CN102459621B - 制备2-酮羧酸的方法 - Google Patents

制备2-酮羧酸的方法 Download PDF

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Publication number
CN102459621B
CN102459621B CN201080024741.3A CN201080024741A CN102459621B CN 102459621 B CN102459621 B CN 102459621B CN 201080024741 A CN201080024741 A CN 201080024741A CN 102459621 B CN102459621 B CN 102459621B
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acid
keto
salt
methods
genes encoding
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Chinese (zh)
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CN102459621A (zh
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A·卡劳
N·莫兰
R·格斯特迈尔
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Evonik Operations GmbH
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Evonik Degussa GmbH
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/50—Polycarboxylic acids having keto groups, e.g. 2-ketoglutaric acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/15—Corynebacterium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/843—Corynebacterium

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201080024741.3A 2009-06-05 2010-05-10 制备2-酮羧酸的方法 Active CN102459621B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09162079 2009-06-05
EP09162079.9 2009-06-05
PCT/EP2010/056345 WO2010139527A2 (en) 2009-06-05 2010-05-10 A method for the preparation of 2-keto carboxylic acid

Publications (2)

Publication Number Publication Date
CN102459621A CN102459621A (zh) 2012-05-16
CN102459621B true CN102459621B (zh) 2015-01-28

Family

ID=43016582

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080024741.3A Active CN102459621B (zh) 2009-06-05 2010-05-10 制备2-酮羧酸的方法

Country Status (7)

Country Link
US (1) US9879289B2 (https=)
EP (1) EP2438181A2 (https=)
JP (1) JP5882202B2 (https=)
KR (2) KR102076532B1 (https=)
CN (1) CN102459621B (https=)
BR (1) BRPI1012007A2 (https=)
WO (1) WO2010139527A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104302765B (zh) * 2012-04-27 2018-09-11 赢创工业化学有限公司 反馈抗性α-异丙基苹果酸合酶
DK2811028T3 (en) 2013-06-03 2017-05-01 Evonik Degussa Gmbh Process for Preparation of L-Valine Using Recombinant Coryn Bacteria Containing the Propionate Inducible IlvBN Operon
WO2018063423A1 (en) * 2016-09-30 2018-04-05 Dow Global Technologies Llc Processes to prepare elongated 2-ketoacids and c5-c10 compounds therefrom via genetic modifications to microbial metabolic pathways
US12168642B2 (en) * 2019-02-08 2024-12-17 Basf Se Process for producing 4,4′-dichlorodiphenyl sulfoxide
KR102344689B1 (ko) * 2020-09-01 2021-12-29 씨제이제일제당 주식회사 L-발린 생산 미생물 및 이를 이용한 l-발린 생산 방법
CN114507127A (zh) * 2020-11-17 2022-05-17 中国科学院上海高等研究院 一种2-酮基泛解酸的合成方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006082252A2 (en) * 2005-02-07 2006-08-10 Metabolic Explorer Method for the enzymatic production of alpha-ketobutyrate
EP1767616A2 (de) * 2005-09-22 2007-03-28 Degussa GmbH Verfahren zur Herstellung von L-Aminosäuren oder Ketosäuren unter Verwendung coryneformer Bakterien mit abgeschwächter aceE (pdhA) Expression

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52108086A (en) * 1976-03-08 1977-09-10 Ajinomoto Co Inc Preparation of alpha-keto-acid
JPS5542550A (en) * 1978-09-22 1980-03-25 Nippon Kayaku Co Ltd Production of alpha-ketoacid
CA2321759A1 (en) * 1998-03-02 1999-09-10 Elankovan Ponnampalam Purification of organic acids using anion exchange chromatography
DE19907567B4 (de) 1999-02-22 2007-08-09 Forschungszentrum Jülich GmbH Verfahren zur mikrobiellen Herstellung von L-Valin
US6288275B1 (en) * 1999-07-09 2001-09-11 Henkel Corporation Separation and purification of carboxylic acids from fermentation broths
BR0215459A (pt) * 2002-01-03 2005-04-05 Staley Mfg Co A E Processo para purificar ácidos orgânicos tal como ácido láctico
DE10212322A1 (de) * 2002-03-20 2003-10-02 Degussa Herstellung von Alkalisalzen von alpha-Ketoncarbonsäuren
DE102007016715A1 (de) 2007-04-04 2008-10-09 Evonik Degussa Gmbh Nahrungsergänzungsmittel enthaltend alpha-Ketosäuren
DE102009016119A1 (de) 2009-04-03 2010-10-14 Evonik Degussa Gmbh Nahrungsergänzungsmittel enthaltend alpha-Ketosäuren zur Unterstützung der Diabetestherapie

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006082252A2 (en) * 2005-02-07 2006-08-10 Metabolic Explorer Method for the enzymatic production of alpha-ketobutyrate
EP1767616A2 (de) * 2005-09-22 2007-03-28 Degussa GmbH Verfahren zur Herstellung von L-Aminosäuren oder Ketosäuren unter Verwendung coryneformer Bakterien mit abgeschwächter aceE (pdhA) Expression

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
THE ACCUMULATION OF KETO ACIDS AND ACETALDEHYDE BY A STRAIN OF NEUROSPORA INHIBITED BY THREONINE;R. P. Wagner etal;《Journal of biological chemistry》;19551231;第251卷;第251-252页 *

Also Published As

Publication number Publication date
WO2010139527A3 (en) 2011-03-03
BRPI1012007A2 (pt) 2015-09-22
CN102459621A (zh) 2012-05-16
US20120065428A1 (en) 2012-03-15
KR20170121313A (ko) 2017-11-01
WO2010139527A2 (en) 2010-12-09
JP5882202B2 (ja) 2016-03-09
KR102076532B1 (ko) 2020-02-13
US9879289B2 (en) 2018-01-30
EP2438181A2 (en) 2012-04-11
KR20120036821A (ko) 2012-04-18
JP2012528577A (ja) 2012-11-15

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Address after: Essen, Germany

Patentee after: Evonik Operations Limited

Address before: Essen, Germany

Patentee before: EVONIK DEGUSSA GmbH