MX2018014374A - Tiofeno, método de fabricación y aplicación farmacéutica del mismo. - Google Patents

Tiofeno, método de fabricación y aplicación farmacéutica del mismo.

Info

Publication number
MX2018014374A
MX2018014374A MX2018014374A MX2018014374A MX2018014374A MX 2018014374 A MX2018014374 A MX 2018014374A MX 2018014374 A MX2018014374 A MX 2018014374A MX 2018014374 A MX2018014374 A MX 2018014374A MX 2018014374 A MX2018014374 A MX 2018014374A
Authority
MX
Mexico
Prior art keywords
thiophene
manufacturing
same
pharmaceutical application
preparing
Prior art date
Application number
MX2018014374A
Other languages
English (en)
Inventor
Zhang Yang
Chen Shuhui
Wang Jianfei
Zhu Wenyuan
Original Assignee
Cstone Pharmaceuticals Shanghai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cstone Pharmaceuticals Shanghai Co Ltd filed Critical Cstone Pharmaceuticals Shanghai Co Ltd
Publication of MX2018014374A publication Critical patent/MX2018014374A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion describe un tiofeno utilizado como un inhibidor del transportador de acido urico (URAT1) y la aplicacion del tiofeno en la preparacion de un producto farmaceutico para el tratamiento de una enfermedad relacionada con niveles de acido urico anormales, especificamente en la preparacion de un producto farmaceutico para tratar hiperuricemia y artritis gotosa; la invencion esta especificamente relacionada con un compuesto como representado por la Formula (I) (ver fórmula) o una sal farmaceuticamente aceptable del mismo.
MX2018014374A 2016-05-23 2017-05-23 Tiofeno, método de fabricación y aplicación farmacéutica del mismo. MX2018014374A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610343321 2016-05-23
PCT/CN2017/085458 WO2017202291A1 (zh) 2016-05-23 2017-05-23 噻吩化合物及其合成方法和其在医药上的应用

Publications (1)

Publication Number Publication Date
MX2018014374A true MX2018014374A (es) 2019-05-20

Family

ID=60411095

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018014374A MX2018014374A (es) 2016-05-23 2017-05-23 Tiofeno, método de fabricación y aplicación farmacéutica del mismo.

Country Status (12)

Country Link
US (1) US10829483B2 (es)
EP (1) EP3466946B1 (es)
JP (1) JP6724246B2 (es)
KR (1) KR102244216B1 (es)
CN (1) CN109790155B (es)
AU (1) AU2017270858B2 (es)
CA (1) CA3025078C (es)
ES (1) ES2961901T3 (es)
MX (1) MX2018014374A (es)
NZ (1) NZ749427A (es)
RU (1) RU2709473C9 (es)
WO (1) WO2017202291A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015371308A1 (en) 2014-12-23 2017-08-03 Intellectual Property Associates, Llc Methods and formulations for transdermal administration
US20190083527A1 (en) 2017-09-15 2019-03-21 Ampersand Biopharmaceuticals, Inc. Method of administration and treatment
CA3083295C (en) * 2017-11-23 2021-05-04 Medshine Discovery Inc. Crystal form of urat1 inhibitor, and preparation method therefor
CN111943957B (zh) * 2019-05-17 2023-01-06 中国医学科学院药物研究所 喹啉甲酰胺类化合物及其制备方法和用途
US20230322703A1 (en) * 2019-10-30 2023-10-12 Dongbao Purple Star (Hangzhou) Biopharmaceutical Co., Ltd. Thiophene derivatives as xanthine oxidase inhibitors and application thereof
KR20220119651A (ko) 2019-12-20 2022-08-30 바이엘 악티엔게젤샤프트 치환된 티오펜 카르복스아미드, 티오펜 카르복실산 및 그의 유도체
CN113368067A (zh) * 2020-07-23 2021-09-10 太阳升(亳州)生物医药科技有限公司 制备用于降低血液尿酸水平的口服药物片剂的方法
CN113368032A (zh) * 2020-07-23 2021-09-10 太阳升(亳州)生物医药科技有限公司 药物组合物、口服固体制剂及其制备方法和用途
CN113368073A (zh) * 2020-07-23 2021-09-10 太阳升(亳州)生物医药科技有限公司 制备用于降低血液尿酸水平的药物制剂的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2431815T3 (es) * 2007-04-11 2013-11-28 Kissei Pharmaceutical Co., Ltd. Derivado de (aza)indol y uso del mismo para fines médicos
SI2217577T1 (sl) 2007-11-27 2014-11-28 Ardea Biosciences, Inc. Nove spojine in sestavki ter metode uporabe
KR101294872B1 (ko) * 2008-09-04 2013-08-08 아디아 바이오사이언스즈 인크. 요산 수치를 조절하기 위한 화합물, 조성물 및 이들의 사용 방법
CA2813555C (en) * 2010-10-15 2014-11-25 Ardea Biosciences, Inc. Methods for treating hyperuricemia and related diseases
EP3339302A1 (en) 2012-11-14 2018-06-27 Teijin Pharma Limited Pyridine derivative
CN108516958B (zh) * 2015-03-24 2020-07-17 上海璎黎药业有限公司 稠环衍生物、其制备方法、中间体、药物组合物及应用
CN105399694B (zh) * 2015-12-11 2017-09-15 浙江京新药业股份有限公司 药物Lesinurad轴手性对映体

Also Published As

Publication number Publication date
JP6724246B2 (ja) 2020-07-15
CA3025078A1 (en) 2017-11-30
CA3025078C (en) 2021-04-13
EP3466946A4 (en) 2019-11-06
NZ749427A (en) 2019-11-29
WO2017202291A1 (zh) 2017-11-30
KR102244216B1 (ko) 2021-04-26
CN109790155A (zh) 2019-05-21
RU2709473C9 (ru) 2020-06-16
RU2709473C1 (ru) 2019-12-18
AU2017270858B2 (en) 2019-09-19
BR112018074027A2 (pt) 2019-02-26
JP2019519606A (ja) 2019-07-11
EP3466946A1 (en) 2019-04-10
ES2961901T3 (es) 2024-03-14
EP3466946B1 (en) 2023-08-30
US10829483B2 (en) 2020-11-10
CN109790155B (zh) 2022-02-18
KR20190009377A (ko) 2019-01-28
US20200140423A1 (en) 2020-05-07
AU2017270858A1 (en) 2019-01-17

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