KR102125695B1 - 단백질 정제 방법 - Google Patents
단백질 정제 방법 Download PDFInfo
- Publication number
- KR102125695B1 KR102125695B1 KR1020157011544A KR20157011544A KR102125695B1 KR 102125695 B1 KR102125695 B1 KR 102125695B1 KR 1020157011544 A KR1020157011544 A KR 1020157011544A KR 20157011544 A KR20157011544 A KR 20157011544A KR 102125695 B1 KR102125695 B1 KR 102125695B1
- Authority
- KR
- South Korea
- Prior art keywords
- haptoglobin
- hemopexin
- solution
- transferrin
- resin
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1722—Plasma globulins, lactoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4717—Plasma globulins, lactoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Marine Sciences & Fisheries (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261709342P | 2012-10-03 | 2012-10-03 | |
US61/709,342 | 2012-10-03 | ||
US13/803,525 | 2013-03-14 | ||
US13/803,525 US9534029B2 (en) | 2012-10-03 | 2013-03-14 | Method of purifying proteins |
AU2013203930A AU2013203930B2 (en) | 2012-10-03 | 2013-04-11 | A method of purifying proteins |
AU2013203930 | 2013-04-11 | ||
EP13170202.9 | 2013-06-03 | ||
EP13170202 | 2013-06-03 | ||
PCT/US2013/062916 WO2014055552A1 (en) | 2012-10-03 | 2013-10-01 | A method of purifying proteins |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020207017157A Division KR102231613B1 (ko) | 2012-10-03 | 2013-10-01 | 단백질 정제 방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20150063547A KR20150063547A (ko) | 2015-06-09 |
KR102125695B1 true KR102125695B1 (ko) | 2020-06-24 |
Family
ID=52824845
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020157011544A KR102125695B1 (ko) | 2012-10-03 | 2013-10-01 | 단백질 정제 방법 |
KR1020207017157A KR102231613B1 (ko) | 2012-10-03 | 2013-10-01 | 단백질 정제 방법 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020207017157A KR102231613B1 (ko) | 2012-10-03 | 2013-10-01 | 단백질 정제 방법 |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP2904005A1 (ja) |
JP (2) | JP6370792B2 (ja) |
KR (2) | KR102125695B1 (ja) |
CN (2) | CN112717125A (ja) |
CA (2) | CA3129057C (ja) |
HK (1) | HK1212995A1 (ja) |
SG (1) | SG11201501921SA (ja) |
WO (1) | WO2014055552A1 (ja) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2887588T3 (es) * | 2015-08-13 | 2021-12-23 | Kamada Ltd | Composiciones derivadas de pasta de fracción de Cohn y uso de las mismas |
KR20180129791A (ko) * | 2016-03-29 | 2018-12-05 | 교와 핫꼬 기린 가부시키가이샤 | 혈 중에서 합토글로빈에 결합하여 다가의 면역 복합체를 형성하는 항체를 유효 성분으로 하는 자기 면역 질환 치료제 |
KR20200038507A (ko) * | 2017-08-08 | 2020-04-13 | 체에스엘 베링 아게 | 헤모펙신 제형 |
US20200393472A1 (en) * | 2018-04-18 | 2020-12-17 | Sekisui Medical Co., Ltd. | Haemoglobin analysis method |
CA3138650A1 (en) | 2019-05-17 | 2020-11-26 | Universitaet Zuerich | Haptoglobin for use in treating an adverse secondary neurological outcome following a haemorrhagic stroke |
WO2022162218A1 (en) | 2021-02-01 | 2022-08-04 | Csl Behring Ag | Method of treating or preventing an adverse secondary neurological outcome following a haemorrhagic stroke |
US20240034749A1 (en) * | 2021-02-04 | 2024-02-01 | Green Cross Corporation | Method for purification of hemopexin and haptoglobin |
