202031248A (zh) 2020-09-01
IL279833B (en) 2022-03-01
US20240293374A1 (en) 2024-09-05
NZ731963A (en) 2024-03-22
JP2017536398A (ja) 2017-12-07
MA41107A (fr) 2017-10-10
WO2016090098A1 (en) 2016-06-09
CL2017001371A1 (es) 2018-01-05
CR20170216A (es) 2017-08-30
TWI702966B (zh) 2020-09-01
BR112017011788A2 (pt) 2017-12-26
EA201791222A1 (ru) 2017-09-29
MX2021013965A (es) 2022-01-04
IL279833A (en) 2021-01-31
EP3226841A1 (en) 2017-10-11
IL252323B (en) 2021-04-29
KR20200141533A (ko) 2020-12-18
AU2015358490B2 (en) 2021-04-08
KR20170086656A (ko) 2017-07-26
HRP20241719T1 (hr) 2025-02-14
SG11201704267VA (en) 2017-06-29
CN106999431B (zh) 2022-03-04
JP6937692B2 (ja) 2021-09-22
AU2021201979A1 (en) 2021-04-29
JP2020143069A (ja) 2020-09-10
RS66323B1 (sr) 2025-01-31
SMT202400518T1 (it) 2025-01-14
EP3226841C0 (en) 2024-10-09
PH12017500964A1 (en) 2017-10-18
CN106999431A (zh) 2017-08-01
MA41107B1 (fr) 2025-01-31
UA120950C2 (uk) 2020-03-10
US12303493B2 (en) 2025-05-20
TW201630592A (zh) 2016-09-01
MX2017007203A (es) 2017-08-28
EP3226841B1 (en) 2024-10-09
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PL3226841T3 (pl) 2025-03-03
IL252323A0 (en) 2017-07-31
US20230233529A1 (en) 2023-07-27
CO2017005572A2 (es) 2017-09-20
HUE069689T2 (hu) 2025-04-28
AR102926A1 (es) 2017-04-05
NZ770528A (en) 2024-03-22
JP7174006B2 (ja) 2022-11-17
US20170360754A1 (en) 2017-12-21
TWI754258B (zh) 2022-02-01
CA2969656A1 (en) 2016-06-09
AU2021201979B2 (en) 2023-02-02
MD3226841T2 (ro) 2025-06-30
ES2996833T3 (en) 2025-02-13
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