KR102251127B1 - 이온 교환 크로마토그래피 입력 최적화의 설명 - Google Patents

이온 교환 크로마토그래피 입력 최적화의 설명 Download PDF

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KR102251127B1
KR102251127B1 KR1020167003178A KR20167003178A KR102251127B1 KR 102251127 B1 KR102251127 B1 KR 102251127B1 KR 1020167003178 A KR1020167003178 A KR 1020167003178A KR 20167003178 A KR20167003178 A KR 20167003178A KR 102251127 B1 KR102251127 B1 KR 102251127B1
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polypeptide
antibody
buffer
gradient
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KR20160030251A (ko
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다니엘 맥도날드
토마스 페타포프
야준 왕
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제넨테크, 인크.
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8658—Optimising operation parameters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3847—Multimodal interactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Confectionery (AREA)
KR1020167003178A 2013-07-12 2014-07-11 이온 교환 크로마토그래피 입력 최적화의 설명 Active KR102251127B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361845890P 2013-07-12 2013-07-12
US61/845,890 2013-07-12
PCT/US2014/046338 WO2015006686A1 (en) 2013-07-12 2014-07-11 Elucidation of ion exchange chromatography input optimization

Publications (2)

Publication Number Publication Date
KR20160030251A KR20160030251A (ko) 2016-03-16
KR102251127B1 true KR102251127B1 (ko) 2021-05-11

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US (2) US10274466B2 (enExample)
EP (2) EP3536699A1 (enExample)
JP (2) JP6462681B2 (enExample)
KR (1) KR102251127B1 (enExample)
CN (1) CN105377873B (enExample)
AU (1) AU2014287044B2 (enExample)
BR (1) BR112016000231A8 (enExample)
CA (1) CA2918052A1 (enExample)
ES (1) ES2705700T3 (enExample)
HR (1) HRP20190071T1 (enExample)
IL (1) IL243305B (enExample)
MX (1) MX368107B (enExample)
PL (1) PL3019516T3 (enExample)
RU (1) RU2016104542A (enExample)
SG (1) SG11201600221YA (enExample)
SI (1) SI3019516T1 (enExample)
TR (1) TR201818966T4 (enExample)
WO (1) WO2015006686A1 (enExample)

Families Citing this family (7)

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ES2705700T3 (es) 2013-07-12 2019-03-26 Hoffmann La Roche Elucidación de la optimización de entrada en cromatografía de intercambio iónico
CN107110835B (zh) 2014-11-12 2019-07-26 通用电气健康护理生物科学股份公司 用于确定实验参数对液相色谱协议的影响的方法和系统
GB2539420B (en) * 2015-06-16 2021-01-13 Cytiva Sweden Ab Determination of chromatography conditions
BR112020019882A2 (pt) * 2018-04-02 2021-01-05 Amgen Inc. Composições de erenumabe e seus usos
JP2021530247A (ja) * 2018-07-05 2021-11-11 オベーション ダイアグノスティクス エルエルシー 癌の診断のためのＢＣｌ−２抗体とイムノアッセイ
KR20200080748A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 음이온 교환 크로마토그래피를 이용한 인슐린 전구체의 정제방법
WO2024261724A1 (en) * 2023-06-23 2024-12-26 Lupin Limited Ion-exchange chromatography for separation and analysis of charge variants

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003500633A (ja) 1999-03-15 2003-01-07 ノボ ノルディスク アクティーゼルスカブ 溶出ステップにおける有機モディファイアでのタンパク質及びペプチドのイオン交換クロマトグラフィー
US20080312425A1 (en) 2004-08-30 2008-12-18 Lonza Biologics Plc. Ion Exchange Chromatography and Purification of Antibodies
JP2010089001A (ja) 2008-10-07 2010-04-22 Japan Organo Co Ltd クロマト分離方法
JP2013530406A (ja) 2010-07-09 2013-07-25 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ クロマトグラフィー方法及びそれに使用される媒体

