KR101920503B1 - 변이된 프로토포르피리노겐 ix 산화효소(ppx) 유전자 - Google Patents

변이된 프로토포르피리노겐 ix 산화효소(ppx) 유전자 Download PDF

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KR101920503B1
KR101920503B1 KR1020137005453A KR20137005453A KR101920503B1 KR 101920503 B1 KR101920503 B1 KR 101920503B1 KR 1020137005453 A KR1020137005453 A KR 1020137005453A KR 20137005453 A KR20137005453 A KR 20137005453A KR 101920503 B1 KR101920503 B1 KR 101920503B1
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seq
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mutation
mutated ppx
plant
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KR20130093615A (ko
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그레고리 에프.떠블류. 고칼
피터 알. 비썸
오라 드 숍크
사라 덤
제임스 피어스
크리스찬 숍크
키스 에이. 월커
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시버스 유에스 엘엘씨
시버스 유럽 비.브이.
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8213—Targeted insertion of genes into the plant genome by homologous recombination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8274—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for herbicide resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
    • C12Y103/03—Oxidoreductases acting on the CH-CH group of donors (1.3) with oxygen as acceptor (1.3.3)
    • C12Y103/03004—Protoporphyrinogen oxidase (1.3.3.4)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
    • Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants

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  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Catching Or Destruction (AREA)
  • Enzymes And Modification Thereof (AREA)
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KR1020137005453A 2010-08-03 2011-08-02 변이된 프로토포르피리노겐 ix 산화효소(ppx) 유전자 Active KR101920503B1 (ko)

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US37043610P 2010-08-03 2010-08-03
US61/370,436 2010-08-03
PCT/US2011/046330 WO2012018862A2 (en) 2010-08-03 2011-08-02 Mutated protoporphyrinogen ix oxidase (ppx) genes

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KR20130093615A KR20130093615A (ko) 2013-08-22
KR101920503B1 true KR101920503B1 (ko) 2018-11-20

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EP (3) EP4534659A3 (cg-RX-API-DMAC10.html)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11111500B2 (en) 2010-08-03 2021-09-07 Cibus Us Llc Mutated protoporphyrinogen IX oxidase (PPX) genes

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA112969C2 (uk) * 2010-08-03 2016-11-25 Сібас Юс Ллс Рослина, стійка до одного або більше ррх-інгібуючих гербіцидів, яка містить мутантний ген протопорфіриноген ix оксидази (ррх)
JP6334169B2 (ja) 2010-12-16 2018-05-30 ビーエーエスエフ アグロ ベー．ブイ． 除草剤耐性の増大した植物
AR091489A1 (es) * 2012-06-19 2015-02-11 Basf Se Plantas que tienen una mayor tolerancia a herbicidas inhibidores de la protoporfirinogeno oxidasa (ppo)
US10041087B2 (en) 2012-06-19 2018-08-07 BASF Agro B.V. Plants having increased tolerance to herbicides
US9957515B2 (en) 2013-03-15 2018-05-01 Cibus Us Llc Methods and compositions for targeted gene modification
US12331303B2 (en) 2013-03-15 2025-06-17 Cibus Us Llc Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
IL290273B2 (en) * 2013-03-15 2024-03-01 Cibus Us Llc Methods and compositions for increasing efficiency of increased efficiency of targeted gene modification using oligonucleotide-mediated gene repair
EP3033426A4 (en) 2013-08-12 2017-08-02 BASF Agro B.V. Plants having increased tolerance to herbicides
BR112016002851B1 (pt) * 2013-08-12 2022-02-22 BASF Agro B.V. Molécula de ácido nucleico, constructo de ácido nucleico, vetor, polipeptídeo ppo, método para controlar vegetação indesejada e uso do ácido nucleico
CA3208184A1 (en) * 2014-03-14 2015-09-17 Cibus Us Llc Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
MX389329B (es) 2015-06-17 2025-03-11 Basf Agro Bv Plantas que tienen una mayor tolerancia a herbicidas.
BR112019022737A2 (pt) * 2017-05-05 2020-05-19 Inst Genetics & Developmental Biology Cas métodos para isolar células sem o uso de sequências marcadoras transgênicas
WO2018202199A1 (en) * 2017-05-05 2018-11-08 Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences Methods for isolating cells without the use of transgenic marker sequences
CN110093325B (zh) * 2019-02-27 2020-12-29 华中师范大学 烟草线粒体的原卟啉原氧化酶突变体及其编码基因和应用
CN115247157A (zh) * 2021-04-02 2022-10-28 青岛清原化合物有限公司 对ppo抑制剂类除草剂具有耐受性的ppo多肽及应用
CN118956784A (zh) 2021-04-02 2024-11-15 青岛清原种子科学有限公司 对ppo抑制剂类除草剂具有耐受性的ppo多肽及应用
WO2022233271A1 (en) * 2021-05-02 2022-11-10 Qingdao Kingagroot Chemical Compound Co., Ltd. Method for generating new gene in organism and use thereof
AU2023243482A1 (en) * 2022-03-29 2024-09-12 Qingdao Kingagroot Chemical Compound Co., Ltd. Ppo2 polypeptide having tolerance to ppo inhibitor herbicide and application

