KR101995302B1 - 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 모노클로날 항체 - Google Patents

조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 모노클로날 항체 Download PDF

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Publication number
KR101995302B1
KR101995302B1 KR1020137028821A KR20137028821A KR101995302B1 KR 101995302 B1 KR101995302 B1 KR 101995302B1 KR 1020137028821 A KR1020137028821 A KR 1020137028821A KR 20137028821 A KR20137028821 A KR 20137028821A KR 101995302 B1 KR101995302 B1 KR 101995302B1
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seq
monoclonal antibody
residue
ser
tfpi
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Korean (ko)
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KR20140019428A (ko
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쯔오즈시 왕
존 머피
토비아스 마르쿠아르트
디터 모스마이어
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바이엘 헬스케어 엘엘씨
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020137028821A 2011-04-01 2012-03-30 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 모노클로날 항체 Expired - Fee Related KR101995302B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161471101P 2011-04-01 2011-04-01
US61/471,101 2011-04-01
PCT/US2012/031538 WO2012135671A2 (en) 2011-04-01 2012-03-30 Monoclonal antibodies against tissue factor pathway inhibitor (tfpi)

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020197018445A Division KR20190079698A (ko) 2011-04-01 2012-03-30 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 모노클로날 항체

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Publication Number Publication Date
KR20140019428A KR20140019428A (ko) 2014-02-14
KR101995302B1 true KR101995302B1 (ko) 2019-07-02

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ID=46932389

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KR1020137028821A Expired - Fee Related KR101995302B1 (ko) 2011-04-01 2012-03-30 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 모노클로날 항체
KR1020197018445A Ceased KR20190079698A (ko) 2011-04-01 2012-03-30 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 모노클로날 항체

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KR1020197018445A Ceased KR20190079698A (ko) 2011-04-01 2012-03-30 조직 인자 경로 억제제 (ｔｆｐｉ)에 대한 모노클로날 항체

