TWI680774B - 緩釋藥物配方 - Google Patents

緩釋藥物配方 Download PDF

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Publication number
TWI680774B
TWI680774B TW103137471A TW103137471A TWI680774B TW I680774 B TWI680774 B TW I680774B TW 103137471 A TW103137471 A TW 103137471A TW 103137471 A TW103137471 A TW 103137471A TW I680774 B TWI680774 B TW I680774B
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TW
Taiwan
Prior art keywords
item
layer
patent application
polymer material
drug
Prior art date
Application number
TW103137471A
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English (en)
Chinese (zh)
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TW201542243A (zh
Inventor
費雷普 何塞 奧力維拉 瓦倫
岡薩雷茲 羅伯托 卡洛斯 布拉
湯瑪士 布塞
Original Assignee
迪洛特醫藥有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from US14/066,054 external-priority patent/US9814681B2/en
Application filed by 迪洛特醫藥有限公司 filed Critical 迪洛特醫藥有限公司
Publication of TW201542243A publication Critical patent/TW201542243A/zh
Application granted granted Critical
Publication of TWI680774B publication Critical patent/TWI680774B/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/005Coating of tablets or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/60Salicylic acid; Derivatives thereof
    • A61K31/606Salicylic acid; Derivatives thereof having amino groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/284Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/284Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846Poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893Tablet coating processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW103137471A 2013-10-29 2014-10-29 緩釋藥物配方 TWI680774B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14/066,054 US9814681B2 (en) 2012-04-30 2013-10-29 Delayed release drug formulation
US14/066054 2013-10-29
PCT/EP2013/072648 WO2015062640A1 (en) 2013-10-29 2013-10-29 A delayed release drug formulation
WOPCT/EP2013/072648 2013-10-29

Publications (2)

Publication Number Publication Date
TW201542243A TW201542243A (zh) 2015-11-16
TWI680774B true TWI680774B (zh) 2020-01-01

Family

ID=49515360

Family Applications (3)

Application Number Title Priority Date Filing Date
TW108122234A TWI725458B (zh) 2013-10-29 2014-10-29 緩釋藥物配方
TW108142795A TWI736031B (zh) 2013-10-29 2014-10-29 緩釋藥物配方
TW103137471A TWI680774B (zh) 2013-10-29 2014-10-29 緩釋藥物配方

Family Applications Before (2)

Application Number Title Priority Date Filing Date
TW108122234A TWI725458B (zh) 2013-10-29 2014-10-29 緩釋藥物配方
TW108142795A TWI736031B (zh) 2013-10-29 2014-10-29 緩釋藥物配方

Country Status (25)

Country Link
US (1) US10799515B2 (enExample)
EP (2) EP3542791A1 (enExample)
JP (1) JP6273356B2 (enExample)
KR (2) KR102174942B1 (enExample)
CN (2) CN110279669B (enExample)
AU (2) AU2013404367B2 (enExample)
BR (2) BR122020013726B1 (enExample)
CA (1) CA2923063C (enExample)
CR (1) CR20160192A (enExample)
CU (1) CU20160055A7 (enExample)
EA (1) EA032504B1 (enExample)
HK (1) HK1222547A1 (enExample)
IL (2) IL244260B (enExample)
MA (1) MA38847B2 (enExample)
MX (2) MX382146B (enExample)
MY (1) MY189394A (enExample)
NZ (2) NZ717159A (enExample)
PH (2) PH12020551522A1 (enExample)
SA (2) SA116370660B1 (enExample)
SG (1) SG11201600501UA (enExample)
TN (1) TN2016000119A1 (enExample)
TW (3) TWI725458B (enExample)
UA (1) UA117260C2 (enExample)
WO (1) WO2015062640A1 (enExample)
ZA (1) ZA201600630B (enExample)

