KR102002581B1 - 혈액암 치료를 위한 hdac 저해제 및 프로테아좀 억제제 또는 면역조절성 약물을 포함하는 약학적 조합물 - Google Patents

혈액암 치료를 위한 hdac 저해제 및 프로테아좀 억제제 또는 면역조절성 약물을 포함하는 약학적 조합물 Download PDF

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KR102002581B1
KR102002581B1 KR1020160127767A KR20160127767A KR102002581B1 KR 102002581 B1 KR102002581 B1 KR 102002581B1 KR 1020160127767 A KR1020160127767 A KR 1020160127767A KR 20160127767 A KR20160127767 A KR 20160127767A KR 102002581 B1 KR102002581 B1 KR 102002581B1
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active ingredient
formula
combination
present
inhibitor
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KR1020160127767A
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Korean (ko)
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KR20180037507A (ko
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김수진
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주식회사 종근당
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Priority to KR1020160127767A priority Critical patent/KR102002581B1/ko
Application filed by 주식회사 종근당 filed Critical 주식회사 종근당
Priority to RU2019108930A priority patent/RU2721409C1/ru
Priority to BR112019006633A priority patent/BR112019006633A2/pt
Priority to JP2019537733A priority patent/JP2019529562A/ja
Priority to PCT/KR2017/011015 priority patent/WO2018066946A1/en
Priority to MX2019003907A priority patent/MX2019003907A/es
Priority to CN201780061019.9A priority patent/CN109789138A/zh
Priority to CA3038019A priority patent/CA3038019A1/en
Priority to AU2017338564A priority patent/AU2017338564B2/en
Priority to EP17858740.8A priority patent/EP3522891A4/en
Publication of KR20180037507A publication Critical patent/KR20180037507A/ko
Priority to ZA2019/02340A priority patent/ZA201902340B/en
Application granted granted Critical
Publication of KR102002581B1 publication Critical patent/KR102002581B1/ko
Priority to JP2020180411A priority patent/JP2021020953A/ja

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/4161,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/69Boron compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/005Enzyme inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05Dipeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020160127767A 2016-10-04 2016-10-04 혈액암 치료를 위한 hdac 저해제 및 프로테아좀 억제제 또는 면역조절성 약물을 포함하는 약학적 조합물 KR102002581B1 (ko)

Priority Applications (12)

Application Number Priority Date Filing Date Title
KR1020160127767A KR102002581B1 (ko) 2016-10-04 2016-10-04 혈액암 치료를 위한 hdac 저해제 및 프로테아좀 억제제 또는 면역조절성 약물을 포함하는 약학적 조합물
AU2017338564A AU2017338564B2 (en) 2016-10-04 2017-09-29 Pharmaceutical combinations of histone deacetylase inhibitor and proteasome inhibitor or immunomodulatory drug for the treatment of hematological cancer
JP2019537733A JP2019529562A (ja) 2016-10-04 2017-09-29 血液癌治療のためのhdac阻害剤およびプロテアソーム抑制剤または免疫調節性薬物を含む薬学的調合物
PCT/KR2017/011015 WO2018066946A1 (en) 2016-10-04 2017-09-29 Pharmaceutical combinations of histone deacetylase inhibitor and proteasome inhibitor or immunomodulatory drug for the treatment of hematological cancer
MX2019003907A MX2019003907A (es) 2016-10-04 2017-09-29 Combinaciones farmaceuticas de inhibidor de histona desacetilasa e inhibidor de proteasoma o farmaco inmunomodulador para el tratamiento de cancer hematologico.
CN201780061019.9A CN109789138A (zh) 2016-10-04 2017-09-29 用于治疗血液癌症的组蛋白脱乙酰酶抑制剂和蛋白酶体抑制剂或免疫调节药物的药物组合物
RU2019108930A RU2721409C1 (ru) 2016-10-04 2017-09-29 Фармацевтические комбинации ингибитора гистондеацетилаз и ингибитора протеасом или иммуномодулирующего лекарственного средства для лечения рака крови
BR112019006633A BR112019006633A2 (pt) 2016-10-04 2017-09-29 combinações farmacêuticas de inibidor de histona desacetilase e inibidor de proteassoma ou fármaco imunomodulador para o tratamento de câncer hematológico
EP17858740.8A EP3522891A4 (en) 2016-10-04 2017-09-29 PHARMACEUTICAL COMBINATIONS OF A HISTONE DEACETYLASE INHIBITOR AND PROTEASOM INHIBITOR OR IMMUNOMODULATOR FOR THE TREATMENT OF BLOOD CANCER DISEASES
CA3038019A CA3038019A1 (en) 2016-10-04 2017-09-29 Pharmaceutical combinations of histone deacetylase inhibitor and proteasome inhibitor or immunomodulatory drug for the treatment of hematological cancer
ZA2019/02340A ZA201902340B (en) 2016-10-04 2019-04-12 Pharmaceutical combinations of histone deacetylase inhibitor and proteasome inhibitor or immunomodulatory drug for the treatment of hematological cancer
JP2020180411A JP2021020953A (ja) 2016-10-04 2020-10-28 血液癌治療のためのhdac阻害剤およびプロテアソーム抑制剤または免疫調節性薬物を含む薬学的調合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020160127767A KR102002581B1 (ko) 2016-10-04 2016-10-04 혈액암 치료를 위한 hdac 저해제 및 프로테아좀 억제제 또는 면역조절성 약물을 포함하는 약학적 조합물

