KR102180174B1 - 화합물 - Google Patents

화합물 Download PDF

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KR102180174B1
KR102180174B1 KR1020157003692A KR20157003692A KR102180174B1 KR 102180174 B1 KR102180174 B1 KR 102180174B1 KR 1020157003692 A KR1020157003692 A KR 1020157003692A KR 20157003692 A KR20157003692 A KR 20157003692A KR 102180174 B1 KR102180174 B1 KR 102180174B1
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South Korea
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group
compound
mmol
amino
product
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KR20150039208A (ko
Inventor
존 에릭 브랜든
콜린 배리 차르녹
아스락 고달
조 클라베니스
닐스 올라브 닐슨
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포토큐어 에이에스에이
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020157003692A 2012-08-03 2013-08-02 화합물 Active KR102180174B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12179277 2012-08-03
EP12179277.4 2012-08-03
EP12197305.1 2012-12-14
EP12197305 2012-12-14
PCT/EP2013/066317 WO2014020164A1 (en) 2012-08-03 2013-08-02 Compounds

Publications (2)

Publication Number Publication Date
KR20150039208A KR20150039208A (ko) 2015-04-09
KR102180174B1 true KR102180174B1 (ko) 2020-11-19

Family

ID=48948407

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020157003692A Active KR102180174B1 (ko) 2012-08-03 2013-08-02 화합물

Country Status (18)

Country Link
US (1) US9249086B2 (enExample)
EP (1) EP2880012B1 (enExample)
JP (1) JP6280117B2 (enExample)
KR (1) KR102180174B1 (enExample)
CN (1) CN104661994B (enExample)
AU (1) AU2013298525B2 (enExample)
BR (1) BR112015002390B1 (enExample)
CA (1) CA2880422C (enExample)
CL (1) CL2015000233A1 (enExample)
ES (1) ES2908080T3 (enExample)
IL (1) IL236965B (enExample)
IN (1) IN2015DN00837A (enExample)
MX (1) MX364940B (enExample)
NZ (1) NZ629914A (enExample)
RU (1) RU2635563C2 (enExample)
SG (1) SG11201500805VA (enExample)
WO (1) WO2014020164A1 (enExample)
ZA (1) ZA201500778B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112016014073A2 (pt) 2013-12-20 2017-08-08 Galderma Res & Dev Tratamento fotodinâmico de pulso de pele fotodanificada
CA2999367C (en) * 2015-09-23 2023-09-26 Xw Laboratories Inc. Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof
GB201522309D0 (en) * 2015-12-17 2016-02-03 Photocure Asa Use
CN119345612A (zh) * 2015-12-17 2025-01-24 光治疗Asa公司 用于膀胱癌的光动力疗法（pdt）的方法
GB201522398D0 (en) 2015-12-18 2016-02-03 Photocure As Device for photodynamic therapy
CN106187793A (zh) 2016-01-26 2016-12-07 赵鸣 5‑氨基酮戊酸及其衍生物的盐化合物和应用
ES2965514T3 (es) * 2017-06-21 2024-04-15 Photocure Asa Procedimiento de preparación de una composición farmacéutica líquida y dispositivo para su uso en dicho procedimiento
CA3128067C (en) 2019-02-13 2025-11-25 Alpheus Medical, Inc. NON-INVASIVE SOUND DYNAMIC THERAPY
WO2020243319A1 (en) 2019-05-29 2020-12-03 Sonalasense, Inc. Sonosensitization
CN116209470A (zh) 2020-08-07 2023-06-02 阿尔菲斯医疗股份有限公司 用于治疗癌症的用于增强的声动力疗法的超声阵列
AU2024231397A1 (en) 2023-03-07 2025-09-25 Photocure Asa Therapy for bladder cancer

Citations (2)

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Publication number Priority date Publication date Assignee Title
KR100444007B1 (ko) * 1995-03-10 2004-12-03 포토큐레 에이에스에이 광화학치료또는진단에사용하기위한5-아미노레불린산의에스테르
WO2009077960A1 (en) * 2007-12-14 2009-06-25 Photoderma Sa Novel compounds useful in therapeutic and cosmetic methods

