ES2908080T3 - Compuestos - Google Patents
Compuestos Download PDFInfo
- Publication number
- ES2908080T3 ES2908080T3 ES13745829T ES13745829T ES2908080T3 ES 2908080 T3 ES2908080 T3 ES 2908080T3 ES 13745829 T ES13745829 T ES 13745829T ES 13745829 T ES13745829 T ES 13745829T ES 2908080 T3 ES2908080 T3 ES 2908080T3
- Authority
- ES
- Spain
- Prior art keywords
- compound
- group
- amino
- optionally substituted
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 186
- 125000002947 alkylene group Chemical group 0.000 claims abstract description 38
- 150000003839 salts Chemical class 0.000 claims abstract description 34
- 125000001424 substituent group Chemical group 0.000 claims abstract description 29
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 19
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 18
- 125000000732 arylene group Chemical group 0.000 claims abstract description 15
- 125000005843 halogen group Chemical group 0.000 claims abstract description 15
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 13
- 125000002993 cycloalkylene group Chemical group 0.000 claims abstract description 12
- 125000000547 substituted alkyl group Chemical group 0.000 claims abstract description 10
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 7
- 125000001188 haloalkyl group Chemical group 0.000 claims abstract description 7
- 125000001475 halogen functional group Chemical group 0.000 claims abstract description 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 3
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- 238000000034 method Methods 0.000 claims description 75
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- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 5
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 12
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Classifications
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- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
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- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
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- Rheumatology (AREA)
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- Biotechnology (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
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| EP12179277 | 2012-08-03 | ||
| EP12197305 | 2012-12-14 | ||
| PCT/EP2013/066317 WO2014020164A1 (en) | 2012-08-03 | 2013-08-02 | Compounds |
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| ES2908080T3 true ES2908080T3 (es) | 2022-04-27 |
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| CA (1) | CA2880422C (enExample) |
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| ES (1) | ES2908080T3 (enExample) |
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| IN (1) | IN2015DN00837A (enExample) |
| MX (1) | MX364940B (enExample) |
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| SG (1) | SG11201500805VA (enExample) |
| WO (1) | WO2014020164A1 (enExample) |
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| BR112016014073A2 (pt) | 2013-12-20 | 2017-08-08 | Galderma Res & Dev | Tratamento fotodinâmico de pulso de pele fotodanificada |
| CA3207643A1 (en) * | 2015-09-23 | 2017-03-30 | XWPharma Ltd. | Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof |
| GB201522309D0 (en) * | 2015-12-17 | 2016-02-03 | Photocure Asa | Use |
| AU2016372575B2 (en) | 2015-12-17 | 2022-12-08 | Photocure Asa | Method of photodynamic therapy (PDT) for bladder cancer |
| GB201522398D0 (en) | 2015-12-18 | 2016-02-03 | Photocure As | Device for photodynamic therapy |
| CN112010772A (zh) * | 2016-01-26 | 2020-12-01 | 赵鸣 | 5-氨基酮戊酸及其衍生物的盐化合物和应用 |
