KR101892768B1 - Metap-2 저해제의 결정질 고체 및 그의 제조 및 이용 방법 - Google Patents

Metap-2 저해제의 결정질 고체 및 그의 제조 및 이용 방법 Download PDF

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Publication number
KR101892768B1
KR101892768B1 KR1020137014698A KR20137014698A KR101892768B1 KR 101892768 B1 KR101892768 B1 KR 101892768B1 KR 1020137014698 A KR1020137014698 A KR 1020137014698A KR 20137014698 A KR20137014698 A KR 20137014698A KR 101892768 B1 KR101892768 B1 KR 101892768B1
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crystalline
delete delete
dimethylaminoethoxy
cinnamoylpumagillol
solution
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Korean (ko)
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KR20140009994A (ko
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토마스 크로포드
헤일리 에이. 리스
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자프겐 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/32—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020137014698A 2010-11-09 2011-11-09 Metap-2 저해제의 결정질 고체 및 그의 제조 및 이용 방법 Expired - Fee Related KR101892768B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41165510P 2010-11-09 2010-11-09
US61/411,655 2010-11-09
PCT/US2011/059966 WO2012064838A1 (en) 2010-11-09 2011-11-09 Crystalline solids of a metap-2 inhibitor and methods of making and using same

Publications (2)

Publication Number Publication Date
KR20140009994A KR20140009994A (ko) 2014-01-23
KR101892768B1 true KR101892768B1 (ko) 2018-08-28

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KR1020137014698A Expired - Fee Related KR101892768B1 (ko) 2010-11-09 2011-11-09 Metap-2 저해제의 결정질 고체 및 그의 제조 및 이용 방법

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US (4) US8349891B2 (https=)
EP (1) EP2638023B1 (https=)
JP (1) JP6239977B2 (https=)
KR (1) KR101892768B1 (https=)
CN (2) CN103347870A (https=)
AU (1) AU2011326566B2 (https=)
BR (1) BR112013011550A2 (https=)
CA (1) CA2817199C (https=)
EA (1) EA029941B1 (https=)
ES (1) ES2610216T3 (https=)
IL (1) IL226238B (https=)
MX (1) MX2013005208A (https=)
MY (1) MY177039A (https=)
NZ (1) NZ610569A (https=)
PH (1) PH12013500934A1 (https=)
SG (1) SG190688A1 (https=)
UA (1) UA111479C2 (https=)
WO (1) WO2012064838A1 (https=)

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US8815309B2 (en) 2010-01-08 2014-08-26 Zafgen, Inc. Methods of treating a subject with benign prostate hyperplasia
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PH12013500934A1 (en) 2010-11-09 2022-10-24 Zafgen Inc Crystalline solids of a metap-2 inhibitor and methods of making and using same
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CN105431426A (zh) 2013-04-10 2016-03-23 新德发制药有限公司 Metap2抑制剂和治疗肥胖症的方法
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CN106432255A (zh) 2015-08-11 2017-02-22 扎夫根公司 烟曲霉素醇螺环化合物和制备和使用其的方法
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CN108697807B (zh) * 2016-01-11 2021-11-26 辛德弗雷克斯公司 代谢功能障碍引起的肿瘤的治疗
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US8735447B2 (en) 2014-05-27
PH12013500934A1 (en) 2022-10-24
US20130197078A1 (en) 2013-08-01
AU2011326566B2 (en) 2016-12-01
JP6239977B2 (ja) 2017-11-29
IL226238A0 (en) 2013-07-31
CA2817199C (en) 2019-01-15
CN106905267A (zh) 2017-06-30
EA029941B1 (ru) 2018-06-29
MY177039A (en) 2020-09-03
US20170087119A1 (en) 2017-03-30
EP2638023B1 (en) 2016-09-07
US9827221B2 (en) 2017-11-28
MX2013005208A (es) 2013-08-01
US9371312B2 (en) 2016-06-21
WO2012064838A1 (en) 2012-05-18
SG190688A1 (en) 2013-07-31
ES2610216T3 (es) 2017-04-26
AU2011326566A1 (en) 2013-05-30
EP2638023A1 (en) 2013-09-18
US8349891B2 (en) 2013-01-08
US20150018413A1 (en) 2015-01-15
KR20140009994A (ko) 2014-01-23
CA2817199A1 (en) 2012-05-18
UA111479C2 (uk) 2016-05-10
US20120316233A1 (en) 2012-12-13
BR112013011550A2 (pt) 2017-10-24
NZ610569A (en) 2015-06-26
EA201390675A1 (ru) 2013-08-30
JP2013543867A (ja) 2013-12-09
IL226238B (en) 2019-02-28
CN103347870A (zh) 2013-10-09

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