KR102310697B1 - 치료적 사용을 위한 리포솜 캡슐화 빈크리스틴을 제조하기 위한 개선된 방법 - Google Patents

치료적 사용을 위한 리포솜 캡슐화 빈크리스틴을 제조하기 위한 개선된 방법 Download PDF

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KR102310697B1
KR102310697B1 KR1020207034162A KR20207034162A KR102310697B1 KR 102310697 B1 KR102310697 B1 KR 102310697B1 KR 1020207034162 A KR1020207034162 A KR 1020207034162A KR 20207034162 A KR20207034162 A KR 20207034162A KR 102310697 B1 KR102310697 B1 KR 102310697B1
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pharmaceutically acceptable
liquid composition
acceptable liquid
solution
vincristine
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KR20200136060A (ko
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윌리암 티. 몬트
크리스토퍼 제임스 바보사
토마스 필립 웨버
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스펙트럼 파마슈티컬즈 인크
아뷰터스 바이오파마 코포레이션
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020207034162A 2012-11-20 2013-11-20 치료적 사용을 위한 리포솜 캡슐화 빈크리스틴을 제조하기 위한 개선된 방법 Active KR102310697B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261728378P 2012-11-20 2012-11-20
US61/728,378 2012-11-20
KR1020157014525A KR102186116B1 (ko) 2012-11-20 2013-11-20 치료적 사용을 위한 리포솜 캡슐화 빈크리스틴을 제조하기 위한 개선된 방법
PCT/US2013/071096 WO2014081887A1 (en) 2012-11-20 2013-11-20 Improved method for the preparation of liposome encapsulated vincristine for therapeutic use

Related Parent Applications (1)

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KR1020157014525A Division KR102186116B1 (ko) 2012-11-20 2013-11-20 치료적 사용을 위한 리포솜 캡슐화 빈크리스틴을 제조하기 위한 개선된 방법

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KR20200136060A KR20200136060A (ko) 2020-12-04
KR102310697B1 true KR102310697B1 (ko) 2021-10-12

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KR1020157014525A Expired - Fee Related KR102186116B1 (ko) 2012-11-20 2013-11-20 치료적 사용을 위한 리포솜 캡슐화 빈크리스틴을 제조하기 위한 개선된 방법

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US (1) US9801874B2 (enExample)
EP (2) EP2922529B1 (enExample)
JP (1) JP6419710B2 (enExample)
KR (2) KR102310697B1 (enExample)
CN (1) CN104837483B (enExample)
AU (1) AU2013347990B2 (enExample)
CA (1) CA2891656C (enExample)
ES (1) ES2730405T3 (enExample)
IL (1) IL238555B (enExample)
IN (1) IN2015DN04310A (enExample)
MX (1) MX2015005992A (enExample)
RU (1) RU2655964C2 (enExample)
TR (1) TR201908531T4 (enExample)
WO (1) WO2014081887A1 (enExample)

Families Citing this family (3)

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IN2015DN04310A (enExample) 2012-11-20 2015-10-16 Spectrum Pharmaceuticals
TWI678213B (zh) * 2015-07-22 2019-12-01 美商史倍壯製藥公司 用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物
TWI719105B (zh) * 2016-01-04 2021-02-21 中央硏究院 基於酯化/皂化用於微脂體負載之方法

Citations (1)

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MX2015005992A (es) 2016-03-07
JP6419710B2 (ja) 2018-11-07
TR201908531T4 (tr) 2019-08-21
RU2015117412A (ru) 2017-01-10
IN2015DN04310A (enExample) 2015-10-16
US9801874B2 (en) 2017-10-31
CA2891656A1 (en) 2014-05-30
WO2014081887A1 (en) 2014-05-30
CA2891656C (en) 2021-05-04
KR102186116B1 (ko) 2020-12-03
IL238555A0 (en) 2015-06-30
KR20150108350A (ko) 2015-09-25
AU2013347990A1 (en) 2015-05-21
EP2922529A1 (en) 2015-09-30
JP2016500077A (ja) 2016-01-07
ES2730405T3 (es) 2019-11-11
AU2013347990B2 (en) 2018-01-18
EP3470061A1 (en) 2019-04-17
IL238555B (en) 2019-05-30
EP2922529B1 (en) 2019-03-13
CN104837483B (zh) 2017-09-01
KR20200136060A (ko) 2020-12-04
CN104837483A (zh) 2015-08-12
US20150290184A1 (en) 2015-10-15
RU2655964C2 (ru) 2018-05-30

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