WO2024134608A1 (en) | 2022-12-22 | 2024-06-27 | Csl Behring Ag | Method of purifying hemopexin using mixed-mode chromatography |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS5337406B2 (ja) * | 1973-11-15 | 1978-10-09 | ||
GB1426039A (en) * | 1973-11-15 | 1976-02-25 | Green Cross Corp | Haptoglobin in aqueous solution and process for tits preparation |
US4129648A (en) * | 1977-11-21 | 1978-12-12 | Collier Harry O J | Method for reducing endogenous prostaglandin synthesis |
US4764369A (en) | 1983-07-14 | 1988-08-16 | New York Blood Center Inc. | Undenatured virus-free biologically active protein derivatives |
US4540573A (en) * | 1983-07-14 | 1985-09-10 | New York Blood Center, Inc. | Undenatured virus-free biologically active protein derivatives |
JPS6317899A (ja) * | 1986-07-09 | 1988-01-25 | Green Cross Corp:The | ハプトグロビンの精製方法 |
JPH01305036A (ja) * | 1988-05-31 | 1989-12-08 | Green Cross Corp:The | 血漿蛋白成分の加熱処理方法および血漿蛋白成分製剤 |
US5169936A (en) * | 1989-04-14 | 1992-12-08 | Biogen, Inc. | Protein purification on immobilized metal affinity resins effected by elution using a weak ligand |
US5138034A (en) * | 1989-07-12 | 1992-08-11 | The Green Cross Corporation | Method of fractionating plasma proteins |
FR2672604B1 (fr) * | 1991-02-07 | 1995-05-05 | Pasteur Merieux Serums Vacc | Procede pour isoler de l'albumine humaine a partir du surnageant iv, notamment iv-4, ou de la fraction v de cohn ou d'un surnageant ou fraction analogue. |
SE9301582D0 (sv) * | 1993-05-07 | 1993-05-07 | Kabi Pharmacia Ab | Purification of plasma proteins |
DE19830914C1 (de) * | 1998-07-10 | 1999-06-24 | Centeon Pharma Gmbh | Verfahren zur Herstellung einer Proteinlösung |
US6093804A (en) * | 1998-09-24 | 2000-07-25 | American National Red Cross | Method for purification of alpha-1 proteinase inhibitor |
US6815181B2 (en) * | 2001-07-09 | 2004-11-09 | Applera Corporation | Nucleic acid molecules encoding human secreted hemopexin-related proteins |
DE10211632A1 (de) * | 2002-03-15 | 2003-10-09 | Aventis Behring Gmbh | Verfahren zur Abtrennung von Viren aus einer Proteinlösung durch Nanofiltration |
DE10215315A1 (de) * | 2002-04-05 | 2003-11-20 | Aventis Behring Gmbh Intellect | Human-Transferrin zur Behandlung der Anaemia of Chronic Disease (ACD) und des funktionellen Eisenmangels |
AU2002307776A1 (en) * | 2002-04-16 | 2003-10-27 | Kamada Ltd. | Ultrapure transferrin for pharmaceutical compositions |
DE10261126A1 (de) | 2002-08-13 | 2004-03-04 | Aventis Behring Gmbh | Lagerungsstabile, flüssige Fibrinogen-Formulierung |
JP2004224793A (ja) * | 2003-01-17 | 2004-08-12 | Research Corp Technologies Inc | 子宮内膜症の治療方法 |
JP2004256463A (ja) * | 2003-02-26 | 2004-09-16 | Univ Waseda | 多形核白血球の細胞接着抑制剤及び細胞接着抑制方法 |
GB0423196D0 (en) * | 2004-10-19 | 2004-11-24 | Nat Blood Authority | Method |
US7291338B2 (en) * | 2005-03-09 | 2007-11-06 | Idexx Laboratories, Inc. | Method and device for detecting feline immunodeficiency virus |
JP2009537812A (ja) * | 2006-05-15 | 2009-10-29 | デジラブ インコーポレーテッド | 2型糖尿病プリフォームのバイオマーカー、及び2型糖尿病プリフォームの存在又は不在を検出する方法 |
CA2694854C (en) * | 2007-08-17 | 2016-09-27 | Csl Behring Gmbh | Methods for purification of alpha-1-antitrypsin and apolipoprotein a-i |
