KR102237356B1 - 지연 방출 약물 제형 - Google Patents

지연 방출 약물 제형 Download PDF

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Publication number
KR102237356B1
KR102237356B1 KR1020207017564A KR20207017564A KR102237356B1 KR 102237356 B1 KR102237356 B1 KR 102237356B1 KR 1020207017564 A KR1020207017564 A KR 1020207017564A KR 20207017564 A KR20207017564 A KR 20207017564A KR 102237356 B1 KR102237356 B1 KR 102237356B1
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Prior art keywords
drug
coating
layer
polymeric material
polymer
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Korean (ko)
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KR20200075041A (ko
Inventor
펠리페 요세 올리베이라 바룸
곤잘레스 로베르토 카를로스 브라보
토마스 부세르
아브덜 와세 바싯
애나 크리스티나 프레이레
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틸로츠 파마 아게
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/606—Salicylic acid; Derivatives thereof having amino groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/005—Coating of tablets or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020207017564A 2013-10-29 2013-10-29 지연 방출 약물 제형 Active KR102237356B1 (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2013/072648 WO2015062640A1 (en) 2013-10-29 2013-10-29 A delayed release drug formulation

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020167007738A Division KR102174942B1 (ko) 2013-10-29 2013-10-29 지연 방출 약물 제형

Publications (2)

Publication Number Publication Date
KR20200075041A KR20200075041A (ko) 2020-06-25
KR102237356B1 true KR102237356B1 (ko) 2021-04-08

Family

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Application Number Title Priority Date Filing Date
KR1020207017564A Active KR102237356B1 (ko) 2013-10-29 2013-10-29 지연 방출 약물 제형
KR1020167007738A Active KR102174942B1 (ko) 2013-10-29 2013-10-29 지연 방출 약물 제형

Family Applications After (1)

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Country Status (25)

Country Link
US (1) US10799515B2 (enExample)
EP (2) EP3542791A1 (enExample)
JP (1) JP6273356B2 (enExample)
KR (2) KR102237356B1 (enExample)
CN (2) CN105555260B (enExample)
AU (2) AU2013404367B2 (enExample)
BR (2) BR122020013726B1 (enExample)
CA (1) CA2923063C (enExample)
CR (1) CR20160192A (enExample)
CU (1) CU20160055A7 (enExample)
EA (1) EA032504B1 (enExample)
HK (1) HK1222547A1 (enExample)
IL (2) IL244260B (enExample)
MA (1) MA38847B2 (enExample)
MX (2) MX388063B (enExample)
MY (1) MY189394A (enExample)
NZ (2) NZ747731A (enExample)
PH (2) PH12020551522A1 (enExample)
SA (2) SA116370660B1 (enExample)
SG (1) SG11201600501UA (enExample)
TN (1) TN2016000119A1 (enExample)
TW (3) TWI680774B (enExample)
UA (1) UA117260C2 (enExample)
WO (1) WO2015062640A1 (enExample)
ZA (1) ZA201600630B (enExample)

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SI2659881T1 (en) 2012-04-30 2018-03-30 Tillotts Pharma Ag Formulation of the delayed release medicinal product
CN108283000B (zh) 2015-09-23 2021-04-13 凯瑞康宁生物工程（武汉）有限公司 γ-羟基丁酸的前药及其组合物和用途
EP3162362A1 (de) * 2015-10-30 2017-05-03 Dr. Falk Pharma Gmbh Optimierte mesalazinhaltige hochdosistablette
EP3257501A1 (en) 2016-06-14 2017-12-20 Tillotts Pharma AG Multiple unit dosage form comprising a core with individual core units covered by a mucoadhesive material, and an enteric core coating
WO2019126200A1 (en) * 2017-12-21 2019-06-27 Pepsico, Inc. Multi-ingredient ephemeral beverage pod for making a beverage
EP3662895A1 (en) 2018-12-07 2020-06-10 Tillotts Pharma AG A process for manufacturing reducing sugar-free 5-asa tablet cores
EP3662898A1 (en) 2018-12-07 2020-06-10 Tillotts Pharma AG Solid composition comprising mesalazine
EP3662902B1 (en) * 2018-12-07 2024-07-31 Tillotts Pharma AG Colonic drug delivery formulation
ES3002632T3 (en) 2018-12-07 2025-03-07 Tillotts Pharma Ag Delayed release drug formulation comprising an outerlayer with an enzymatically degradable polymer, its composition and its method of manufacturing
EP3662900A1 (en) * 2018-12-07 2020-06-10 Tillotts Pharma AG Colonic drug delivery formulation
GB201906917D0 (en) * 2019-05-16 2019-07-03 Intract Pharma Ltd Novel compositions
CN114828833A (zh) 2019-12-11 2022-07-29 赢创运营有限公司 包含碱剂和肠溶包衣层的剂型
ES2975442T3 (es) 2019-12-11 2024-07-05 Evonik Operations Gmbh Forma farmacéutica para su uso en el tratamiento o la prevención de una enfermedad

