ZA201902340B - Pharmaceutical combinations of histone deacetylase inhibitor and proteasome inhibitor or immunomodulatory drug for the treatment of hematological cancer - Google Patents
Pharmaceutical combinations of histone deacetylase inhibitor and proteasome inhibitor or immunomodulatory drug for the treatment of hematological cancerInfo
- Publication number
- ZA201902340B ZA201902340B ZA2019/02340A ZA201902340A ZA201902340B ZA 201902340 B ZA201902340 B ZA 201902340B ZA 2019/02340 A ZA2019/02340 A ZA 2019/02340A ZA 201902340 A ZA201902340 A ZA 201902340A ZA 201902340 B ZA201902340 B ZA 201902340B
- Authority
- ZA
- South Africa
- Prior art keywords
- inhibitor
- treatment
- histone deacetylase
- hematological cancer
- pharmaceutical combinations
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 229940079156 Proteasome inhibitor Drugs 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 230000002489 hematologic effect Effects 0.000 title 1
- 229940121372 histone deacetylase inhibitor Drugs 0.000 title 1
- 239000003276 histone deacetylase inhibitor Substances 0.000 title 1
- 229940124622 immune-modulator drug Drugs 0.000 title 1
- 239000003207 proteasome inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/005—Enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020160127767A KR102002581B1 (en) | 2016-10-04 | 2016-10-04 | Pharmaceutical combinations of histone deacetylase inhibitor and proteasome inhibitor or immunomodulatory drug for the treatment of hematological cancer |
| PCT/KR2017/011015 WO2018066946A1 (en) | 2016-10-04 | 2017-09-29 | Pharmaceutical combinations of histone deacetylase inhibitor and proteasome inhibitor or immunomodulatory drug for the treatment of hematological cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201902340B true ZA201902340B (en) | 2020-08-26 |
Family
ID=61832016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2019/02340A ZA201902340B (en) | 2016-10-04 | 2019-04-12 | Pharmaceutical combinations of histone deacetylase inhibitor and proteasome inhibitor or immunomodulatory drug for the treatment of hematological cancer |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP3522891A4 (en) |
| JP (2) | JP2019529562A (en) |
| KR (1) | KR102002581B1 (en) |
| CN (1) | CN109789138A (en) |
| AU (1) | AU2017338564B2 (en) |
| BR (1) | BR112019006633A2 (en) |
| CA (1) | CA3038019A1 (en) |
| MX (1) | MX2019003907A (en) |
| RU (1) | RU2721409C1 (en) |
| WO (1) | WO2018066946A1 (en) |
| ZA (1) | ZA201902340B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7415973B2 (en) | 2021-02-12 | 2024-01-17 | 信越化学工業株式会社 | Chemically amplified positive resist composition and resist pattern forming method |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1781639B1 (en) * | 2004-07-28 | 2012-01-25 | Janssen Pharmaceutica NV | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
| JP5377968B2 (en) * | 2005-11-10 | 2013-12-25 | トポターゲット ユーケー リミテッド | Histone deacetylase (HDAC) inhibitors used alone or in combination with chemotherapeutic drugs for cancer treatment |
| MX2009002925A (en) * | 2006-09-15 | 2009-03-31 | Janssen Pharmaceutica Nv | Histone deacetylase inhibitors with combined activity on class-i and class-iib histone deacetylases in combination with proteasome inhibitors. |
| EP2389068A4 (en) * | 2009-01-23 | 2012-07-18 | Cancer Rec Tech Ltd | Hedgehog pathway inhibitors |
| KR101168801B1 (en) * | 2009-03-27 | 2012-07-25 | 주식회사종근당 | Novel hydroxamate derivatives, method for the preparation thereof, and pharmaceutical composition containing the same |
| WO2010124009A2 (en) * | 2009-04-21 | 2010-10-28 | Schering Corporation | Fully human anti-vegf antibodies and methods of using |
| US8610434B2 (en) | 2011-07-21 | 2013-12-17 | ColdEdge Technologies, Inc. | Cryogen-free cooling system for electron paramagnetic resonance system |
| WO2013021032A1 (en) * | 2011-08-11 | 2013-02-14 | Janssen Pharmaceutica Nv | Histone deacetylase inhibitors in combination with proteasome inhibitors and dexamethasone |
| NZ628078A (en) * | 2012-08-09 | 2017-01-27 | Celgene Corp | Methods of treating cancer using 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione |
| CR20160200A (en) * | 2013-10-11 | 2016-08-29 | Acetylon Pharmaceuticals Inc | COMBINATIONS OF HISTONE DEACETILASE INHIBITORS AND IMMUNOMODULATING DRUGS |
| TR201900057T4 (en) * | 2013-12-12 | 2019-01-21 | Chong Kun Dang Pharmaceutical Corp | New azaindole derivatives and pharmaceutical compositions containing them as selective histone deacetylase (HDAC) inhibitors. |
-
2016
- 2016-10-04 KR KR1020160127767A patent/KR102002581B1/en active IP Right Grant
-
2017
- 2017-09-29 CN CN201780061019.9A patent/CN109789138A/en active Pending
- 2017-09-29 CA CA3038019A patent/CA3038019A1/en active Pending
- 2017-09-29 JP JP2019537733A patent/JP2019529562A/en active Pending
- 2017-09-29 RU RU2019108930A patent/RU2721409C1/en active
- 2017-09-29 AU AU2017338564A patent/AU2017338564B2/en not_active Ceased
- 2017-09-29 WO PCT/KR2017/011015 patent/WO2018066946A1/en unknown
- 2017-09-29 EP EP17858740.8A patent/EP3522891A4/en not_active Withdrawn
- 2017-09-29 MX MX2019003907A patent/MX2019003907A/en unknown
- 2017-09-29 BR BR112019006633A patent/BR112019006633A2/en not_active Application Discontinuation
-
2019
- 2019-04-12 ZA ZA2019/02340A patent/ZA201902340B/en unknown
-
2020
- 2020-10-28 JP JP2020180411A patent/JP2021020953A/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| MX2019003907A (en) | 2019-08-05 |
| JP2021020953A (en) | 2021-02-18 |
| JP2019529562A (en) | 2019-10-17 |
| WO2018066946A1 (en) | 2018-04-12 |
| AU2017338564A1 (en) | 2019-05-02 |
| AU2017338564B2 (en) | 2020-07-09 |
| BR112019006633A2 (en) | 2019-07-02 |
| CN109789138A (en) | 2019-05-21 |
| KR20180037507A (en) | 2018-04-12 |
| EP3522891A4 (en) | 2020-04-15 |
| KR102002581B1 (en) | 2019-07-22 |
| EP3522891A1 (en) | 2019-08-14 |
| CA3038019A1 (en) | 2018-04-12 |
| RU2721409C1 (en) | 2020-05-19 |
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