KR102180174B1 - 화합물 - Google Patents

화합물 Download PDF

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Publication number
KR102180174B1
KR102180174B1 KR1020157003692A KR20157003692A KR102180174B1 KR 102180174 B1 KR102180174 B1 KR 102180174B1 KR 1020157003692 A KR1020157003692 A KR 1020157003692A KR 20157003692 A KR20157003692 A KR 20157003692A KR 102180174 B1 KR102180174 B1 KR 102180174B1
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South Korea
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group
compound
mmol
amino
product
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Korean (ko)
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KR20150039208A (ko
Inventor
존 에릭 브랜든
콜린 배리 차르녹
아스락 고달
조 클라베니스
닐스 올라브 닐슨
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포토큐어 에이에스에이
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020157003692A 2012-08-03 2013-08-02 화합물 Active KR102180174B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12179277.4 2012-08-03
EP12179277 2012-08-03
EP12197305 2012-12-14
EP12197305.1 2012-12-14
PCT/EP2013/066317 WO2014020164A1 (en) 2012-08-03 2013-08-02 Compounds

Publications (2)

Publication Number Publication Date
KR20150039208A KR20150039208A (ko) 2015-04-09
KR102180174B1 true KR102180174B1 (ko) 2020-11-19

Family

ID=48948407

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020157003692A Active KR102180174B1 (ko) 2012-08-03 2013-08-02 화합물

Country Status (18)

Country Link
US (1) US9249086B2 (enExample)
EP (1) EP2880012B1 (enExample)
JP (1) JP6280117B2 (enExample)
KR (1) KR102180174B1 (enExample)
CN (1) CN104661994B (enExample)
AU (1) AU2013298525B2 (enExample)
BR (1) BR112015002390B1 (enExample)
CA (1) CA2880422C (enExample)
CL (1) CL2015000233A1 (enExample)
ES (1) ES2908080T3 (enExample)
IL (1) IL236965B (enExample)
IN (1) IN2015DN00837A (enExample)
MX (1) MX364940B (enExample)
NZ (1) NZ629914A (enExample)
RU (1) RU2635563C2 (enExample)
SG (1) SG11201500805VA (enExample)
WO (1) WO2014020164A1 (enExample)
ZA (1) ZA201500778B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105899201A (zh) 2013-12-20 2016-08-24 盖尔德马研究及发展公司 光损伤的皮肤的脉冲光动力治疗
CN108283000B (zh) * 2015-09-23 2021-04-13 凯瑞康宁生物工程（武汉）有限公司 γ-羟基丁酸的前药及其组合物和用途
GB201522309D0 (en) * 2015-12-17 2016-02-03 Photocure Asa Use
EP3389716B1 (en) * 2015-12-17 2022-03-23 Photocure ASA Method of photodynamic therapy (pdt) for bladder cancer
GB201522398D0 (en) 2015-12-18 2016-02-03 Photocure As Device for photodynamic therapy
CN112010772A (zh) 2016-01-26 2020-12-01 赵鸣 5-氨基酮戊酸及其衍生物的盐化合物和应用
DK3641882T3 (da) * 2017-06-21 2023-12-18 Photocure Asa Fremgangsmåde til fremstilling af en flydende farmaceutisk sammensætning og indretning til anvendelse i en sådan fremgangsmåde
CN113677397A (zh) 2019-02-13 2021-11-19 阿尔菲斯医疗股份有限公司 无创声动力学治疗
AU2020282737A1 (en) 2019-05-29 2021-12-16 Sonalasense, Inc. Sonosensitization
CA3185803A1 (en) 2020-08-07 2022-02-10 Vijay Agarwal Ultrasound arrays for enhanced sonodynamic therapy for treating cancer
KR20250154511A (ko) 2023-03-07 2025-10-28 포토큐어 에이에스에이 방광암 치료

Citations (2)

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KR100444007B1 (ko) * 1995-03-10 2004-12-03 포토큐레 에이에스에이 광화학치료또는진단에사용하기위한5-아미노레불린산의에스테르
WO2009077960A1 (en) * 2007-12-14 2009-06-25 Photoderma Sa Novel compounds useful in therapeutic and cosmetic methods

