KR102311518B1 - 선택적 nr2b 길항제 - Google Patents
선택적 nr2b 길항제 Download PDFInfo
- Publication number
- KR102311518B1 KR102311518B1 KR1020167021356A KR20167021356A KR102311518B1 KR 102311518 B1 KR102311518 B1 KR 102311518B1 KR 1020167021356 A KR1020167021356 A KR 1020167021356A KR 20167021356 A KR20167021356 A KR 20167021356A KR 102311518 B1 KR102311518 B1 KR 102311518B1
- Authority
- KR
- South Korea
- Prior art keywords
- fluoro
- piperidin
- mmol
- hydroxyphenyl
- pyrrolidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 COc(ccc(C1(CC*CC1)O)c1)c1F Chemical compound COc(ccc(C1(CC*CC1)O)c1)c1F 0.000 description 3
- FYTOCUHAQHZOGJ-RTWAWAEBSA-N CC(C)(C)OC(N(CC[C@@H]1c(cc2)ccc2OCc2ccccc2)C[C@@H]1O)=O Chemical compound CC(C)(C)OC(N(CC[C@@H]1c(cc2)ccc2OCc2ccccc2)C[C@@H]1O)=O FYTOCUHAQHZOGJ-RTWAWAEBSA-N 0.000 description 1
- CPFHAKFXMLIKII-SNAWJCMRSA-N CC/C=C(\C)/C(C(F)(F)F)C(N)=O Chemical compound CC/C=C(\C)/C(C(F)(F)F)C(N)=O CPFHAKFXMLIKII-SNAWJCMRSA-N 0.000 description 1
- WIZVAIFXSYSDST-UHFFFAOYSA-N COc1ccc(C(CCN(C2)C(CCN3Cc(cc4)ccc4F)C3=O)C2=O)cc1 Chemical compound COc1ccc(C(CCN(C2)C(CCN3Cc(cc4)ccc4F)C3=O)C2=O)cc1 WIZVAIFXSYSDST-UHFFFAOYSA-N 0.000 description 1
- NQXYVDTXOJUWOR-NEPJUHHUSA-N COc1ccc([C@@H](CCNC2)[C@H]2O)cc1 Chemical compound COc1ccc([C@@H](CCNC2)[C@H]2O)cc1 NQXYVDTXOJUWOR-NEPJUHHUSA-N 0.000 description 1
- UABGYPZTPVMCOT-UGGDCYSXSA-N COc1ccc([C@H](CCN(C2)C(CCN3Cc(cc4)ccc4F)C3=O)[C@@H]2F)cc1 Chemical compound COc1ccc([C@H](CCN(C2)C(CCN3Cc(cc4)ccc4F)C3=O)[C@@H]2F)cc1 UABGYPZTPVMCOT-UGGDCYSXSA-N 0.000 description 1
- NQXYVDTXOJUWOR-NWDGAFQWSA-N COc1ccc([C@H](CCNC2)[C@@H]2O)cc1 Chemical compound COc1ccc([C@H](CCNC2)[C@@H]2O)cc1 NQXYVDTXOJUWOR-NWDGAFQWSA-N 0.000 description 1
- VORAXNUWZGHPKU-RVHYNSKXSA-N C[C@@H](c(cc1)ccc1F)N(CC[C@@H]1N(CC[C@@H]2c(cc3)ccc3O)CC2(F)F)C1=O Chemical compound C[C@@H](c(cc1)ccc1F)N(CC[C@@H]1N(CC[C@@H]2c(cc3)ccc3O)CC2(F)F)C1=O VORAXNUWZGHPKU-RVHYNSKXSA-N 0.000 description 1
- XLERPYDVNGAEHV-NZYDNVMFSA-N C[C@@H](c(cc1)ccc1F)N(CC[C@@H]1N(CC[C@@H]2c(cc3)ccc3O)C[C@@H]2F)C1=O Chemical compound C[C@@H](c(cc1)ccc1F)N(CC[C@@H]1N(CC[C@@H]2c(cc3)ccc3O)C[C@@H]2F)C1=O XLERPYDVNGAEHV-NZYDNVMFSA-N 0.000 description 1
- VORAXNUWZGHPKU-JHVJFLLYSA-N C[C@@H](c(cc1)ccc1F)N(CC[C@@H]1N(CC[C@H]2c(cc3)ccc3O)CC2(F)F)C1=O Chemical compound C[C@@H](c(cc1)ccc1F)N(CC[C@@H]1N(CC[C@H]2c(cc3)ccc3O)CC2(F)F)C1=O VORAXNUWZGHPKU-JHVJFLLYSA-N 0.000 description 1
