KR102076532B1 - 2-케토 카르복실산의 제조 방법 - Google Patents

2-케토 카르복실산의 제조 방법 Download PDF

Info

Publication number
KR102076532B1
KR102076532B1 KR1020177030286A KR20177030286A KR102076532B1 KR 102076532 B1 KR102076532 B1 KR 102076532B1 KR 1020177030286 A KR1020177030286 A KR 1020177030286A KR 20177030286 A KR20177030286 A KR 20177030286A KR 102076532 B1 KR102076532 B1 KR 102076532B1
Authority
KR
South Korea
Prior art keywords
salt
acid
culture broth
ion exchange
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020177030286A
Other languages
English (en)
Korean (ko)
Other versions
KR20170121313A (ko
Inventor
안드레아스 카라우
니콜라 모랭
로버트 게르스트마이르
Original Assignee
에보니크 오퍼레이션즈 게엠베하
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에보니크 오퍼레이션즈 게엠베하 filed Critical 에보니크 오퍼레이션즈 게엠베하
Publication of KR20170121313A publication Critical patent/KR20170121313A/ko
Application granted granted Critical
Publication of KR102076532B1 publication Critical patent/KR102076532B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/50—Polycarboxylic acids having keto groups, e.g. 2-ketoglutaric acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12R1/15—
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/15—Corynebacterium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/843—Corynebacterium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020177030286A 2009-06-05 2010-05-10 2-케토 카르복실산의 제조 방법 Active KR102076532B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09162079 2009-06-05
EP09162079.9 2009-06-05
PCT/EP2010/056345 WO2010139527A2 (en) 2009-06-05 2010-05-10 A method for the preparation of 2-keto carboxylic acid

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020117028941A Division KR20120036821A (ko) 2009-06-05 2010-05-10 2-케토 카르복실산의 제조 방법

Publications (2)

Publication Number Publication Date
KR20170121313A KR20170121313A (ko) 2017-11-01
KR102076532B1 true KR102076532B1 (ko) 2020-02-13

Family

ID=43016582

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020177030286A Active KR102076532B1 (ko) 2009-06-05 2010-05-10 2-케토 카르복실산의 제조 방법
KR1020117028941A Ceased KR20120036821A (ko) 2009-06-05 2010-05-10 2-케토 카르복실산의 제조 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020117028941A Ceased KR20120036821A (ko) 2009-06-05 2010-05-10 2-케토 카르복실산의 제조 방법

Country Status (7)

Country Link
US (1) US9879289B2 (https=)
EP (1) EP2438181A2 (https=)
JP (1) JP5882202B2 (https=)
KR (2) KR102076532B1 (https=)
CN (1) CN102459621B (https=)
BR (1) BRPI1012007A2 (https=)
WO (1) WO2010139527A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104302765B (zh) * 2012-04-27 2018-09-11 赢创工业化学有限公司 反馈抗性α-异丙基苹果酸合酶
DK2811028T3 (en) 2013-06-03 2017-05-01 Evonik Degussa Gmbh Process for Preparation of L-Valine Using Recombinant Coryn Bacteria Containing the Propionate Inducible IlvBN Operon
WO2018063423A1 (en) * 2016-09-30 2018-04-05 Dow Global Technologies Llc Processes to prepare elongated 2-ketoacids and c5-c10 compounds therefrom via genetic modifications to microbial metabolic pathways
US12168642B2 (en) * 2019-02-08 2024-12-17 Basf Se Process for producing 4,4′-dichlorodiphenyl sulfoxide
KR102344689B1 (ko) * 2020-09-01 2021-12-29 씨제이제일제당 주식회사 L-발린 생산 미생물 및 이를 이용한 l-발린 생산 방법
CN114507127A (zh) * 2020-11-17 2022-05-17 中国科学院上海高等研究院 一种2-酮基泛解酸的合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006082252A2 (en) * 2005-02-07 2006-08-10 Metabolic Explorer Method for the enzymatic production of alpha-ketobutyrate