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JP2012153724A (ja) 2005-05-02 2012-08-16 Aptalis Pharmatech Inc 時限パルス放出システム

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US20020192282A1 (en) 2000-03-17 2002-12-19 Thomas Beckert Multilayer pharmaceutical product for release in the colon
JP2012153724A (ja) 2005-05-02 2012-08-16 Aptalis Pharmatech Inc 時限パルス放出システム
JP2008543929A (ja) * 2005-06-20 2008-12-04 カディラ・ヘルスケア・リミテッド デュロキセチンの調節放出型の投与製剤
US20090175935A1 (en) 2006-08-14 2009-07-09 Torrent Research Ltd. Pharmaceutical compositions of duloxetine
JP2008214249A (ja) 2007-03-02 2008-09-18 Takeda Chem Ind Ltd 製剤における溶出改善方法および溶出性の改善された製剤
WO2008135090A1 (en) * 2007-05-07 2008-11-13 Evonik Röhm Gmbh Solid dosage forms comprising an enteric coating with accelerated drug release
US20090162434A1 (en) 2007-12-21 2009-06-25 Disphar International Bv Mesalazine tablet

Also Published As

Publication number Publication date
AU2020201365B2 (en) 2021-09-16
IL265381A (en) 2019-05-30
PH12016500307A1 (en) 2016-05-16
EP3062776A1 (en) 2016-09-07
AU2020201365A1 (en) 2020-03-12
CA2923063C (en) 2021-09-07
JP2016535030A (ja) 2016-11-10
CN110279669B (zh) 2022-02-15
KR102174942B1 (ko) 2020-11-06
KR20160077040A (ko) 2016-07-01
ZA201600630B (en) 2017-05-31
MX382146B (es) 2025-03-13
CA2923063A1 (en) 2015-05-07
JP6273356B2 (ja) 2018-01-31
TWI725458B (zh) 2021-04-21
TW202011945A (zh) 2020-04-01
TW201944984A (zh) 2019-12-01
TWI680774B (zh) 2020-01-01
IL244260B (en) 2021-08-31
US20160250232A1 (en) 2016-09-01
PH12016500307B1 (en) 2022-02-11
MA38847A1 (fr) 2017-08-31
MA38847B2 (fr) 2021-02-26
CR20160192A (es) 2016-07-13
TW201542243A (zh) 2015-11-16
BR112016004863A8 (pt) 2020-02-11
MX2016001840A (es) 2016-08-11
PH12020551522A1 (en) 2022-11-14
CN105555260A (zh) 2016-05-04
EP3542791A1 (en) 2019-09-25
MY189394A (en) 2022-02-09
EA032504B1 (ru) 2019-06-28
HK1222547A1 (zh) 2017-07-07
US10799515B2 (en) 2020-10-13
MX388063B (es) 2025-03-19
MX2019002162A (es) 2019-06-17
EA201690596A1 (ru) 2016-08-31
NZ747731A (en) 2020-02-28
CU20160055A7 (es) 2016-10-28
TN2016000119A1 (en) 2017-10-06
IL244260A0 (en) 2016-04-21
UA117260C2 (uk) 2018-07-10
AU2013404367A1 (en) 2016-02-18
CN105555260B (zh) 2021-04-23
WO2015062640A1 (en) 2015-05-07
IL265381B (en) 2022-05-01
CN110279669A (zh) 2019-09-27
NZ717159A (en) 2019-06-28
SA114360006B1 (ar) 2016-11-09
BR122020013726B1 (pt) 2022-11-01
BR112016004863B1 (pt) 2022-09-20
SG11201600501UA (en) 2016-02-26
TWI736031B (zh) 2021-08-11
AU2013404367B2 (en) 2020-02-27
SA116370660B1 (ar) 2019-02-24
KR20200075041A (ko) 2020-06-25

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