| US12194098B2 (en) * | 2017-06-21 | 2025-01-14 | Photocure Asa | Method for preparing a liquid pharmaceutical composition and device for use in such method |
| JP7474773B2 (ja) | 2019-02-13 | 2024-04-25 | アルフェウス メディカル，インク． | 非侵襲的音響化学療法 |
| US20220226471A1 (en) | 2019-05-29 | 2022-07-21 | Sonalasense,Inc. | Sonosensitization |
| CA3185803A1 (en) | 2020-08-07 | 2022-02-10 | Vijay Agarwal | Ultrasound arrays for enhanced sonodynamic therapy for treating cancer |
| AU2024231397A1 (en) | 2023-03-07 | 2025-09-25 | Photocure Asa | Therapy for bladder cancer |
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| JPH07188133A (ja) | 1993-12-27 | 1995-07-25 | Asahi Chem Ind Co Ltd | δ−アミノレブリン酸またはその同族体の製造法 |
| US7530461B2 (en) | 1995-03-10 | 2009-05-12 | Photocure Asa | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
| CZ291132B6 (cs) * | 1995-03-10 | 2002-12-11 | Photocure Asa | Estery kyselin 5-aminolevulových a farmaceutický prostředek s jejich obsahem |
| US6992107B1 (en) | 1995-03-10 | 2006-01-31 | Photocure Asa | Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy |
| US6492420B2 (en) | 1995-03-10 | 2002-12-10 | Photocure As | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
| JPH1112197A (ja) | 1997-06-18 | 1999-01-19 | Cosmo Sogo Kenkyusho:Kk | 悪性腫瘍診断剤及び治療剤 |
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| DE10202487A1 (de) | 2002-01-23 | 2003-07-31 | Photonamic Gmbh & Co Kg | Dermales Applikationssystem für Aminolävulinsäure-Derivate |
| DE10312659A1 (de) | 2003-03-21 | 2004-10-07 | Universität Regensburg | 5-Aminolävulinsäurederivate und ihre Verwendung |
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| ES2355978T3 (es) * | 2004-03-30 | 2011-04-01 | Cosmo Oil Co., Ltd. | Sal de fosfato de ácido 5-aminolevulinico, proceso para producir la misma y uso de la misma. |
| JP4719483B2 (ja) | 2004-03-30 | 2011-07-06 | コスモ石油株式会社 | ５−アミノレブリン酸スルホン酸塩の製造方法 |
| JP4417865B2 (ja) | 2004-03-30 | 2010-02-17 | コスモ石油株式会社 | ５−アミノレブリン酸リン酸塩、その製造方法及びその用途 |
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| JP5404995B2 (ja) | 2006-08-10 | 2014-02-05 | コスモ石油株式会社 | 植物のポリフェノール増量剤 |
| JP5039389B2 (ja) | 2007-02-02 | 2012-10-03 | コスモ石油株式会社 | ホップのアルファ酸又はホップオイル含量向上剤 |
| AU2008238787B2 (en) | 2007-03-30 | 2013-05-02 | Cosmo Trade & Service Co., Ltd. | Agent for improving alkali resistance of plant and method for improving alkali resistance of plant |
| JP4705616B2 (ja) | 2007-07-20 | 2011-06-22 | コスモ石油株式会社 | 植物における金属成分の吸収向上剤 |
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| JP2011506425A (ja) * | 2007-12-14 | 2011-03-03 | フォトデルマ エスアー | 治療的及び美容的方法に有用な新規化合物 |
| ES2822122T3 (es) | 2008-04-22 | 2021-04-29 | Sbi Pharmaceuticals Co Ltd | Método de detección del cáncer de vejiga |
| JP5276894B2 (ja) | 2008-05-13 | 2013-08-28 | コスモ石油株式会社 | イネの健苗育成向上剤 |
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| JP5323539B2 (ja) | 2009-03-11 | 2013-10-23 | コスモ石油株式会社 | 農作物の収穫部位の収量向上剤 |
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| AU2013298525B2 (en) | 2017-12-14 |
| IN2015DN00837A (enExample) | 2015-06-12 |
| ZA201500778B (en) | 2016-04-28 |
| BR112015002390B1 (pt) | 2020-03-24 |
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| CA2880422A1 (en) | 2014-02-06 |
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| RU2635563C2 (ru) | 2017-11-14 |
| CN104661994A (zh) | 2015-05-27 |
| JP2015528814A (ja) | 2015-10-01 |
| HK1211283A1 (en) | 2016-05-20 |
| CA2880422C (en) | 2021-02-09 |
| AU2013298525A1 (en) | 2015-03-05 |
| EP2880012A1 (en) | 2015-06-10 |
| CL2015000233A1 (es) | 2015-04-24 |
| MX2015001374A (es) | 2015-09-07 |
| KR102180174B1 (ko) | 2020-11-19 |
| KR20150039208A (ko) | 2015-04-09 |
| RU2015104830A (ru) | 2016-09-27 |
| EP2880012B1 (en) | 2021-12-15 |
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