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52108086A (en) * 1976-03-08 1977-09-10 Ajinomoto Co Inc Preparation of alpha-keto-acid
JPS5542550A (en) * 1978-09-22 1980-03-25 Nippon Kayaku Co Ltd Production of alpha-ketoacid
CA2321759A1 (en) * 1998-03-02 1999-09-10 Elankovan Ponnampalam Purification of organic acids using anion exchange chromatography
DE19907567B4 (de) 1999-02-22 2007-08-09 Forschungszentrum Jülich GmbH Verfahren zur mikrobiellen Herstellung von L-Valin
US6288275B1 (en) * 1999-07-09 2001-09-11 Henkel Corporation Separation and purification of carboxylic acids from fermentation broths
BR0215459A (pt) * 2002-01-03 2005-04-05 Staley Mfg Co A E Processo para purificar ácidos orgânicos tal como ácido láctico
DE10212322A1 (de) * 2002-03-20 2003-10-02 Degussa Herstellung von Alkalisalzen von alpha-Ketoncarbonsäuren
DE102005045301A1 (de) * 2005-09-22 2007-04-05 Degussa Ag Verfahren zur Herstellung von organisch-chemischen Verbindungen unter Verwendung coryneformer Bakterien
DE102007016715A1 (de) 2007-04-04 2008-10-09 Evonik Degussa Gmbh Nahrungsergänzungsmittel enthaltend alpha-Ketosäuren
DE102009016119A1 (de) 2009-04-03 2010-10-14 Evonik Degussa Gmbh Nahrungsergänzungsmittel enthaltend alpha-Ketosäuren zur Unterstützung der Diabetestherapie

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006082252A2 (en) * 2005-02-07 2006-08-10 Metabolic Explorer Method for the enzymatic production of alpha-ketobutyrate

Also Published As

Publication number Publication date
CN102459621B (zh) 2015-01-28
WO2010139527A3 (en) 2011-03-03
BRPI1012007A2 (pt) 2015-09-22
CN102459621A (zh) 2012-05-16
US20120065428A1 (en) 2012-03-15
KR20170121313A (ko) 2017-11-01
WO2010139527A2 (en) 2010-12-09
JP5882202B2 (ja) 2016-03-09
US9879289B2 (en) 2018-01-30
EP2438181A2 (en) 2012-04-11
KR20120036821A (ko) 2012-04-18
JP2012528577A (ja) 2012-11-15

Similar Documents

Publication Publication Date Title
KR102076532B1 (ko) 2-케토 카르복실산의 제조 방법
DK202100114U1 (en) Separation of 2'-fl from a fermentation broth
JP5541758B2 (ja) ミオイノシトール誘導体
JPH05130882A (ja) 発酵法によるｌ−イソロイシンの製造法
US20020006645A1 (en) Method for producing optically active compound
Hwang et al. The fermentation process for L-phenylalanine production using an auxotrophic regulatory mutant of Escherichia coli
JP2012528577A5 (https=)
CN105612257A (zh) 使用高沸点溶剂的尸胺纯化
US20210087060A1 (en) Method of Recovering Phosphori Acid from Fermentation Broth of Fermentation Waste Liquor and Reusing the Same
US20150252397A1 (en) Continuous biotransformation of substituted aromatic carboxylic acids to their selective aldehydes and alcohols
US20180355390A1 (en) Method to produce L-methionine by a fermentative production
CN104178540B (zh) 一种生物催化法合成腺苷蛋氨酸的方法
CN116199591A (zh) 左卡尼汀的产业化制备方法
NO167024B (no) Fremgangsmaate for rensing av karnitin.
JP4484027B2 (ja) 光学活性２―アルキル−ｄ−システインアミド又はその塩、及びこれらの化合物の製造方法。
JP3078599B2 (ja) Ｌ−３，４−ジヒドロキシフェニルセリン誘導体の製造法
WO2025109220A1 (en) Method of purification of ectoine and composition thereof
CA1322183C (en) Selective production of l-phenylserine isomers by shmt
CN110283862B (zh) 一种稳定同位素标记葡萄糖的制备方法
JP2011098934A (ja) Ｌ−カルニチンに含まれる不純物の除去方法
EP1829975A1 (de) Verfahren zur Herstellung chiralen 2-Hydroxy-4-(methylthio)buttersäureamids durch Nitrilhydratase-katalysierte Hydrolyse des entsprechenden chiralen 2-Hydroxy-4-(methylthio)buttersäurenitrils
US20230348353A1 (en) Method for recovering malonate from a fermentation broth
CN114395590A (zh) 一种微生物发酵生产左旋多巴的方法及应用
WO2022259458A1 (ja) （ｓ）－３－ハロゲノ－２－メチル－１，２－プロパンジオールを製造する方法
JP2009278914A (ja) 光学活性芳香族アミノ酸および光学活性芳香族アミノ酸アミドの製造方法

Legal Events

Date Code Title Description
A107 Divisional application of patent
PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A18-div-PA0104

St.27 status event code: A-0-1-A10-A16-div-PA0104

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T13-X000 Administrative time limit extension granted

St.27 status event code: U-3-3-T10-T13-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PN2301 Change of applicant

St.27 status event code: A-3-3-R10-R13-asn-PN2301

St.27 status event code: A-3-3-R10-R11-asn-PN2301

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-OTH-PR1001 (AS PROVIDED BY THE NATIONAL OFFICE)

Year of fee payment: 7