SG10201701780RA - Nucleophilic catalysts for oxime linkage - Google Patents

Nucleophilic catalysts for oxime linkage

Info

Publication number
SG10201701780RA
SG10201701780RA SG10201701780RA SG10201701780RA SG10201701780RA SG 10201701780R A SG10201701780R A SG 10201701780RA SG 10201701780R A SG10201701780R A SG 10201701780RA SG 10201701780R A SG10201701780R A SG 10201701780RA SG 10201701780R A SG10201701780R A SG 10201701780RA
Authority
SG
Singapore
Prior art keywords
oxime linkage
nucleophilic catalysts
nucleophilic
catalysts
oxime
Prior art date
Application number
SG10201701780RA
Inventor
Juergen Siekmann
Stefan Haider
Hanspeter Rottensteiner
Peter Turecek
Original Assignee
Baxalta Inc
Baxalta GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/488,043 external-priority patent/US8809501B2/en
Application filed by Baxalta Inc, Baxalta GmbH filed Critical Baxalta Inc
Publication of SG10201701780RA publication Critical patent/SG10201701780RA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
SG10201701780RA 2012-05-16 2013-05-16 Nucleophilic catalysts for oxime linkage SG10201701780RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261647814P 2012-05-16 2012-05-16
US13/488,043 US8809501B2 (en) 2009-07-27 2012-06-04 Nucleophilic catalysts for oxime linkage

Publications (1)

Publication Number Publication Date
SG10201701780RA true SG10201701780RA (en) 2017-04-27

Family

ID=48579473

Family Applications (3)

Application Number Title Priority Date Filing Date
SG10201911328QA SG10201911328QA (en) 2012-05-16 2013-05-16 Nucleophilic catalysts for oxime linkage
SG11201407597XA SG11201407597XA (en) 2012-05-16 2013-05-16 Nucleophilic catalysts for oxime linkage
SG10201701780RA SG10201701780RA (en) 2012-05-16 2013-05-16 Nucleophilic catalysts for oxime linkage

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SG10201911328QA SG10201911328QA (en) 2012-05-16 2013-05-16 Nucleophilic catalysts for oxime linkage
SG11201407597XA SG11201407597XA (en) 2012-05-16 2013-05-16 Nucleophilic catalysts for oxime linkage

Country Status (13)

Country Link
EP (3) EP4019049A1 (en)
JP (5) JP6195611B2 (en)
KR (4) KR102326360B1 (en)
CN (2) CN109620963B (en)
AU (1) AU2013204754C1 (en)
BR (1) BR112014028636B1 (en)
CA (1) CA2873756C (en)
EA (2) EA028186B9 (en)
HK (1) HK1209024A1 (en)
MX (1) MX360594B (en)
NZ (4) NZ701945A (en)
SG (3) SG10201911328QA (en)
WO (2) WO2013173557A1 (en)

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AU2013204754C1 (en) * 2012-05-16 2018-10-11 Takeda Pharmaceutical Company Limited Nucleophilic Catalysts for Oxime Linkage
JP2019535707A (en) * 2016-11-14 2019-12-12 ノバルティス アーゲー Methods and compositions for the treatment of cartilage damage and arthritis
JP7002036B2 (en) * 2016-11-17 2022-01-20 パナソニックＩｐマネジメント株式会社 Membrane electrode assembly and solid oxide fuel cell
US11786586B2 (en) 2016-12-23 2023-10-17 Aoa Dx Carbohydrate structures and uses thereof
CN108503901B (en) * 2018-04-17 2020-07-07 哈尔滨工业大学 Preparation method of antibacterial pullulan/chitosan composite food packaging film
WO2020154268A2 (en) 2019-01-23 2020-07-30 Regeneron Pharmaceuticals, Inc. Treatment of ophthalmic conditions with angiopoietin-like 7 (angptl7) inhibitors
US11845989B2 (en) 2019-01-23 2023-12-19 Regeneron Pharmaceuticals, Inc. Treatment of ophthalmic conditions with angiopoietin-like 7 (ANGPTL7) inhibitors
WO2022182768A1 (en) 2021-02-26 2022-09-01 Regeneron Pharmaceuticals, Inc. Treatment of inflammation with glucocorticoids and angiopoietin-like 7 (angptl7) inhibitors

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Also Published As

Publication number Publication date
JP2019089810A (en) 2019-06-13
JP2020111599A (en) 2020-07-27
CA2873756A1 (en) 2013-11-21
KR102237306B1 (en) 2021-04-08
JP6195611B2 (en) 2017-09-13
JP6560712B2 (en) 2019-08-14
JP7304402B2 (en) 2023-07-06
JP2015520163A (en) 2015-07-16
BR112014028636B1 (en) 2022-09-20
JP6711935B2 (en) 2020-06-17
WO2013173543A1 (en) 2013-11-21
EP2849795B1 (en) 2022-04-06
NZ738846A (en) 2019-05-31
WO2013173557A1 (en) 2013-11-21
KR20150008192A (en) 2015-01-21
CN104487095A (en) 2015-04-01
MX360594B (en) 2018-11-09
BR112014028636A2 (en) 2017-08-15
EA201492115A1 (en) 2015-05-29
SG11201407597XA (en) 2014-12-30
EP2849795A1 (en) 2015-03-25
JP7014844B2 (en) 2022-02-01
EP2849794A1 (en) 2015-03-25
NZ738844A (en) 2018-12-21
CN109620963A (en) 2019-04-16
KR102110622B1 (en) 2020-05-14
KR20210041629A (en) 2021-04-15
NZ701945A (en) 2016-10-28
NZ724828A (en) 2018-02-23
HK1209024A1 (en) 2016-03-24
EA028186B9 (en) 2018-05-31
KR102287040B1 (en) 2021-08-09
JP2017145260A (en) 2017-08-24
AU2013204754C1 (en) 2018-10-11
EA201790935A1 (en) 2017-12-29
EP4019049A1 (en) 2022-06-29
AU2013204754B2 (en) 2015-11-05
EA028186B1 (en) 2017-10-31
KR20210099187A (en) 2021-08-11
CA2873756C (en) 2022-08-16
KR102326360B1 (en) 2021-11-15
EA035506B1 (en) 2020-06-25
JP2022034075A (en) 2022-03-02
MX2014013919A (en) 2015-06-05
SG10201911328QA (en) 2020-01-30
CN104487095B (en) 2018-12-07
KR20200053636A (en) 2020-05-18
CN109620963B (en) 2022-10-28

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