KR102308594B1 - 마이크로유체 장치에서의 버블 제거 - Google Patents

마이크로유체 장치에서의 버블 제거 Download PDF

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KR102308594B1
KR102308594B1 KR1020197003605A KR20197003605A KR102308594B1 KR 102308594 B1 KR102308594 B1 KR 102308594B1 KR 1020197003605 A KR1020197003605 A KR 1020197003605A KR 20197003605 A KR20197003605 A KR 20197003605A KR 102308594 B1 KR102308594 B1 KR 102308594B1
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pressure
fluid
bubble
microchannel
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KR20190028468A (ko
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다니엘 레브너
조시아 다니엘 슬리츠
크리스토퍼 데이비드 히노조사
조슈아 고메즈
경 진 장
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에뮬레이트, 인크.
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
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    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
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    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/40—Manifolds; Distribution pieces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
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    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/20—Degassing; Venting; Bubble traps
    • C—CHEMISTRY; METALLURGY
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    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
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    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics

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  • Chemical & Material Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Clinical Laboratory Science (AREA)
  • Sustainable Development (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Degasification And Air Bubble Elimination (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Liquid Developers In Electrophotography (AREA)
KR1020197003605A 2016-07-12 2017-07-12 마이크로유체 장치에서의 버블 제거 Active KR102308594B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020217031073A KR102450873B1 (ko) 2016-07-12 2017-07-12 마이크로유체 장치에서의 버블 제거

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662361266P 2016-07-12 2016-07-12
US62/361,266 2016-07-12
PCT/US2017/041656 WO2018013646A1 (en) 2016-07-12 2017-07-12 Removing bubbles in a microfluidic device

Related Child Applications (1)

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KR1020217031073A Division KR102450873B1 (ko) 2016-07-12 2017-07-12 마이크로유체 장치에서의 버블 제거

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KR20190028468A KR20190028468A (ko) 2019-03-18
KR102308594B1 true KR102308594B1 (ko) 2021-10-05

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KR1020197003605A Active KR102308594B1 (ko) 2016-07-12 2017-07-12 마이크로유체 장치에서의 버블 제거
KR1020227033971A Active KR102634221B1 (ko) 2016-07-12 2017-07-12 마이크로유체 장치에서의 버블 제거
KR1020217031073A Active KR102450873B1 (ko) 2016-07-12 2017-07-12 마이크로유체 장치에서의 버블 제거
KR1020247003890A Ceased KR20240023193A (ko) 2016-07-12 2017-07-12 마이크로유체 장치에서 유체의 기체 보유 능력을 증가시키고 유체 내에 존재하는 임의의 버블을 제거하는 방법

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KR1020227033971A Active KR102634221B1 (ko) 2016-07-12 2017-07-12 마이크로유체 장치에서의 버블 제거
KR1020217031073A Active KR102450873B1 (ko) 2016-07-12 2017-07-12 마이크로유체 장치에서의 버블 제거
KR1020247003890A Ceased KR20240023193A (ko) 2016-07-12 2017-07-12 마이크로유체 장치에서 유체의 기체 보유 능력을 증가시키고 유체 내에 존재하는 임의의 버블을 제거하는 방법

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Country Link
US (7) US10335788B2 (enExample)
EP (2) EP4325111A3 (enExample)
JP (4) JP7398955B2 (enExample)
KR (4) KR102308594B1 (enExample)
AU (1) AU2017296322A1 (enExample)
CA (2) CA3030421C (enExample)
GB (2) GB2555892B (enExample)
SG (1) SG11201900081QA (enExample)
WO (1) WO2018013646A1 (enExample)

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EP4026616B1 (en) * 2015-08-26 2024-12-11 Emulate, Inc. Perfusion manifold assembly
US11285478B2 (en) 2016-04-04 2022-03-29 Combinati Incorporated Microfluidic siphoning array for nucleic acid quantification
US10335788B2 (en) * 2016-07-12 2019-07-02 EMULATE, Inc. Removing bubbles in a microfluidic device
USD860471S1 (en) * 2016-07-12 2019-09-17 EMULATE, Inc. Perfusion module lid
KR102422907B1 (ko) * 2016-11-17 2022-07-21 콤비네티 인코포레이티드 핵산 분석 및 정량화를 위한 방법 및 시스템
EP3749453A4 (en) * 2018-02-07 2021-12-15 The Trustees of the University of Pennsylvania HIGH RATE MICROFLUIDIC DEVICE
WO2019160491A1 (en) * 2018-02-16 2019-08-22 Astrego Diagnostics Ab Microfluidic device
EP3847234A2 (en) 2018-09-04 2021-07-14 The Charles Stark Draper Laboratory, Inc. Method and device for high field strength electrotransfection of microvescicles and cells
AU2019397371B2 (en) 2018-12-10 2025-09-18 Combinati Incorporated Microfluidic array for sample digitization
FR3094012B1 (fr) 2019-03-20 2022-08-12 Cherry Biotech Sas Procédé d'enrichissement en gaz et simultanément de déplacement d’un fluide et dispositif pour le contrôle de l'environnement cellulaire sur une plaque de culture cellulaire multipuits correspondant.
EP4040164A4 (en) * 2019-09-30 2023-10-04 Tokyo Ohka Kogyo Co., Ltd. CELL SCREENING DEVICE AND CELL SCREENING KIT
JP7500225B2 (ja) 2020-02-28 2024-06-17 キヤノン株式会社 液体吐出装置および液体補給容器
IT202000014815A1 (it) * 2020-06-19 2021-12-19 Univ Degli Studi Magna Graecia Di Catanzaro Dispositivo microfuidico per colture e screening cellulari e relativo metodo di produzione
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