- VORAXNUWZGHPKU-IWMITWMQSA-N C[C@@H](c(cc1)ccc1F)N(CC[C@H]1N(CC[C@@H]2c(cc3)ccc3O)CC2(F)F)C1=O Chemical compound C[C@@H](c(cc1)ccc1F)N(CC[C@H]1N(CC[C@@H]2c(cc3)ccc3O)CC2(F)F)C1=O VORAXNUWZGHPKU-IWMITWMQSA-N 0.000 description 1
- XLERPYDVNGAEHV-QWIYEXKTSA-N C[C@@H](c(cc1)ccc1F)N(CC[C@H]1N(CC[C@@H]2c(cc3)ccc3O)C[C@@H]2F)C1=O Chemical compound C[C@@H](c(cc1)ccc1F)N(CC[C@H]1N(CC[C@@H]2c(cc3)ccc3O)C[C@@H]2F)C1=O XLERPYDVNGAEHV-QWIYEXKTSA-N 0.000 description 1
- VORAXNUWZGHPKU-ONGXBYRLSA-N C[C@@H](c(cc1)ccc1F)N(CC[C@H]1N(CC[C@H]2c(cc3)ccc3O)CC2(F)F)C1=O Chemical compound C[C@@H](c(cc1)ccc1F)N(CC[C@H]1N(CC[C@H]2c(cc3)ccc3O)CC2(F)F)C1=O VORAXNUWZGHPKU-ONGXBYRLSA-N 0.000 description 1
- BMZJNRARCKRJGN-GESRLHNRSA-N Cc(ccc(CN(CC1)C2OC2[C@@H]1N(CC[C@H]1c(cc2)cc(F)c2O)C[C@H]1F)c1)c1F Chemical compound Cc(ccc(CN(CC1)C2OC2[C@@H]1N(CC[C@H]1c(cc2)cc(F)c2O)C[C@H]1F)c1)c1F BMZJNRARCKRJGN-GESRLHNRSA-N 0.000 description 1
- YDYIBWVPPQZWMY-UHFFFAOYSA-N Cc(ccc(CN(CCC1N(CC2)CCC2c(cc2)ccc2O)C1=O)c1)c1Cl Chemical compound Cc(ccc(CN(CCC1N(CC2)CCC2c(cc2)ccc2O)C1=O)c1)c1Cl YDYIBWVPPQZWMY-UHFFFAOYSA-N 0.000 description 1
- SNRJCPGNGTZAMT-LJDIEGPPSA-N Cc(ccc(CN(CCC1N(CC[C@@H]2c(cc3F)ccc3OC)C[C@@H]2F)C1=O)c1)c1F Chemical compound Cc(ccc(CN(CCC1N(CC[C@@H]2c(cc3F)ccc3OC)C[C@@H]2F)C1=O)c1)c1F SNRJCPGNGTZAMT-LJDIEGPPSA-N 0.000 description 1
- LAKBGWVRKNIOGO-BAGYTPMASA-N Cc(ccc(CN(CC[C@H]1N(CC[C@@H]2c(cc3)ccc3O)C[C@@H]2F)C1=O)c1)c1F Chemical compound Cc(ccc(CN(CC[C@H]1N(CC[C@@H]2c(cc3)ccc3O)C[C@@H]2F)C1=O)c1)c1F LAKBGWVRKNIOGO-BAGYTPMASA-N 0.000 description 1
- ILUHFPBBZNEUNW-UHFFFAOYSA-N Cc1ccc(CN(CCC2N(CC3)CCC3c(cc3)ccc3O)C2=O)cc1 Chemical compound Cc1ccc(CN(CCC2N(CC3)CCC3c(cc3)ccc3O)C2=O)cc1 ILUHFPBBZNEUNW-UHFFFAOYSA-N 0.000 description 1
- UNVYDSCXINFREZ-LKXRKSRJSA-N Cc1ccc(CN(CCC2N(CC[C@@H]3c(cc4)ccc4O)C[C@@H]3F)C2=O)cc1 Chemical compound Cc1ccc(CN(CCC2N(CC[C@@H]3c(cc4)ccc4O)C[C@@H]3F)C2=O)cc1 UNVYDSCXINFREZ-LKXRKSRJSA-N 0.000 description 1
- OURREPNUOUKLLI-UHFFFAOYSA-N FC(CNCC1)(C1c(cc1)ccc1OCc1ccccc1)F Chemical compound FC(CNCC1)(C1c(cc1)ccc1OCc1ccccc1)F OURREPNUOUKLLI-UHFFFAOYSA-N 0.000 description 1
- VUVFCLPWBOECEY-MSOLQXFVSA-N O[C@@H](CNCC1)[C@H]1c(cc1)ccc1OCc1ccccc1 Chemical compound O[C@@H](CNCC1)[C@H]1c(cc1)ccc1OCc1ccccc1 VUVFCLPWBOECEY-MSOLQXFVSA-N 0.000 description 1
