CN104661994B - 化合物 - Google Patents
化合物 Download PDFInfo
- Publication number
- CN104661994B CN104661994B CN201380048873.3A CN201380048873A CN104661994B CN 104661994 B CN104661994 B CN 104661994B CN 201380048873 A CN201380048873 A CN 201380048873A CN 104661994 B CN104661994 B CN 104661994B
- Authority
- CN
- China
- Prior art keywords
- compound
- amino
- mmol
- pharmaceutically acceptable
- product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 CN(*)CC(CCCC(O*C(*)=O)=O)=O Chemical compound CN(*)CC(CCCC(O*C(*)=O)=O)=O 0.000 description 3
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Biotechnology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12179277.4 | 2012-08-03 | ||
| EP12179277 | 2012-08-03 | ||
| EP12197305 | 2012-12-14 | ||
| EP12197305.1 | 2012-12-14 | ||
| PCT/EP2013/066317 WO2014020164A1 (en) | 2012-08-03 | 2013-08-02 | Compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104661994A CN104661994A (zh) | 2015-05-27 |
| CN104661994B true CN104661994B (zh) | 2017-08-08 |
Family
ID=48948407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380048873.3A Active CN104661994B (zh) | 2012-08-03 | 2013-08-02 | 化合物 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9249086B2 (enExample) |
| EP (1) | EP2880012B1 (enExample) |
| JP (1) | JP6280117B2 (enExample) |
| KR (1) | KR102180174B1 (enExample) |
| CN (1) | CN104661994B (enExample) |
| AU (1) | AU2013298525B2 (enExample) |
| BR (1) | BR112015002390B1 (enExample) |
| CA (1) | CA2880422C (enExample) |
| CL (1) | CL2015000233A1 (enExample) |
| ES (1) | ES2908080T3 (enExample) |
| IL (1) | IL236965B (enExample) |
| IN (1) | IN2015DN00837A (enExample) |
| MX (1) | MX364940B (enExample) |
| NZ (1) | NZ629914A (enExample) |
| RU (1) | RU2635563C2 (enExample) |
| SG (1) | SG11201500805VA (enExample) |
| WO (1) | WO2014020164A1 (enExample) |
| ZA (1) | ZA201500778B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11235168B2 (en) | 2015-12-17 | 2022-02-01 | Photocure Asa | Method of photodynamic therapy (PDT) for bladder cancer |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112016014073A2 (pt) | 2013-12-20 | 2017-08-08 | Galderma Res & Dev | Tratamento fotodinâmico de pulso de pele fotodanificada |
| EP4119539A1 (en) * | 2015-09-23 | 2023-01-18 | XWPharma Ltd. | Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof |
| GB201522309D0 (en) * | 2015-12-17 | 2016-02-03 | Photocure Asa | Use |
| GB201522398D0 (en) | 2015-12-18 | 2016-02-03 | Photocure As | Device for photodynamic therapy |
| CN112010772A (zh) | 2016-01-26 | 2020-12-01 | 赵鸣 | 5-氨基酮戊酸及其衍生物的盐化合物和应用 |
| FI3641882T3 (fi) * | 2017-06-21 | 2023-12-14 | Photocure Asa | Menetelmä nestemäisen farmaseuttisen koostumuksen valmistamiseksi ja laite käytettäväksi sellaisessa menetelmässä |
| IL285384B2 (en) | 2019-02-13 | 2024-11-01 | Alpheus Medical Inc | Non-invasive sonodynamic therapy |
