KR102318274B1 - 로라제팜의 지속 방출성 제제 - Google Patents

로라제팜의 지속 방출성 제제 Download PDF

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Publication number
KR102318274B1
KR102318274B1 KR1020157020977A KR20157020977A KR102318274B1 KR 102318274 B1 KR102318274 B1 KR 102318274B1 KR 1020157020977 A KR1020157020977 A KR 1020157020977A KR 20157020977 A KR20157020977 A KR 20157020977A KR 102318274 B1 KR102318274 B1 KR 102318274B1
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lorazepam
release
hours
beads
sustained release
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Korean (ko)
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KR20150118119A (ko
Inventor
더글라스 에이. 살텔
마이클 바콘
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엣지몬트 파마슈티칼스 엘엘씨 트러스트
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020157020977A 2013-01-09 2014-01-09 로라제팜의 지속 방출성 제제 Active KR102318274B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361750797P 2013-01-09 2013-01-09
US61/750,797 2013-01-09
US201361762833P 2013-02-08 2013-02-08
US61/762,833 2013-02-08
PCT/US2014/010854 WO2014110245A1 (en) 2013-01-09 2014-01-09 Sustained release formulations of lorazepam

Publications (2)

Publication Number Publication Date
KR20150118119A KR20150118119A (ko) 2015-10-21
KR102318274B1 true KR102318274B1 (ko) 2021-10-26

Family

ID=50064764

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Application Number Title Priority Date Filing Date
KR1020157020977A Active KR102318274B1 (ko) 2013-01-09 2014-01-09 로라제팜의 지속 방출성 제제

Country Status (30)

Country Link
US (3) US8999393B1 (https=)
EP (1) EP2943185B1 (https=)
JP (2) JP6039823B2 (https=)
KR (1) KR102318274B1 (https=)
CN (1) CN105209018B (https=)
AU (1) AU2014205440B2 (https=)
BR (1) BR112015016304A8 (https=)
CA (1) CA2897302C (https=)
CL (1) CL2015001920A1 (https=)
CY (1) CY1123933T1 (https=)
DK (1) DK2943185T3 (https=)
ES (1) ES2856181T3 (https=)
HR (1) HRP20210236T1 (https=)
HU (1) HUE054005T2 (https=)
IL (1) IL239777B (https=)
LT (1) LT2943185T (https=)
MX (1) MX367364B (https=)
NZ (1) NZ710860A (https=)
PE (1) PE20151432A1 (https=)
PH (1) PH12015501534B1 (https=)
PL (1) PL2943185T3 (https=)
PT (1) PT2943185T (https=)
RS (1) RS61857B1 (https=)
RU (1) RU2678324C2 (https=)
SG (1) SG11201505349RA (https=)
SI (1) SI2943185T1 (https=)
SM (1) SMT202100091T1 (https=)
UA (1) UA117233C2 (https=)
WO (1) WO2014110245A1 (https=)
ZA (1) ZA201505082B (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019039836A2 (ko) * 2017-08-22 2019-02-28 아주대학교산학협력단 퇴행성 신경질환 치료용 복합 제형 조성물
RU2020117757A (ru) 2017-11-01 2021-11-29 Эджмонт Фармасьютикалс, Ллк Траст Оральные фармацевтические композиции лоразепама, устойчивые к спирту

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WO2009137067A1 (en) * 2008-05-08 2009-11-12 Supernus Pharmaceuticals Inc. Controlled release formulations of alprazolam

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WO2009137067A1 (en) * 2008-05-08 2009-11-12 Supernus Pharmaceuticals Inc. Controlled release formulations of alprazolam

Also Published As

Publication number Publication date
EP2943185A1 (en) 2015-11-18
MX2015008756A (es) 2016-03-31
HRP20210236T1 (hr) 2021-03-19
RU2015128915A (ru) 2017-02-10
EP2943185B1 (en) 2020-11-18
BR112015016304A2 (pt) 2017-07-11
JP2017019880A (ja) 2017-01-26
AU2014205440A1 (en) 2015-08-27
PH12015501534A1 (en) 2015-10-05
PH12015501534B1 (en) 2015-10-05
DK2943185T3 (da) 2021-02-15
SG11201505349RA (en) 2015-08-28
WO2014110245A1 (en) 2014-07-17
CN105209018A (zh) 2015-12-30
UA117233C2 (uk) 2018-07-10
JP2016504390A (ja) 2016-02-12
LT2943185T (lt) 2021-03-10
HUE054005T2 (hu) 2021-08-30
SMT202100091T1 (it) 2021-03-15
IL239777A0 (en) 2015-08-31
HK1213770A1 (zh) 2016-07-15
CL2015001920A1 (es) 2016-01-29
SI2943185T1 (sl) 2021-04-30
US8999393B1 (en) 2015-04-07
RU2678324C2 (ru) 2019-01-28
US20150110874A1 (en) 2015-04-23
IL239777B (en) 2019-03-31
ES2856181T3 (es) 2021-09-27
US20160228378A1 (en) 2016-08-11
NZ710860A (en) 2020-05-29
JP6039823B2 (ja) 2016-12-07
AU2014205440B2 (en) 2018-07-05
PT2943185T (pt) 2021-02-18
US20150174078A1 (en) 2015-06-25
KR20150118119A (ko) 2015-10-21
PL2943185T3 (pl) 2022-01-17
CY1123933T1 (el) 2022-05-27
BR112015016304A8 (pt) 2018-01-23
RS61857B1 (sr) 2021-06-30
CA2897302C (en) 2022-05-31
PE20151432A1 (es) 2015-09-23
MX367364B (es) 2019-08-16
CN105209018B (zh) 2019-06-25
CA2897302A1 (en) 2014-07-17
ZA201505082B (en) 2021-04-28

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