KR101877587B1 - 다발성 경화증(ms)의 새로운 치료 - Google Patents

다발성 경화증(ms)의 새로운 치료 Download PDF

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Publication number
KR101877587B1
KR101877587B1 KR1020137010891A KR20137010891A KR101877587B1 KR 101877587 B1 KR101877587 B1 KR 101877587B1 KR 1020137010891 A KR1020137010891 A KR 1020137010891A KR 20137010891 A KR20137010891 A KR 20137010891A KR 101877587 B1 KR101877587 B1 KR 101877587B1
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South Korea
Prior art keywords
flubiprofen
pharmaceutical composition
coo
treatment
enantiomer
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Expired - Fee Related
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KR1020137010891A
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English (en)
Korean (ko)
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KR20140017494A (ko
Inventor
이름가르트 테제데
게르트 게이스링거
Original Assignee
프라운호퍼-게젤샤프트 추르 푀르데룽 데어 안제반텐 포르슝 에 파우
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Publication of KR20140017494A publication Critical patent/KR20140017494A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/132—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020137010891A 2010-11-03 2011-11-03 다발성 경화증(ms)의 새로운 치료 Expired - Fee Related KR101877587B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1018519.7A GB2485169A (en) 2010-11-03 2010-11-03 (R)-flurbiprofen for use in the treatment of multiple sclerosis
GB1018519.7 2010-11-03
PCT/EP2011/069319 WO2012059541A1 (en) 2010-11-03 2011-11-03 Novel treatment of multiple sclerosis (ms)

Publications (2)

Publication Number Publication Date
KR20140017494A KR20140017494A (ko) 2014-02-11
KR101877587B1 true KR101877587B1 (ko) 2018-07-11

Family

ID=43401688

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020137010891A Expired - Fee Related KR101877587B1 (ko) 2010-11-03 2011-11-03 다발성 경화증(ms)의 새로운 치료

Country Status (10)

Country Link
US (1) US20130309199A1 (https=)
EP (1) EP2635271A1 (https=)
JP (1) JP5903438B2 (https=)
KR (1) KR101877587B1 (https=)
CN (1) CN103209692A (https=)
BR (1) BR112013010883A2 (https=)
CA (1) CA2816911C (https=)
GB (1) GB2485169A (https=)
RU (1) RU2595861C2 (https=)
WO (1) WO2012059541A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017080989A1 (en) 2015-11-09 2017-05-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. (r)-fluriprofen for the prevention and/or treatment of diabetes
US12097292B2 (en) 2016-08-28 2024-09-24 Mapi Pharma Ltd. Process for preparing microparticles containing glatiramer acetate
HUE071047T2 (hu) 2016-08-31 2025-07-28 Mapi Pharma Ltd Glatiramer-acetátot tartalmazó depórendszerek
CN110382052A (zh) 2017-03-26 2019-10-25 Mapi医药公司 用于治疗进展型形式的多发性硬化症的格拉替雷储库系统
EP3709986B1 (en) 2017-11-14 2023-11-01 Merck Sharp & Dohme LLC Novel substituted biaryl compounds as indoleamine 2,3-dioxygenase (ido) inhibitors
CN111344287B (zh) 2017-11-14 2023-12-19 默沙东有限责任公司 作为吲哚胺2，3-双加氧酶(ido)抑制剂的新型取代的联芳基化合物
EA035792B1 (ru) * 2018-06-21 2020-08-11 Государственное Научное Учреждение "Институт Биоорганической Химии Национальной Академии Наук Беларуси" Лекарственное средство пролонгированного действия для лечения рассеянного склероза (варианты)
CN113880899B (zh) * 2020-10-30 2023-06-23 杭州拉林智能科技有限公司 黄酮苷-有机胺类神经激动剂复盐化合物及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008034244A1 (en) * 2006-09-21 2008-03-27 Waratah Pharmaceuticals Inc. The combination of a cyclohexanehexol and a nsaid for the treatment of neurodegenerative diseases
WO2008036733A2 (en) * 2006-09-19 2008-03-27 Myriad Genetics, Inc. Methods for treatment of vesicle transport disorders
WO2009083115A1 (de) * 2007-12-21 2009-07-09 Paz Arzneimittel-Entwicklungsgesellschaft Mbh Arzneimittel sowie deren herstellung und verwendung bei der behandlung von schmerzhaften neuropathien

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19907895A1 (de) * 1999-02-24 2000-11-16 Paz Arzneimittelentwicklung Verwendung von R-Arylpropionsäuren zur Herstellung von Arzneimitteln zur Behandlung von Erkrankungen bei Mensch und Tier, welche durch die Hemmung der Aktivierung von NF-kB therapeutisch beeinflußt werden können
EP1587798A4 (en) * 2003-01-14 2007-06-27 Merck & Co Inc GEMINAL DISUBSTITUTED SODIUM DERIVATIVES AS ABETA 42 SUBSTITUTING AGENTS
US20090162421A1 (en) * 2007-12-21 2009-06-25 Paz Arzneimittel-Entwicklungsgesellschaft Mbh Drugs as well as their production and use in the treatment of pain-associated neuropathies
RU2565066C2 (ru) * 2010-04-21 2015-10-20 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Производные 1-(2-фторбифенил-4-ил)-алкилкарбоновой кислоты для лечения транстиретинового амилоидоза

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008036733A2 (en) * 2006-09-19 2008-03-27 Myriad Genetics, Inc. Methods for treatment of vesicle transport disorders
WO2008034244A1 (en) * 2006-09-21 2008-03-27 Waratah Pharmaceuticals Inc. The combination of a cyclohexanehexol and a nsaid for the treatment of neurodegenerative diseases
WO2009083115A1 (de) * 2007-12-21 2009-07-09 Paz Arzneimittel-Entwicklungsgesellschaft Mbh Arzneimittel sowie deren herstellung und verwendung bei der behandlung von schmerzhaften neuropathien

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Roberto Furlan 등, Journal of Neuroimmunology, 2004, Vol. 150, pp. 10-19. *
Roberto Furlan 등, Journal of Neuroimmunology, 2004, Vol. 150, pp. 10-19. 1부. *
Roberto Furlan 등, Journal of Neuroimmunology, 2004, Vol. 150, pp. 10-19.*
Seok Jae Kang 등, J. Clin. Neurol., 2009, Vol. 5, pp. 146-148. *
Seok Jae Kang 등, J. Clin. Neurol., 2009, Vol. 5, pp. 146-148. 1부. *
Seok Jae Kang 등, J. Clin. Neurol., 2009, Vol. 5, pp. 146-148.*

Also Published As

Publication number Publication date
CA2816911A1 (en) 2012-05-10
RU2013125470A (ru) 2014-12-10
BR112013010883A2 (pt) 2016-09-13
GB2485169A (en) 2012-05-09
WO2012059541A1 (en) 2012-05-10
GB201018519D0 (en) 2010-12-15
KR20140017494A (ko) 2014-02-11
CN103209692A (zh) 2013-07-17
US20130309199A1 (en) 2013-11-21
JP5903438B2 (ja) 2016-04-13
EP2635271A1 (en) 2013-09-11
RU2595861C2 (ru) 2016-08-27
CA2816911C (en) 2018-09-25
JP2014505015A (ja) 2014-02-27

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