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050081259A1 (en) 1994-06-16 2005-04-14 Syngenta Participations Ag Herbicide tolerance achieved through plastid transformation
US20100100988A1 (en) * 2005-08-25 2010-04-22 Patrick Tranel Herbicide Resistance Gene, Compositions and Methods

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380831A (en) 1986-04-04 1995-01-10 Mycogen Plant Science, Inc. Synthetic insecticidal crystal protein gene
US5100792A (en) 1984-11-13 1992-03-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues
US4945050A (en) 1984-11-13 1990-07-31 Cornell Research Foundation, Inc. Method for transporting substances into living cells and tissues and apparatus therefor
US5569597A (en) 1985-05-13 1996-10-29 Ciba Geigy Corp. Methods of inserting viral DNA into plant material
US5268463A (en) 1986-11-11 1993-12-07 Jefferson Richard A Plant promoter α-glucuronidase gene construct
US5608142A (en) 1986-12-03 1997-03-04 Agracetus, Inc. Insecticidal cotton plants
US5302523A (en) 1989-06-21 1994-04-12 Zeneca Limited Transformation of plant cells
ES2187497T3 (es) 1990-04-12 2003-06-16 Syngenta Participations Ag Promotores preferentemente en tejidos.
US5204253A (en) 1990-05-29 1993-04-20 E. I. Du Pont De Nemours And Company Method and apparatus for introducing biological substances into living cells
US5498830A (en) 1990-06-18 1996-03-12 Monsanto Company Decreased oil content in plant seeds
US5399680A (en) 1991-05-22 1995-03-21 The Salk Institute For Biological Studies Rice chitinase promoter
DE4216134A1 (de) 1991-06-20 1992-12-24 Europ Lab Molekularbiolog Synthetische katalytische oligonukleotidstrukturen
JPH06510187A (ja) 1991-08-27 1994-11-17 ノバルティス　アクチエンゲゼルシャフト 同翅類昆虫に対する殺虫性質を有したタンパク質及び植物保護におけるそれらの用法
TW261517B (cg-RX-API-DMAC10.html) 1991-11-29 1995-11-01 Mitsubishi Shozi Kk
US5593874A (en) 1992-03-19 1997-01-14 Monsanto Company Enhanced expression in plants
IT230274Y1 (it) 1993-06-11 1999-06-02 Silc Spa Pannolone assorbente sagomato per incontinenza
DK0733059T3 (da) 1993-12-09 2000-10-16 Univ Jefferson Forbindelser og fremgangsmåder til site-rettede mutationer i eukaryote celler
ES2203635T3 (es) 1994-04-27 2004-04-16 Novartis Ag Nucleosidos y oligonucleotidos con grupos 2'-eter.
US5767373A (en) * 1994-06-16 1998-06-16 Novartis Finance Corporation Manipulation of protoporphyrinogen oxidase enzyme activity in eukaryotic organisms
US5608144A (en) 1994-08-12 1997-03-04 Dna Plant Technology Corp. Plant group 2 promoters and uses thereof
US5780296A (en) 1995-01-17 1998-07-14 Thomas Jefferson University Compositions and methods to promote homologous recombination in eukaryotic cells and organisms
US5659026A (en) 1995-03-24 1997-08-19 Pioneer Hi-Bred International ALS3 promoter
US6084155A (en) 1995-06-06 2000-07-04 Novartis Ag Herbicide-tolerant protoporphyrinogen oxidase ("protox") genes
US20020073443A1 (en) * 1996-02-28 2002-06-13 Heifetz Peter B. Herbicide tolerance achieved through plastid transformation