- VTJFGLLDBNXRQF-SCZZXKLOSA-N Oc(ccc([C@@H](CCNC1)[C@H]1F)c1)c1F Chemical compound Oc(ccc([C@@H](CCNC1)[C@H]1F)c1)c1F VTJFGLLDBNXRQF-SCZZXKLOSA-N 0.000 description 1
- DJTTVXQTWUDOBA-UHFFFAOYSA-N Oc1ccc(C(CC2)CCN2C(CCCN2Cc3ccccc3)C2=O)cc1 Chemical compound Oc1ccc(C(CC2)CCN2C(CCCN2Cc3ccccc3)C2=O)cc1 DJTTVXQTWUDOBA-UHFFFAOYSA-N 0.000 description 1
- ONAABSNIFZNNAW-NRFANRHFSA-N Oc1ccc(C(CC2)CCN2[C@@H](CCN2Cc(cc3)cc(F)c3F)C2=O)cc1 Chemical compound Oc1ccc(C(CC2)CCN2[C@@H](CCN2Cc(cc3)cc(F)c3F)C2=O)cc1 ONAABSNIFZNNAW-NRFANRHFSA-N 0.000 description 1
- PHBBGHAXNTZALA-OAQYLSRUSA-N Oc1ccc(C(CC2)CCN2[C@H](CCN2Cc3ccccc3)C2=O)cc1 Chemical compound Oc1ccc(C(CC2)CCN2[C@H](CCN2Cc3ccccc3)C2=O)cc1 PHBBGHAXNTZALA-OAQYLSRUSA-N 0.000 description 1
- VIWNTDGHOMVIMW-UHFFFAOYSA-N Oc1ccc(C(CCN(C2)C(CCN3Cc(cc4)cc(Cl)c4F)C3=O)C2(F)F)cc1 Chemical compound Oc1ccc(C(CCN(C2)C(CCN3Cc(cc4)cc(Cl)c4F)C3=O)C2(F)F)cc1 VIWNTDGHOMVIMW-UHFFFAOYSA-N 0.000 description 1
- UMACWEJWGGYMLA-UHFFFAOYSA-N Oc1ccc(C(CCN(C2)C(CCN3c(cc4Cl)ccc4OC(F)F)C3=O)C2(F)F)cc1 Chemical compound Oc1ccc(C(CCN(C2)C(CCN3c(cc4Cl)ccc4OC(F)F)C3=O)C2(F)F)cc1 UMACWEJWGGYMLA-UHFFFAOYSA-N 0.000 description 1
- VLIVVRVETMYTHW-OZBJMMHXSA-N Oc1ccc(C(CCN(C2)[C@@H](CCN3Cc(cc4)cc(F)c4F)C3=O)C2(F)F)cc1 Chemical compound Oc1ccc(C(CCN(C2)[C@@H](CCN3Cc(cc4)cc(F)c4F)C3=O)C2(F)F)cc1 VLIVVRVETMYTHW-OZBJMMHXSA-N 0.000 description 1
- OIMXBHXLIVXEEQ-ANYOKISRSA-N Oc1ccc(C(CCN(C2)[C@@H](CCN3Cc(cc4)ccc4Cl)C3=O)C2(F)F)cc1 Chemical compound Oc1ccc(C(CCN(C2)[C@@H](CCN3Cc(cc4)ccc4Cl)C3=O)C2(F)F)cc1 OIMXBHXLIVXEEQ-ANYOKISRSA-N 0.000 description 1
- UMACWEJWGGYMLA-DAFXYXGESA-N Oc1ccc(C(CCN(C2)[C@@H](CCN3c(cc4Cl)ccc4OC(F)F)C3=O)C2(F)F)cc1 Chemical compound Oc1ccc(C(CCN(C2)[C@@H](CCN3c(cc4Cl)ccc4OC(F)F)C3=O)C2(F)F)cc1 UMACWEJWGGYMLA-DAFXYXGESA-N 0.000 description 1
- SVPPSJNIPGZMHE-GFOWMXPYSA-N Oc1ccc(C(CCN(C2)[C@H](CCN3Cc4ccc(C(F)(F)F)cc4)C3=O)C2(F)F)cc1 Chemical compound Oc1ccc(C(CCN(C2)[C@H](CCN3Cc4ccc(C(F)(F)F)cc4)C3=O)C2(F)F)cc1 SVPPSJNIPGZMHE-GFOWMXPYSA-N 0.000 description 1
- UMACWEJWGGYMLA-UHUGOGIASA-N Oc1ccc(C(CCN(C2)[C@H](CCN3c(cc4Cl)ccc4OC(F)F)C3=O)C2(F)F)cc1 Chemical compound Oc1ccc(C(CCN(C2)[C@H](CCN3c(cc4Cl)ccc4OC(F)F)C3=O)C2(F)F)cc1 UMACWEJWGGYMLA-UHUGOGIASA-N 0.000 description 1
- GXCCYLLPBRUNGP-UHFFFAOYSA-N Oc1ccc(C(CCNC2)C2(F)F)cc1 Chemical compound Oc1ccc(C(CCNC2)C2(F)F)cc1 GXCCYLLPBRUNGP-UHFFFAOYSA-N 0.000 description 1
