JP6419710B2 - 治療的使用のためのリポソーム封入ビンクリスチンの調製のための改良法 - Google Patents

治療的使用のためのリポソーム封入ビンクリスチンの調製のための改良法 Download PDF

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JP6419710B2
JP6419710B2 JP2015543149A JP2015543149A JP6419710B2 JP 6419710 B2 JP6419710 B2 JP 6419710B2 JP 2015543149 A JP2015543149 A JP 2015543149A JP 2015543149 A JP2015543149 A JP 2015543149A JP 6419710 B2 JP6419710 B2 JP 6419710B2
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solution
vincristine
liposome
mol
sphingomyelin
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JP2016500077A (ja
Inventor
モンテ，ウィリアム，ティー．
バーボサ，クリストファー，ジェームズ
ウェーバー，トーマス，フィリップ
Original Assignee
スペクトラム ファーマシューティカルズ
スペクトラム ファーマシューティカルズ
アービュタス バイオファーマ コーポレーション
アービュタス バイオファーマ コーポレーション
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2015543149A 2012-11-20 2013-11-20 治療的使用のためのリポソーム封入ビンクリスチンの調製のための改良法 Expired - Fee Related JP6419710B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261728378P 2012-11-20 2012-11-20
US61/728,378 2012-11-20
PCT/US2013/071096 WO2014081887A1 (en) 2012-11-20 2013-11-20 Improved method for the preparation of liposome encapsulated vincristine for therapeutic use

Publications (2)

Publication Number Publication Date
JP2016500077A JP2016500077A (ja) 2016-01-07
JP6419710B2 true JP6419710B2 (ja) 2018-11-07

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JP2015543149A Expired - Fee Related JP6419710B2 (ja) 2012-11-20 2013-11-20 治療的使用のためのリポソーム封入ビンクリスチンの調製のための改良法

Country Status (14)

Country Link
US (1) US9801874B2 (enExample)
EP (2) EP2922529B1 (enExample)
JP (1) JP6419710B2 (enExample)
KR (2) KR102310697B1 (enExample)
CN (1) CN104837483B (enExample)
AU (1) AU2013347990B2 (enExample)
CA (1) CA2891656C (enExample)
ES (1) ES2730405T3 (enExample)
IL (1) IL238555B (enExample)
IN (1) IN2015DN04310A (enExample)
MX (1) MX2015005992A (enExample)
RU (1) RU2655964C2 (enExample)
TR (1) TR201908531T4 (enExample)
WO (1) WO2014081887A1 (enExample)

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Publication number Priority date Publication date Assignee Title
IN2015DN04310A (enExample) 2012-11-20 2015-10-16 Spectrum Pharmaceuticals
TWI678213B (zh) * 2015-07-22 2019-12-01 美商史倍壯製藥公司 用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物
TWI719105B (zh) * 2016-01-04 2021-02-21 中央硏究院 基於酯化/皂化用於微脂體負載之方法

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MX2015005992A (es) 2016-03-07
KR102310697B1 (ko) 2021-10-12
TR201908531T4 (tr) 2019-08-21
RU2015117412A (ru) 2017-01-10
IN2015DN04310A (enExample) 2015-10-16
US9801874B2 (en) 2017-10-31
CA2891656A1 (en) 2014-05-30
WO2014081887A1 (en) 2014-05-30
CA2891656C (en) 2021-05-04
KR102186116B1 (ko) 2020-12-03
IL238555A0 (en) 2015-06-30
KR20150108350A (ko) 2015-09-25
AU2013347990A1 (en) 2015-05-21
EP2922529A1 (en) 2015-09-30
JP2016500077A (ja) 2016-01-07
ES2730405T3 (es) 2019-11-11
AU2013347990B2 (en) 2018-01-18
EP3470061A1 (en) 2019-04-17
IL238555B (en) 2019-05-30
EP2922529B1 (en) 2019-03-13
CN104837483B (zh) 2017-09-01
KR20200136060A (ko) 2020-12-04
CN104837483A (zh) 2015-08-12
US20150290184A1 (en) 2015-10-15
RU2655964C2 (ru) 2018-05-30

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