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US (5) US20140294832A1 (cg-RX-API-DMAC7.html)
EP (1) EP2694544B1 (cg-RX-API-DMAC7.html)
JP (4) JP6170903B2 (cg-RX-API-DMAC7.html)
KR (2) KR101995302B1 (cg-RX-API-DMAC7.html)
CN (2) CN107090046A (cg-RX-API-DMAC7.html)
AU (3) AU2012236296A1 (cg-RX-API-DMAC7.html)
BR (1) BR112013025376A2 (cg-RX-API-DMAC7.html)
CA (2) CA2831907C (cg-RX-API-DMAC7.html)
CL (1) CL2013002811A1 (cg-RX-API-DMAC7.html)
CO (1) CO6890074A2 (cg-RX-API-DMAC7.html)
CR (1) CR20130499A (cg-RX-API-DMAC7.html)
CU (1) CU20130128A7 (cg-RX-API-DMAC7.html)
CY (1) CY1121538T1 (cg-RX-API-DMAC7.html)
DK (1) DK2694544T3 (cg-RX-API-DMAC7.html)
DO (1) DOP2013000218A (cg-RX-API-DMAC7.html)
EA (2) EA201991704A3 (cg-RX-API-DMAC7.html)
EC (1) ECSP13012913A (cg-RX-API-DMAC7.html)
ES (1) ES2722824T3 (cg-RX-API-DMAC7.html)
GT (1) GT201300229A (cg-RX-API-DMAC7.html)
HK (1) HK1243426A1 (cg-RX-API-DMAC7.html)
HR (1) HRP20190467T1 (cg-RX-API-DMAC7.html)
HU (1) HUE042706T2 (cg-RX-API-DMAC7.html)
IL (4) IL228633B (cg-RX-API-DMAC7.html)
LT (1) LT2694544T (cg-RX-API-DMAC7.html)
MX (1) MX2013011218A (cg-RX-API-DMAC7.html)
MY (2) MY165499A (cg-RX-API-DMAC7.html)
PE (1) PE20141149A1 (cg-RX-API-DMAC7.html)
PH (4) PH12013502039B1 (cg-RX-API-DMAC7.html)
PL (1) PL2694544T3 (cg-RX-API-DMAC7.html)
PT (1) PT2694544T (cg-RX-API-DMAC7.html)
RS (1) RS58633B1 (cg-RX-API-DMAC7.html)
SG (2) SG10201602606UA (cg-RX-API-DMAC7.html)
SI (1) SI2694544T1 (cg-RX-API-DMAC7.html)
TR (1) TR201905101T4 (cg-RX-API-DMAC7.html)
UA (1) UA113623C2 (cg-RX-API-DMAC7.html)
WO (1) WO2012135671A2 (cg-RX-API-DMAC7.html)
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Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104984319B (zh) 2008-12-19 2025-05-09 武田药品工业株式会社 Tfpi抑制剂和使用方法
ES2458665T5 (es) † 2008-12-22 2021-06-30 Novo Nordisk As Anticuerpos contra el inhibidor de la vía del factor tisular
HUE047173T2 (hu) 2010-03-01 2020-04-28 Bayer Healthcare Llc Optimalizált monoklonális ellenanyagok szöveti faktor útvonal inhibitor (TFPI) ellen
EP3146977B1 (en) 2010-03-19 2024-05-08 Takeda Pharmaceutical Company Limited Tfpi inhibitors and methods of use
EA201991704A3 (ru) * 2011-04-01 2020-06-30 Байер Хелфкеа Ллк Моноклональные антитела против ингибитора пути тканевого фактора (tfpi)
KR102263685B1 (ko) 2012-03-21 2021-06-11 다케다 야쿠힌 고교 가부시키가이샤 Tfpi 저해제 및 사용 방법
KR20150030639A (ko) * 2012-03-30 2015-03-20 바이엘 헬스케어 엘엘씨 프로테아제로 조절된 항체
US9592297B2 (en) 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
ES2926773T3 (es) * 2013-03-15 2022-10-28 Novo Nordisk As Anticuerpos capaces de unirse específicamente a dos epítopos en el inhibidor de la ruta del factor tisular
SI2970497T1 (en) 2013-03-15 2018-04-30 Bayer Healthcare Llc Variants of anti-TFPI antibodies with differential binding over the pH range for improved pharmacokinetic properties
JP6584397B2 (ja) * 2013-07-19 2019-10-02 ノヴォ ノルディスク アー／エス 凝血促進活性を誘発することができる組織因子経路インヒビターのｎ末端部分を認識する抗体
ES2905085T3 (es) * 2014-09-17 2022-04-07 Novo Nordisk As Anticuerpos que pueden unirse a dos epítopos en el inhibidor de la vía del factor tisular (1-161)
CA2977621C (en) * 2015-02-25 2021-11-23 Mogam Institute For Biomedical Research Antibody binding to tfpi and composition comprising the same
SG10201912817YA (en) * 2015-08-19 2020-02-27 Pfizer Tissue factor pathway inhibitor antibodies and uses thereof
CN112424593A (zh) * 2018-07-25 2021-02-26 索尼公司 凝血系统分析装置
CN112442127A (zh) * 2019-08-29 2021-03-05 苏州康宁杰瑞生物科技有限公司 针对tfpi的单克隆抗体

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010017196A2 (en) * 2008-08-04 2010-02-11 Bayer Healthcare Llc Monoclonal antibodies against tissue factor pathway inhibitor (tfpi)
WO2010072691A1 (en) * 2008-12-22 2010-07-01 Novo Nordisk A/S Antibodies against tissue factor pathway inhibitor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06153985A (ja) * 1992-11-16 1994-06-03 Teijin Ltd モノクローナル抗体
HUE047173T2 (hu) * 2010-03-01 2020-04-28 Bayer Healthcare Llc Optimalizált monoklonális ellenanyagok szöveti faktor útvonal inhibitor (TFPI) ellen
EA201991704A3 (ru) * 2011-04-01 2020-06-30 Байер Хелфкеа Ллк Моноклональные антитела против ингибитора пути тканевого фактора (tfpi)
US9592297B2 (en) * 2012-08-31 2017-03-14 Bayer Healthcare Llc Antibody and protein formulations
US8613919B1 (en) * 2012-08-31 2013-12-24 Bayer Healthcare, Llc High concentration antibody and protein formulations