- JHGABUJRIZEJET-HXOQZHHGSA-N Oc1ccc([C@@H](CCN(C2)C(CCN3Cc(cc4)cc(Cl)c4Cl)C3=O)[C@H]2F)cc1 Chemical compound Oc1ccc([C@@H](CCN(C2)C(CCN3Cc(cc4)cc(Cl)c4Cl)C3=O)[C@H]2F)cc1 JHGABUJRIZEJET-HXOQZHHGSA-N 0.000 description 1
- ZINNJNWQBUSWGG-FAZYOCGDSA-N Oc1ccc([C@@H](CCN(C2)C(CCN3c(cc4Cl)ccc4OC(F)F)C3=O)[C@H]2F)cc1 Chemical compound Oc1ccc([C@@H](CCN(C2)C(CCN3c(cc4Cl)ccc4OC(F)F)C3=O)[C@H]2F)cc1 ZINNJNWQBUSWGG-FAZYOCGDSA-N 0.000 description 1
- SESJORIIMPHFEV-HKBOAZHASA-N Oc1ccc([C@@H](CCN(C2)[C@@H](CCN3Cc4ccccc4)C3=O)[C@H]2F)cc1 Chemical compound Oc1ccc([C@@H](CCN(C2)[C@@H](CCN3Cc4ccccc4)C3=O)[C@H]2F)cc1 SESJORIIMPHFEV-HKBOAZHASA-N 0.000 description 1
- XFXAVVJYLLLZPG-PWRODBHTSA-N Oc1ccc([C@H](CCN(C2)[C@H](CCN3Cc(cc4)ccc4F)C3=O)[C@@H]2F)cc1 Chemical compound Oc1ccc([C@H](CCN(C2)[C@H](CCN3Cc(cc4)ccc4F)C3=O)[C@@H]2F)cc1 XFXAVVJYLLLZPG-PWRODBHTSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461925363P | 2014-01-09 | 2014-01-09 | |
| US61/925,363 | 2014-01-09 | ||
| PCT/US2015/010262 WO2015105772A1 (en) | 2014-01-09 | 2015-01-06 | Selective nr2b antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20160105885A KR20160105885A (ko) | 2016-09-07 |
| KR102311518B1 true KR102311518B1 (ko) | 2021-10-08 |
Family
ID=52463126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167021356A Expired - Fee Related KR102311518B1 (ko) | 2014-01-09 | 2015-01-06 | 선택적 nr2b 길항제 |
Country Status (28)
| Country | Link |
|---|---|
| US (10) | US9221796B2 (enExample) |
| EP (1) | EP3092224B1 (enExample) |
| JP (1) | JP6543259B2 (enExample) |
| KR (1) | KR102311518B1 (enExample) |
| CN (1) | CN106061961B (enExample) |
| AR (1) | AR099071A1 (enExample) |
| AU (1) | AU2015205001A1 (enExample) |
| CA (1) | CA2936293A1 (enExample) |
| CL (1) | CL2016001763A1 (enExample) |
| DK (1) | DK3092224T3 (enExample) |
| EA (1) | EA201691413A1 (enExample) |
| ES (1) | ES2693250T3 (enExample) |
| HR (1) | HRP20181585T1 (enExample) |
| HU (1) | HUE041986T2 (enExample) |
| IL (1) | IL246599A0 (enExample) |
| LT (1) | LT3092224T (enExample) |
| MX (1) | MX2016008898A (enExample) |
| PE (1) | PE20160933A1 (enExample) |
| PL (1) | PL3092224T3 (enExample) |
| PT (1) | PT3092224T (enExample) |
| RS (1) | RS57830B1 (enExample) |
| SG (1) | SG11201605618WA (enExample) |
| SI (1) | SI3092224T1 (enExample) |
| SM (1) | SMT201800619T1 (enExample) |
| TR (1) | TR201815579T4 (enExample) |
