KR102007516B1 - 신규한 인돌리진 유도체, 이의 생성을 위한 방법 및 이를 함유하는 약학적 조성물 - Google Patents

신규한 인돌리진 유도체, 이의 생성을 위한 방법 및 이를 함유하는 약학적 조성물 Download PDF

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KR102007516B1
KR102007516B1 KR1020167004588A KR20167004588A KR102007516B1 KR 102007516 B1 KR102007516 B1 KR 102007516B1 KR 1020167004588 A KR1020167004588 A KR 1020167004588A KR 20167004588 A KR20167004588 A KR 20167004588A KR 102007516 B1 KR102007516 B1 KR 102007516B1
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methyl
compound
formula
group
mmol
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KR20160034387A (ko
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아노드 레 티란
티에리 레 디궈레
제롬-베노이트 스탁
진-미첼 헨린
기욤 데 낭퇴이유
올리비어 제네스테
제임스 에드워드 폴 데이비슨
제임스 브루크 머래이
아이-젠 첸
Original Assignee
르 라보레또레 쎄르비에르
베르날리스 (알 앤드 디) 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020167004588A 2013-07-23 2014-07-22 신규한 인돌리진 유도체, 이의 생성을 위한 방법 및 이를 함유하는 약학적 조성물 Expired - Fee Related KR102007516B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR13/57265 2013-07-23
FR1357265A FR3008976A1 (fr) 2013-07-23 2013-07-23 "nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"
PCT/FR2014/051885 WO2015011397A1 (fr) 2013-07-23 2014-07-22 Nouveaux dérivés d'indolizine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent

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Publication Number Publication Date
KR20160034387A KR20160034387A (ko) 2016-03-29
KR102007516B1 true KR102007516B1 (ko) 2019-08-05

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KR1020167004588A Expired - Fee Related KR102007516B1 (ko) 2013-07-23 2014-07-22 신규한 인돌리진 유도체, 이의 생성을 위한 방법 및 이를 함유하는 약학적 조성물

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US (3) US9944620B2 (https=)
EP (1) EP3024833B1 (https=)
JP (1) JP6458029B2 (https=)
KR (1) KR102007516B1 (https=)
CN (1) CN105579450B (https=)
AP (1) AP2016008990A0 (https=)
AR (1) AR099913A1 (https=)
AU (1) AU2014294867B2 (https=)
BR (1) BR112016001328B1 (https=)
CA (1) CA2918217C (https=)
CL (1) CL2016000063A1 (https=)
CR (1) CR20160031A (https=)
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CY (1) CY1119652T1 (https=)
DK (1) DK3024833T3 (https=)
DO (1) DOP2016000014A (https=)
EA (1) EA030323B1 (https=)
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FR (1) FR3008976A1 (https=)
GE (1) GEP20176804B (https=)
GT (1) GT201600017A (https=)
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FR2986002B1 (fr) 2012-01-24 2014-02-21 Servier Lab Nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR3008976A1 (fr) * 2013-07-23 2015-01-30 Servier Lab "nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"
WO2018015526A1 (en) 2016-07-22 2018-01-25 Les Laboratoires Servier Combination of a bcl-2 inhibitor and a mcl-1 inhibitor, uses and pharmaceutical compositions thereof
WO2018158225A1 (en) 2017-02-28 2018-09-07 Les Laboratoires Servier Combination of a bcl-2 inhibitor and a mdm2 inhibitor, uses and pharmaceutical compositions thereof
MX2020003242A (es) 2017-09-22 2020-09-18 Jubilant Epipad LLC Compuestos heterociclicos como inhibidores de pad.
AU2018352142B2 (en) 2017-10-18 2022-08-25 Jubilant Epipad LLC Imidazo-pyridine compounds as PAD inhibitors
FR3072679B1 (fr) * 2017-10-25 2020-10-30 Servier Lab Nouveaux derives macrocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
KR20200085836A (ko) 2017-11-06 2020-07-15 주빌런트 프로델 엘엘씨 Pd1/pd-l1 활성화 억제제로서의 피리미딘 유도체
BR112020010322A2 (pt) 2017-11-24 2020-11-17 Jubilant Episcribe Llc composto da fórmula i; composto da fórmula ia; composto da fórmula ib; processo de preparação de compostos da fórmula i; composição farmacêutica; método para o tratamento e/ou prevenção de várias doenças; uso dos compostos; método para o tratamento de câncer; e método para o tratamento e/ou prevenção de uma afecção mediada por prmt5 ou um distúrbio proliferativo ou câncer
SG11202008950PA (en) 2018-03-13 2020-10-29 Jubilant Prodel LLC Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation
EP3969639B1 (en) * 2019-05-13 2025-03-12 Ecolab Usa Inc. 1,2,4-triazolo[1,5-a] pyrimidine derivative as copper corrosion inhibitor
AR125076A1 (es) * 2021-03-12 2023-06-07 Eil Therapeutics Inc Compuestos que tienen tetrahidroindolizina-1-carboxamida como inhibidores de bcl-2
US20250115577A1 (en) * 2021-12-29 2025-04-10 Eil Therapeutics, Inc. BCL-2 Inhibitors
CN120787162A (zh) 2022-05-20 2025-10-14 诺华股份有限公司 抗肿瘤化合物的抗体-药物缀合物及其使用方法
TW202540186A (zh) 2023-11-22 2025-10-16 瑞士商諾華公司 抗ｃｄ７抗體藥物結合物及其使用方法
PY24103486A (es) 2023-11-22 2025-06-06 Servier Lab Conjugados de anticuerpo anti-cd74-fármaco y métodos de uso de los mismos

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