HUP9900623A3 (en) * 1996-02-28 2001-11-28 Novartis Ag Promoters from plant protoporphyrinogen oxidase genes
US5731181A (en) 1996-06-17 1998-03-24 Thomas Jefferson University Chimeric mutational vectors having non-natural nucleotides
US5888983A (en) 1996-05-01 1999-03-30 Thomas Jefferson University Method and oligonucleobase compounds for curing diseases caused by mutations
US5760012A (en) 1996-05-01 1998-06-02 Thomas Jefferson University Methods and compounds for curing diseases caused by mutations
US6072050A (en) 1996-06-11 2000-06-06 Pioneer Hi-Bred International, Inc. Synthetic promoters
US6524613B1 (en) 1997-04-30 2003-02-25 Regents Of The University Of Minnesota Hepatocellular chimeraplasty
NZ500694A (en) 1997-04-30 2001-09-28 Univ Minnesota Use of chimeric mutational vector (CMV), a macromolecule and a ligand for cell surface receptor adhesion molecule (clatherin) in gene therapy; the CMV vector derived from REC2 homologous pairing with Ustilago maydis
AU748015B2 (en) 1997-08-05 2002-05-30 Valigen (Us), Inc. The use of mixed duplex oligonucleotides to effect localized genetic changes in plants
EP1020525A4 (en) 1997-09-11 2004-08-25 Nihon Nohyaku Co Ltd PROTOPORPHYRINOGEN OXIDASE, WHICH IS TOLERANT TO HERBICIDES NEEDING LIGHT
AU4545497A (en) 1997-10-07 1999-04-27 Embrapa-Empresa Brasileira De Pesquisa Agropecuaria A process for obtaining transgenic leguminous plants (leguminosae) containing exogenous dna
ES2270227T3 (es) 1998-02-26 2007-04-01 Pioneer Hi-Bred International, Inc. Promotor met-1 del maiz.
AU769868B2 (en) 1998-04-10 2004-02-05 Sumitomo Chemical Company, Limited A method for evaluating the ability of a compound to inhibit the protoporphyrinogen oxidase activity
US6010907A (en) 1998-05-12 2000-01-04 Kimeragen, Inc. Eukaryotic use of non-chimeric mutational vectors
US6004804A (en) 1998-05-12 1999-12-21 Kimeragen, Inc. Non-chimeric mutational vectors
US6271360B1 (en) 1999-08-27 2001-08-07 Valigen (Us), Inc. Single-stranded oligodeoxynucleotide mutational vectors
JP2003511049A (ja) * 1999-10-11 2003-03-25 バク、キョン−ウァン プロトポルフィリノーゲンオキシダーゼ遺伝子を利用した作物の収量またはバイオマスの増大方法
AU2001260114A1 (en) 2000-03-14 2001-09-24 Syngenta Participations Ag Protoporphyrinogen oxidase ("protox") genes
US6936467B2 (en) * 2000-03-27 2005-08-30 University Of Delaware Targeted chromosomal genomic alterations with modified single stranded oligonucleotides
BR122018070228B1 (pt) * 2007-10-05 2023-01-10 Cibus Europe B.V. Método para produção de planta brassica resistente à herbicida
HUE028066T2 (en) * 2008-07-31 2016-11-28 Anglo Netherlands Grain Bv Herbicide-resistant sunflower plants
NZ592464A (en) * 2008-09-26 2013-05-31 Basf Agrochemical Products Bv Herbicide resistant acetohydroxyacid synthase large subunit (AHAS) mutants and methods of use thereof
UA112969C2 (uk) * 2010-08-03 2016-11-25 Сібас Юс Ллс Рослина, стійка до одного або більше ррх-інгібуючих гербіцидів, яка містить мутантний ген протопорфіриноген ix оксидази (ррх)

