KR101995302B1 - 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 모노클로날 항체 - Google Patents

조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 모노클로날 항체 Download PDF

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Publication number
KR101995302B1
KR101995302B1 KR1020137028821A KR20137028821A KR101995302B1 KR 101995302 B1 KR101995302 B1 KR 101995302B1 KR 1020137028821 A KR1020137028821 A KR 1020137028821A KR 20137028821 A KR20137028821 A KR 20137028821A KR 101995302 B1 KR101995302 B1 KR 101995302B1
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seq
monoclonal antibody
residue
ser
tfpi
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Korean (ko)
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KR20140019428A (ko
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쯔오즈시 왕
존 머피
토비아스 마르쿠아르트
디터 모스마이어
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바이엘 헬스케어 엘엘씨
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020137028821A 2011-04-01 2012-03-30 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 모노클로날 항체 Expired - Fee Related KR101995302B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161471101P 2011-04-01 2011-04-01
US61/471,101 2011-04-01
PCT/US2012/031538 WO2012135671A2 (en) 2011-04-01 2012-03-30 Monoclonal antibodies against tissue factor pathway inhibitor (tfpi)

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020197018445A Division KR20190079698A (ko) 2011-04-01 2012-03-30 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 모노클로날 항체

Publications (2)

Publication Number Publication Date
KR20140019428A KR20140019428A (ko) 2014-02-14
KR101995302B1 true KR101995302B1 (ko) 2019-07-02

Family

ID=46932389

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020137028821A Expired - Fee Related KR101995302B1 (ko) 2011-04-01 2012-03-30 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 모노클로날 항체
KR1020197018445A Ceased KR20190079698A (ko) 2011-04-01 2012-03-30 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 모노클로날 항체

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KR1020197018445A Ceased KR20190079698A (ko) 2011-04-01 2012-03-30 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 모노클로날 항체

Country Status (37)

Country Link
US (5) US20140294832A1 (enExample)
EP (1) EP2694544B1 (enExample)
JP (4) JP6170903B2 (enExample)
KR (2) KR101995302B1 (enExample)
CN (2) CN103797030B (enExample)
AU (3) AU2012236296A1 (enExample)
BR (1) BR112013025376A2 (enExample)
CA (2) CA2831907C (enExample)
CL (1) CL2013002811A1 (enExample)
CO (1) CO6890074A2 (enExample)
CR (1) CR20130499A (enExample)
CU (1) CU20130128A7 (enExample)
CY (1) CY1121538T1 (enExample)
DK (1) DK2694544T3 (enExample)
DO (1) DOP2013000218A (enExample)
EA (2) EA034214B1 (enExample)
EC (1) ECSP13012913A (enExample)
ES (1) ES2722824T3 (enExample)
GT (1) GT201300229A (enExample)
HK (1) HK1243426A1 (enExample)
HR (1) HRP20190467T1 (enExample)
HU (1) HUE042706T2 (enExample)
IL (4) IL228633B (enExample)
LT (1) LT2694544T (enExample)
MX (1) MX2013011218A (enExample)
MY (2) MY165499A (enExample)
PE (1) PE20141149A1 (enExample)
PH (4) PH12013502039A1 (enExample)
PL (1) PL2694544T3 (enExample)
PT (1) PT2694544T (enExample)
RS (1) RS58633B1 (enExample)
SG (2) SG193594A1 (enExample)
SI (1) SI2694544T1 (enExample)
TR (1) TR201905101T4 (enExample)
UA (1) UA113623C2 (enExample)
WO (1) WO2012135671A2 (enExample)
ZA (1) ZA201308169B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5739816B2 (ja) 2008-12-19 2015-06-24 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ Ｔｆｐｉインヒビターおよび使用法
KR101745394B1 (ko) † 2008-12-22 2017-06-09 노보 노르디스크 에이/에스 조직 인자 경로 억제자에 대한 항체
SG183443A1 (en) 2010-03-01 2012-09-27 Bayer Healthcare Llc Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi)
WO2011115712A2 (en) 2010-03-19 2011-09-22 Baxter International Inc Tfpi inhibitors and methods of use
CA2831907C (en) * 2011-04-01 2020-03-24 Bayer Healthcare Llc Monoclonal antibodies against tissue factor pathway inhibitor (tfpi)
SI2827883T1 (sl) * 2012-03-21 2019-08-30 Baxalta GmbH Inhibitorji TFPI in postopki uporabe
RU2014143639A (ru) 2012-03-30 2016-05-27 Байер Хелскеа Ллк Регулируемые протеазой антитела
US9592297B2 (en) 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
CN105452298B (zh) 2013-03-15 2021-08-31 拜尔健康护理有限责任公司 改善药代动力学的具有跨pH范围差异结合的抗TFPI抗体变体
EP2970499B1 (en) 2013-03-15 2022-08-10 Novo Nordisk A/S Antibodies capable of specifically binding two epitopes on tissue factor pathway inhibitor
US10457743B2 (en) 2013-07-19 2019-10-29 Novo Nordisk A/S Antibodies recognizing the N-terminal part of tissue factor pathway inhibitor capable of eliciting pro-coagulant activity
ES2905085T3 (es) * 2014-09-17 2022-04-07 Novo Nordisk As Anticuerpos que pueden unirse a dos epítopos en el inhibidor de la vía del factor tisular (1-161)
WO2016137108A1 (en) 2015-02-25 2016-09-01 Mogam Biotechnology Institute Novel antibody binding to tfpi and composition comprising the same
PE20240142A1 (es) * 2015-08-19 2024-02-01 Pfizer Anticuerpos inhibidores via del factor tisular y usos de los mismos
US20210263052A1 (en) * 2018-07-25 2021-08-26 Sony Corporation Blood coagulation system analysis device
CN112442127A (zh) * 2019-08-29 2021-03-05 苏州康宁杰瑞生物科技有限公司 针对tfpi的单克隆抗体