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JPH07188133A (ja) 1993-12-27 1995-07-25 Asahi Chem Ind Co Ltd δ−アミノレブリン酸またはその同族体の製造法
US6992107B1 (en) 1995-03-10 2006-01-31 Photocure Asa Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy
US7530461B2 (en) 1995-03-10 2009-05-12 Photocure Asa Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
US6492420B2 (en) 1995-03-10 2002-12-10 Photocure As Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
JPH1112197A (ja) 1997-06-18 1999-01-19 Cosmo Sogo Kenkyusho:Kk 悪性腫瘍診断剤及び治療剤
GB0018528D0 (en) 2000-07-27 2000-09-13 Photocure Asa Compounds
DE10202487A1 (de) 2002-01-23 2003-07-31 Photonamic Gmbh & Co Kg Dermales Applikationssystem für Aminolävulinsäure-Derivate
DE10312659A1 (de) 2003-03-21 2004-10-07 Universität Regensburg 5-Aminolävulinsäurederivate und ihre Verwendung
GB0406917D0 (en) 2004-03-26 2004-04-28 Photocure Asa Compounds
JP4719483B2 (ja) 2004-03-30 2011-07-06 コスモ石油株式会社 ５−アミノレブリン酸スルホン酸塩の製造方法
JP4417865B2 (ja) 2004-03-30 2010-02-17 コスモ石油株式会社 ５−アミノレブリン酸リン酸塩、その製造方法及びその用途
ES2355978T3 (es) * 2004-03-30 2011-04-01 Cosmo Oil Co., Ltd. Sal de fosfato de ácido 5-aminolevulinico, proceso para producir la misma y uso de la misma.
GB0424833D0 (en) * 2004-11-10 2004-12-15 Photocure Asa Method
JP5404995B2 (ja) 2006-08-10 2014-02-05 コスモ石油株式会社 植物のポリフェノール増量剤
JP5039389B2 (ja) 2007-02-02 2012-10-03 コスモ石油株式会社 ホップのアルファ酸又はホップオイル含量向上剤
WO2008126374A1 (ja) 2007-03-30 2008-10-23 Cosmo Oil Co., Ltd. 植物の耐アルカリ性向上剤及び耐アルカリ性向上方法
JP4705616B2 (ja) 2007-07-20 2011-06-22 コスモ石油株式会社 植物における金属成分の吸収向上剤
GB0724279D0 (en) 2007-12-12 2008-01-23 Photocure Asa Use
DK2272538T3 (da) 2008-04-22 2020-10-26 Sbi Pharmaceuticals Co Ltd Fremgangsmåde til påvisning af blærecancer
AU2009247547B2 (en) 2008-05-13 2013-10-10 Cosmo Trade & Service Co., Ltd. Agent for improving lawn grass qualities
JP5276894B2 (ja) 2008-05-13 2013-08-28 コスモ石油株式会社 イネの健苗育成向上剤
JP5323539B2 (ja) 2009-03-11 2013-10-23 コスモ石油株式会社 農作物の収穫部位の収量向上剤

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100444007B1 (ko) * 1995-03-10 2004-12-03 포토큐레 에이에스에이 광화학치료또는진단에사용하기위한5-아미노레불린산의에스테르
WO2009077960A1 (en) * 2007-12-14 2009-06-25 Photoderma Sa Novel compounds useful in therapeutic and cosmetic methods

Also Published As

Publication number Publication date
RU2015104830A (ru) 2016-09-27
AU2013298525B2 (en) 2017-12-14
WO2014020164A1 (en) 2014-02-06
HK1211283A1 (en) 2016-05-20
BR112015002390A8 (pt) 2019-07-30
MX2015001374A (es) 2015-09-07
BR112015002390A2 (pt) 2017-07-04
NZ629914A (en) 2017-02-24
EP2880012B1 (en) 2021-12-15
CN104661994B (zh) 2017-08-08
US20150191419A1 (en) 2015-07-09
SG11201500805VA (en) 2015-02-27
CN104661994A (zh) 2015-05-27
CL2015000233A1 (es) 2015-04-24
JP6280117B2 (ja) 2018-02-14
US9249086B2 (en) 2016-02-02
IN2015DN00837A (enExample) 2015-06-12
JP2015528814A (ja) 2015-10-01
RU2635563C2 (ru) 2017-11-14
IL236965B (en) 2019-03-31
BR112015002390B1 (pt) 2020-03-24
CA2880422A1 (en) 2014-02-06
MX364940B (es) 2019-05-15
EP2880012A1 (en) 2015-06-10
CA2880422C (en) 2021-02-09
KR20150039208A (ko) 2015-04-09
AU2013298525A1 (en) 2015-03-05
ZA201500778B (en) 2016-04-28
ES2908080T3 (es) 2022-04-27

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