| TW (1) | TWI640515B (enExample) |
| UY (1) | UY35947A (enExample) |
| WO (1) | WO2015105772A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9221796B2 (en) * | 2014-01-09 | 2015-12-29 | Bristol-Myers Squibb Company | Selective NR2B antagonists |
| CN107849010B (zh) * | 2015-06-01 | 2021-11-09 | 卢郡控股(开曼)有限公司 | 作为nr2b nmda受体拮抗剂的3,3‐二氟哌啶氨基甲酸酯杂环化合物 |
| WO2017066366A1 (en) * | 2015-10-14 | 2017-04-20 | Bristol-Myers Squibb Company | Selective nr2b antagonists |
| ES2822830T3 (es) * | 2015-10-14 | 2021-05-05 | Bristol Myers Squibb Co | Antagonistas selectivos de NR2B |
| CN108203404A (zh) * | 2018-03-02 | 2018-06-26 | 上海博邦医药科技有限公司 | (r)-3-苯基哌啶或/和(s)-3-苯基哌啶以及尼拉帕尼的手性中间体的合成方法 |
| US10781172B2 (en) | 2018-06-21 | 2020-09-22 | Northwestern University | Catalysts and methods for enantioselective conjugate additions of amines to unsaturated electrophiles |
| WO2024197289A1 (en) * | 2023-03-22 | 2024-09-26 | Gilgamesh Pharmaceuticals, Inc. | Negative allosteric modulators of glun2b receptors and methods of making and using the same |
| WO2025113519A1 (zh) * | 2023-11-28 | 2025-06-05 | 成都地奥制药集团有限公司 | 内酰胺环类化合物及其用途 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001081295A1 (en) | 2000-04-26 | 2001-11-01 | Warner-Lambert Company | Cyclohexylamine derivative as subtype selective nmda receptor antagonists |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2744448B1 (fr) | 1996-02-02 | 1998-04-24 | Pf Medicament | Nouvelles piperidines derivees d'aryl piperazine, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments |
| WO2000063173A1 (en) | 1999-04-14 | 2000-10-26 | F. Hoffmann-La Roche Ag | Process for the preparation of substituted piperidines |
| US6476041B1 (en) | 1999-10-29 | 2002-11-05 | Merck & Co., Inc. | 1,4 substituted piperidinyl NMDA/NR2B antagonists |
| JPWO2003035641A1 (ja) | 2001-10-22 | 2005-02-10 | 塩野義製薬株式会社 | 新規カルバモイルピロリドン誘導体 |
| EP1648882B1 (en) | 2003-06-04 | 2008-08-06 | Merck & Co., Inc. | 3-fluoro-piperidines as nmda/nr2b antagonists |
| JP2007508288A (ja) | 2003-10-08 | 2007-04-05 | ファイザー株式会社 | 縮合ラクタム化合物 |
| EP1988077A4 (en) | 2006-02-23 | 2009-09-02 | Shionogi & Co | NUCLEIC HETEROCYCLIC DERIVATIVES SUBSTITUTED BY CYCLIC GROUPS |
| KR20100045983A (ko) * | 2007-06-29 | 2010-05-04 | 에모리 유니버시티 | 신경보호를 위한 ｎｍｄａ 수용체 길항물질 |
| US9221796B2 (en) * | 2014-01-09 | 2015-12-29 | Bristol-Myers Squibb Company | Selective NR2B antagonists |