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050081259A1 (en) 1994-06-16 2005-04-14 Syngenta Participations Ag Herbicide tolerance achieved through plastid transformation
US20100100988A1 (en) * 2005-08-25 2010-04-22 Patrick Tranel Herbicide Resistance Gene, Compositions and Methods

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Plant physiology, (1989)90, 1239-1242

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11111500B2 (en) 2010-08-03 2021-09-07 Cibus Us Llc Mutated protoporphyrinogen IX oxidase (PPX) genes
US12570993B2 (en) 2010-08-03 2026-03-10 Cibus Us Llc Mutated protoporphyrinogen IX oxidase (PPX) genes

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ZA202403837B (en) 2025-08-27
DK2600710T3 (en) 2018-10-22
CA2807035A1 (en) 2012-02-09
EP3441469B1 (en) 2024-11-20
JP2019004899A (ja) 2019-01-17
CN107384911A (zh) 2017-11-24
PL2600710T3 (pl) 2019-02-28
ZA202205535B (en) 2024-09-25
CN103327809A (zh) 2013-09-25
CN107384911B (zh) 2021-06-01
EP3441469A1 (en) 2019-02-13
AU2011285830B2 (en) 2015-09-24
JP6058536B2 (ja) 2017-01-11
JP7354205B2 (ja) 2023-10-02
WO2012018862A2 (en) 2012-02-09
EP4534659A2 (en) 2025-04-09
JP2016220685A (ja) 2016-12-28
MX348704B (es) 2017-06-26
JP7707250B2 (ja) 2025-07-14
CA3084764C (en) 2023-10-10
LT2600710T (lt) 2018-12-10
EP2600710A2 (en) 2013-06-12
JP6965219B2 (ja) 2021-11-10
JP2022023150A (ja) 2022-02-07
EA035397B1 (ru) 2020-06-05
EP2600710B1 (en) 2018-08-01
MX2020011389A (es) 2020-11-24
UA112969C2 (uk) 2016-11-25
IL224535B (en) 2019-05-30
NZ607627A (en) 2015-10-30
MX2013001299A (es) 2013-10-28
NZ761237A (en) 2024-08-30
CA3084764A1 (en) 2012-02-09
JP2023183416A (ja) 2023-12-27
KR20130093615A (ko) 2013-08-22
BR112013002543B1 (pt) 2020-10-27
JP6396958B2 (ja) 2018-09-26
WO2012018862A3 (en) 2012-05-31
ZA201301067B (en) 2017-08-30
NZ811395A (en) 2025-11-28
EP2600710A4 (en) 2014-01-22
JP2013545434A (ja) 2013-12-26
IN2013MN00188A (cg-RX-API-DMAC10.html) 2015-05-29
IL266730A (en) 2019-07-31
CA2807035C (en) 2020-09-01
EP4534659A3 (en) 2025-08-27
EA202090661A1 (ru) 2020-09-30
EA201390034A1 (ru) 2013-09-30
ES2688285T3 (es) 2018-10-31
MX376540B (es) 2025-03-07
SI2600710T1 (sl) 2019-01-31
AU2011285830A1 (en) 2013-03-21
IL294685A (en) 2022-09-01
CN113957091A (zh) 2022-01-21
JP2025143393A (ja) 2025-10-01
ZA201703129B (en) 2021-08-25
CL2013000341A1 (es) 2013-12-13
CN113957091B (zh) 2024-08-16
ZA201903183B (en) 2022-11-30
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