KR102244216B1 - 티오펜 화합물 및 이의 합성 방법과 이의 의약에서의 용도 - Google Patents
티오펜 화합물 및 이의 합성 방법과 이의 의약에서의 용도 Download PDFInfo
- Publication number
- KR102244216B1 KR102244216B1 KR1020187037287A KR20187037287A KR102244216B1 KR 102244216 B1 KR102244216 B1 KR 102244216B1 KR 1020187037287 A KR1020187037287 A KR 1020187037287A KR 20187037287 A KR20187037287 A KR 20187037287A KR 102244216 B1 KR102244216 B1 KR 102244216B1
- Authority
- KR
- South Korea
- Prior art keywords
- group
- compound
- acid
- pharmaceutically acceptable
- acceptable salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610343321.0 | 2016-05-23 | ||
| CN201610343321 | 2016-05-23 | ||
| PCT/CN2017/085458 WO2017202291A1 (zh) | 2016-05-23 | 2017-05-23 | 噻吩化合物及其合成方法和其在医药上的应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20190009377A KR20190009377A (ko) | 2019-01-28 |
| KR102244216B1 true KR102244216B1 (ko) | 2021-04-26 |
Family
ID=60411095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187037287A KR102244216B1 (ko) | 2016-05-23 | 2017-05-23 | 티오펜 화합물 및 이의 합성 방법과 이의 의약에서의 용도 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10829483B2 (zh) |
| EP (1) | EP3466946B1 (zh) |
| JP (1) | JP6724246B2 (zh) |
| KR (1) | KR102244216B1 (zh) |
| CN (1) | CN109790155B (zh) |
| AU (1) | AU2017270858B2 (zh) |
| CA (1) | CA3025078C (zh) |
| ES (1) | ES2961901T3 (zh) |
| MX (1) | MX2018014374A (zh) |
| NZ (1) | NZ749427A (zh) |
| RU (1) | RU2709473C9 (zh) |
| WO (1) | WO2017202291A1 (zh) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3236903B1 (en) | 2014-12-23 | 2021-04-21 | Intellectual Property Associates, LLC | Methods and formulations for transdermal administration |
| EP3681479B1 (en) | 2017-09-15 | 2024-01-31 | Dyve Biosciences, Inc. | Sodium bicarbonate for use in the treatment of gout and related disorders |
| KR102246619B1 (ko) * | 2017-11-23 | 2021-04-30 | 메드샤인 디스커버리 아이엔씨. | Urat1 억제제의 결정형 및 그의 제조 방법 |
| CN111943957B (zh) * | 2019-05-17 | 2023-01-06 | 中国医学科学院药物研究所 | 喹啉甲酰胺类化合物及其制备方法和用途 |
| EP4053114B1 (en) * | 2019-10-30 | 2024-10-09 | Dongbao Purple Star (Hangzhou) Biopharmaceutical Co., Ltd. | Thiophene derivatives as xanthine oxidase inhibitors and application thereof |
| BR112022010735A2 (pt) | 2019-12-20 | 2022-08-23 | Bayer Ag | Tiofeno carboxamidas substituídos, ácidos tiofeno carboxílicos e derivados dos mesmos |
| CN113368073A (zh) * | 2020-07-23 | 2021-09-10 | 太阳升(亳州)生物医药科技有限公司 | 制备用于降低血液尿酸水平的药物制剂的方法 |
| CN113368067A (zh) * | 2020-07-23 | 2021-09-10 | 太阳升(亳州)生物医药科技有限公司 | 制备用于降低血液尿酸水平的口服药物片剂的方法 |
| CN113368032A (zh) * | 2020-07-23 | 2021-09-10 | 太阳升(亳州)生物医药科技有限公司 | 药物组合物、口服固体制剂及其制备方法和用途 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012050589A1 (en) | 2010-10-15 | 2012-04-19 | Ardea Biosciences, Inc. | Methods for treating hyperuricemia and related diseases |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2682391C (en) * | 2007-04-11 | 2014-07-08 | Kissei Pharmaceutical Co., Ltd. | (aza)indole derivative and use thereof for medical purposes |