-
2015
- 2015-01-05 US US14/589,205 patent/US9221796B2/en active Active
- 2015-01-06 HU HUE15703328A patent/HUE041986T2/hu unknown
- 2015-01-06 PL PL15703328T patent/PL3092224T3/pl unknown
- 2015-01-06 KR KR1020167021356A patent/KR102311518B1/ko not_active Expired - Fee Related
- 2015-01-06 AU AU2015205001A patent/AU2015205001A1/en not_active Abandoned
- 2015-01-06 PT PT15703328T patent/PT3092224T/pt unknown
- 2015-01-06 EP EP15703328.3A patent/EP3092224B1/en active Active
- 2015-01-06 PE PE2016001107A patent/PE20160933A1/es not_active Application Discontinuation
- 2015-01-06 SG SG11201605618WA patent/SG11201605618WA/en unknown
- 2015-01-06 SM SM20180619T patent/SMT201800619T1/it unknown
- 2015-01-06 RS RS20181296A patent/RS57830B1/sr unknown
- 2015-01-06 ES ES15703328.3T patent/ES2693250T3/es active Active
- 2015-01-06 WO PCT/US2015/010262 patent/WO2015105772A1/en not_active Ceased
- 2015-01-06 SI SI201530408T patent/SI3092224T1/sl unknown
- 2015-01-06 DK DK15703328.3T patent/DK3092224T3/en active
- 2015-01-06 MX MX2016008898A patent/MX2016008898A/es unknown
- 2015-01-06 JP JP2016545819A patent/JP6543259B2/ja not_active Expired - Fee Related
- 2015-01-06 CN CN201580012735.9A patent/CN106061961B/zh active Active
- 2015-01-06 HR HRP20181585TT patent/HRP20181585T1/hr unknown
- 2015-01-06 LT LTEP15703328.3T patent/LT3092224T/lt unknown
- 2015-01-06 TR TR2018/15579T patent/TR201815579T4/tr unknown
- 2015-01-06 CA CA2936293A patent/CA2936293A1/en not_active Abandoned
- 2015-01-06 EA EA201691413A patent/EA201691413A1/ru unknown
- 2015-01-08 TW TW104100592A patent/TWI640515B/zh not_active IP Right Cessation
- 2015-01-09 UY UY0001035947A patent/UY35947A/es unknown
- 2015-01-09 AR ARP150100065A patent/AR099071A1/es unknown
- 2015-10-13 US US14/882,041 patent/US20160081995A1/en not_active Abandoned
-
2016
- 2016-07-04 IL IL246599A patent/IL246599A0/en unknown
- 2016-07-08 CL CL2016001763A patent/CL2016001763A1/es unknown
-
2017
- 2017-05-25 US US15/604,904 patent/US20170258777A1/en not_active Abandoned
- 2017-09-15 US US15/706,172 patent/US20180000807A1/en not_active Abandoned
- 2017-12-19 US US15/846,672 patent/US20180110766A1/en not_active Abandoned
-
2018
- 2018-05-04 US US15/971,067 patent/US20180250283A1/en not_active Abandoned
- 2018-12-19 US US16/225,850 patent/US20190117638A1/en not_active Abandoned
-
2019
