BR112013011550A2 - sólidos cristalinos de um inibidor de metap-2 e métodos para fazer e usar os mesmos - Google Patents

sólidos cristalinos de um inibidor de metap-2 e métodos para fazer e usar os mesmos

Info

Publication number
BR112013011550A2
BR112013011550A2 BR112013011550A BR112013011550A BR112013011550A2 BR 112013011550 A2 BR112013011550 A2 BR 112013011550A2 BR 112013011550 A BR112013011550 A BR 112013011550A BR 112013011550 A BR112013011550 A BR 112013011550A BR 112013011550 A2 BR112013011550 A2 BR 112013011550A2
Authority
BR
Brazil
Prior art keywords
metap
inhibitor
making
methods
crystalline solids
Prior art date
Application number
BR112013011550A
Other languages
English (en)
Portuguese (pt)
Inventor
A Reece Hayley
Crawford Thomas
Original Assignee
Zafgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zafgen Inc filed Critical Zafgen Inc
Publication of BR112013011550A2 publication Critical patent/BR112013011550A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/32—Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicinal Preparation (AREA)
BR112013011550A 2010-11-09 2011-11-09 sólidos cristalinos de um inibidor de metap-2 e métodos para fazer e usar os mesmos BR112013011550A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41165510P 2010-11-09 2010-11-09
PCT/US2011/059966 WO2012064838A1 (en) 2010-11-09 2011-11-09 Crystalline solids of a metap-2 inhibitor and methods of making and using same

Publications (1)

Publication Number Publication Date
BR112013011550A2 true BR112013011550A2 (pt) 2017-10-24

Family

ID=45048246

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013011550A BR112013011550A2 (pt) 2010-11-09 2011-11-09 sólidos cristalinos de um inibidor de metap-2 e métodos para fazer e usar os mesmos

Country Status (18)

Country Link
US (4) US8349891B2 (https=)
EP (1) EP2638023B1 (https=)
JP (1) JP6239977B2 (https=)
KR (1) KR101892768B1 (https=)
CN (2) CN106905267A (https=)
AU (1) AU2011326566B2 (https=)
BR (1) BR112013011550A2 (https=)
CA (1) CA2817199C (https=)
EA (1) EA029941B1 (https=)
ES (1) ES2610216T3 (https=)
IL (1) IL226238B (https=)
MX (1) MX2013005208A (https=)
MY (1) MY177039A (https=)
NZ (1) NZ610569A (https=)
PH (1) PH12013500934A1 (https=)
SG (1) SG190688A1 (https=)
UA (1) UA111479C2 (https=)
WO (1) WO2012064838A1 (https=)

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Also Published As

Publication number Publication date
IL226238A0 (en) 2013-07-31
CN106905267A (zh) 2017-06-30
EA201390675A1 (ru) 2013-08-30
MX2013005208A (es) 2013-08-01
ES2610216T3 (es) 2017-04-26
CN103347870A (zh) 2013-10-09
US8735447B2 (en) 2014-05-27
WO2012064838A1 (en) 2012-05-18
PH12013500934A1 (en) 2022-10-24
IL226238B (en) 2019-02-28
KR20140009994A (ko) 2014-01-23
UA111479C2 (uk) 2016-05-10
US20120316233A1 (en) 2012-12-13
KR101892768B1 (ko) 2018-08-28
SG190688A1 (en) 2013-07-31
JP2013543867A (ja) 2013-12-09
EA029941B1 (ru) 2018-06-29
EP2638023A1 (en) 2013-09-18
AU2011326566A1 (en) 2013-05-30
US20150018413A1 (en) 2015-01-15
US8349891B2 (en) 2013-01-08
MY177039A (en) 2020-09-03
US9827221B2 (en) 2017-11-28
US20130197078A1 (en) 2013-08-01
CA2817199A1 (en) 2012-05-18
CA2817199C (en) 2019-01-15
US20170087119A1 (en) 2017-03-30
NZ610569A (en) 2015-06-26
US9371312B2 (en) 2016-06-21
EP2638023B1 (en) 2016-09-07
JP6239977B2 (ja) 2017-11-29
AU2011326566B2 (en) 2016-12-01

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
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