| DK2217577T3 (da) * | 2007-11-27 | 2014-10-20 | Ardea Biosciences Inc | Hidtil ukendte forbindelser og præparater og fremgangsmåder til anvendelse deraf |
| JP2012502050A (ja) * | 2008-09-04 | 2012-01-26 | アルディア バイオサイエンス，インク． | 尿酸値を調節するための化合物、組成物及びそれを使用する方法。 |
| HUE037736T2 (hu) | 2012-11-14 | 2018-09-28 | Teijin Pharma Ltd | Piridin származékok |
| WO2016150255A1 (zh) * | 2015-03-24 | 2016-09-29 | 上海璎黎药业有限公司 | 稠环衍生物、其制备方法、中间体、药物组合物及应用 |
| CN105399694B (zh) * | 2015-12-11 | 2017-09-15 | 浙江京新药业股份有限公司 | 药物Lesinurad轴手性对映体 |
-
2017
- 2017-05-23 WO PCT/CN2017/085458 patent/WO2017202291A1/zh unknown
- 2017-05-23 US US16/303,767 patent/US10829483B2/en active Active
- 2017-05-23 CN CN201780031676.9A patent/CN109790155B/zh active Active
- 2017-05-23 EP EP17802137.4A patent/EP3466946B1/en active Active
- 2017-05-23 AU AU2017270858A patent/AU2017270858B2/en active Active
- 2017-05-23 RU RU2018144818A patent/RU2709473C9/ru active
- 2017-05-23 ES ES17802137T patent/ES2961901T3/es active Active
- 2017-05-23 MX MX2018014374A patent/MX2018014374A/es unknown
- 2017-05-23 NZ NZ74942717A patent/NZ749427A/en unknown
- 2017-05-23 JP JP2019514169A patent/JP6724246B2/ja active Active
- 2017-05-23 KR KR1020187037287A patent/KR102244216B1/ko active IP Right Grant
- 2017-05-23 CA CA3025078A patent/CA3025078C/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012050589A1 (en) | 2010-10-15 | 2012-04-19 | Ardea Biosciences, Inc. | Methods for treating hyperuricemia and related diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017202291A1 (zh) | 2017-11-30 |
| US10829483B2 (en) | 2020-11-10 |
| AU2017270858A1 (en) | 2019-01-17 |
| JP2019519606A (ja) | 2019-07-11 |
| CN109790155B (zh) | 2022-02-18 |
| NZ749427A (en) | 2019-11-29 |
| MX2018014374A (es) | 2019-05-20 |
| US20200140423A1 (en) | 2020-05-07 |
| KR20190009377A (ko) | 2019-01-28 |
| AU2017270858B2 (en) | 2019-09-19 |
| JP6724246B2 (ja) | 2020-07-15 |
| EP3466946B1 (en) | 2023-08-30 |
| CA3025078A1 (en) | 2017-11-30 |
| BR112018074027A2 (pt) | 2019-02-26 |
| EP3466946A1 (en) | 2019-04-10 |
| ES2961901T3 (es) | 2024-03-14 |
| RU2709473C9 (ru) | 2020-06-16 |
| CN109790155A (zh) | 2019-05-21 |
| CA3025078C (en) | 2021-04-13 |
| EP3466946A4 (en) | 2019-11-06 |
| RU2709473C1 (ru) | 2019-12-18 |
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| A201 | Request for examination | ||
| AMND | Amendment | ||
| E902 | Notification of reason for refusal | ||
| AMND | Amendment | ||
| E601 | Decision to refuse application | ||
| AMND | Amendment | ||
| X701 | Decision to grant (after re-examination) | ||
| GRNT | Written decision to grant |