KR101868991B1 - 피라졸 유도체 및 그 의약용도 - Google Patents

피라졸 유도체 및 그 의약용도 Download PDF

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Publication number
KR101868991B1
KR101868991B1 KR1020147033887A KR20147033887A KR101868991B1 KR 101868991 B1 KR101868991 B1 KR 101868991B1 KR 1020147033887 A KR1020147033887 A KR 1020147033887A KR 20147033887 A KR20147033887 A KR 20147033887A KR 101868991 B1 KR101868991 B1 KR 101868991B1
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South Korea
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constipation
group
compound
day
administration
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Korean (ko)
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KR20150013671A (ko
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마사유키 이사지
마사아키 타케무라
히데토시 이사와
유키히코 호테이
이타루 미야시타
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깃세이 야쿠힌 고교 가부시키가이샤
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020147033887A 2012-05-07 2013-05-02 피라졸 유도체 및 그 의약용도 Expired - Fee Related KR101868991B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012105847 2012-05-07
JPJP-P-2012-105847 2012-05-07
PCT/JP2013/062755 WO2013168671A1 (ja) 2012-05-07 2013-05-02 ピラゾール誘導体及びその医薬用途

Publications (2)

Publication Number Publication Date
KR20150013671A KR20150013671A (ko) 2015-02-05
KR101868991B1 true KR101868991B1 (ko) 2018-06-19

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ID=49550709

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KR1020147033887A Expired - Fee Related KR101868991B1 (ko) 2012-05-07 2013-05-02 피라졸 유도체 및 그 의약용도

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Country Link
US (2) US9273085B2 (https=)
EP (1) EP2848254B1 (https=)
JP (2) JP5663699B2 (https=)
KR (1) KR101868991B1 (https=)
CN (1) CN104284665B (https=)
AU (1) AU2013258566B2 (https=)
BR (1) BR112014027841B1 (https=)
CA (1) CA2872002C (https=)
DK (1) DK2848254T3 (https=)
ES (1) ES2601127T3 (https=)
MX (1) MX359988B (https=)
PL (1) PL2848254T3 (https=)
PT (1) PT2848254T (https=)
RU (1) RU2602739C2 (https=)
WO (1) WO2013168671A1 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2687027T3 (es) 2010-11-04 2018-10-23 Albireo Ab Inhibidores de ibat para el tratamiento de enfermedades hepáticas
JP5663699B2 (ja) * 2012-05-07 2015-02-04 キッセイ薬品工業株式会社 ピラゾール誘導体及びその医薬用途
MY176162A (en) 2013-02-04 2020-07-24 Taisho Pharmaceutical Co Ltd Prophylactic or therapeutic drug for constipation
CN106659726A (zh) 2014-06-25 2017-05-10 Ea制药株式会社 固体制剂及其着色防止或着色减少方法
CA2952405A1 (en) * 2014-06-25 2015-12-30 Ea Pharma Co., Ltd. Solid formulation and method for stabilizing the same
WO2019191352A1 (en) 2018-03-28 2019-10-03 Avolynt Method for treating post-prandial hypoglycemia
CN112449637B (zh) 2018-06-05 2024-03-19 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
PL3810581T3 (pl) 2018-06-20 2025-04-28 Albireo Ab Modyfikacje kryształu odewiksibatu
US11801226B2 (en) 2018-06-20 2023-10-31 Albireo Ab Pharmaceutical formulation of odevixibat
US11007142B2 (en) 2018-08-09 2021-05-18 Albireo Ab Oral cholestyramine formulation and use thereof
US11549878B2 (en) 2018-08-09 2023-01-10 Albireo Ab In vitro method for determining the adsorbing capacity of an insoluble adsorbant
TWI835997B (zh) 2019-02-06 2024-03-21 瑞典商艾爾比瑞歐公司 苯并噻氮呯化合物及其用作膽酸調節劑之用途
CN118852054A (zh) 2019-02-06 2024-10-29 阿尔比里奥公司 苯并硫杂二氮杂环庚三烯化合物及其用作胆汁酸调节剂的用途
US11014898B1 (en) 2020-12-04 2021-05-25 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
EP4069247B1 (en) 2019-12-04 2025-03-26 Albireo AB Benzothiadiazepine compounds and their use as bile acid modulators
ES2973355T3 (es) 2019-12-04 2024-06-19 Albireo Ab Compuestos de benzotia(di)azepina y su uso como moduladores del ácido biliar
JP7696898B2 (ja) 2019-12-04 2025-06-23 アルビレオ・アクチボラグ ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
IL293379B2 (en) 2019-12-04 2026-04-01 Albireo Ab Benzothia(dia)azepine compounds and their use as bile acid modulators
EP4188541B1 (en) 2020-08-03 2024-12-25 Albireo AB Benzothia(di)azepine compounds and their use as bile acid modulators
CA3196488A1 (en) 2020-11-12 2022-05-19 Albireo Ab Odevixibat for treating progressive familial intrahepatic cholestasis (pfic)
BR112023010799A2 (pt) 2020-12-04 2023-10-03 Albireo Ab Compostos de benzotia(di)azepina e seus usos como moduladores de ácidos biliares
TW202313579A (zh) 2021-06-03 2023-04-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009084531A1 (ja) * 2007-12-27 2009-07-09 Kissei Pharmaceutical Co., Ltd. ピラゾール誘導体のモノセバシン酸塩
WO2009128421A1 (ja) * 2008-04-16 2009-10-22 キッセイ薬品工業株式会社 ピラゾール誘導体の１／２フマル酸塩

