KR102180250B1 - X-선 조영제 성분의 정제 방법 - Google Patents

X-선 조영제 성분의 정제 방법 Download PDF

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KR102180250B1
KR102180250B1 KR1020157015950A KR20157015950A KR102180250B1 KR 102180250 B1 KR102180250 B1 KR 102180250B1 KR 1020157015950 A KR1020157015950 A KR 1020157015950A KR 20157015950 A KR20157015950 A KR 20157015950A KR 102180250 B1 KR102180250 B1 KR 102180250B1
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contrast agent
agent component
dimeric
membrane
ray contrast
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Korean (ko)
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KR20150094639A (ko
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얀 세르벤카
미켈 타닝
안드레아스 올슨
크리스티안 글뢰가르트
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지이 헬스케어 에이에스
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
KR1020157015950A 2012-12-19 2013-11-19 X-선 조영제 성분의 정제 방법 Active KR102180250B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12198020.5 2012-12-19
EP12198020 2012-12-19
PCT/US2013/070699 WO2014099214A1 (en) 2012-12-19 2013-11-19 Purification of x-ray contrast agents

Publications (2)

Publication Number Publication Date
KR20150094639A KR20150094639A (ko) 2015-08-19
KR102180250B1 true KR102180250B1 (ko) 2020-11-18

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KR1020157015950A Active KR102180250B1 (ko) 2012-12-19 2013-11-19 X-선 조영제 성분의 정제 방법

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US (1) US9938233B2 (https=)
EP (1) EP2935204B1 (https=)
JP (2) JP6342421B2 (https=)
KR (1) KR102180250B1 (https=)
CN (1) CN104854080B (https=)
AU (1) AU2013364113B2 (https=)
CA (1) CA2890449C (https=)
ES (1) ES2690128T3 (https=)
HU (1) HUE039458T2 (https=)
IN (1) IN2015DN03980A (https=)
NZ (1) NZ708503A (https=)
PL (1) PL2935204T3 (https=)
RU (1) RU2662941C2 (https=)
SG (1) SG11201504201RA (https=)
WO (1) WO2014099214A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ708503A (en) 2012-12-19 2019-08-30 Ge Healthcare As Purification of x-ray contrast agents
KR101699539B1 (ko) * 2015-12-30 2017-02-13 (주)솔레이어 나노 여과 모듈 및 이를 이용한 농축 방법
CN113121377A (zh) * 2019-12-31 2021-07-16 江苏汉邦科技有限公司 碘克沙醇的纯化方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100198407B1 (ko) * 1991-02-26 1999-06-15 다이아나 브라코 유기 화합물의 농축 및 정제방법
KR100436529B1 (ko) * 1996-02-23 2004-12-16 브라코 이미징 에스.피.에이. 불투명조영제의정제방법
US20110021823A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Processing crude iodixanol mixture by nanofiltration
WO2012084926A1 (en) * 2010-12-21 2012-06-28 Ge Healthcare As Desalination of a composition comprising a contrast agent

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5447635A (en) * 1991-02-26 1995-09-05 Bracco International B.V. Process of concentration and purification of organic compounds
US5221485A (en) * 1991-12-03 1993-06-22 Mallinckrodt Medical, Inc. Purification of X-ray contrast agent, magnetic resonance imaging agent, or radiopharmaceuticals using reverse osmosis
DE69416015D1 (de) * 1993-02-26 1999-03-04 Createrra Inc Verfahren zur Herstellung von Substanzen zur Reinigung von Wasser
IL110391A (en) * 1993-07-30 1998-12-06 Zambon Spa Process for the crystallization of iopamidol
US5811581A (en) 1994-08-04 1998-09-22 Dibra S.P.A. Process for the purification of opacifying contrast agents
US6425885B1 (en) 1999-12-20 2002-07-30 Ultradent Products, Inc. Hydraulic syringe
NO20043305D0 (no) 2004-08-09 2004-08-09 Amersham Health As Preparation of lodixanol
NO20053676D0 (no) * 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process
NO20055643D0 (no) * 2005-11-29 2005-11-29 Amersham Health As Preparation of lodixanol
EP2178568B1 (en) 2007-07-12 2014-07-02 Ge Healthcare As Contrast agents
EP2240432B1 (en) * 2008-01-14 2012-07-04 Mallinckrodt LLC Process for the preparation of iosimenol
US8766002B2 (en) * 2009-11-26 2014-07-01 Imax Diagnostic Imaging Holding Limited Preparation and purification of iodixanol
NZ708503A (en) 2012-12-19 2019-08-30 Ge Healthcare As Purification of x-ray contrast agents

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100198407B1 (ko) * 1991-02-26 1999-06-15 다이아나 브라코 유기 화합물의 농축 및 정제방법
KR100436529B1 (ko) * 1996-02-23 2004-12-16 브라코 이미징 에스.피.에이. 불투명조영제의정제방법
US20110021823A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Processing crude iodixanol mixture by nanofiltration
WO2012084926A1 (en) * 2010-12-21 2012-06-28 Ge Healthcare As Desalination of a composition comprising a contrast agent

Also Published As

Publication number Publication date
EP2935204A4 (en) 2016-08-17
AU2013364113A1 (en) 2015-05-28
HUE039458T2 (hu) 2019-01-28
JP2018115193A (ja) 2018-07-26
CA2890449A1 (en) 2014-06-26
IN2015DN03980A (https=) 2015-10-02
SG11201504201RA (en) 2015-07-30
RU2662941C2 (ru) 2018-07-31
EP2935204A1 (en) 2015-10-28
ES2690128T3 (es) 2018-11-19
RU2015121502A (ru) 2017-01-26
WO2014099214A1 (en) 2014-06-26
CA2890449C (en) 2020-12-29
PL2935204T3 (pl) 2018-12-31
EP2935204B1 (en) 2018-09-05
CN104854080B (zh) 2018-07-03
US20160304440A1 (en) 2016-10-20
KR20150094639A (ko) 2015-08-19
JP6342421B2 (ja) 2018-06-13
JP2016503054A (ja) 2016-02-01
US9938233B2 (en) 2018-04-10
CN104854080A (zh) 2015-08-19
AU2013364113B2 (en) 2018-01-18
NZ708503A (en) 2019-08-30

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