KR102326360B1 - 옥심 결합을 위한 친핵성 촉매 - Google Patents

옥심 결합을 위한 친핵성 촉매 Download PDF

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Publication number
KR102326360B1
KR102326360B1 KR1020217024432A KR20217024432A KR102326360B1 KR 102326360 B1 KR102326360 B1 KR 102326360B1 KR 1020217024432 A KR1020217024432 A KR 1020217024432A KR 20217024432 A KR20217024432 A KR 20217024432A KR 102326360 B1 KR102326360 B1 KR 102326360B1
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soluble polymer
therapeutic protein
psa
buffer
protein
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KR20210099187A (ko
Inventor
위르겐 지크만
스테판 하이더
한스페터 로텐스타이너
페터 투레첵
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다케다 야쿠힌 고교 가부시키가이샤
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Priority claimed from US13/488,043 external-priority patent/US8809501B2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • Y10S514/886—

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Water Supply & Treatment (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020217024432A 2012-05-16 2013-05-16 옥심 결합을 위한 친핵성 촉매 Active KR102326360B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261647814P 2012-05-16 2012-05-16
US61/647,814 2012-05-16
US13/488,043 2012-06-04
US13/488,043 US8809501B2 (en) 2009-07-27 2012-06-04 Nucleophilic catalysts for oxime linkage
PCT/US2013/041280 WO2013173543A1 (en) 2012-05-16 2013-05-16 Nucleophilic catalysts for oxime linkage
KR1020217009701A KR102287040B1 (ko) 2012-05-16 2013-05-16 옥심 결합을 위한 친핵성 촉매

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020217009701A Division KR102287040B1 (ko) 2012-05-16 2013-05-16 옥심 결합을 위한 친핵성 촉매

Publications (2)

Publication Number Publication Date
KR20210099187A KR20210099187A (ko) 2021-08-11
KR102326360B1 true KR102326360B1 (ko) 2021-11-15

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KR1020217009701A Active KR102287040B1 (ko) 2012-05-16 2013-05-16 옥심 결합을 위한 친핵성 촉매
KR1020207013096A Active KR102237306B1 (ko) 2012-05-16 2013-05-16 옥심 결합을 위한 친핵성 촉매
KR1020147035113A Active KR102110622B1 (ko) 2012-05-16 2013-05-16 옥심 결합을 위한 친핵성 촉매
KR1020217024432A Active KR102326360B1 (ko) 2012-05-16 2013-05-16 옥심 결합을 위한 친핵성 촉매

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KR1020217009701A Active KR102287040B1 (ko) 2012-05-16 2013-05-16 옥심 결합을 위한 친핵성 촉매
KR1020207013096A Active KR102237306B1 (ko) 2012-05-16 2013-05-16 옥심 결합을 위한 친핵성 촉매
KR1020147035113A Active KR102110622B1 (ko) 2012-05-16 2013-05-16 옥심 결합을 위한 친핵성 촉매

Country Status (12)

Country Link
EP (3) EP2849794A1 (enExample)
JP (5) JP6195611B2 (enExample)
KR (4) KR102287040B1 (enExample)
CN (2) CN109620963B (enExample)
AU (1) AU2013204754C1 (enExample)
BR (1) BR112014028636B1 (enExample)
CA (1) CA2873756C (enExample)
EA (2) EA035506B1 (enExample)
MX (1) MX360594B (enExample)
NZ (4) NZ738844A (enExample)
SG (3) SG11201407597XA (enExample)
WO (2) WO2013173543A1 (enExample)

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JP7002036B2 (ja) * 2016-11-17 2022-01-20 パナソニックＩｐマネジメント株式会社 膜電極接合体および固体酸化物形燃料電池
WO2018112669A1 (en) * 2016-12-23 2018-06-28 Realist Pharma, Inc. Ganglioside carbohydrate structures and uses thereof
CN108503901B (zh) * 2018-04-17 2020-07-07 哈尔滨工业大学 一种抗菌普鲁兰多糖/壳聚糖复合食品包装膜的制备方法
US11845989B2 (en) 2019-01-23 2023-12-19 Regeneron Pharmaceuticals, Inc. Treatment of ophthalmic conditions with angiopoietin-like 7 (ANGPTL7) inhibitors
EP3914711A2 (en) 2019-01-23 2021-12-01 Regeneron Pharmaceuticals, Inc. Treatment of ophthalmic conditions with angiopoietin-like 7 (angptl7) inhibitors
MX2023009987A (es) 2021-02-26 2023-09-06 Regeneron Pharma Tratamiento de la inflamacion con glucocorticoides e inhibidores de angiopoyetina tipo 7 (angptl7).
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Also Published As

Publication number Publication date
WO2013173543A1 (en) 2013-11-21
KR20150008192A (ko) 2015-01-21
CN104487095B (zh) 2018-12-07
EP4019049A1 (en) 2022-06-29
JP6560712B2 (ja) 2019-08-14
EP2849795B1 (en) 2022-04-06
MX2014013919A (es) 2015-06-05
JP2020111599A (ja) 2020-07-27
EA201492115A1 (ru) 2015-05-29
JP6711935B2 (ja) 2020-06-17
JP6195611B2 (ja) 2017-09-13
EA028186B9 (ru) 2018-05-31
JP2019089810A (ja) 2019-06-13
SG11201407597XA (en) 2014-12-30
CN109620963B (zh) 2022-10-28
SG10201701780RA (en) 2017-04-27
SG10201911328QA (en) 2020-01-30
KR102237306B1 (ko) 2021-04-08
JP2015520163A (ja) 2015-07-16
KR20210099187A (ko) 2021-08-11
EP2849795A1 (en) 2015-03-25
MX360594B (es) 2018-11-09
NZ738846A (en) 2019-05-31
NZ701945A (en) 2016-10-28
BR112014028636B1 (pt) 2022-09-20
JP7304402B2 (ja) 2023-07-06
EA035506B1 (ru) 2020-06-25
KR102110622B1 (ko) 2020-05-14
BR112014028636A2 (enExample) 2017-08-15
CN109620963A (zh) 2019-04-16
CA2873756A1 (en) 2013-11-21
NZ738844A (en) 2018-12-21
JP2022034075A (ja) 2022-03-02
NZ724828A (en) 2018-02-23
CA2873756C (en) 2022-08-16
EA028186B1 (ru) 2017-10-31
KR20210041629A (ko) 2021-04-15
KR102287040B1 (ko) 2021-08-09
AU2013204754C1 (en) 2018-10-11
JP2017145260A (ja) 2017-08-24
WO2013173557A1 (en) 2013-11-21
KR20200053636A (ko) 2020-05-18
AU2013204754B2 (en) 2015-11-05
CN104487095A (zh) 2015-04-01
EP2849794A1 (en) 2015-03-25
EA201790935A1 (ru) 2017-12-29
HK1209024A1 (en) 2016-03-24
JP7014844B2 (ja) 2022-02-01

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St.27 status event code: A-5-5-R10-R18-oth-X000