| WO2020243319A1 (en) | 2019-05-29 | 2020-12-03 | Sonalasense, Inc. | Sonosensitization |
| WO2022032283A2 (en) | 2020-08-07 | 2022-02-10 | Alpheus Medical, Inc. | Ultrasound arrays for enhanced sonodynamic therapy for treating cancer |
| EP4676462A1 (en) | 2023-03-07 | 2026-01-14 | Photocure ASA | Therapy for bladder cancer |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1942430A (zh) * | 2004-03-30 | 2007-04-04 | 克斯莫石油株式会社 | 5－氨基乙酰丙酸盐、其制备方法及其用途 |
| WO2009077960A1 (en) * | 2007-12-14 | 2009-06-25 | Photoderma Sa | Novel compounds useful in therapeutic and cosmetic methods |
| CN101896203A (zh) * | 2007-12-12 | 2010-11-24 | 光治疗Asa公司 | 固体形式的5-氨基酮戊酸和衍生物在光动力治疗和诊断中的应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07188133A (ja) | 1993-12-27 | 1995-07-25 | Asahi Chem Ind Co Ltd | δ−アミノレブリン酸またはその同族体の製造法 |
| WO1996028412A1 (en) * | 1995-03-10 | 1996-09-19 | Photocure As | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
| US6992107B1 (en) | 1995-03-10 | 2006-01-31 | Photocure Asa | Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy |
| US7530461B2 (en) | 1995-03-10 | 2009-05-12 | Photocure Asa | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
| US6492420B2 (en) | 1995-03-10 | 2002-12-10 | Photocure As | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
| JPH1112197A (ja) | 1997-06-18 | 1999-01-19 | Cosmo Sogo Kenkyusho:Kk | 悪性腫瘍診断剤及び治療剤 |
| GB0018528D0 (en) | 2000-07-27 | 2000-09-13 | Photocure Asa | Compounds |
| DE10202487A1 (de) | 2002-01-23 | 2003-07-31 | Photonamic Gmbh & Co Kg | Dermales Applikationssystem für Aminolävulinsäure-Derivate |
| DE10312659A1 (de) | 2003-03-21 | 2004-10-07 | Universität Regensburg | 5-Aminolävulinsäurederivate und ihre Verwendung |
| GB0406917D0 (en) | 2004-03-26 | 2004-04-28 | Photocure Asa | Compounds |
| JP4417865B2 (ja) | 2004-03-30 | 2010-02-17 | コスモ石油株式会社 | ５−アミノレブリン酸リン酸塩、その製造方法及びその用途 |
| JP4719483B2 (ja) | 2004-03-30 | 2011-07-06 | コスモ石油株式会社 | ５−アミノレブリン酸スルホン酸塩の製造方法 |
| GB0424833D0 (en) * | 2004-11-10 | 2004-12-15 | Photocure Asa | Method |
| JP5404995B2 (ja) | 2006-08-10 | 2014-02-05 | コスモ石油株式会社 | 植物のポリフェノール増量剤 |
| JP5039389B2 (ja) | 2007-02-02 | 2012-10-03 | コスモ石油株式会社 | ホップのアルファ酸又はホップオイル含量向上剤 |
| PT2130435E (pt) | 2007-03-30 | 2015-11-30 | Cosmo Ala Co Ltd | Agente para melhorar a resistência de plantas a bases e método para melhorar a resistência de plantas a bases |
| JP4705616B2 (ja) | 2007-07-20 | 2011-06-22 | コスモ石油株式会社 | 植物における金属成分の吸収向上剤 |
| ES2822122T3 (es) | 2008-04-22 | 2021-04-29 | Sbi Pharmaceuticals Co Ltd | Método de detección del cáncer de vejiga |
| WO2009139106A1 (ja) | 2008-05-13 | 2009-11-19 | コスモ石油株式会社 | 芝草の品質向上剤 |
| JP5276894B2 (ja) | 2008-05-13 | 2013-08-28 | コスモ石油株式会社 | イネの健苗育成向上剤 |
| JP5323539B2 (ja) | 2009-03-11 | 2013-10-23 | コスモ石油株式会社 | 農作物の収穫部位の収量向上剤 |
-
2013
- 2013-08-02 EP EP13745829.5A patent/EP2880012B1/en active Active
