TWI680774B - 緩釋藥物配方 - Google Patents

緩釋藥物配方 Download PDF

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Publication number
TWI680774B
TWI680774B TW103137471A TW103137471A TWI680774B TW I680774 B TWI680774 B TW I680774B TW 103137471 A TW103137471 A TW 103137471A TW 103137471 A TW103137471 A TW 103137471A TW I680774 B TWI680774 B TW I680774B
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TW
Taiwan
Prior art keywords
item
layer
patent application
polymer material
drug
Prior art date
Application number
TW103137471A
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English (en)
Chinese (zh)
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TW201542243A (zh
Inventor
費雷普 何塞 奧力維拉 瓦倫
岡薩雷茲 羅伯托 卡洛斯 布拉
湯瑪士 布塞
Original Assignee
迪洛特醫藥有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from US14/066,054 external-priority patent/US9814681B2/en
Application filed by 迪洛特醫藥有限公司 filed Critical 迪洛特醫藥有限公司
Publication of TW201542243A publication Critical patent/TW201542243A/zh
Application granted granted Critical
Publication of TWI680774B publication Critical patent/TWI680774B/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/005—Coating of tablets or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/606—Salicylic acid; Derivatives thereof having amino groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW103137471A 2013-10-29 2014-10-29 緩釋藥物配方 TWI680774B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US14/066,054 US9814681B2 (en) 2012-04-30 2013-10-29 Delayed release drug formulation
US14/066054 2013-10-29
PCT/EP2013/072648 WO2015062640A1 (en) 2013-10-29 2013-10-29 A delayed release drug formulation
WOPCT/EP2013/072648 2013-10-29

Publications (2)

Publication Number Publication Date
TW201542243A TW201542243A (zh) 2015-11-16
TWI680774B true TWI680774B (zh) 2020-01-01

Family

ID=49515360

Family Applications (3)

Application Number Title Priority Date Filing Date
TW103137471A TWI680774B (zh) 2013-10-29 2014-10-29 緩釋藥物配方
TW108142795A TWI736031B (zh) 2013-10-29 2014-10-29 緩釋藥物配方
TW108122234A TWI725458B (zh) 2013-10-29 2014-10-29 緩釋藥物配方

Family Applications After (2)

Application Number Title Priority Date Filing Date
TW108142795A TWI736031B (zh) 2013-10-29 2014-10-29 緩釋藥物配方
TW108122234A TWI725458B (zh) 2013-10-29 2014-10-29 緩釋藥物配方

Country Status (25)

Country Link
US (1) US10799515B2 (enExample)
EP (2) EP3542791A1 (enExample)
JP (1) JP6273356B2 (enExample)
KR (2) KR102237356B1 (enExample)
CN (2) CN105555260B (enExample)
AU (2) AU2013404367B2 (enExample)
BR (2) BR122020013726B1 (enExample)
CA (1) CA2923063C (enExample)
CR (1) CR20160192A (enExample)
CU (1) CU20160055A7 (enExample)
EA (1) EA032504B1 (enExample)
HK (1) HK1222547A1 (enExample)
IL (2) IL244260B (enExample)
MA (1) MA38847B2 (enExample)
MX (2) MX388063B (enExample)
MY (1) MY189394A (enExample)
NZ (2) NZ747731A (enExample)
PH (2) PH12020551522A1 (enExample)
SA (2) SA116370660B1 (enExample)
SG (1) SG11201600501UA (enExample)
TN (1) TN2016000119A1 (enExample)
TW (3) TWI680774B (enExample)
UA (1) UA117260C2 (enExample)
WO (1) WO2015062640A1 (enExample)
ZA (1) ZA201600630B (enExample)

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SI2659881T1 (en) 2012-04-30 2018-03-30 Tillotts Pharma Ag Formulation of the delayed release medicinal product
CN108283000B (zh) 2015-09-23 2021-04-13 凯瑞康宁生物工程(武汉)有限公司 γ-羟基丁酸的前药及其组合物和用途
EP3162362A1 (de) * 2015-10-30 2017-05-03 Dr. Falk Pharma Gmbh Optimierte mesalazinhaltige hochdosistablette
EP3257501A1 (en) 2016-06-14 2017-12-20 Tillotts Pharma AG Multiple unit dosage form comprising a core with individual core units covered by a mucoadhesive material, and an enteric core coating
WO2019126200A1 (en) * 2017-12-21 2019-06-27 Pepsico, Inc. Multi-ingredient ephemeral beverage pod for making a beverage
EP3662895A1 (en) 2018-12-07 2020-06-10 Tillotts Pharma AG A process for manufacturing reducing sugar-free 5-asa tablet cores
EP3662898A1 (en) 2018-12-07 2020-06-10 Tillotts Pharma AG Solid composition comprising mesalazine
EP3662902B1 (en) * 2018-12-07 2024-07-31 Tillotts Pharma AG Colonic drug delivery formulation
ES3002632T3 (en) 2018-12-07 2025-03-07 Tillotts Pharma Ag Delayed release drug formulation comprising an outerlayer with an enzymatically degradable polymer, its composition and its method of manufacturing
EP3662900A1 (en) * 2018-12-07 2020-06-10 Tillotts Pharma AG Colonic drug delivery formulation
GB201906917D0 (en) * 2019-05-16 2019-07-03 Intract Pharma Ltd Novel compositions
CN114828833A (zh) 2019-12-11 2022-07-29 赢创运营有限公司 包含碱剂和肠溶包衣层的剂型
ES2975442T3 (es) 2019-12-11 2024-07-05 Evonik Operations Gmbh Forma farmacéutica para su uso en el tratamiento o la prevención de una enfermedad

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Publication number Priority date Publication date Assignee Title
CN1233170A (zh) * 1996-10-11 1999-10-27 普罗克特和甘保尔公司 具有多重肠溶聚合物包衣的供结肠释放的药物剂型
CN102319218A (zh) * 2011-09-22 2012-01-18 贝沃特医药技术(上海)有限公司 一种治疗肠道疾病的药物缓控释微粒制剂及其制备方法

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Publication number Publication date
AU2020201365B2 (en) 2021-09-16
IL265381A (en) 2019-05-30
PH12016500307A1 (en) 2016-05-16
EP3062776A1 (en) 2016-09-07
AU2020201365A1 (en) 2020-03-12
CA2923063C (en) 2021-09-07
JP2016535030A (ja) 2016-11-10
CN110279669B (zh) 2022-02-15
KR102174942B1 (ko) 2020-11-06
KR20160077040A (ko) 2016-07-01
ZA201600630B (en) 2017-05-31
MX382146B (es) 2025-03-13
KR102237356B1 (ko) 2021-04-08
CA2923063A1 (en) 2015-05-07
JP6273356B2 (ja) 2018-01-31
TWI725458B (zh) 2021-04-21
TW202011945A (zh) 2020-04-01
TW201944984A (zh) 2019-12-01
IL244260B (en) 2021-08-31
US20160250232A1 (en) 2016-09-01
PH12016500307B1 (en) 2022-02-11
MA38847A1 (fr) 2017-08-31
MA38847B2 (fr) 2021-02-26
CR20160192A (es) 2016-07-13
TW201542243A (zh) 2015-11-16
BR112016004863A8 (pt) 2020-02-11
MX2016001840A (es) 2016-08-11
PH12020551522A1 (en) 2022-11-14
CN105555260A (zh) 2016-05-04
EP3542791A1 (en) 2019-09-25
MY189394A (en) 2022-02-09
EA032504B1 (ru) 2019-06-28
HK1222547A1 (zh) 2017-07-07
US10799515B2 (en) 2020-10-13
MX388063B (es) 2025-03-19
MX2019002162A (es) 2019-06-17
EA201690596A1 (ru) 2016-08-31
NZ747731A (en) 2020-02-28
CU20160055A7 (es) 2016-10-28
TN2016000119A1 (en) 2017-10-06
IL244260A0 (en) 2016-04-21
UA117260C2 (uk) 2018-07-10
AU2013404367A1 (en) 2016-02-18
CN105555260B (zh) 2021-04-23
WO2015062640A1 (en) 2015-05-07
IL265381B (en) 2022-05-01
CN110279669A (zh) 2019-09-27
NZ717159A (en) 2019-06-28
SA114360006B1 (ar) 2016-11-09
BR122020013726B1 (pt) 2022-11-01
BR112016004863B1 (pt) 2022-09-20
SG11201600501UA (en) 2016-02-26
TWI736031B (zh) 2021-08-11
AU2013404367B2 (en) 2020-02-27
SA116370660B1 (ar) 2019-02-24
KR20200075041A (ko) 2020-06-25

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