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010017196A2 (en) * 2008-08-04 2010-02-11 Bayer Healthcare Llc Monoclonal antibodies against tissue factor pathway inhibitor (tfpi)
WO2010072691A1 (en) * 2008-12-22 2010-07-01 Novo Nordisk A/S Antibodies against tissue factor pathway inhibitor

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CR20130499A (es) 2013-10-24
MX2013011218A (es) 2013-10-17
ECSP13012913A (es) 2014-02-28
TR201905101T4 (tr) 2019-05-21
PE20141149A1 (es) 2014-08-28
IL274686A (en) 2020-06-30
CN103797030A (zh) 2014-05-14
WO2012135671A2 (en) 2012-10-04
IL274686B (en) 2021-09-30
PH12019500439A1 (en) 2020-10-12
IL257145A (en) 2018-03-29
CA2831907C (en) 2020-03-24
AU2019201814A1 (en) 2019-04-04
RS58633B1 (sr) 2019-05-31
PL2694544T3 (pl) 2019-07-31
CN107090046A (zh) 2017-08-25
CA2831907A1 (en) 2012-10-04
ZA201308169B (en) 2016-03-30
PT2694544T (pt) 2019-04-02
EP2694544A4 (en) 2015-03-25
HRP20190467T1 (hr) 2019-05-03
SG193594A1 (en) 2013-10-30
US20190194353A1 (en) 2019-06-27
PH12019500441A1 (en) 2020-10-12
DK2694544T3 (en) 2019-04-15
MY165499A (en) 2018-03-27
ES2722824T3 (es) 2019-08-19
HUE042706T2 (hu) 2019-07-29
PH12013502039A1 (en) 2013-12-16
EA201991704A3 (ru) 2020-06-30
JP2018172411A (ja) 2018-11-08
WO2012135671A3 (en) 2012-12-13
AU2012236296A1 (en) 2013-10-24
UA113623C2 (uk) 2017-02-27
CU20130128A7 (es) 2014-03-26
IL228633B (en) 2018-03-29
IL283829A (en) 2021-07-29
AU2017203105A1 (en) 2017-06-01
EA034214B1 (ru) 2020-01-17
LT2694544T (lt) 2019-04-25
CN103797030B (zh) 2017-05-31
CO6890074A2 (es) 2014-03-10
JP2014511685A (ja) 2014-05-19
KR20140019428A (ko) 2014-02-14
DOP2013000218A (es) 2013-11-15
EA201991704A2 (ru) 2020-03-31
US20170107298A1 (en) 2017-04-20
NZ615969A (en) 2016-01-29
KR20190079698A (ko) 2019-07-05
CL2013002811A1 (es) 2014-02-28
GT201300229A (es) 2014-11-13
EP2694544A2 (en) 2014-02-12
JP6170903B2 (ja) 2017-07-26
US20220041752A1 (en) 2022-02-10
EP2694544B1 (en) 2019-01-23
CY1121538T1 (el) 2020-05-29
JP2017113019A (ja) 2017-06-29
EA201301107A1 (ru) 2014-11-28
BR112013025376A2 (pt) 2017-07-25
MY190951A (en) 2022-05-24
PH12019500440A1 (en) 2020-10-12
PH12013502039B1 (en) 2013-12-16
US20140294832A1 (en) 2014-10-02
SI2694544T1 (sl) 2019-06-28
SG10201602606UA (en) 2016-04-28
JP2021019619A (ja) 2021-02-18
CA3068997A1 (en) 2012-10-04
JP6363747B2 (ja) 2018-07-25
US20180194857A1 (en) 2018-07-12
HK1243426A1 (zh) 2018-07-13
IL228633A0 (en) 2013-12-31

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