- 2013-08-02 BR BR112015002390-8A patent/BR112015002390B1/pt active IP Right Grant
- 2013-08-02 CA CA2880422A patent/CA2880422C/en active Active
- 2013-08-02 US US14/419,125 patent/US9249086B2/en active Active
- 2013-08-02 NZ NZ629914A patent/NZ629914A/en unknown
- 2013-08-02 JP JP2015524805A patent/JP6280117B2/ja active Active
- 2013-08-02 IN IN837DEN2015 patent/IN2015DN00837A/en unknown
- 2013-08-02 AU AU2013298525A patent/AU2013298525B2/en active Active
- 2013-08-02 MX MX2015001374A patent/MX364940B/es active IP Right Grant
- 2013-08-02 KR KR1020157003692A patent/KR102180174B1/ko active Active
- 2013-08-02 WO PCT/EP2013/066317 patent/WO2014020164A1/en not_active Ceased
- 2013-08-02 SG SG11201500805VA patent/SG11201500805VA/en unknown
- 2013-08-02 CN CN201380048873.3A patent/CN104661994B/zh active Active
- 2013-08-02 RU RU2015104830A patent/RU2635563C2/ru active
- 2013-08-02 ES ES13745829T patent/ES2908080T3/es active Active
-
2015
- 2015-01-28 IL IL236965A patent/IL236965B/en active IP Right Grant
- 2015-01-30 CL CL2015000233A patent/CL2015000233A1/es unknown
- 2015-02-03 ZA ZA2015/00778A patent/ZA201500778B/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1942430A (zh) * | 2004-03-30 | 2007-04-04 | 克斯莫石油株式会社 | 5－氨基乙酰丙酸盐、其制备方法及其用途 |
| CN101896203A (zh) * | 2007-12-12 | 2010-11-24 | 光治疗Asa公司 | 固体形式的5-氨基酮戊酸和衍生物在光动力治疗和诊断中的应用 |
| WO2009077960A1 (en) * | 2007-12-14 | 2009-06-25 | Photoderma Sa | Novel compounds useful in therapeutic and cosmetic methods |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11235168B2 (en) | 2015-12-17 | 2022-02-01 | Photocure Asa | Method of photodynamic therapy (PDT) for bladder cancer |
| US11980772B2 (en) | 2015-12-17 | 2024-05-14 | Photocure Asa | Method of photodynamic therapy (PDT) for bladder cancer |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2908080T3 (es) | 2022-04-27 |
| CN104661994A (zh) | 2015-05-27 |
| IN2015DN00837A (enExample) | 2015-06-12 |
| CA2880422C (en) | 2021-02-09 |
| RU2635563C2 (ru) | 2017-11-14 |
| AU2013298525A1 (en) | 2015-03-05 |
| ZA201500778B (en) | 2016-04-28 |
| US9249086B2 (en) | 2016-02-02 |
| MX2015001374A (es) | 2015-09-07 |
| BR112015002390B1 (pt) | 2020-03-24 |
| MX364940B (es) | 2019-05-15 |
| US20150191419A1 (en) | 2015-07-09 |
| HK1211283A1 (en) | 2016-05-20 |
| WO2014020164A1 (en) | 2014-02-06 |
| BR112015002390A8 (pt) | 2019-07-30 |
| CA2880422A1 (en) | 2014-02-06 |
| JP6280117B2 (ja) | 2018-02-14 |
| AU2013298525B2 (en) | 2017-12-14 |
| EP2880012A1 (en) | 2015-06-10 |
| SG11201500805VA (en) | 2015-02-27 |
| BR112015002390A2 (pt) | 2017-07-04 |
| IL236965B (en) | 2019-03-31 |
| RU2015104830A (ru) | 2016-09-27 |
| KR102180174B1 (ko) | 2020-11-19 |
| EP2880012B1 (en) | 2021-12-15 |
| KR20150039208A (ko) | 2015-04-09 |
| JP2015528814A (ja) | 2015-10-01 |
| CL2015000233A1 (es) | 2015-04-24 |
| NZ629914A (en) | 2017-02-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |