KR102254380B1 - ＳＥＲＰＩＮＣ1 ｉＲＮＡ 조성물 및 그의 이용 방법 - Google Patents

ＳＥＲＰＩＮＣ1 ｉＲＮＡ 조성물 및 그의 이용 방법 Download PDF

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KR102254380B1
KR102254380B1 KR1020207021811A KR20207021811A KR102254380B1 KR 102254380 B1 KR102254380 B1 KR 102254380B1 KR 1020207021811 A KR1020207021811 A KR 1020207021811A KR 20207021811 A KR20207021811 A KR 20207021811A KR 102254380 B1 KR102254380 B1 KR 102254380B1
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irna
dsrna
serpinc1
acid
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KR20200093691A (ko
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아킨 아킨크
알피카 세갈
이반카 토우드자르스카
도날드 포스터
스튜어트 밀스테인
브라이언 베텐코트
마르틴 마이에르
클라우스 카리쎄
사트야나라야나 쿠치만치
칼란토타틸 지. 라제브
무티아 마노하란
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젠자임 코포레이션
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N2310/30—Chemical structure
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    • C12N2310/3521—Methyl
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3523—Allyl
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3525—MOE, methoxyethoxy
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3533—Halogen
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    • C12N2320/30—Special therapeutic applications
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020207021811A 2012-04-26 2013-04-25 ＳＥＲＰＩＮＣ1 ｉＲＮＡ 조성물 및 그의 이용 방법 Active KR102254380B1 (ko)

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KR1020217014582A KR102375607B1 (ko) 2012-04-26 2013-04-25 ＳＥＲＰＩＮＣ1 ｉＲＮＡ 조성물 및 그의 이용 방법

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US201261638952P 2012-04-26 2012-04-26
US61/638,952 2012-04-26
US201261669249P 2012-07-09 2012-07-09
US61/669,249 2012-07-09
US201261734573P 2012-12-07 2012-12-07
US61/734,573 2012-12-07
US13/837,129 2013-03-15
US13/837,129 US9127274B2 (en) 2012-04-26 2013-03-15 Serpinc1 iRNA compositions and methods of use thereof
KR1020147032288A KR102139918B1 (ko) 2012-04-26 2013-04-25 ＳＥＲＰＩＮＣ1 ｉＲＮＡ 조성물 및 그의 이용 방법
PCT/US2013/038218 WO2013163430A2 (en) 2012-04-26 2013-04-25 Serpinc1 irna compositions and methods of use thereof

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KR102254380B1 true KR102254380B1 (ko) 2021-05-25

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KR1020227008361A Pending KR20220038521A (ko) 2012-04-26 2013-04-25 ＳＥＲＰＩＮＣ1 ｉＲＮＡ 조성물 및 그의 이용 방법
KR1020257029360A Pending KR20250134150A (ko) 2012-04-26 2013-04-25 ＳＥＲＰＩＮＣ1 ｉＲＮＡ 조성물 및 그의 이용 방법
KR1020147032288A Active KR102139918B1 (ko) 2012-04-26 2013-04-25 ＳＥＲＰＩＮＣ1 ｉＲＮＡ 조성물 및 그의 이용 방법
KR1020217014582A Active KR102375607B1 (ko) 2012-04-26 2013-04-25 ＳＥＲＰＩＮＣ1 ｉＲＮＡ 조성물 및 그의 이용 방법

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KR1020257029360A Pending KR20250134150A (ko) 2012-04-26 2013-04-25 ＳＥＲＰＩＮＣ1 ｉＲＮＡ 조성물 및 그의 이용 방법
KR1020147032288A Active KR102139918B1 (ko) 2012-04-26 2013-04-25 ＳＥＲＰＩＮＣ1 ｉＲＮＡ 조성물 및 그의 이용 방법
KR1020217014582A Active KR102375607B1 (ko) 2012-04-26 2013-04-25 ＳＥＲＰＩＮＣ1 ｉＲＮＡ 조성물 및 그의 이용 방법

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Country Link
US (6) US9127274B2 (https=)
EP (2) EP2841443B1 (https=)
JP (5) JP6466832B2 (https=)
KR (5) KR102254380B1 (https=)
CN (4) CN104520310B (https=)
AR (1) AR090869A1 (https=)
AU (5) AU2013251494A1 (https=)
CA (1) CA2869922A1 (https=)
CL (1) CL2016000188A1 (https=)
CO (1) CO7240361A2 (https=)
ES (1) ES2934152T3 (https=)
FI (1) FI2841443T3 (https=)
HR (1) HRP20221498T1 (https=)
HU (1) HUE060846T2 (https=)
IL (4) IL234941B (https=)
LT (1) LT2841443T (https=)
MX (2) MX365419B (https=)
PL (1) PL2841443T3 (https=)
PT (1) PT2841443T (https=)
RS (1) RS63838B1 (https=)
RU (1) RU2691580C2 (https=)
SI (1) SI2841443T1 (https=)
WO (1) WO2013163430A2 (https=)
ZA (2) ZA201407293B (https=)

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TW201607559A (zh) * 2014-05-12 2016-03-01 阿尼拉製藥公司 治療ｓｅｒｐｉｎｃ１相關疾患之方法和組成物
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KR20210116509A (ko) 2019-01-16 2021-09-27 젠자임 코포레이션 Serpinc1 irna 조성물 및 그의 이용 방법
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