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JPH07188133A (ja) 1993-12-27 1995-07-25 Asahi Chem Ind Co Ltd δ−アミノレブリン酸またはその同族体の製造法
US6492420B2 (en) 1995-03-10 2002-12-10 Photocure As Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US7530461B2 (en) 1995-03-10 2009-05-12 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US6992107B1 (en) 1995-03-10 2006-01-31 Photocure Asa Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy
JPH1112197A (ja) 1997-06-18 1999-01-19 Cosmo Sogo Kenkyusho:Kk 悪性腫瘍診断剤及び治療剤
GB0018528D0 (en) 2000-07-27 2000-09-13 Photocure Asa Compounds
DE10202487A1 (de) 2002-01-23 2003-07-31 Photonamic Gmbh & Co Kg Dermales Applikationssystem für Aminolävulinsäure-Derivate
DE10312659A1 (de) 2003-03-21 2004-10-07 Universität Regensburg 5-Aminolävulinsäurederivate und ihre Verwendung
GB0406917D0 (en) 2004-03-26 2004-04-28 Photocure Asa Compounds
JP4417865B2 (ja) 2004-03-30 2010-02-17 コスモ石油株式会社 ５−アミノレブリン酸リン酸塩、その製造方法及びその用途
ES2355978T3 (es) * 2004-03-30 2011-04-01 Cosmo Oil Co., Ltd. Sal de fosfato de ácido 5-aminolevulinico, proceso para producir la misma y uso de la misma.
JP4719483B2 (ja) 2004-03-30 2011-07-06 コスモ石油株式会社 ５−アミノレブリン酸スルホン酸塩の製造方法
GB0424833D0 (en) * 2004-11-10 2004-12-15 Photocure Asa Method
JP5404995B2 (ja) 2006-08-10 2014-02-05 コスモ石油株式会社 植物のポリフェノール増量剤
JP5039389B2 (ja) 2007-02-02 2012-10-03 コスモ石油株式会社 ホップのアルファ酸又はホップオイル含量向上剤
JP5156737B2 (ja) 2007-03-30 2013-03-06 コスモ石油株式会社 植物の耐アルカリ性向上剤及び耐アルカリ性向上方法
JP4705616B2 (ja) 2007-07-20 2011-06-22 コスモ石油株式会社 植物における金属成分の吸収向上剤
GB0724279D0 (en) * 2007-12-12 2008-01-23 Photocure Asa Use
CA2721042C (en) 2008-04-22 2017-07-11 Sbi Alapromo Co., Ltd. Method of detecting bladder cancer
JP5276894B2 (ja) 2008-05-13 2013-08-28 コスモ石油株式会社 イネの健苗育成向上剤
CA2715901C (en) 2008-05-13 2016-05-17 Cosmo Oil Co., Ltd. Agent for improving lawn grass qualities comprising 5-aminolevulinic acid or a derivative thereof and a gibberellin biosynthesis inhibitor
JP5323539B2 (ja) 2009-03-11 2013-10-23 コスモ石油株式会社 農作物の収穫部位の収量向上剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100444007B1 (ko) * 1995-03-10 2004-12-03 포토큐레 에이에스에이 광화학치료또는진단에사용하기위한5-아미노레불린산의에스테르
WO2009077960A1 (en) * 2007-12-14 2009-06-25 Photoderma Sa Novel compounds useful in therapeutic and cosmetic methods

Also Published As

Publication number Publication date
JP6280117B2 (ja) 2018-02-14
US20150191419A1 (en) 2015-07-09
MX2015001374A (es) 2015-09-07
CL2015000233A1 (es) 2015-04-24
CA2880422A1 (en) 2014-02-06
EP2880012A1 (en) 2015-06-10
BR112015002390A2 (pt) 2017-07-04
CN104661994B (zh) 2017-08-08
JP2015528814A (ja) 2015-10-01
BR112015002390B1 (pt) 2020-03-24
CN104661994A (zh) 2015-05-27
HK1211283A1 (en) 2016-05-20
ES2908080T3 (es) 2022-04-27
IL236965B (en) 2019-03-31
EP2880012B1 (en) 2021-12-15
CA2880422C (en) 2021-02-09
ZA201500778B (en) 2016-04-28
US9249086B2 (en) 2016-02-02
IN2015DN00837A (enExample) 2015-06-12
NZ629914A (en) 2017-02-24
SG11201500805VA (en) 2015-02-27
MX364940B (es) 2019-05-15
RU2015104830A (ru) 2016-09-27
KR20150039208A (ko) 2015-04-09
WO2014020164A1 (en) 2014-02-06
BR112015002390A8 (pt) 2019-07-30
AU2013298525B2 (en) 2017-12-14
RU2635563C2 (ru) 2017-11-14
AU2013298525A1 (en) 2015-03-05

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