KR102113363B1 - Cdk4/6 억제제 및 b-raf 억제제의 제약 조합물 - Google Patents

Cdk4/6 억제제 및 b-raf 억제제의 제약 조합물 Download PDF

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KR102113363B1
KR102113363B1 KR1020157001594A KR20157001594A KR102113363B1 KR 102113363 B1 KR102113363 B1 KR 102113363B1 KR 1020157001594 A KR1020157001594 A KR 1020157001594A KR 20157001594 A KR20157001594 A KR 20157001594A KR 102113363 B1 KR102113363 B1 KR 102113363B1
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combination
compound
inhibitor
raf
cancer
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KR20150036146A (ko
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지오다노 카포니그로
다린 스튜어트
선규 김
앨리스 루
스콧 델라치
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노파르티스 아게
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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KR1020157001594A 2012-07-26 2013-07-25 Cdk4/6 억제제 및 b-raf 억제제의 제약 조합물 Active KR102113363B1 (ko)

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Application Number Priority Date Filing Date Title
US201261676134P 2012-07-26 2012-07-26
US61/676,134 2012-07-26
US201361830911P 2013-06-04 2013-06-04
US61/830,911 2013-06-04
PCT/US2013/051990 WO2014018725A1 (en) 2012-07-26 2013-07-25 Pharmaceutical combinations of a cdk4/6 inhibitor and a b-raf inhibitor

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KR20150036146A KR20150036146A (ko) 2015-04-07
KR102113363B1 true KR102113363B1 (ko) 2020-05-21

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US (1) US9700557B2 (https=)
EP (1) EP2877174B1 (https=)
JP (1) JP6320379B2 (https=)
KR (1) KR102113363B1 (https=)
CN (1) CN104507474B (https=)
AR (1) AR091876A1 (https=)
AU (1) AU2013295771B2 (https=)
CA (1) CA2874860C (https=)
ES (1) ES2778059T3 (https=)
IN (1) IN2015DN00376A (https=)
JO (1) JO3776B1 (https=)
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RU (1) RU2685250C2 (https=)
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WO (1) WO2014018725A1 (https=)

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EP3279201B1 (en) * 2015-04-01 2019-10-23 Crystal Pharmatech Co., Ltd. Cdk inhibitor, eutectic crystal of mek inhibitor, and preparation method therefor
CN105753869B (zh) * 2015-04-01 2018-09-25 苏州晶云药物科技有限公司 一种cdk抑制剂和mek抑制剂的共晶及其制备方法
US20190365741A1 (en) * 2015-08-28 2019-12-05 Novartis Ag Combinations of the cdk4/6 inhibitor lee011 and the mek1/2 inhibitor trametinib, optionally further comprising the pi3k inhibitor byl719 to treat cancer
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BR112019003722A2 (pt) * 2016-08-23 2019-05-28 Eisai R&D Man Co Ltd terapias de combinação para o tratamento de carcinoma hepatocelular
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US11395821B2 (en) 2017-01-30 2022-07-26 G1 Therapeutics, Inc. Treatment of EGFR-driven cancer with fewer side effects
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EP3738084A4 (en) 2018-01-08 2021-11-17 G1 Therapeutics, Inc. SUPERIOR G1T38 DOSING SCHEMES
JP2021514359A (ja) 2018-02-15 2021-06-10 ニューベイション・バイオ・インコーポレイテッドＮｕｖａｔｉｏｎ Ｂｉｏ Ｉｎｃ． キナーゼ阻害剤としての複素環式化合物
WO2019195959A1 (en) * 2018-04-08 2019-10-17 Cothera Biosciences, Inc. Combination therapy for cancers with braf mutation
US11633401B2 (en) 2018-07-06 2023-04-25 Memorial Sloan Kettering Cancer Center Combination therapy with MEK inhibitor and CDK4/6 inhibitor to treat pancreatic cancer
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TW202114667A (zh) * 2019-09-11 2021-04-16 大陸商江蘇恒瑞醫藥股份有限公司 Mek抑制劑與cdk4/6抑制劑聯合在製備治療腫瘤的藥物中的用途
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RU2015106524A (ru) 2016-09-20
RU2685250C2 (ru) 2019-04-17
TW201412316A (zh) 2014-04-01
CN104507474A (zh) 2015-04-08
CN104507474B (zh) 2018-01-02
IN2015DN00376A (https=) 2015-06-12
KR20150036146A (ko) 2015-04-07
JP2015523397A (ja) 2015-08-13
MX2015001122A (es) 2015-04-08
WO2014018725A1 (en) 2014-01-30
TWI599357B (zh) 2017-09-21
AR091876A1 (es) 2015-03-04
CA2874860C (en) 2020-06-23
CA2874860A1 (en) 2014-01-30
EP2877174A1 (en) 2015-06-03
JO3776B1 (ar) 2021-01-31
US20150164897A1 (en) 2015-06-18
BR112014033118A2 (pt) 2017-06-27
US9700557B2 (en) 2017-07-11
BR112014033118A8 (pt) 2023-01-31
AU2013295771B2 (en) 2016-08-11
HK1210721A1 (en) 2016-05-06
AU2013295771A1 (en) 2014-12-11
ES2778059T3 (es) 2020-08-07
EP2877174B1 (en) 2020-01-01
MX360045B (es) 2018-10-19
JP6320379B2 (ja) 2018-05-09

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