- 2019-06-27 US US16/454,831 patent/US20190314358A1/en not_active Abandoned
-
2020
- 2020-01-30 US US16/777,114 patent/US20200163949A1/en not_active Abandoned
- 2020-09-04 US US17/012,781 patent/US20210121453A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001081295A1 (en) | 2000-04-26 | 2001-11-01 | Warner-Lambert Company | Cyclohexylamine derivative as subtype selective nmda receptor antagonists |
Non-Patent Citations (1)
| Title |
|---|
| DATABASE REGISTRY [Online], CAS Registry Number: 1385072-30-9 (2012.08.01.)* |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102311518B1 (ko) | 선택적 nr2b 길항제 | |
| JP6843853B2 (ja) | 選択的ｎｒ２ｂアンタゴニスト | |
| EP3092223B1 (en) | (r)-3-((3s,4s)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one and its prodrugs for the treatment of psychiatric disorders | |
| ES2668873T3 (es) | Compuestos de indazol como agonistas del receptor 5-ht4 | |
| KR20180063306A (ko) | 선택적 nr2b 길항제 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-3-3-R10-R18-oth-X000 |
|
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
|
| R17-X000 | Change to representative recorded |
St.27 status event code: A-3-3-R10-R17-oth-X000 |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| R17-X000 | Change to representative recorded |
St.27 status event code: A-3-3-R10-R17-oth-X000 |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
St.27 status event code: A-1-2-D10-D22-exm-PE0701 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
St.27 status event code: A-2-4-F10-F11-exm-PR0701 |
|
| PR1002 | Payment of registration fee |
St.27 status event code: A-2-2-U10-U12-oth-PR1002 Fee payment year number: 1 |
|
| PG1601 | Publication of registration |
St.27 status event code: A-4-4-Q10-Q13-nap-PG1601 |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-5-5-R10-R18-oth-X000 |
|
| PC1903 | Unpaid annual fee |
St.27 status event code: A-4-4-U10-U13-oth-PC1903 Not in force date: 20241006 Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE |
|
| H13 | Ip right lapsed |
Free format text: ST27 STATUS EVENT CODE: N-4-6-H10-H13-OTH-PC1903 (AS PROVIDED BY THE NATIONAL OFFICE); TERMINATION CATEGORY : DEFAULT_OF_REGISTRATION_FEE Effective date: 20241006 |
|
| PC1903 | Unpaid annual fee |
St.27 status event code: N-4-6-H10-H13-oth-PC1903 Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE Not in force date: 20241006 |