KR101952453B1 - 수용체 특이성이 변경된 키메라 섬유모세포 성장 인자 - Google Patents

수용체 특이성이 변경된 키메라 섬유모세포 성장 인자 Download PDF

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KR101952453B1
KR101952453B1 KR1020127012353A KR20127012353A KR101952453B1 KR 101952453 B1 KR101952453 B1 KR 101952453B1 KR 1020127012353 A KR1020127012353 A KR 1020127012353A KR 20127012353 A KR20127012353 A KR 20127012353A KR 101952453 B1 KR101952453 B1 KR 101952453B1
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polypeptide
fgf19
chimeric
sequence
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KR20120095392A (ko
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주니치로 소노다
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제넨테크, 인크.
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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KR1020127012353A 2009-10-15 2010-10-15 수용체 특이성이 변경된 키메라 섬유모세포 성장 인자 Expired - Fee Related KR101952453B1 (ko)

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Application Number Priority Date Filing Date Title
US25207409P 2009-10-15 2009-10-15
US61/252,074 2009-10-15
PCT/US2010/052852 WO2011047267A1 (en) 2009-10-15 2010-10-15 Chimeric fibroblast growth factors with altered receptor specificity

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KR20120095392A KR20120095392A (ko) 2012-08-28
KR101952453B1 true KR101952453B1 (ko) 2019-02-26

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US (3) US8535912B2 (https=)
EP (1) EP2488643A4 (https=)
JP (1) JP6016636B2 (https=)
KR (1) KR101952453B1 (https=)
CN (1) CN102656266B (https=)
BR (1) BR112012008907A2 (https=)
CA (1) CA2777717C (https=)
MX (2) MX368790B (https=)
RU (1) RU2573896C2 (https=)
WO (1) WO2011047267A1 (https=)

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US8889621B2 (en) * 2009-10-30 2014-11-18 New York University Inhibiting binding of FGF23 to the binary FGFR-Klotho complex for the treatment of hypophosphatemia
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US9464126B2 (en) * 2012-06-07 2016-10-11 New York University Chimeric fibroblast growth factor 21 proteins and methods of use
US9657075B2 (en) 2012-06-07 2017-05-23 New York University Chimeric fibroblast growth factor 23 proteins and methods of use
US9474785B2 (en) 2012-06-07 2016-10-25 New York University Chimeric fibroblast growth factor 19 proteins and methods of use
US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
HK1214832A1 (zh) 2012-11-28 2016-08-05 恩格姆生物制药公司 用於代謝病症和疾病治療的組合物和方法
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US9550820B2 (en) 2013-02-22 2017-01-24 New York University Chimeric fibroblast growth factor 23/fibroblast growth factor 19 proteins and methods of use
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WO2015061331A1 (en) 2013-10-21 2015-04-30 Salk Institute For Biological Studies Chimeric fibroblast growth factor (fgf) 2/fgf1 peptides and methods of use
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CN103816533A (zh) * 2014-02-27 2014-05-28 中国药科大学 Fgf19通过抑制胆汁酸合成发挥抗炎作用的应用
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WO2017116207A1 (ko) * 2015-12-31 2017-07-06 한미약품 주식회사 Fgf21 아날로그, fgf21 결합체, 및 이의 용도
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CN112972654B (zh) * 2021-03-05 2022-07-01 温州医科大学慈溪生物医药研究院 Fgf21在制备治疗脑神经损伤的药物中的应用
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