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2413974A1 (fr) 1978-01-06 1979-08-03 David Bernard Sechoir pour feuilles imprimees par serigraphie
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4666855A (en) * 1985-07-31 1987-05-19 Massachusetts Institute Of Technology Rapid method for determining the isoelectric point for amphoteric molecules
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
ES2037273T3 (es) 1987-04-11 1993-06-16 Ciba-Geigy Ag Proceso de focalizacion isoelectrica y medios para llevar a cabo dicho proceso.
DE3850542T2 (de) 1987-09-23 1994-11-24 Bristol Myers Squibb Co Antikörper-Heterokonjugate zur Töting von HIV-infizierten Zellen.
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
ATE144793T1 (de) 1989-06-29 1996-11-15 Medarex Inc Bispezifische reagenzien für die aids-therapie
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
JPH06500011A (ja) 1990-06-29 1994-01-06 ラージ　スケール　バイオロジー　コーポレイション 形質転換された微生物によるメラニンの製造
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
WO1992020373A1 (en) 1991-05-14 1992-11-26 Repligen Corporation Heteroconjugate antibodies for treatment of hiv infection
EP0590058B1 (en) 1991-06-14 2003-11-26 Genentech, Inc. HUMANIZED Heregulin ANTIBODy
MX9204374A (es) 1991-07-25 1993-03-01 Idec Pharma Corp Anticuerpo recombinante y metodo para su produccion.
WO1993006217A1 (en) 1991-09-19 1993-04-01 Genentech, Inc. EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab')2 ANTIBODIES
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
FI941572L (fi) 1991-10-07 1994-05-27 Oncologix Inc Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
AU3178993A (en) 1991-11-25 1993-06-28 Enzon, Inc. Multivalent antigen-binding proteins
ATE419355T1 (de) 1992-02-06 2009-01-15 Novartis Vaccines & Diagnostic Marker für krebs und biosynthetisches bindeprotein dafür
EP0626012B1 (en) 1992-02-11 2003-07-09 Cell Genesys, Inc. Homogenotization of gene-targeting events
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
ATE149570T1 (de) 1992-08-17 1997-03-15 Genentech Inc Bispezifische immunoadhesine
ES2091684T3 (es) 1992-11-13 1996-11-01 Idec Pharma Corp Aplicacion terapeutica de anticuerpos quimericos y radiomarcados contra el antigeno de diferenciacion restringida de los linfocitos b humanos para el tratamiento del linfoma de las celulas b.
US5534615A (en) 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
US5789199A (en) 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US5712374A (en) 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
ATE321066T1 (de) 1998-05-06 2006-04-15 Genentech Inc Anti-her2 antikörperzusammensetzung
SE9803838D0 (sv) * 1998-11-09 1998-11-09 Knut Irgum A chromatography method and a column material useful in said method
IL127127A0 (en) 1998-11-18 1999-09-22 Peptor Ltd Small functional units of antibody heavy chain variable regions
DE60017888T2 (de) 1999-04-05 2006-01-19 Emisphere Technologies, Inc. Dinatrium-salze, monohydrate und ethanol-solvate
US8372954B2 (en) 2000-12-22 2013-02-12 National Research Council Of Canada Phage display libraries of human VH fragments
JP2005289809A (ja) 2001-10-24 2005-10-20 Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) 突然変異重鎖抗体
AU2003265994B2 (en) 2002-09-11 2010-04-01 Genentech, Inc. Protein purification
WO2004103519A2 (en) 2003-05-16 2004-12-02 Cryobiophysica, Inc. External gradient chromatofocusing
DK1639011T3 (da) 2003-06-30 2009-02-16 Domantis Ltd Pegylerede enkelt-domæne antistoffer (dAb)
US7906630B2 (en) 2004-04-27 2011-03-15 PerkinElmer Heath Sciences, Inc. Method for identifying peptides in a biological sample
EP1756852B1 (en) 2004-05-20 2014-04-30 Waters Technologies Corporation Method and apparatus for identifying proteins in mixtures
CA2583081A1 (en) 2004-06-16 2006-01-19 Bio-Rad Laboratories, Inc. Multichemistry fractionation
WO2006031370A2 (en) 2004-08-19 2006-03-23 Genentech, Inc. Polypeptide variants with altered effector function
ES2579805T3 (es) 2004-09-23 2016-08-16 Genentech, Inc. Anticuerpos y conjugados modificados por ingeniería genética con cisteína
JP2006087394A (ja) * 2004-09-27 2006-04-06 Wako Pure Chem Ind Ltd 核酸抽出方法および核酸抽出キット
GB0613753D0 (en) 2006-07-11 2006-08-23 Norwegian Radium Hospital Res Method
CA2754528A1 (en) 2009-03-06 2010-09-10 Genetech, Inc. Antibody formulation
WO2011009623A1 (en) * 2009-07-24 2011-01-27 F. Hoffmann-La Roche Ag Optimizing the production of antibodies
CA2772653C (en) * 2009-09-01 2019-06-25 Genentech, Inc. Enhanced protein purification through a modified protein a elution
WO2012102104A1 (ja) 2011-01-24 2012-08-02 シャープ株式会社 露光装置、液晶表示装置及びその製造方法
JP2014510734A (ja) 2011-03-31 2014-05-01 アポテックス テクノロジーズ インコーポレイテッド Ｄ−ガンマ−グルタミル−ｄ−トリプトファンおよびｄ−ガンマ−グルタミル−ｌ−トリプトファンのプロドラッグ
WO2014078729A1 (en) 2012-11-15 2014-05-22 Genentech, Inc. IONIC STRENGTH-MEDIATED pH GRADIENT ION EXCHANGE CHROMATOGRAPHY
ES2705700T3 (es) 2013-07-12 2019-03-26 Hoffmann La Roche Elucidación de la optimización de entrada en cromatografía de intercambio iónico