EP2027875A1 (en) * | 2007-08-23 | 2009-02-25 | Octapharma AG | A Process for Isolation and Purification of a Target Protein free of Prion Protein (PrPSC) |
KR101426039B1 (ko) * | 2008-09-11 | 2014-08-01 | 삼성테크윈 주식회사 | 얼굴/물체 인식을 위한 특징점 검출 장치 및 방법 |
FR2942233B1 (fr) * | 2009-02-19 | 2015-03-13 | Lfb Biotechnologies | Moyens pour la purification d'une proteine du plasma sanguin, et procedes pour sa mise en oeuvre |
EP2236617A1 (en) * | 2009-03-31 | 2010-10-06 | Leukocare Ag | Methods of terminal sterilization of biofunctional compositions |
WO2011002070A1 (ja) * | 2009-07-02 | 2011-01-06 | 協和発酵キリン株式会社 | Gdf7/bmp12蛋白質を含有する鉄過剰疾患または鉄濃度を低下させることが有効な疾患に対する治療用医薬組成物 |
EP2453892B1 (en) * | 2009-07-16 | 2013-05-29 | Institut National de la Santé et de la Recherche Medicale | Pharmaceutical compositions and their use for treating cancer |
ES2360782B1 (es) * | 2009-07-28 | 2012-03-12 | Grifols, S.A. | Medios para cultivo de células de mamíferos que comprenden sobrenadante de etapas del fraccionamiento de Cohn y uso de los mismos. |
MX346473B (es) * | 2009-08-11 | 2017-03-22 | Biocon Ltd | Procesos cromatograficos y compuestos purificados de los mismos. |
WO2011131720A1 (en) * | 2010-04-20 | 2011-10-27 | Octapharma Ag | New stabilizing agent for pharmaceutical proteins |
WO2012050874A2 (en) * | 2010-09-28 | 2012-04-19 | Soares Miguel P | Targeting heme for the treatment of immune mediated inflammatory diseases |
-
2013
- 2013-10-01 JP JP2015535745A patent/JP6370792B2/ja active Active
- 2013-10-01 CN CN202110206879.5A patent/CN112717125A/zh active Pending
- 2013-10-01 CA CA3129057A patent/CA3129057C/en active Active
- 2013-10-01 EP EP13777203.4A patent/EP2904005A1/en not_active Withdrawn
- 2013-10-01 KR KR1020157011544A patent/KR102125695B1/ko active IP Right Grant
- 2013-10-01 CN CN201380051960.4A patent/CN104968676A/zh active Pending
- 2013-10-01 SG SG11201501921SA patent/SG11201501921SA/en unknown
- 2013-10-01 KR KR1020207017157A patent/KR102231613B1/ko active IP Right Grant
- 2013-10-01 WO PCT/US2013/062916 patent/WO2014055552A1/en active Application Filing
- 2013-10-01 CA CA2886726A patent/CA2886726C/en active Active
-
2016
- 2016-01-26 HK HK16100830.6A patent/HK1212995A1/zh unknown
-
2018
- 2018-07-10 JP JP2018130335A patent/JP6876655B2/ja active Active
Non-Patent Citations (3)
Title |
---|
BIOCHIMIE.,57:551-557(1975.) |
Journal of Chromatography.,326:373-385(1985.6.19.)* |
영국 공개특허공보 1426039(1976.2.25.)* |
Also Published As
Publication number | Publication date |
---|---|
CA3129057A1 (en) | 2014-04-10 |
CA2886726C (en) | 2021-11-23 |
HK1212995A1 (zh) | 2016-06-24 |
SG11201501921SA (en) | 2015-04-29 |
JP2018172426A (ja) | 2018-11-08 |
WO2014055552A1 (en) | 2014-04-10 |
JP6876655B2 (ja) | 2021-05-26 |
JP6370792B2 (ja) | 2018-08-08 |
CA3129057C (en) | 2023-03-07 |
CN112717125A (zh) | 2021-04-30 |
CA2886726A1 (en) | 2014-04-10 |
CN104968676A (zh) | 2015-10-07 |
EP2904005A1 (en) | 2015-08-12 |
JP2015532301A (ja) | 2015-11-09 |
KR102231613B1 (ko) | 2021-03-25 |
KR20150063547A (ko) | 2015-06-09 |
KR20200075027A (ko) | 2020-06-25 |
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GRNT | Written decision to grant |