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EP3257501A1 (en) 2016-06-14 2017-12-20 Tillotts Pharma AG Multiple unit dosage form comprising a core with individual core units covered by a mucoadhesive material, and an enteric core coating
AU2018388566A1 (en) * 2017-12-21 2020-06-18 Pepsico, Inc. Multi-ingredient ephemeral beverage pod for making a beverage
EP3662900A1 (en) * 2018-12-07 2020-06-10 Tillotts Pharma AG Colonic drug delivery formulation
ES2994844T3 (en) * 2018-12-07 2025-02-03 Tillotts Pharma Ag Colonic drug delivery formulation
EP3662901B1 (en) 2018-12-07 2025-01-01 Tillotts Pharma AG Delayed release drug formulation comprising an outerlayer with an enzymatically degradable polymer, its composition and its method of manufacturing
EP3662898A1 (en) * 2018-12-07 2020-06-10 Tillotts Pharma AG Solid composition comprising mesalazine
EP3662895A1 (en) 2018-12-07 2020-06-10 Tillotts Pharma AG A process for manufacturing reducing sugar-free 5-asa tablet cores
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EP4072532B1 (en) * 2019-12-11 2024-01-24 Evonik Operations GmbH Dosage form for use in treating or preventing of a disease

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Publication number Priority date Publication date Assignee Title
CN1233170A (zh) * 1996-10-11 1999-10-27 普罗克特和甘保尔公司 具有多重肠溶聚合物包衣的供结肠释放的药物剂型
CN102319218A (zh) * 2011-09-22 2012-01-18 贝沃特医药技术(上海)有限公司 一种治疗肠道疾病的药物缓控释微粒制剂及其制备方法

Also Published As

Publication number Publication date
TWI725458B (zh) 2021-04-21
MX382146B (es) 2025-03-13
EA201690596A1 (ru) 2016-08-31
US10799515B2 (en) 2020-10-13
MX388063B (es) 2025-03-19
JP6273356B2 (ja) 2018-01-31
NZ747731A (en) 2020-02-28
MY189394A (en) 2022-02-09
CR20160192A (es) 2016-07-13
KR102174942B1 (ko) 2020-11-06
IL244260B (en) 2021-08-31
ZA201600630B (en) 2017-05-31
SA114360006B1 (ar) 2016-11-09
CN105555260A (zh) 2016-05-04
EP3062776A1 (en) 2016-09-07
CN105555260B (zh) 2021-04-23
BR112016004863A8 (pt) 2020-02-11
CU20160055A7 (es) 2016-10-28
PH12016500307A1 (en) 2016-05-16
MA38847A1 (fr) 2017-08-31
AU2013404367A1 (en) 2016-02-18
IL265381B (en) 2022-05-01
MX2019002162A (es) 2019-06-17
TW201542243A (zh) 2015-11-16
NZ717159A (en) 2019-06-28
EA032504B1 (ru) 2019-06-28
KR20160077040A (ko) 2016-07-01
SG11201600501UA (en) 2016-02-26
TWI736031B (zh) 2021-08-11
BR122020013726B1 (pt) 2022-11-01
KR20200075041A (ko) 2020-06-25
MX2016001840A (es) 2016-08-11
JP2016535030A (ja) 2016-11-10
KR102237356B1 (ko) 2021-04-08
AU2020201365B2 (en) 2021-09-16
IL244260A0 (en) 2016-04-21
BR112016004863B1 (pt) 2022-09-20
IL265381A (en) 2019-05-30
PH12020551522A1 (en) 2022-11-14
CA2923063A1 (en) 2015-05-07
US20160250232A1 (en) 2016-09-01
CN110279669B (zh) 2022-02-15
CN110279669A (zh) 2019-09-27
MA38847B2 (fr) 2021-02-26
TW202011945A (zh) 2020-04-01
EP3542791A1 (en) 2019-09-25
AU2013404367B2 (en) 2020-02-27
HK1222547A1 (zh) 2017-07-07
TW201944984A (zh) 2019-12-01
AU2020201365A1 (en) 2020-03-12
SA116370660B1 (ar) 2019-02-24
WO2015062640A1 (en) 2015-05-07
CA2923063C (en) 2021-09-07
UA117260C2 (uk) 2018-07-10
TN2016000119A1 (en) 2017-10-06
PH12016500307B1 (en) 2022-02-11

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