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003500633A (ja) 1999-03-15 2003-01-07 ノボ ノルディスク アクティーゼルスカブ 溶出ステップにおける有機モディファイアでのタンパク質及びペプチドのイオン交換クロマトグラフィー
US20080312425A1 (en) 2004-08-30 2008-12-18 Lonza Biologics Plc. Ion Exchange Chromatography and Purification of Antibodies
JP2010089001A (ja) 2008-10-07 2010-04-22 Japan Organo Co Ltd クロマト分離方法
JP2013530406A (ja) 2010-07-09 2013-07-25 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ クロマトグラフィー方法及びそれに使用される媒体

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US20160161455A1 (en) 2016-06-09
JP2019090818A (ja) 2019-06-13
WO2015006686A8 (en) 2018-10-04
MX368107B (es) 2019-09-18
EP3019516A1 (en) 2016-05-18
HRP20190071T1 (hr) 2019-02-22
WO2015006686A1 (en) 2015-01-15
HK1222183A1 (zh) 2017-06-23
US10274466B2 (en) 2019-04-30
RU2016104542A (ru) 2017-08-17
EP3536699A1 (en) 2019-09-11
CN105377873B (zh) 2021-03-30
PL3019516T3 (pl) 2019-04-30
IL243305A0 (en) 2016-03-31
SG11201600221YA (en) 2016-02-26
MX2016000181A (es) 2016-03-09
CA2918052A1 (en) 2015-01-15
KR20160030251A (ko) 2016-03-16
ES2705700T3 (es) 2019-03-26
EP3019516B1 (en) 2018-11-14
BR112016000231A8 (pt) 2019-12-31
AU2014287044B2 (en) 2020-02-06
CN105377873A (zh) 2016-03-02
TR201818966T4 (tr) 2019-01-21
IL243305B (en) 2019-09-26
SI3019516T1 (sl) 2019-02-28
JP6462681B2 (ja) 2019-01-30
US10921297B2 (en) 2021-02-16
JP2016529489A (ja) 2016-09-23
AU2014287044A1 (en) 2016-02-11
US20190310234A1 (en) 2019-10-10

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