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010017196A2 (en) * 2008-08-04 2010-02-11 Bayer Healthcare Llc Monoclonal antibodies against tissue factor pathway inhibitor (tfpi)
WO2010072691A1 (en) * 2008-12-22 2010-07-01 Novo Nordisk A/S Antibodies against tissue factor pathway inhibitor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06153985A (ja) * 1992-11-16 1994-06-03 Teijin Ltd モノクローナル抗体
SG183443A1 (en) * 2010-03-01 2012-09-27 Bayer Healthcare Llc Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi)
CA2831907C (en) * 2011-04-01 2020-03-24 Bayer Healthcare Llc Monoclonal antibodies against tissue factor pathway inhibitor (tfpi)
US9592297B2 (en) * 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
US8613919B1 (en) * 2012-08-31 2013-12-24 Bayer Healthcare, Llc High concentration antibody and protein formulations

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010017196A2 (en) * 2008-08-04 2010-02-11 Bayer Healthcare Llc Monoclonal antibodies against tissue factor pathway inhibitor (tfpi)
WO2010072691A1 (en) * 2008-12-22 2010-07-01 Novo Nordisk A/S Antibodies against tissue factor pathway inhibitor

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KR20190079698A (ko) 2019-07-05
CU20130128A7 (es) 2014-03-26
PH12019500440A1 (en) 2020-10-12
MY165499A (en) 2018-03-27
JP2017113019A (ja) 2017-06-29
IL283829A (en) 2021-07-29
IL274686A (en) 2020-06-30
IL228633B (en) 2018-03-29
GT201300229A (es) 2014-11-13
EP2694544B1 (en) 2019-01-23
PH12013502039B1 (en) 2013-12-16
AU2019201814A1 (en) 2019-04-04
KR20140019428A (ko) 2014-02-14
EP2694544A4 (en) 2015-03-25
CN107090046A (zh) 2017-08-25
TR201905101T4 (tr) 2019-05-21
SG10201602606UA (en) 2016-04-28
CN103797030A (zh) 2014-05-14
AU2012236296A1 (en) 2013-10-24
US20190194353A1 (en) 2019-06-27
CA3068997A1 (en) 2012-10-04
SG193594A1 (en) 2013-10-30
HK1243426A1 (zh) 2018-07-13
HRP20190467T1 (hr) 2019-05-03
LT2694544T (lt) 2019-04-25
CO6890074A2 (es) 2014-03-10
EA201991704A2 (ru) 2020-03-31
WO2012135671A2 (en) 2012-10-04
US20140294832A1 (en) 2014-10-02
SI2694544T1 (sl) 2019-06-28
CL2013002811A1 (es) 2014-02-28
JP2018172411A (ja) 2018-11-08
MY190951A (en) 2022-05-24
ZA201308169B (en) 2016-03-30
JP6170903B2 (ja) 2017-07-26
CA2831907A1 (en) 2012-10-04
DK2694544T3 (en) 2019-04-15
US20220041752A1 (en) 2022-02-10
JP2014511685A (ja) 2014-05-19
ECSP13012913A (es) 2014-02-28
PE20141149A1 (es) 2014-08-28
IL257145A (en) 2018-03-29
MX2013011218A (es) 2013-10-17
DOP2013000218A (es) 2013-11-15
PH12019500441A1 (en) 2020-10-12
WO2012135671A3 (en) 2012-12-13
IL274686B (en) 2021-09-30
HUE042706T2 (hu) 2019-07-29
IL228633A0 (en) 2013-12-31
PL2694544T3 (pl) 2019-07-31
JP2021019619A (ja) 2021-02-18
EA201991704A3 (ru) 2020-06-30
RS58633B1 (sr) 2019-05-31
BR112013025376A2 (pt) 2017-07-25
CA2831907C (en) 2020-03-24
JP6363747B2 (ja) 2018-07-25
EA034214B1 (ru) 2020-01-17
US20180194857A1 (en) 2018-07-12
CN103797030B (zh) 2017-05-31
NZ615969A (en) 2016-01-29
EA201301107A1 (ru) 2014-11-28
PH12013502039A1 (en) 2013-12-16
AU2017203105A1 (en) 2017-06-01
US20170107298A1 (en) 2017-04-20
EP2694544A2 (en) 2014-02-12
PH12019500439A1 (en) 2020-10-12
UA113623C2 (uk) 2017-02-27
ES2722824T3 (es) 2019-08-19
CR20130499A (es) 2013-10-24
PT2694544T (pt) 2019-04-02
CY1121538T1 (el) 2020-05-29

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