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004137245A (ja) 2002-08-23 2004-05-13 Kissei Pharmaceut Co Ltd ピラゾール誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体
TW200801012A (en) * 2006-04-26 2008-01-01 Piramed Ltd Phosphoinositide 3-kinase inhibitor compounds and methods of use
WO2011002001A1 (ja) * 2009-07-01 2011-01-06 キッセイ薬品工業株式会社 ピラゾール誘導体とビグアナイド薬との組み合わせ医薬
AR087701A1 (es) 2011-08-31 2014-04-09 Japan Tobacco Inc Derivados de pirazol con actividad inhibidora de sglt1
JP5663699B2 (ja) * 2012-05-07 2015-02-04 キッセイ薬品工業株式会社 ピラゾール誘導体及びその医薬用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009084531A1 (ja) * 2007-12-27 2009-07-09 Kissei Pharmaceutical Co., Ltd. ピラゾール誘導体のモノセバシン酸塩
WO2009128421A1 (ja) * 2008-04-16 2009-10-22 キッセイ薬品工業株式会社 ピラゾール誘導体の１／２フマル酸塩

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Diabetes Journal, 31(3), 86-91, 2003. *
Mdern Physician, 18(6), 717-719, 1998. *

Also Published As

Publication number Publication date
PL2848254T3 (pl) 2017-03-31
JP5663699B2 (ja) 2015-02-04
JP6105546B2 (ja) 2017-03-29
AU2013258566B2 (en) 2017-03-16
ES2601127T3 (es) 2017-02-14
CN104284665A (zh) 2015-01-14
PT2848254T (pt) 2016-10-05
CA2872002C (en) 2019-01-15
DK2848254T3 (en) 2016-10-31
CN104284665B (zh) 2016-11-16
HK1204773A1 (en) 2015-12-04
EP2848254A1 (en) 2015-03-18
EP2848254A4 (en) 2015-07-15
RU2602739C2 (ru) 2016-11-20
RU2014149181A (ru) 2016-06-27
BR112014027841B1 (pt) 2022-08-09
EP2848254B1 (en) 2016-08-03
MX2014013696A (es) 2015-02-05
CA2872002A1 (en) 2013-11-14
AU2013258566A1 (en) 2014-11-27
MX359988B (es) 2018-10-18
KR20150013671A (ko) 2015-02-05
BR112014027841A2 (pt) 2017-06-27
US20150141631A1 (en) 2015-05-21
US20160129031A1 (en) 2016-05-12
JP2015083580A (ja) 2015-04-30
BR112014027841A8 (pt) 2021-09-28
JPWO2013168671A1 (ja) 2016-01-07
US9694027B2 (en) 2017-07-04
WO2013168671A1 (ja) 2013-11-14
US9273085B2 (en) 2016-03-01

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