Publications (2)

Publication Number Publication Date
KR20180037507A KR20180037507A (ko) 2018-04-12
KR102002581B1 true KR102002581B1 (ko) 2019-07-22

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KR1020160127767A KR102002581B1 (ko) 2016-10-04 2016-10-04 혈액암 치료를 위한 hdac 저해제 및 프로테아좀 억제제 또는 면역조절성 약물을 포함하는 약학적 조합물

Country Status (11)

Country Link
EP (1) EP3522891A4 (pt)
JP (2) JP2019529562A (pt)
KR (1) KR102002581B1 (pt)
CN (1) CN109789138A (pt)
AU (1) AU2017338564B2 (pt)
BR (1) BR112019006633A2 (pt)
CA (1) CA3038019A1 (pt)
MX (1) MX2019003907A (pt)
RU (1) RU2721409C1 (pt)
WO (1) WO2018066946A1 (pt)
ZA (1) ZA201902340B (pt)

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JP7415973B2 (ja) 2021-02-12 2024-01-17 信越化学工業株式会社 化学増幅ポジ型レジスト組成物及びレジストパターン形成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013021032A1 (en) * 2011-08-11 2013-02-14 Janssen Pharmaceutica Nv Histone deacetylase inhibitors in combination with proteasome inhibitors and dexamethasone

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG156687A1 (en) * 2004-07-28 2009-11-26 Janssen Pharmaceutica Nv Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
CA2627923C (en) * 2005-11-10 2016-01-12 Topotarget Uk Limited Histone deacetylase (hdac) inhibitors (pxdlol) for the treatment of cancer
AU2007296256B2 (en) * 2006-09-15 2013-05-30 Janssen Pharmaceutica Nv Histone deacetylase inhibitors with combined activity on class-I and class-IIB histone deacetylases in combination with proteasome inhibitors
CA2750639A1 (en) * 2009-01-23 2010-07-29 Cancer Research Technology Limited Hedgehog pathway inhibitors
KR101168801B1 (ko) 2009-03-27 2012-07-25 주식회사종근당 신규한 하이드록사메이트 유도체, 이의 제조방법, 및 이를 함유하는 약제학적 조성물
WO2010124009A2 (en) * 2009-04-21 2010-10-28 Schering Corporation Fully human anti-vegf antibodies and methods of using
US8610434B2 (en) 2011-07-21 2013-12-17 ColdEdge Technologies, Inc. Cryogen-free cooling system for electron paramagnetic resonance system
TWI723266B (zh) * 2012-08-09 2021-04-01 美商西建公司 利用3-(4-((4-(嗎啉基甲基)苄基)氧基)-1-氧異吲哚啉-2-基)六氫吡啶-2,6-二酮治療癌症之方法
WO2015054175A1 (en) * 2013-10-11 2015-04-16 Acetylon Pharmaceuticals, Inc. Combinations of histone deactylase inhibitors and immunomodulatory drugs
WO2015087151A1 (en) * 2013-12-12 2015-06-18 Chong Kun Dang Pharmaceutical Corp. Novel azaindole derivatives as selective histone deacetylase (hdac) inhibitors and pharmaceutical compositions comprising the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013021032A1 (en) * 2011-08-11 2013-02-14 Janssen Pharmaceutica Nv Histone deacetylase inhibitors in combination with proteasome inhibitors and dexamethasone

Also Published As

Publication number Publication date
KR20180037507A (ko) 2018-04-12
CA3038019A1 (en) 2018-04-12
AU2017338564B2 (en) 2020-07-09
JP2021020953A (ja) 2021-02-18
JP2019529562A (ja) 2019-10-17
RU2721409C1 (ru) 2020-05-19
AU2017338564A1 (en) 2019-05-02
EP3522891A1 (en) 2019-08-14
MX2019003907A (es) 2019-08-05
CN109789138A (zh) 2019-05-21
WO2018066946A1 (en) 2018-04-12
ZA201902340B (en) 2020-08-26
BR112019006633A2 (pt) 2019-07-02
EP3522891A4 (en) 2020-04-15

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